刘华 , 贺建华 . 吡咯喹啉醌的生物学功能及其在动物营养中的应用[J]. 动物营养学报, 2020 , 32(3) : 1010 -1018 . DOI: 10.3969/j.issn.1006-267x.2020.03.006

[1] HAUGE J G.Glucose dehydrogenase of Bacterium anitratum:an enzyme with a novel prosthetic group[J].The Journal of Biological Chemistry,1964,239(11):3630-3639.
[2] SALISBURY S A,FORREST H S,CRUSE W B T,et al.A novel coenzyme from bacterial primary alcohol dehydrogenases[J].Nature,1979,280(5725):843-844.  
[3] DUINE J A,JZN J F,VAN ZEELAND J K.Glucose dehydrogenase from Acinetobacter calcoaceticus[J].FEBS Letters,1979,108(2):443-446.  
[4] DOOLEY D M.Structure and biogenesis of topaquinone and related cofactors[J].JBIC Journal of Biological Inorganic Chemistry,1999,4(1):1-11.  
[5] DUINE J A.Quinoproteins:enzymes containing the quinonoid cofactor pyrroloquinoline quinone,topaquinone or tryptophan-tryptophan quinone[J].European Journal of Biochemistry,1991,200(2):271-284.  
[6] KILLGORE J,SMIDT C,DUICH L,et al.Nutritional importance of pyrroloquinoline quinone[J].Science,1989,245(4920):850-852.  
[7] EFSA Panel on Dietetic Products,Nutrition and Allergies (NDA).Safety of pyrroloquinoline quinone disodium salt as a novel food pursuant to regulation (EC) No 258/97[J].EFSA Journal,2017,15(11):e05058.
[8] RUCKER R,CHOWANADISAI W,NAKANO M.Potential physiological importance of pyrroloquinoline quinone[J].Alternative Medicine Review,2009,14(3):268-277.
[9] DUINE J A,FRANK JZN J,JONGEJAN J A.PQQ and quinoprotein enzymes in microbial oxidations[J].FEMS Microbiology Letters,1986,32(3/4):165-178.
[10] MITCHELL A E,JONES A D,MERCER R S,et al.Characterization of pyrroloquinoline quinone amino acid derivatives by electrospray ionization mass spectrometry and detection in human milk[J].Analytical Biochemistry,1999,269(2):317-325.  
[11] RUCKER R,STITES T,STEINBERG F,et al.Physiological importance of pyrroloquinoline quinone[M]//IRIARTE A,MARTINEZ-CARRION M,KAGAN H M.Biochemistry and molecular biology of vitamin B₆ and PQQ-dependent proteins.Basel:Birkhäuser,2000:61-66.
[12] PAZ M A,FLÜCKIGER R,GALLOP P M.Comment:redox-cycling is a property of PQQ but not of ascorbate[J].FEBS Letters,1990,264(2):283-284.  
[13] KUMAZAWA T,SATO K,SENO H,et al.Levels of pyrroloquinoline quinone in various foods[J].Biochemical Journal,1995,307(2):331-333.  
[14] AMEYAMA M,HAYASHI M,MATSUSHITA K,et al.Microbial production of pyrroloquinoline quinone[J].Agricultural and Biological Chemistry,1984,48(2):561-565.
[15] CHOWANADISAI W,BAUERLY K A,TCHAPARIAN E,et al.Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α expression[J].The Journal of Biological Chemistry,2010,285(1):142-152.  
[16] TCHAPARIAN E,MARSHAL L,CUTLER G,et al.Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression,and the JAK/STAT and MAPK pathways[J].Biochemical Journal,2010,429(3):515-526.  
[17] STITES T,STORMS D,BAUERLY K,et al.Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice[J].The Journal of Nutrition,2006,136(2):390-396.  
[18] BAUERLY K A,STORMS D H,HARRIS C B,et al.Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat[J].Biochimica et Biophysica Acta (BBA):General Subjects,2006,1760(11):1741-1748.  
[19] BAUERLY K,HARRIS C,CHOWANADISAI W,et al.Altering pyrroloquinoline quinone nutritional status modulates mitochondrial,lipid,and energy metabolism in rats[J].PLoS One,2011,6(7):e21779.
[20] HE K,NUKADA H,URAKAMI T,et al.Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ):implications for its function in biological systems[J].Biochemical Pharmacology,2003,65(1):67-74.  
[21] OUCHI A,NAKANO M,NAGAOKA S I,et al.Kinetic study of the antioxidant activity of pyrroloquinolinequinol (PQQH₂,a reduced form of pyrroloquinolinequinone) in micellar solution[J].Journal of Agricultural and Food Chemistry,2009,57(2):450-456.  
[22] OUCHI A,IKEMOTO K,NAKANO M,et al.Kinetic study of aroxyl radical scavenging and α-tocopheroxyl regeneration rates of pyrroloquinolinequinol (PQQH₂,a reduced form of pyrroloquinolinequinone) in dimethyl sulfoxide solution:finding of synergistic effect on the reaction rate due to the coexistence of α-tocopherol and PQQH₂[J].Journal of Agricultural and Food Chemistry,2013,61(46):11048-11060.  
[23] MISRA H S,KHAIRNAR N P,BARIK A,et al.Pyrroloquinoline-quinone:a reactive oxygen species scavenger in bacteria[J].FEBS Letters,2004,578(1/2):26-30.
[24] HARA H,HIRAMATSU H,ADACHI T.Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine-induced neurotoxicity[J].Neurochemical Research,2007,32(3):489-495.  
[25] TAO R,KARLINER J S,SIMONIS U,et al.Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes[J].Biochemical and Biophysical Research Communications,2007,363(2):257-262.  
[26] JENSEN F E,GARDNER G J,WILLIAMS A P,et al.The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury[J].Neuroscience,1994,62(2):399-406.  
[27] SAMUEL K G,ZHANG H J,WANG J,et al.Effects of dietary pyrroloquinoline quinone disodium on growth performance,carcass yield and antioxidant status of broiler chicks[J].Animal,2015,9(3):409-416.  
[28] MISRA H S,RAJPUROHIT Y S,KHAIRNAR N P.Pyrroloquinoline-quinone and its versatile roles in biological processes[J].Journal of Biosciences,2012,37(2):313-325.  
[29] AKAGAWA M,NAKANO M,IKEMOTO K.Recent progress in studies on the health benefits of pyrroloquinoline quinone[J].Bioscience,Biotechnology,and Biochemistry,2016,80(1):13-22.  
[30] AMEYAMA M,MATSUSHITA K,SHINAGAWA E,et al.Pyrroloquinoline quinone:excretion by methylotrophs and growth stimulation for microorganisms[J].BioFactors (Oxford,England),1988,1(1):51-53.
[31] NAVEED M,TARIQ K,SADIA H,et al.The life history of pyrroloquinoline quinone (PQQ):a versatile molecule with novel impacts on living systems[J].International Journal of Molecular Biology:Open Access,2016,1(1):29-46.
[32] KIMURA K,TAKADA M,ISHII T,et al.Pyrroloquinoline quinone stimulates epithelial cell proliferation by activating epidermal growth factor receptor through redox cycling[J].Free Radical Biology and Medicine,2012,53(6):1239-1251.  
[33] STEINBERG F M,GERSHWIN M E,RUCKER R B.Dietary pyrroloquinoline quinone:growth and immune response in BALB/c mice[J].The Journal of Nutrition,1994,124(5):744-753.  
[34] ZHANG B R,YANG W,ZHANG H Y,et al.Effect of pyrroloquinoline quinone disodium in female rats during gestating and lactating on reproductive performance and the intestinal barrier functions in the progeny[J].British Journal of Nutrition,2019,121(7):818-830.  
[35] YIN X D,MING D X,BAI L L,et al.Effects of pyrroloquinoline quinone supplementation on growth performance and small intestine characteristics in weaned pigs[J].Journal of Animal Science,2019,97(1):246-256.  
[36] OMATA J,FUKATSU K,MURAKOSHI S,et al.Influence of adding pyrroloquinoline quinone to parenteral nutrition on gut-associated lymphoid tissue[J].Journal of Parenteral and Enteral Nutrition,2011,35(5):616-625.  
[37] YANG C F,YU L F,KONG L B,et al.Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-κB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice[J].PLoS One,2014,9(10):e109502.
[38] HARRIS C B,CHOWANADISAI W,MISHCHUK D O,et al.Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects[J].The Journal of Nutritional Biochemistry,2013,24(12):2076-2084.  
[39] NUNOME K,MIYAZAKI S,NAKANO M,et al.Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1[J].Biological and Pharmaceutical Bulletin,2008,31(7):1321-1326.  
[40] YAMAGUCHI K,SASANO A,URAKAMI T,et al.Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo[J].Bioscience,Biotechnology,and Biochemistry,1993,57(7):1231-1233.  
[41] MURASE K,HATTORI A,KOHNO M,et al.Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes[J].Biochemistry and Molecular Biology International,1993,30(4):615-621.
[42] ZHANG P,XU Y P,SUN J X,et al.Protection of pyrroloquinoline quinone against methylmercury-induced neurotoxicity via reducing oxidative stress[J].Free Radical Research,2009,43(3):224-233.  
[43] ZHANG Q,DING M,CAO Z,et al.Pyrroloquinoline quinine protects rat brain cortex against acute glutamate-induced neurotoxicity[J].Neurochemical Research,2013,38(8):1661-1671.  
[44] ZHANG J J,ZHANG R F,MENG X K.Protective effect of pyrroloquinoline quinone against Aβ-induced neurotoxicity in human neuroblastoma SH-SY5Y cells[J].Neuroscience Letters,2009,464(3):165-169.  
[45] HIRAKAWA A,SHIMIZU K,FUKUMITSU H,et al.Pyrroloquinoline quinone attenuates iNOS gene expression in the injured spinal cord[J].Biochemical and Biophysical Research Communications,2009,378(2):308-312.  
[46] OHWADA K,TAKEDA H,YAMAZAKI M,et al.Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats[J].Journal of Clinical Biochemistry and Nutrition,2008,42(1):29-34.  
[47] ITOH Y,HINE K,MIURA H,et al.Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ^TM) on cognitive functions[M]//ELWELL C E,LEUNG T S,HARRISON D K.Oxygen transport to tissue XXXVII.New York,NY:Springer,2016:319-325.
[48] NAKANO M,YAMAMOTO T,OKAMURA H,et al.Effects of oral supplementation with pyrroloquinoline quinone on stress,fatigue,and sleep[J].Functional Foods in Health and Disease,2012,2(8):307-324.  
[49] SMIDT C R,UNKEFER C J,HOUCK D R,et al.Intestinal absorption and tissue distribution of[14C]pyrroloquinoline quinone in mice[J].Proceedings of the Society for Experimental Biology and Medicine,1991,197(1):27-31.  
[50] NAKANO M,SUZUKI H,IMAMURA T,et al.Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ^TM)[J].Regulatory Toxicology and Pharmacology,2013,67(2):189-197.  
[51] NAKANO M,TAKAHASHI H,KOURA S,et al.Acute and subchronic toxicity studies of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ^TM) in rats[J].Regulatory Toxicology and Pharmacology,2014,70(1):107-121.  
[52] LIANG C L,ZHANG X,WANG W,et al.A subchronic oral toxicity study on pyrroloquinoline quinone (PQQ) disodium salt in rats[J].Food and Chemical Toxicology,2015,75:146-150.
[53] NAKANO M,KAWASAKI Y,SUZUKI N,et al.Effects of pyrroloquinoline quinone disodium salt intake on the serum cholesterol levels of healthy Japanese adults[J].Journal of Nutritional Science and Vitaminology,2015,61(3):233-240.  
[54] WANG J,ZHANG H J,SAMUEL K G,et al.Effects of dietary pyrroloquinoline quinone disodium on growth,carcass characteristics,redox status,and mitochondria metabolism in broilers[J].Poultry Science,2015,94(2):215-225.  
[55] 张亚男,齐博,武书庚,等.吡咯喹啉醌二钠对饲喂氧化鸭油肉仔鸡生长性能、血浆脂质代谢及抗氧化能力的影响[J].动物营养学报,2015,27(9):2884-2893.
[56] 孙光明,董雪玉,廖秀冬,等.吡咯喹啉醌二钠对肉仔鸡的生物安全性评价[J].动物营养学报,2018,30(7):2831-2840.
[57] 赵芹.吡咯喹啉醌钠(PQQNa₂)对蛋鸡脂肪肝的调控作用[D].硕士学位论文.北京:中国农业科学院,2014.
[58] WANG J,ZHANG H J,XU L,et al.Dietary supplementation of pyrroloquinoline quinone disodium protects against oxidative stress and liver damage in laying hens fed an oxidized sunflower oil-added diet[J].Animal,2016,10(7):1129-1136.  
[59] 徐磊,张海军,武书庚,等.吡咯喹啉醌对蛋鸡生产性能、蛋品质及抗氧化功能的影响[J].动物营养学报,2011,23(8):1370-1377.
[60] 王晶,杨林林,张海军,等.吡咯喹啉醌二钠对产蛋鸡生产性能、抗氧化状态和血浆生化指标的影响[J].动物营养学报,2018,30(2):667-677.
[61] 孙丽敏,张海军,武书庚,等.吡咯喹啉醌二钠对蛋鸡生产性能和鸡蛋胆固醇含量的影响[J].动物营养学报,2014,26(9):2565-2573.
[62] ZHANG B R,WANG C X,YANG W,et al.Transcriptome analysis of the effect of pyrroloquinoline quinone disodium (PQQ·Na₂) on reproductive performance in sows during gestation and lactation[J].Journal of Animal Science and Biotechnology,2019,10:62.
[63] 肖俊峰,史庆超,柒启恩,等.饲粮添加吡咯喹啉醌对围产期母猪繁殖性能和抗氧化功能的影响[J].动物营养学报,2017,29(8):2906-2911.