综述 Review

鹿科动物生理周期性骨质疏松特点及研究进展

  • 孙伟丽 ,
  • 赵海平 ,
  • 钟伟 ,
  • 李光玉
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  • 中国农业科学院特产研究所, 吉林省特种经济动物分子生物学国家重点实验室, 长春 130112
孙伟丽(1982-),女,黑龙江牡丹江人,博士,从事特种经济动物营养与饲养的研究。E-mail:sunweili@caas.cn

收稿日期: 2019-06-21

  网络出版日期: 2019-12-13

基金资助

国家重点研发计划(2018YFC1706602);吉林省医药健康技术攻关项目(20190304007YY)

Characteristics of Physiologic Periodicity Osteoporosis and Research Progresses in Cervidae

  • SUN Weili ,
  • ZHAO Haiping ,
  • ZHONG Wei ,
  • LI Guangyu
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  • Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Animal and Plant Sciences, Chinese Academy of Agriculture Sciences, Changchun 130112, China

Received date: 2019-06-21

  Online published: 2019-12-13

摘要

鹿科动物具有生理周期性骨质疏松的矿物质代谢特点,利用鹿科动物作为骨质疏松研究模型是未来的研究思路和方向。本文综述了鹿科动物骨质疏松代谢相关的研究进展,旨在利用代谢组学等技术,筛选负责调控骨质疏松恢复的关键因子,为进一步研究骨质疏松机理及寻找新的药物靶点提供理论依据和研究基础。

关键词: 骨质疏松; 鹿科动物

本文引用格式

孙伟丽 , 赵海平 , 钟伟 , 李光玉 . 鹿科动物生理周期性骨质疏松特点及研究进展[J]. 动物营养学报, 2019 , 31(12) : 5407 -5411 . DOI: 10.3969/j.issn.1006-267x.2019.12.003

Abstract

Cervidae has the features of mineral metabolism of physiological periodicity osteoporosis, using cervidae as an osteoporosis model is the future research ideas and directions. This paper summarizes the related research progress of osteoporosis metabolism in cervidae, aims to screen the key regulation factors for osteoporosis recovery using metabonomics and other techniques, to provide the theoretical basis and research basis for further study of osteoporosis mechanism and finding new drug targets.

Key words: osteoporosis; cervidae

参考文献

[1] BORSY A,PODANI J,STÉGER V,et al.Identifying novel genes involved in both deer physiological and human pathological osteoporosis[J].Molecular Genetics and Genomics,2009,281(3):301-313.  
[2] GYURJÁN I,Jr,MOLNÁR A,BORSY A,et al.Gene expression dynamics in deer antler:mesenchymal differentiation toward chondrogenesis[J].Molecular Genetics and Genomics,2007,277(3):221-235.  
[3] MOLNÁR A,GYURJÁN I,KORPOS É,et al.Identification of differentially expressed enes in the developing antler of red deer Cervus elaphus[J].Molecular Genetics and Genomics,2007,277(3):237-248.  
[4] STÉGER V,MOLNÁR A,BORSY A,et al.Antler development and coupled osteoporosis in the skeleton of red deer Cervus elaphus:expression dynamics for regulatory and effector genes[J].Molecular Genetics and Genomics,2010,284(4):273-287.  
[5] LI C Y,SUTTIE J M.Histological studies of pedicle skin formation and its transformation to antler velvet in red deer (Cervus elaphus)[J].Anatomical Record,2000,260(1):62-71.  
[6] SUTTIE J M,WENHAM G,KAY R N.Simple in vivo method for determining calcium and phosphorus content of the metacarpus of red deer using radiography[J].Veterinary Record,1983,113(17):393-394.  
[7] LI C Y,YANG F H,SHEPPARD A.Adult stem cells and mammalian epimorphic regeneration-insights from studying annual renewal of deer antlers[J].Current Stem Cell Research & Therapy,2009,4(3):237-251.  
[8] STEWART K M,BOWYER R T,KIE J G,et al.Antler size relative to body mass in moose:tradeoffs associated with reproduction[J].Alces,2000,36:77-83.
[9] CHAPMAN D I.Antler-bones of contention[J].Mammal Review,1975,5(4):121-172.  
[10] MEADOWS S D,HAKONSON T E.Contribution of tissues to body mass in elk[J].The Journal of Wildlife Management,1982,46(3):838-841.  
[11] MUIR P D,SYKES A R,BARRELL G K.Growth and mineralisation of antlers in red deer (Cervus elaphus)[J].New Zealand Journal of Agricultural Research,1987,30(3):305-315.  
[12] MUIR P D,SYKES A R,BARRELL G K.Calcium metabolism in red deer (Cervus elaphus) offered herbages during antlerogenesis:kinetic and stable balance studies[J].The Journal of Agricultural Science,1987,109(2):357-364.  
[13] MEISTER W W.Changes in histological structure of the long bones of white-tailed deer (Odocoileus virginianus) during the growth of the antlers[J].Anatomical Record,1956,124(4):709-721.  
[14] BANKS W J,Jr,EPLING G P,KAINER R A,et al.Antler growth and osteoporosis Ⅰ.Morphological and morphometric changes in the costal compacta during the antler growth cycle[J].Anatomical Record,1968,162(4):387-398.  
[15] BANKS W J,Jr,EPLING G P,KAINER R A,et al.Antler growth and osteoporosis Ⅱ.Gravimetric and chemical changes in the antler growth cycle[J].Anatomical Record,1968,162(4):399-406.  
[16] BAXTER B J,ANDREWS R N,BARRELL G K.Bone turnover associated with antler growth in red deer (Cervus elaphus)[J].Anatomical Record,1999,256(1):14-19.  
[17] PRITZKER K P H,GRYNPAS M D,BROWN R D.Bone quality and bone kinetics in cyclic osteoporosis[J].Conn Tiss Res,1989,22(1/2/3/4):910.
[18] HILLMAN J R,DAVIS R W,ABDELBAKI Y Z.Cyclic bone remodeling in deer[J].Calcified Tissue Research,1973,12(1):323-330.  
[19] BAKSI S N,NEWBREY J W.Bone metabolism during antler growth in female reindeer[J].Calcified Tissue International,1989,45(5):314-317.  
[20] MOEN R,PASTOR J.Simulating antler growth and energy,nitrogen,calcium and phosphorus metabolism in caribou[J].Rangifer,1996,10:85-98.
[21] TURNER A S.Animal models of osteoporosis-necessity and limitations[J].European Cells and Materials,2001,1:66-81.
[22] THORNDIKE E A,TURNER A S.In search of an animal model for postmenopausal diseases[J].Frontiers in Bioscience,1998,3:c17-c26.
[23] KANIS J A,MELTON Ⅲ L J,CHRISTIANSEN C,et al.The diagnosis of osteoporosis[J].Journal of Bone and Mineral Research,1994,9(8):1137-1141.
[24] KAMEL H K.Postmenopausal osteoporosis:etiology,current diagnostic strategies,and nonprescription interventions[J].Journal of Managed Care Pharmacy,2006,12(6):S4-S9.
[25] STEPHENSON D C,BROWN R D.Calcium kinetics in male white-tailed deer[J].The Journal of Nutrition,1984,114(6):1014-1024.  
[26] BROWN R D.Nutrition and antler development[M]//BUBENIK G A,BUBENIK A B.Horns,pronghorns,and antlers.New York,NY:Sptinger,1990.
[27] FRENCH C E,MCEWEN L C,MAGRUDER N D,et al.Nutrient requirements for growth and antler development in the white-tailed deer[J].The Journal of Wildlife Management,1956,20(3):221-232.  
[28] MUIR P D,SYKES A R.Effect of winter nutrition on antler development in red deer (Cervus elaphus):a field study[J].New Zealand Journal of Agricultural Research,1988,31(2):145-150.  
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