综述 Review

夏季热应激导致奶牛乳蛋白含量降低的分子机制

  • 闵力 ,
  • 李大刚 ,
  • 童雄 ,
  • 王刚
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  • 广东省农业科学院动物科学研究所, 畜禽育种国家重点实验室, 农业部华南动物营养与饲料重点实验室, 广东省动物育种与营养公共实验室, 广东省畜禽育种与营养研究重点实验室, 广州 510640
闵力(1988-),男,江西九江人,助理研究员,博士,主要从事反刍动物营养研究。E-mail:min1988317@163.com

收稿日期: 2019-08-23

  网络出版日期: 2020-03-13

基金资助

广东省现代农业产业技术体系创新团队项目(2019KJ114);广东省自然科学基金项目(2018A030313002);广东省农业科学院院长基金项目(201809);郁南县科技计划项目(2018006)

Molecular Mechanism for Milk Protein Content Decreasing of Dairy Cows Caused by Heat Stress during Summer

  • MIN Li ,
  • LI Dagang ,
  • TONG Xiong ,
  • WANG Gang
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  • Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangzhou 510640, China

Received date: 2019-08-23

  Online published: 2020-03-13

摘要

夏季热应激是制约奶牛养殖业发展的重要因素之一。热应激导致奶牛乳蛋白含量显著降低,严重制约了乳品质。本文从蛋白质合成前体物——氨基酸的代谢和转运角度解析乳蛋白含量降低的原因,阐明热应激对乳腺中蛋白质合成信号通路和细胞凋亡相关蛋白的影响,从基因和蛋白质水平解析奶牛热应激后的生理变化,阐明其分子机制,为缓解夏季热应激奶牛的"乳蛋白降低症"提供理论与方法依据。

本文引用格式

闵力 , 李大刚 , 童雄 , 王刚 . 夏季热应激导致奶牛乳蛋白含量降低的分子机制[J]. 动物营养学报, 2020 , 32(3) : 983 -988 . DOI: 10.3969/j.issn.1006-267x.2020.03.002

Abstract

Heat stress is one of the important factors restricting the development of dairy industry during summer. Heat stress causes the decreasing of milk protein content significantly, which seriously restricts the quality of milk. This review focused on the perspective of amino acid metabolism and transport in order to analyze the reasons for the decreasing of milk protein content, illuminated the effects of heat stress on the milk protein synthesis signaling pathways and apoptosis-related proteins in mammary gland, analyzed the physiological changes of cows after heat stress from gene and protein levels and revealed its molecular mechanism, in order to provide theoretical foundations and bases to alleviate the "milk protein decrease syndrome" of heat-stressed dairy cows during summer.

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