综述 Review

烟酸调节动物肠道黏膜屏障功能的分子机制

  • 邱月琴 ,
  • 杨雪芬 ,
  • 王丽 ,
  • 蒋宗勇
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  • 1. 广东省农业科学院动物科学研究所, 畜禽育种国家重点实验室, 农业部华南动物营养与饲料重点实验室, 广东省动物育种与营养公共实验室, 广东省畜禽育种与营养重点实验室, 广州 510640;
    2. 华南农业大学动物科学学院, 广州 510640
邱月琴(1987-),女,广东湛江人,博士研究生,从事动物营养与饲料科学研究。E-mail:qiuyueqin87@126.com

收稿日期: 2019-08-05

  网络出版日期: 2020-02-21

基金资助

国家重点研发计划(2018YFD0500403,2018YFD0500600,2018YFD0501100);广东省现代农业产业技术体系生猪创新团队项目;广东省科技计划项目(2019A050505007);现代农业产业技术体系建设专项资金(CARS-35)

Molecule Mechanism of Niacin Regulate Intestinal Epithelial Barrier Function of Animals

  • QIU Yueqin ,
  • YANG Xuefen ,
  • WANG Li ,
  • JIANG Zongyong
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  • 1. Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science of Ministry of Agriculture in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China;
    2. College of Animal Science, South China Agricultural University, Guangzhou 510640, China

Received date: 2019-08-05

  Online published: 2020-02-21

摘要

作为一种重要的维生素,烟酸在抑制肠道炎症反应及维持肠道健康等方面发挥重要作用。研究表明,烟酸可以直接结合烟酸受体G蛋白偶联受体109A(GPR109A)发挥其生理作用,还能够以辅酶烟酰胺腺嘌呤二核苷酸(NAD+)的形式参与细胞能量代谢。本文主要阐述了烟酸维护肠道黏膜屏障功能的作用机制,为维护断奶仔猪肠道健康提供科学理论依据。

本文引用格式

邱月琴 , 杨雪芬 , 王丽 , 蒋宗勇 . 烟酸调节动物肠道黏膜屏障功能的分子机制[J]. 动物营养学报, 2020 , 32(2) : 481 -486 . DOI: 10.3969/j.issn.1006-267x.2020.02.001

Abstract

As an important vitamin, niacin plays important effects on prevention intestinal inflammation and maintaining intestinal healthy and other aspects. Research shows that niacin can directly bind to niacin receptor G protein-coupled receptor 109A (GPR109A) to play its physiological role, and partakes in cell energy metabolism in form of coenzyme nicotinamide adenine dinucleotide (NAD+). This review mainly expounded the mechanism of niacin maintaining intestinal mucosal barrier function, to provide the scientific theoretical basis for maintaining intestinal health of weaned piglets.

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