综述 Review

葫芦巴生物学功能研究进展及其应用

  • 杨玲 ,
  • 马玉静 ,
  • 肖定福 ,
  • 贺建华
展开
  • 1. 湖南农业大学动物科学技术学院, 长沙 410128;
    2. 湖南畜禽安全生产协同创新中心, 长沙 410128
杨玲(1995-),女,湖南衡山人,硕士研究生,研究方向为动物营养与饲料科学。E-mail:763707648@qq.com

收稿日期: 2019-06-19

  网络出版日期: 2020-01-19

基金资助

国家自然科学基金项目(31872991);湖南农业大学"双一流"建设项目(kxk201801004);湖南省生猪产业技术体系项目

Research Progress in Biological Function Fenugreek and Its Application

  • YANG Ling ,
  • MA Yujing ,
  • XIAO Dingfu ,
  • HE Jianhua
Expand
  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2019-06-19

  Online published: 2020-01-19

Supported by

 

摘要

葫芦巴属一年生豆科草本植物,主要成分为半乳甘露聚糖、皂苷类、黄酮类、葫芦巴碱及4-羟基异亮氨酸等,还含有丰富的蛋白质以及维生素等成分,具有促生长、降血糖和血脂、抗氧化、抗炎及增强机体免疫力等多种生物学功能。本文主要回顾了葫芦巴的应用进展,介绍了葫芦巴的生物学功能及其在畜牧生产中的应用。

本文引用格式

杨玲 , 马玉静 , 肖定福 , 贺建华 . 葫芦巴生物学功能研究进展及其应用[J]. 动物营养学报, 2020 , 32(1) : 62 -70 . DOI: 10.3969/j.issn.1006-267x.2020.01.010

Abstract

Fenugreek is an annual leguminous herb with the main components of galactomannan, saponin, flavonoids, trigonelline and 4-hydroxyisoleucine and rich in protein and vitamins. Fenugreek has many biological functions such as improve growth performance, hypoglycemic, hypocholesterolemic, anti-oxidation, anti-inflammatory and enhance immunity. This article mainly reviewed the application progress of fenugreek and introduced the biological function of fenugreek and its application in livestock and poultry production.

参考文献

[1] 杨玲,夏嗣廷,胡睿智,等.丁酸梭菌的功能性研究进展及其在畜禽生产中的应用[J].中国畜牧兽医,2018,45(11):3077-3085.
[2] 唐茂妍,陈旭东.天然植物提取物替代饲用抗生素的应用研究进展[J].饲料博览,2018(12):17-22.
[3] SINGLETARY K W.Fenugreek:overview of potential health benefits[J].Nutrition Today,2017,52(2):93-111.  
[4] WANI A S,KUMAR P.Fenugreek:a review on its nutraceutical properties and utilization in various food products[J].Journal of the Saudi Society of Agricultural Sciences,2018,17(2):97-106.  
[5] 项昭保.葫芦巴超临界CO2提取物的GC-MS分析及对DPPH自由基的清除作用[J].食品工业科技,2016,37(24):153-156,162.
[6] THAKUR R S,AHIRWAR B.A steroidal derivative from Trigonella foenum graecum L. that induces apoptosis in vitro and in vivo[J].Journal of Food and Drug Analysis,2019,27(1):231-239.  
[7] 马波,王志军,付滨.葫芦巴的研究进展[J].湖南中医杂志,2018,34(8):243-246.
[8] 张宗沂.浅谈葫芦巴多糖及其展望[J].科技经济导刊,2018,26(17):156.
[9] MIRZAIE M,KHALILI M,KIASALARI Z,et al.Neuroprotective and antiapoptotic potential of trigonelline in a striatal 6-hydroxydopamine rat model of Parkinson's disease[J].Neurophysiology,2016,48(3):176-183.  
[10] 刘颖,郑彧,郭忠成,等.中药胡芦巴的研究进展[J].实用药物与临床,2017,20(1):98-101.
[11] FULLER S,STEPHENS J M.Diosgenin,4-hydroxyisoleucine,and fiber from fenugreek:mechanisms of actions and potential effects on metabolic syndrome[J].Advances in Nutrition,2015,6(2):189-197.  
[12] 李琳,高建德,陈正君,等.胡芦巴化学成分及其药理作用研究进展[J].甘肃中医药大学学报,2018,35(2):98-101.
[13] BROCA C,MANTEGHETTI M,GROSS R,et al.4-Hydroxyisoleucine:effects of synthetic and natural analogues on insulin secretion[J].European Journal of Pharmacology,2000,390(3):339-345.  
[14] 汪佳琦.胡芦巴降血糖组分协同增效作用机制研究[D].硕士学位论文.长春:吉林大学,2017.
[15] LU F R,CAI Q,ZAFAR M I,et al.4-hydroxyisoleucine improves hepatic insulin resistance by restoring glycogen synthesis in vitro[J].International Journal of Clinical and Experimental Medicine,2015,8(6):8626-8633.
[16] 刘永巧,魏颖,高佳琪,等.葫芦巴碱对HepG2细胞胰岛素抵抗的影响[J].中医药导报,2018,24(4):7-10.
[17] 王君花.胡芦巴降血糖组分的制备及活性研究[D].硕士学位论文.长春:吉林大学,2018.
[18] SRICHAMROEN A,THOMSON A B R,FIELD C J,et al.In vitro intestinal glucose uptake is inhibited by galactomannan from Canadian fenugreek seed (Trigonella foenum graecum L.) in genetically lean and obese rats[J].Nutrition Research,2009,29(1):49-54.  
[19] VATS V,YADAV S P,GROVER J K.Effect of T. foenumgraecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism[J].Journal of Ethnopharmacology,2003,85(2/3):237-242.
[20] GAD M Z,EL-SAWALHI M M,ISMAIL M F,et al.Biochemical study of the anti-diabetic action of the Egyptian plants Fenugreek and Balanites[J].Molecular and Cellular Biochemistry,2006,281(1/2):173-183.
[21] VIJAYAKUMAR M V,PANDEY V,MISHRA G C,et al.Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and upregulation of LDL receptor[J].Obesity,2010,18(4):667-674.  
[22] UEMURA T,GOTO T,KANG M S,et al.Diosgenin,the main aglycon of fenugreek,inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice[J].The Journal of Nutrition,2011,141(1):17-23.  
[23] 陈挚.胡芦巴调血脂有效部位筛选及其片剂的制备[D].硕士学位论文.银川:宁夏医科大学,2015.
[24] RAMULU P,GIRIDHARAN N V,UDAYASEKHARARAO P.Hypolipidemic effect of soluble dietary fiber (galactomannan) isolated from fenugreek seeds in WNIN (GR-Ob) obese rats[J].Journal of Medicinal Plants Research,2011,5(19):4804-4813.
[25] LI F,FERNANDEZ P P,RAJENDRAN P,et al.Diosgenin,a steroidal saponin,inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells[J].Cancer Letters,2010,292(2):197-207.  
[26] ABDEL-DAIM M M.Pharmacodynamic interaction of Spirulina platensis with erythromycin in Egyptian Baladi bucks (Capra hircus)[J].Small Ruminant Research,2014,120(2/3):234-241.
[27] ABDEL-DAIM M M,ABD ELDAIM M A,HASSAN A G A.Trigonella foenum-graecum ameliorates acrylamide-induced toxicity in rats:roles of oxidative stress,proinflammatory cytokines,and DNA damage[J].Biochemistry and Cell Biology,2015,93(3):192-198.  
[28] YOSHINARI O,AKENAKE A,IGARASHI K.Trigonelline ameliorates oxidative stress in type 2 diabetic Goto-Kakizaki rats[J].Journal of Medicinal Food,2013,16(1):34-41.  
[29] CORDA S,LAPLACE C,VICAUT E,et al.Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-α is mediated by ceramide[J].American Journal of Respiratory Cell and Molecular Biology,2001,24(6):762-768.  
[30] CHATTERJEE S,KUMAR M,KUMAR A.Chemomodulatory effect of Trigonella foenum graecum (L.) seed extract on two stage mouse skin carcinogenesis[J].Toxicology International,2012,19(3):287-294.  
[31] SINDHU G,RATHEESH M,SHYNI G L,et al.Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (fenugreek) on adjuvant induced arthritic rats[J].International Immunopharmacology,2012,12(1):205-211.  
[32] MADHAVA NAIDU M,SHYAMALA B N,PURA NAIK J,et al.Chemical composition and antioxidant activity of the husk and endosperm of fenugreek seeds[J].LWT-Food Science and Technology,2011,44(2):451-456.  
[33] GOYAL S,GUPTA N,KUMAR A,et al.Antibacterial,anticancer and antioxidant potential of silver nanoparticles engineered using Trigonella foenum-graecum seed extract[J].IET Nanobiotechnology,2018,12(4):526-533.  
[34] IRANMANESH M,MOHEBBATI R,FOROUZANFAR F,et al.In vivo and in vitro effects of ethanolic extract of Trigonella foenum-graecum L. seeds on proliferation,angiogenesis and tube formation of endothelial cells[J].Research in Pharmaceutical Sciences,2018,13(4):343-352.  
[35] XIONG J,CHENG G,TANG H F,et al.Ardipusilloside I induces apoptosis in human glioblastoma cells through a caspase-8-independent FasL/Fas-signaling pathway[J].Environmental Toxicology and Pharmacology,2009,27(2):264-270.  
[36] RIEDL S J,SHI Y G.Molecular mechanisms of caspase regulation during apoptosis[J].Nature Reviews Molecular Cell Biology,2004,5(11):897-907.  
[37] SHAFI G,MUNSHI A,HASAN T N,et al.Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa[J].Cancer Cell International,2009,9:29.
[38] ABAS A S M,NAGUIB D M.Effect of germination on anticancer activity of Trigonella foenum seeds extract[J].Biocatalysis and Agricultural Biotechnology,2019,18:101067.
[39] KHALIL M I M,IBRAHIM M M,EL-GAALY G A,et al.Trigonella foenum (fenugreek) induced apoptosis in hepatocellular carcinoma cell line,HepG2,mediated by upregulation of p53 and proliferating cell nuclear antigen[J].BioMed Research International,2015,2015:914645.
[40] JUNG D Y,PARK H J,BYUN H E,et al.Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2,JNK,NF-κB and AP-1 activation[J].International Immunopharmacology,2010,10(9):1047-1054.  
[41] EL-SEBAEY A,ABDELHAMID F,ABDALLA O,et al.Fenugreek (Trigonella foenum graecum) extract mitigates the cyclophosphamide induced immunosuppression,oxidative stress and genotoxicity in rats[J].Annals of Veterinary and Animal Science,2017,4(5):110-131.
[42] 郭亚春,赵晓菲,黄群,等.薯蓣皂苷元体外作用对胶原诱导性关节炎小鼠Th1/Th2型细胞因子的影响[J].中国老年学杂志,2018,38(13):3193-3196.
[43] BAE M J,SHIN H S,CHOI D W,et al.Antiallergic effect of Trigonella foenum-graecum L. extracts on allergic skin inflammation induced by trimellitic anhydride in BALB/c mice[J].Journal of Ethnopharmacology,2012,144(3):514-522.  
[44] JAN T R,WEY S P,KUAN C C,et al.Diosgenin,a steroidal sapogenin,enhances antigen-specific IgG2a and interferon-γ expression in ovalbumin-sensitized BALB/c mice[J].Planta Medica,2007,73(5):421-426.  
[45] ROMICS L,Jr,KODYS K,DOLGANIUC L,et al.Diverse regulation of NF-κB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver[J].Hepatology,2004,40(2):376-385.  
[46] CHOI K W,PARK H J,JUNG D H,et al.Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK,Akt and NF-κB signaling pathways[J].Vascular Pharmacology,2010,53(5/6):273-280.
[47] ALLOUI N,AKSA S B,ALLOUI M N,et al.Utilization of fenugreek (Trigonella foenum-graecum) as growth promoter for broiler chickens[J].Journal of World's Poultry Research,2012,2(2):25-27.
[48] TOAHA S M,MOLLAH B R,AHAMMAD M U.Use of dietary fenugreek (Trigonella foenum-graecum L.) seed for the production of safe broiler lean meat[J].Research in Agriculture Livestock and Fisheries,2016,3(2):305-314.  
[49] WEERASINGHA A S,ATAPATTU N S B M.Effects of fenugreek (Trigonella foenum-graecum L.) seed powder on growth performance,visceral organ weight,serum cholesterol levels and the nitrogen retention of broiler or chicken[J].Tropical Agricultural Research,2013,24(3):289-295.
[50] HOSSAIN M M,BEGUM M,NYACHOTI C M,et al.Dietary fenugreek seed extract improves performance and reduces fecal E. coli counts and fecal gas emission in lactating sows and suckling piglets[J].Canadian Journal of Animal Science,2015,95(4):561-568.  
[51] BEGUM M,HOSSAIN M M,KIM I H.Effects of fenugreek seed extract supplementation on growth performance,nutrient digestibility,diarrhoea scores,blood profiles,faecal microflora and faecal noxious gas emission in weanling piglets[J].Journal of Animal Physiology and Animal Nutrition,2016,100(6):1121-1129.  
[52] 颜陶,王思宇,杨小军,等.胡芦巴粉对肉仔鸡生长性能、肉品质、免疫器官指数及血清抗氧化和生化指标的影响[J].动物营养学报,2017,29(9):3248-3257.
[53] RAHIMIAN Y,AKBARI S M,KARAMI M,et al.Effect of different levels of Fenugreek powder supplementation on performance,influenza,sheep red blood cell,new castle diseases anti-body titer and intestinal microbial flora on Cobb 500 broiler chicks[J].Banat's Journal of Biotechnology,2018,9(19):29-37.
[54] GUARDIOLA F A,BAHI A,ESTEBAN A,et al.Effects of dietary administration of fenugreek seeds on metabolic parameters and immune status of gilthead seabream (Sparus aurata L.)[J].Fish & Shellfish Immunology,2018,74:372-379.
[55] YESUF K Y,MERSSO B T,BEKELE T E.Effects of different levels of turmeric,fenugreek and black cumin on carcass characteristics of broiler chicken[J].Journal of Livestock Science,2017,8:11-17.
[56] SINDHU G,SHYNI G L,PUSHPAN C K,et al.Evaluation of anti-arthritic potential of Trigonella foenum graecum L. (Fenugreek) mucilage against rheumatoid arthritis[J].Prostaglandins & Other Lipid Mediators,2018,138:48-53.
[57] PRABHU A,KRISHNAMOORTHY M.Anticancer activity of Trigonella foenum-graecum on Ehrlich Ascites carcinoma in Mus musculus system[J].Journal of Pharmacy Research,2010,3(6):1181-1183.
[58] HOSSAIN M M,BEGUM M,KIM I H.Effects of fenugreek (Trigonella foenum-graecum L.) seed extract supplementation in different energy density diets on growth performance,nutrient digestibility,blood characteristics,fecal microbiota,and fecal gas emission in growing pigs[J].Canadian Journal of Animal Science,2018,98(2):289-298.  
[59] ABDUL-RAHMAN S Y,SULTAN K H,TAHA A T,et al.The effect of use of fenugreek seeds on the reproductive performance of aged broiler breeder males[J].Journal of Tikrit University Agricultural Science,2010,10:156-163.
文章导航

/