综述 Review

miRNA-33的生物学功能及其对脂代谢的调控

  • 王皓宇 ,
  • 盖叶丹 ,
  • 栾新红
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  • 沈阳农业大学畜牧兽医学院, 沈阳 110866
王皓宇(1995-),男,辽宁锦州人,硕士研究生,从事动物生理学与生殖内分泌学研究。E-mail:872109794@qq.com

收稿日期: 2019-08-15

  网络出版日期: 2020-03-13

基金资助

国家自然科学基金项目(31372395)

Biological Function of miRNA-33 and Its Regulation of Lipid Metabolism

  • WANG Haoyu ,
  • GAI Yedan ,
  • LUAN Xinhong
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  • College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2019-08-15

  Online published: 2020-03-13

摘要

miRNA-33与脂代谢紧密相关,是微小RNA(miRNAs)家族成员中参与脂代谢调控的主要因子。而脂代谢异常是诱发心血管疾病的罪魁祸首,对人类的健康具有重大威胁。实际生产实践中,脂代谢异常对家畜及禽类的影响也逐渐受到重视。研究发现,miRNA-33通过对靶基因转录水平的调控,影响脂代谢相关蛋白的表达水平,从而影响脂肪酸合成、脂质积累、胆固醇流出、胆汁酸代谢、动脉粥样硬化等,进而实现调节机体脂代谢的作用。本文就miRNA-33的生物学功能及其参与脂代谢作用的研究概况进行综述,以期为探讨miRNA-33调控脂代谢作用的机制奠定理论基础。

本文引用格式

王皓宇 , 盖叶丹 , 栾新红 . miRNA-33的生物学功能及其对脂代谢的调控[J]. 动物营养学报, 2020 , 32(3) : 1084 -1089 . DOI: 10.3969/j.issn.1006-267x.2020.03.014

Abstract

miRNA-33 is closely related to lipid metabolism and is the main factor involved in lipid metabolism regulation in members of microRNA (miRNAs) family. However, abnormal lipid metabolism is the culprit of cardiovascular diseases, which poses a great threat to human health. In practice, the effect of abnormal lipid metabolism on livestock and poultry has been gradually paid more attention. Studies have found that miRNA-33 affects the expression level of lipid metabolism-related proteins by regulating the transcription level of target genes, thereby affecting fatty acid synthesis, lipid accumulation, cholesterol outflow, bile acid metabolism, atherosclerosis, etc., so as to regulate the body's lipid metabolism. In this paper, the biological function of miRNA-33 and its involvement in lipid metabolism were reviewed, so as to lay a theoretical foundation for the study on the mechanism of miRNA-33 regulating lipid metabolism.

参考文献

[1] THOMOU T,MORI M A,DREYFUSS J M,et al.Adipose-derived circulating miRNAs regulate gene expression in other tissues[J].Nature,2017,542(7642):450-455.  
[2] SAHEBKAR A,WATTS G F.Developing role of microRNA-33 in lipid metabolism and atherosclerosis[J].Current Opinion in Lipidology,2016,27(2):197-199.  
[3] PRICE N L,HOLTRUP B,KWEI S L,et al.SREBP-1c/MicroRNA 33b genomic loci control adipocyte differentiation[J].Molecular and Cellular Biology,2016,36(7):1180-1193.  
[4] GERIN I,CLERBAUX L A,HAUMONT O,et al.Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation[J].Journal of Biological Chemistry,2010,285(35):33652-33661.
[5] TARLING E J,AHN H,DE AGUIAR VALLIM T Q.The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2015,35(4):787-795.  
[6] VINCENT R,SANYAL A.Recent advances in understanding of NASH:MicroRNAs as both biochemical markers and players[J].Current Pathobiology Reports,2014,2(3):109-116.  
[7] LINSEL-NITSCHKE P,TALL A R.HDL as a target in the treatment of atherosclerotic cardiovascular disease[J].Nature Reviews Drug Discovery,2005,4(3):193-205.  
[8] NAJAFI-SHOUSHTARI S H,KRISTO F,LI Y X,et al.MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis[J].Science,2010,328(5985):1566-1569.  
[9] GOEDEKE L,VALES-LARA F M,FENSTERMAKER M,et al.A regulatory role for MicroRNA 33 in controlling lipid metabolism gene expression[J].Molecular and Cellular Biology,2013,33(11):2339-2352.  
[10] SINGH A K,ARYAL B,ZHANG X B,et al.Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins[J].Seminars in Cell & Developmental Biology,2018,81:129-140.
[11] 张海滨,朱磊.miRNA-33对脂代谢的调节[J].体育世界(学术版),2018(7):189-190.
[12] SHAO F,WANG X G,YU J F,et al.Expression of miR-33 from an SREBF2 intron targets the FTO Gene in the chicken[J].PLoS One,2014,9(3):e91236.
[13] SHAO F,WANG X,YU J,et al.Expression of miR-33 from an SREBP2 intron inhibits the expression of the fatty acid oxidation-regulatory genes CROT and HADHβ in chicken liver[J].British Poultry Science,2019,60(2):115-124.  
[14] ZHENG Y,JIANG S B,ZHANG Y H,et al.Detection of miR-33 expression and the verification of its target genes in the fatty liver of geese[J].International Journal of Molecular Sciences,2015,16(6):12737-12752.
[15] KARUNAKARAN D,RICHARDS L,GEOFFRION M,et al.Therapeutic inhibition of miR-33 promotes fatty acid oxidation but does not ameliorate metabolic dysfunction in diet-induced obesity[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2015,35(12):2536-2543.  
[16] PORITSANOS N J,LEW P S,MIZUNO T M.Relationship between blood glucose levels and hepatic Fto mRNA expression in mice[J].Biochemical and Biophysical Research Communications,2010,400(4):713-717.  
[17] SHAO F,WANG X G,YU J F,et al.Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken[J].PLoS One,2014,9(3):e91236.
[18] SHAO F,WANG X G,YU J F,et al.Expression of miR-33 from an SREBF2 intron targets the FTO gene in the chicken[J].PLoS One,2014,9(3):e91236.
[19] RADER D J,HOVINGH G K.HDL and cardiovascular disease[J].The Lancet,2014,384(9943):618-625.  
[20] ROSENSON R S,BREWER H B,DAVIDSON W S,et al.Cholesterol efflux and atheroprotection:advancing the concept of reverse cholesterol transport[J].Circulation,2012,125(15):1905-1919.  
[21] LINTON M R F,TAO H,LINTON E F,et al.SR-BI:a multifunctional receptor in cholesterol homeostasis and atherosclerosis[J].Trends in Endocrinology & Metabolism,2017,28(6):461-472.  
[22] KARUNAKARAN D,THRUSH A B,NGUYEN M A,et al.Macrophage mitochondrial energy status regulates cholesterol efflux and is enhanced by anti-miR33 in atherosclerosis[J].Circulation Research,2015,117(3):266-278.  
[23] ALLEN R M,MARQUART T J,ALBERT C J,et al.miR-33 controls the expression of biliary transporters,and mediates statin-and diet-induced hepatotoxicity[J].EMBO Molecular Medicine,2012,4(9):882-895.  
[24] ARYAL B,SINGH A K,ROTLLAN N,et al.MicroRNAs and lipid metabolism[J].Current Opinion in Lipidology,2017,28(3):273-280.  
[25] HORIE T,NISHINO T,BABA O,et al.MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice[J].Nature Communications,2013,4:2883.
[26] PRICE N L,SINGH A K,ROTLLAN N,et al.Genetic ablation of miR-33 increases food intake,enhances adipose tissue expansion,and promotes obesity and insulin resistance[J].Cell Reports,2018,22(8):2133-2145.  
[27] ROTLLAN N,RAMIREZ C M,ARYAL B,et al.Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-/- mice-brief report[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2013,33(8):1973-1977.  
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