综述 Review

肠上皮细胞中内质网应激与动物肠道炎症机制的研究进展

  • 文伟 ,
  • 陈凤鸣 ,
  • 黄兴国 ,
  • 李颖慧
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  • 1. 湖南农业大学动物科学技术学院, 长沙 410128;
    2. 湖南省畜禽安全生产协同创新中心, 长沙 410128
文伟(1994-),男,湖南桃源人,硕士研究生,从事动物营养与饲料资源开发利用研究。E-mail:1554788022@qq.com

收稿日期: 2019-07-24

  网络出版日期: 2020-02-21

基金资助

国家自然科学基金青年科学基金项目(31802074);湖南省自然科学基金青年基金项目(2019JJ50264);农业领域重点研发项目(2017NK2310)

Research Progress of Endoplasmic Reticulum Stress and Intestinal Inflammation Mechanism in Intestinal Epithelial Cells

  • WEN Wei ,
  • CHEN Fengming ,
  • HUANG Xingguo ,
  • LI Yinghui
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  • 1. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China;
    2. Hunan Co-Innovation Center of Animal Production Safety, Changsha 410128, China

Received date: 2019-07-24

  Online published: 2020-02-21

摘要

近年来,内质网应激参与动物炎症性肠病发病机制的研究引起了广泛关注,未折叠或错误折叠的蛋白质在内质网腔中过量积累而引发内质网应激,持续的内质网应激则会导致动物肠黏膜屏障损伤并诱发肠道炎症。本文就内质网应激发生机制、未折叠蛋白质反应及内质网应激与肠道炎症互作机制进行了综述,旨在为防治动物肠道炎症提出新的治疗策略。

本文引用格式

文伟 , 陈凤鸣 , 黄兴国 , 李颖慧 . 肠上皮细胞中内质网应激与动物肠道炎症机制的研究进展[J]. 动物营养学报, 2020 , 32(2) : 530 -539 . DOI: 10.3969/j.issn.1006-267x.2020.02.007

Abstract

In recent years, the study of endoplasmic reticulum stress involved in the pathogenesis of inflammatory bowel disease in animals has caused wide attention, unfolded or misfolded proteins accumulate in the lumen of the endoplasmic reticulum and cause endoplasmic reticulum stress, persistent endoplasmic reticulum stress can lead to intestinal mucosal barrier damage and induce intestinal inflammation. This paper reviewed the endoplasmic reticulum stress relieving mechanism, unfolded protein response and interaction mechanism of endoplasmic reticulum stress with intestinal inflammation, aimd to propose a new therapeutic strategy for preventing and curing intestinal inflammation in animals.

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