[1] JIANG T,LUO S,CHEN Q,et al.Effect of integrated application of gamma irradiation and modified atmosphere packaging on physicochemical and microbiological properties of shiitake mushroom (lentinus edodes)[J].Food Chemistry,2010,122(3):761-767.

[2] 陈孜,任国梅.薄层色谱方法鉴别香菇多糖的研究[J].广州医药,1996,27(6):48.
[3] WANG X,XU X,ZHANG L.Thermally induced conformation transition of triple-helical lentinan in NaCl aqueous solution[J].The Journal of Physical Chemistry B,2008,112(33):10343-10351.

[4] CHIHARA G,MAEDA Y,HAMURO J,et al.Inhibition of mouse sarcoma 180 by polysaccharides from lentinus edodes (Berk.)[J].Nature,1969,222(5194):687-688.

[5] YIN C,FAN X,FAN Z,et al.Optimization of enzymes-microwave-ultrasound assisted extraction of,lentinus edodes, polysaccharides and determination of its antioxidant activity[J].International Journal of Biological Macromolecules,2018,111:446-454.
[6] SHARMA S,KHANNA P K,KAPOOR S.Optimised isolation of polysaccharides from lentinula edodes strain NCBI JX915793 using response surface methodology and their antibacterial activities[J].Natural Product Research, 2016,30(5):616-621.

[7] REN G,XU L,LU T,et al.Structural characterization and antiviral activity of lentinan from,lentinus edodes, mycelia against infectious hematopoietic necrosis virus[J].International Journal of Biological Macromolecules,2018,115:1202-1210.
[8] LIU Y,ZHAO J,ZHAO Y,et al.Therapeutic effects of lentinan on inflammatory bowel disease and colitis ssociated cancer[J].Journal of Cellular and Molecular Medicine,2018,23(2):750-760.
[9] RAMBERG J E,NELSON E D,SINNOTT R A.Immunomodulatory dietary polysaccharides:a systematic review of the literature[J].Nutrition Journal,2010,9(1):54.
[10] ZHANG Y,LI S,WANG X,et al.Advances in lentinan:isolation,structure,chain conformation and bioactivities[J].Food Hydrocolloids,2011,25(2):196-206.

[11] SASAKI T.Further study of the structure of lentinan,and anti-tumor polysaccharide from lentinus edodes[J].Carbohydr Res,1976,47(1):99-104.

[12] HAZIME S,OHKI T,SASAKI T.A 13C-nuclear magnetic resonance study of polysaccharide gels.Molecular architecture in the gels consisting of fungal,branched (1→3)-β-
D-glucans (lentinan and schizophyllan) as manifested by conformational changes induced by sodium hydroxide[J].Carbohydrate Research,1979,74(1):227-240.

[13] ZHANG Y,XU X,ZHANG L.Gel formation and low-temperature intramolecular conformation transition of a triple-helical polysaccharide lentinan in water[J].Biopolymers,2010,89(10):852-861.
[14] PARRIS K.Astaxanthin,cell membrane nutrient with diverse clinical benefits and anti-aging potential[J].Alternative Medicine Review,2011,16(4):355-364.
[15] HUANG X,TU Z,JIANG Y,et al.Dynamic high pressure microfluidization-assisted extraction and antioxidant activities of lentinan[J].International Journal of Biological Macromolecules,2012,51(5):926-932.

[16] REN Z,LI J,SONG X,et al.The regulation of inflammation and oxidative status against lung injury of residue polysaccharides by lentinula edodes[J].International Journal of Biological Macromolecules,2018,106:185-192.
[17] REN Z,LIU W,SONG X,et al.Antioxidant and anti-inflammation of enzymatic-hydrolysis residue polysaccharides by lentinula edodes[J].International Journal of Biological Macromolecules,2018(08):114.
[18] BOONSONG S,KLAYPRADIT W,WILAIPUN P.Antioxidant activities of extracts from five edible mushrooms using different extractants[J].Agriculture and Natural Resources,2016,50(2):89-97.

[19] QIAN Y,WANG D,GAN M,et al.Effects of intrinsic metal ions of lentinan with different molecular weights from,lentinus edodes,on the antioxidant capacity and activity against proliferation of cancer cells[J].International Journal of Biological Macromolecules,2018,120(18):73-81.
[20] CHEUNG L M,CHEUNG P C K,OOI V E C.Antioxidant activity and total phenolics of edible mushroom extracts[J].Food Chemistry,2003,81(2):249-255.

[21] ITOH K,WAKABAYASHI N,KATOH Y,et al.Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles[J].Genes to Cells,2010,8(4):379-391.
[22] 王恬,张婧菲.姜黄素的理化特性、抗氧化功能及其在肉鸡生产中的应用[J].动物营养学报,2014,26(10):3101-3107.
[23] CHEN Q,PENG H,DONG L,et al.Activation of the Nrf2-ARE signalling pathway by the ledodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity[J].International Immunopharmacology,2016,36:1-8.
[24] LIU Q,DONG L,LI H,et al.Lentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB B-dependent manner[J].Oncology Reports,2016,36(1):315-323.

[25] XU X,YANG J,NING X.Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota[J].Food Funct,2015,6(8):2653-2663.

[26] LIU Y,ZHAO J,ZHAO Y,et al.Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer[J].Journal of Cellular and Molecular Medicine,2019,23(2):750-760.

[27] AHN H,JEONJ E,KIM J C,et al.Lentinan from shiitake selectivelyattenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production[J].Scientific Reports,2017,7(1):1314.
[28] POMERANTZ J Z,BALTIM O RE D.Two pathways to NF-κB[J].Molecular Cell,2002,10(4):693-695.

[29] 章静,杨成伟,王云,等.香菇多糖对脓毒症小鼠急性肺损伤的保护作用[J].中华医院感染学杂志,2018,28(10):1463-1468.
[30] 刘健雄,徐嘉辉,陈德明,等.香菇多糖对肿瘤坏死因子-α诱导炎症细胞模型的作用[J].海南医学,2017,28(15):2423-2425.
[31] WAJANT H,SCHEURICH P.TNFR1-induced activation of the classical NF-κB pathway[J].Febs Journal,2011,278(6):862-876.

[32] CHIN Y R,HORWITZ M S.Adenovirus RID complex enhances degradation of internalized tumour necrosis factor receptor 1 without affecting its rate of endocytosis[J].Journal of General Virology,2006,87(11):3161-3167.

[33] YOSUKE N,LING Z,MASARU Y,et al.Intestinal anti-inflammatory activity of lentinan:influence on
IL-8 and
TNFR1 expression in intestinal epithelial cells[J].Plos One,2013,8(4):e62441.
[34] DJORDJEVIC B,SKUGOR S,JØRGENSEN S M,et al.Modulation of splenic immune responses to bacterial lipopolysaccharide in rainbow trout (
Oncorhynchus mykiss) fed lentinan,a beta-glucan from mushroom lentinula edodes[J].Fish & Shellfish Immunology,2009,26(2):201-209.

[35] ASTASHKIN A V,ELMORE B O,CHEN L,et al.Pulsed ENDOR dete rmination of the arginine location in the ferrous-NO form of neuronal NOS[J].The Journal of Physical Chemistry A,2012,116(25):6731-6739.

[36] REN G,XU L,LU T,et al.Protective effects of lentinan on lipopolysaccharide induced inflammatory response in intestine of juvenile taimen (
Hucho taimen,pallas)[J].International Journal of Biological Macromolecules, 2019,121:317-325.
[37] MAO X,HU H,XIAO X,et al.Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model[J].Food & Function,2019,10(4):2094-2101.

[38] VAN NEVEL C J,DECUYPERE J A,DIERICK N,et al.The influence of lentinus edodes (shiitake mushroom) preparations on bacteriological and morphological aspects of the small intestine in piglets[J].Archives of Animal Nutrition,2003,57(6):399-412.

[39] GUO F C,WILLIAMS B A,KWAKKEL R P,et al.
In vitro fermentation characteristics of two mushroom species,an herb,and their polysaccharide fractions,using chicken cecal contents as inoculum[J].Poultry Science,2003,82(10):1608-1615.

[40] 江昌盛,周彤,张倩,等.香菇多糖对大肠杆菌攻毒大鼠空肠形态结构、上皮细胞数量和紧密连接蛋白表达的影响[J].动物营养学报,2017,29(10):3592-3597.
[41] SUGA Y,TAKEHANA K.Lentinan diminishes apoptotic bodies in the ileal crypts associated with S-1 administration[J].International Immunopharmacology,2017,50:55-60.
[42] YIPING J,XIANGLING L,YUN W,et al.Effect of lentinan on peyer's patch structure and function in an immunosuppressed mouse model[J].International Journal of Biological Macromolecules,2019,137:169-176.
[43] GUO F C,KWAKKLE R P,WILLLIAMS B A,et al.Effects of mushroom and herb polysaccharides,as alternatives for an antibiotic,on growth performance of broilers[J].British Poultry Science,2004,45(5):684-694.

[44] 楼月琴,杨菲菲.香菇多糖对肉鸡生长性能的影响研究[J].黑龙江畜牧兽医,2007(10):53-54.
[45] 雷莉辉,曹授俊,艾君涛,等.香菇多糖对肉仔鸡生产性能及新城疫疫苗免疫效果的影响[J].饲料研究,2017(3):22-25.
[46] 谢红兵,常新耀,苗志国,等.香菇多糖对肉仔鸡生产性能及免疫器官的影响[J].贵州农业科学,2011(9):149-151.
[47] 霍勤.香菇多糖对雉鸡生长及免疫性能的影响[J].贵州农业科学,2016,44(05):87-89.
[48] 雷莉辉,孙健,艾君涛,乔立东.香菇多糖对肉仔鸡生产性能和部分免疫指标的影响[J].黑龙江畜牧兽医,2017(14):164-166.
[49] CHEN H,LI D,CHANG B,et al.Effects of lentinan on broiler splenocyte proliferation,interleukin-2 production, and signal transduction[J].Poultry Science,2003,82(5):760-766.

[50] 刘鼎阔,朱宏吉,董惠峰,等.香菇多糖对断奶仔猪生产性能的影响[J].天津科技,2014,41(6):92-93.
[51] 薛凌峰.香菇多糖对仔猪生产性能、免疫功能及抗氧化能力影响的研究[D].硕士学位论文.保定:河北农业大学,2008.
[52] 李同洲,薛凌峰,臧素敏,等.香菇多糖对仔猪生产性能、部分血清激素和免疫指标的影响[J].动物营养学报,2009,21(1):101-106.
[53] WANG X,WANG W,WANG L,et al.Lentinan modulates intestinal microbiota and enhances barrier integrity in a piglet model challenged with lipopolysaccharide[J].Food & Function,2019,10(1):479-489.

[54] LAN L,GUANG C,CHANG-HONG Y U,et al.Regulatory effects of lentinan on the dysbacteria in intestinal tract of mice[J].Chinese Journal of Microecology,2013,44(4):529-542.