沃野千里 , 常美楠 , 高铎 , 孙鹏 . 黄芪多糖预防奶牛乳房炎的研究进展[J]. 动物营养学报, 2020 , 32(1) : 42 -47 . DOI: 10.3969/j.issn.1006-267x.2020.01.007

[1] TIAN X Y,ZHENG N,HAN R W,et al.Antimicrobial resistance and virulence genes of Streptococcus isolated from dairy cows with mastitis in China[J].Microbial Pathogenesis,2019,131:33-39.
[2] PAŞCA C,MǍRGHITAŞ L,DEZMIREAN D,et al.Medicinal plants based products tested on pathogens isolated from mastitis milk[J].Molecules,2017,22(9):E1473.
[3] VAN SOEST F J S,MOURITS M C M,BLANCO-PENEDO I,et al.Farm-specific failure costs of production disorders in European organic dairy herds[J].Preventive Veterinary Medicine,2019,168:19-29.
[4] HILLERTON J E,IRVINE C R,BRYAN M A,et al.Use of antimicrobials for animals in New Zealand,and in comparison with other countries[J].New Zealand Veterinary Journal,2017,65(2):71-77.  
[5] WANG J,JIA J Y,SONG L,et al.Extraction,structure,and pharmacological activities of astragalus polysaccharides[J].Applied Sciences,2019,9(1):122.
[6] 高杨,王洪芳,陈辉,等.饲粮添加黄芪多糖对蛋鸡免疫功能及肠道菌群的影响[J].动物营养学报,2011,23(3):447-451.
[7] FARAG M R,ELHADY W M,AHMED S Y A,et al.Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70,NF-κB and Nrf2/HO-1 pathway[J].Research in Veterinary Science,2019,124:137-148.
[8] 苗雨丹,张浩,许妍妍.黄芪多糖对致衰老模型小鼠氧自由基水平的影响[J].中国老年学杂志,2017,37(17):4193-4194.
[9] 贾红杰,史兆国,武书庚,等.山黄粉和黄芪多糖配伍使用对产蛋鸡生产性能、蛋品质、血清抗氧化和生化指标的影响[J].动物营养学报,2019,31(3):1334-1341.
[10] TSAI C C,WU H H,CHANG C P,et al.Calycosin-7-O-β-D-glucoside reduces myocardial injury in heat stroke rats[J].Journal of the Formosan Medical Association,2019,118(3):730-738.  
[11] 武彩红,蒋春茂,李玲,等.3种中药活性成分对猪圆环病毒2型疫苗免疫效果的影响[J].中国预防兽医学报,2017,39(8):611-615.
[12] 李万坤,郭福存,赵兴绪.天然免疫活性多糖替代抗生素添加剂的作用研究[J].家畜生态学报,2007,28(1):10-17.
[13] FEENEY S,RYAN J T,KILCOYNE M,et al.Glycomacropeptide reduces intestinal epithelial cell barrier dysfunction and adhesion of entero-hemorrhagic and entero-pathogenic Escherichia coli in vitro[J].Foods,2017,6(11):93.
[14] BAMOLA V D,GHOSH A,KAPARDAR R K,et al.Gut microbial diversity in health and disease:experience of healthy Indian subjects,and colon carcinoma and inflammatory bowel disease patients[J].Microbial Ecology in Health and Disease,2017,28(1):1322447.
[15] CHE D S,ADAMS S,WEI C,et al.Effects of Astragalus membranaceus fiber on growth performance,nutrient digestibility,microbial composition,VFA production,gut pH,and immunity of weaned pigs[J].MicrobiologyOpen,2019,8(5):e00712.
[16] GUO L L,HUA J,LUAN Z H,et al.Effects of the stems and leaves of Astragalus membranaceus on growth performance,immunological parameters,antioxidant status,and intestinal bacteria of quail[J].Animal Science Journal,2019,90(6):747-756.  
[17] LIU Y M,LIU W,LI J,et al.A polysaccharide extracted from Astragalus membranaceus residue improves cognitive dysfunction by altering gut microbiota in diabetic mice[J].Carbohydrate Polymers,2019,205:500-512.
[18] SUN H L,WANG N J,CANG Z,et al.Modulation of microbiota-gut-brain axis by berberine resulting in improved metabolic status in high-fat diet-fed rats[J].Obesity Facts,2016,9(6):365-378.  
[19] YANG C M,HAN Q J,WANG K L,et al.Astragalus and ginseng polysaccharides improve developmental,intestinal morphological,and immune functional characters of weaned Piglets[J].Frontiers in Physiology,2019,10:418.
[20] RIVERA E,DAGGFELDT A,HU S,et al.Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and Erysipelothrix rhusiopathiae[J].Veterinary Immunology and Immunopathology,2003,91(1):19-27.  
[21] FAN Y P,MA L,ZHANG W M,et al.Liposome can improve the adjuvanticity of Astragalus polysaccharide on the immune response against ovalbumin[J].International Journal of Biological Macromolecules,2013,60:206-212.
[22] LI J F,ZHONG Y G,LI H R,et al.Enhancement of Astragalus polysaccharide on the immune responses in pigs inoculated with foot-and-mouth disease virus vaccine[J].International Journal of Biological Macromolecules,2011,49(3):362-368.  
[23] KALLON S,LI X R,JI J,et al.Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo[J].Journal of Animal Science and Biotechnology,2013,4(1):22.
[24] 林树乾,张燕,杨少华,等.中药黄芪多糖的免疫佐剂作用[J].中国畜牧兽医,2006,33(5):58-60.
[25] ZHANG Y Y,ZHU H Y,HUANG C G,et al.Astragaloside Ⅳ exerts antiviral effects against coxsackievirus B3 by upregulating interferon-γ[J].Journal of Cardiovascular Pharmacology,2006,47(2):190-195.  
[26] PING L,ZHAO H P,LUO Y M.Anti-aging implications of Astragalus membranaceus (Huangqi):a well-known Chinese tonic[J].Aging and Disease,2017,8(6):868-886.  
[27] 李维祖,李卫平,尹艳艳.黄芪总苷及黄芪甲苷对糖皮质激素诱导衰老大鼠氧自由基代谢的影响[J].中国中药杂志,2007,32(23):2539-2542.
[28] 王红丽,吴铁,钱聚标,等.D-半乳糖致衰老模型小鼠皮肤衰老的观察[J].中华老年医学杂志,2004,23(8):566-568.
[29] BI Y L,WANG Y J,QIN Y,et al.Prevalence of bovine mastitis pathogens in bulk tank milk in China[J].PLoS One,2016,11(5):e015562.
[30] 薛利娟,姬志勤,魏少鹏.扁茎黄芪植株中化学成分的分离鉴定及其抑菌活性[J].农药学学报,2019,21(3):389-394.
[31] 杨玉艾,杨林富,杨亮宇,等.黄芪多糖对奶牛乳房炎主要致病菌的体外抑菌作用[J].动物医学进展,2010,31(6):47-49.
[32] 李瑜,周玉,江冠民,等.枸杞多糖与黄芪多糖抑菌活性的研究[J].现代生物医学进展,2012,12(26):5061-5063.
[33] 郭丽丽,王小敏,秦楠,等.黄芪茎叶总皂苷提取物的抑菌活性研究[J].现代食品科技,2019,35(1):82-88.
[34] HARMON R J.Physiology of mastitis and factors affecting somatic cell counts[J].Journal of Dairy Science,1994,77(7):2103-2112.  
[35] NICKERSON S C,PANKEY J W.Neutrophil migration through teat end tissues of bovine mammary quarters experimentally challenged with Staphylococcus aureus[J].Journal of Dairy Science,1984,67(4):826-834.  
[36] CRAVEN N,WILLIAMS M R.Defences of the bovine mammary gland against infection and prospects for their enhancement[J].Veterinary Immunology and Immunopathology,1985,10(1):71-127.  
[37] 韩映梅,朱彤,王生华,等.中药方剂及黄芪素对奶牛乳房炎及其生产性能的影响[J].中兽医医药杂志,2014,33(5):38-39.
[38] 王彩玲,许鸿,张乐年.芪黄素对奶牛乳房炎及其生产性能影响的研究[J].畜牧兽医杂志,2018,37(5):20-22.
[39] 连慧香.发酵黄芪粉对奶牛产奶量及乳成分的影响研究[J].粮食与饲料工业,2015(1):46-48.
[40] 申义君.奶牛口服黄芪多糖对奶牛血液生理生化、口蹄疫抗体水平及抗氧化能力的影响研究[D].硕士学位论文.雅安:四川农业大学,2014:35-37.
[41] LINDEMANN S,SHARAFI M,SPIECKER M,et al.NO reduces PMN adhesion to human vascular endothelial cells due to downregulation of ICAM-1 mRNA and surface expression[J].Thrombosis Research,2000,97(3):113-123.  
[42] LIU X Q,LIU Y,RONG C,et al.Expression localization of angiotensin converting enzyme 2(ACE 2) in dairy cow mammary gland and its anti-inflammation effect[J].Acta Veterinaria et Zootechnica Sinica,2017,48(3):552-560.
[43] TAO H,LI N,ZHANG Z,et al.Erlotinib protects LPS-induced acute lung injury in mice by inhibiting EGFR/TLR4 signaling pathway[J].Shock,2019,51(1):131-138.  
[44] HE X X,WEI Z K,ZHOU E S,et al.Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-κB and MAPK signaling pathways in LPS-induced mastitis in mice[J].International Immunopharmacology,2015,28(1):470-476.  
[45] 孟云.黄芪多糖对LPS诱导奶牛乳腺上皮细胞凋亡的体外保护作用研究[D].硕士学位论文.合肥:安徽农业大学,2014:27-28.
[46] SMYTH M J,CRETNEY E,KERSHAW M H,et al.Cytokines in cancer immunity and immunotherapy[J].Immunological Reviews,2004,202(1):275-293.  
[47] 钟凯.动物乳腺炎的人工诱导及黄芪多糖等对乳腺的保护研究[D].博士学位论文.南京:南京农业大学,2005:88-89.
[48] 周丽菁,汪志学,龙婷婷,等.黄芪多糖在体外巨噬细胞-乳腺癌细胞共培养体系中的作用[J].免疫学杂志,2017,33(6):469-476.
[49] 王金虎,董娟聪,赵继学,等.不同相对分子质量一年生膜荚黄芪多糖对RAW264.7细胞炎症相关因子表达的影响[J].吉林大学学报(医学版),2011,37(6):1051-1056.
[50] SIDNEY L E,BRANCH M J,DUNPHY S E,et al.Concise review:evidence for CD34 as a common marker for diverse progenitors[J].Stem Cells,2014,32(6):1380-1389.  
[51] 张爽,张涛,滕可导,等.黄芪多糖对卵白蛋白致敏大鼠皮肤内微血管及肥大细胞的影响[J].中国农业大学学报,2010,15(1):67-71.
[52] BLASER H,DOSTERT C,MAK T W,et al.TNF and ROS crosstalk in inflammation[J].Trends in Cell Biology,2016,26(4):249-261.  
[53] RADIN L,ŠIMPRAGA M,VINCE S,et al.Metabolic and oxidative status of Saanen goats of different parity during the peripartum period[J].Journal of Dairy Research,2015,82(4):426-433.  
[54] MIRANDA S G,PURDIE N G,OSBORNE V R,et al.Selenomethionine increases proliferation and reduces apoptosis in bovine mammary epithelial cells under oxidative stress[J].Journal of Dairy Science,2011,94(1):165-173.  
[55] JÓŻWIK A,KRZYŻEWSKI J,STRZALKOWSKA N,et al.Relations between the oxidative status,mastitis,milk quality and disorders of reproductive functions in dairy cows-a review[J].Animal Science Papers and Reports,2012,30(4):297-307.
[56] 刘庆华,于军方,梁学武,等.奶牛HSP基因多态性与血清生化指标的相关性[J].福建农林大学学报(自然科学版),2009,38(2):160-165.
[57] 王义翠,刘延鑫,孙宇,等.不同水平黄芪多糖对早期断奶犊牛生长性能及抗氧化能力的影响[J].黑龙江畜牧兽医,2018(20):151-153,156.
[58] 曾涵芳,张林,陈孟姣,等.黄芪多糖对H₂O₂诱导的奶牛乳腺上皮细胞氧化损伤及凋亡的影响[J].南京农业大学学报,2019,42(5):903-910.
[59] 邓六勤,黎梅桂,吴宝仪.黄芪多糖的氧化降解及其抗氧化和抗肿瘤活性研究[J].中国药业,2018,27(1):13-16.
[60] 邱立红.中药黄芪及其活性成分对同型半胱氨酸所致的血管损伤的保护作用的研究[D].博士学位论文.杭州:浙江大学,2018:14-21.