孙丹丹 , 张军民 , 赵青余 , 秦玉昌 . 叶酸在蛋鸡体内吸收代谢及其机制研究进展[J]. 动物营养学报, 2020 , 32(6) : 2467 -2475 . DOI: 10.3969/j.issn.1006-267x.2020.06.004

[1] DE BENOIST B.Conclusions of a WHO technical consultation on folate and vitamin B₁₂ deficiencies[J].Food and Nutrition Bulletin,2008,29(Suppl.2):S238-S244.
[2] 何宇纳,王竹,赵丽云,等.2010-2012年中国居民膳食维生素摄入状况[J].营养学报,2017,39(2):112-115.
[3] FIELD M S,STOVER P J.Safety of folic acid[J].Annals of the New York Academy of Sciences,2018,414(1):59-71.
[4] SCAGLIONE F,PANZAVOLTA G.Folate,folic acid and 5-methyltetrahydrofolate are not the same thing[J].Xenobiotica,2014,44(5):480-488.  
[5] STRANDLER H S,JASTREBOVA J,MATTISSON I.Folate content in Swedish eggs:influence of breed,feed and processing[J].European Food Research and Technology,2011,233(6):923-930.  
[6] SUGIYAMA A,AWAJI H,HORIE K,et al.The beneficial effect of folate-enriched egg on the folate and homocysteine levels in rats fed a folate-and choline-deficient diet[J].Journal of Food Science,2012,77(12):H268-H272.
[7] ALTIC L,MCNULTY H,HOEY L,et al.Validation of folate-enriched eggs as a functional food for improving folate intake in consumers[J].Nutrients,2016,8(12):777.
[8] SEYOUM E,SELHUB J.Properties of food folates determined by stability and susceptibility to intestinal pteroylpolyglutamate hydrolase action[J].The Journal of Nutrition,1998,128(11):1956-1960.  
[9] TACTACAN G B,JING M,THIESSEN S,et al.Characterization of folate-dependent enzymes and indices of folate status in laying hens supplemented with folic acid or 5-methyltetrahydrofolate[J].Poultry Science,2010,89(4):688-696.  
[10] HEBERT K,TACTACAN G B,DICKSON T M,et al.The effect of cereal type and exogenous enzyme use on total folate content of eggs from laying hens consuming diets supplemented with folic acid[J].Journal of Applied Poultry Research,2011,20(3):303-312.  
[11] DICKSON T M,TACTACAN G B,HEBERT K,et al.Optimization of folate deposition in eggs through dietary supplementation of folic acid over the entire production cycle of Hy-Line W36,Hy-Line W98,and CV20 laying hens[J].Journal of Applied Poultry Research,2010,19(1):80-91.  
[12] OGUNDARE M J,BOLU S A.Effects of dietary fortification of vitamin A and folic acid on the composition of chicken egg[J].Chemical Biology,2012:129-138.
[13] HEBERT K,HOUSE J D,GUENTER W.Effect of dietary folic acid supplementation on egg folate content and the performance and folate status of two strains of laying hens[J].Poultry Science,2005,84(10):1533-1538.  
[14] HOUSE J D,BRAUN K,BALLANCE D M,et al.The enrichment of eggs with folic acid through supplementation of the laying hen diet[J].Poultry Science,2002,81(9):1332-1337.  
[15] HOEY L,MCNULTY H,MCCANN E M E,et al.Laying hens can convert high doses of folic acid added to the feed into natural folates in eggs providing a novel source of food folate[J].British Journal of Nutrition,2009,101(2):206-212.
[16] STRANDLER H S,PATRING J,JÄGERSTAD M,et al.Challenges in the determination of unsubstituted food folates:impact of stabilities and conversions on analytical results[J].Journal of Agricultural & Food Chemistry,2015,63(9):2367-2377.  
[17] PUWASTIEN P,PINPRAPAI N,JUDPRASONG K,et al.International inter-laboratory analyses of food folate[J].Journal of Food Composition and Analysis,2005,18(5):387-397.  
[18] NOJAVAN Y,KAMANKESH M,SHAHRAZ F,et al.Ion pair-based dispersive liquid-liquid microextraction followed by high performance liquid chromatography as a new method for determining five folate derivatives in foodstuffs[J].Talanta,2015,137:31-37.
[19] 田传欢,张俊平,唐守营,等.添加叶酸对蛋鸡生产性能及鸡蛋中叶酸含量的影响[J].饲料工业,2015,36(增刊2):34-36.
[20] JING M,MUNYAKA P M,TACTACAN G B,et al.Performance,serum biochemical responses,and gene expression of intestinal folate transporters of young and older laying hens in response to dietary folic acid supplementation and challenge with Escherichia coli lipopolysaccharide[J].Poultry Science,2014,93(1):122-131.  
[21] CHANDLER C J,WANG T T,HALSTED C H.Pteroylpolyglutamate hydrolase from human jejunal brush borders.Purification and characterization.[J].Journal of Biological Chemistry,1986,261(2):928-933.
[22] STEINBERG S E.Mechanisms of folate homeostasis[J].American Journal of Physiology,1984,246(4):G319-G324.
[23] DESAI A,SEQUEIRA J M,QUADROS E V.The metabolic basis for developmental disorders due to defective folate transport[J].Biochimie,2016,126:31-42.
[24] JING M,TACTACAN G B,RODRIGUEZ-LECOMPTE J C,et al.Proton-coupled folate transporter (PCFT):molecular cloning,tissue expression patterns and the effects of dietary folate supplementation on mRNA expression in laying hens[J].British Poultry Science,2010,51(5):635-638.  
[25] JING M,TACTACAN G B,RODRIGUEZ-LECOMPTE J C,et al.Molecular cloning and tissue distribution of reduced folate carrier and effect of dietary folate supplementation on the expression of reduced folate carrier in laying hens[J].Poultry Science,2009,88(9):1939-1947.  
[26] TACTACAN G B,RODRIGUEZ-LECOMPTE J C,KARMIN O,et al.Functional characterization of folic acid transport in the intestine of the laying hen using the everted intestinal sac model[J].Poultry Science,2011,90(1):83-90.  
[27] TACTACAN G B,RODRIGUEZ-LECOMPTE J C,K O,et al.The adaptive transport of folic acid in the intestine of laying hens with increased supplementation of dietary folic acid[J].Poultry Science,2012,91(1):121-128.  
[28] SAID H M,CHATTERJEE N,UL HAQ R,et al.Adaptive regulation of intestinal folate uptake:effect of dietary folate deficiency[J].American Journal of Physiology Cell Physiology,2000,279(6):C1889-C1895.
[29] LIU M J,GE Y B,CABELOF D C,et al.Structure and regulation of the murine reduced folate carrier gene:identification of four noncoding exons and promoters and regulation by dietary folates[J].Journal of Biological Chemistry,2005,280(7):5588-5597.  
[30] STANLEY D,HUGHES R J,MOORE R J.Microbiota of the chicken gastrointestinal tract:influence on health,productivity and disease[J].Applied Microbiology and Biotechnology,2014,98(10):4301-4310.  
[31] MAGNÚSDÓTTIR S,RAVCHEEV D,DE CRÉCY-LAGARD V,et al.Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes[J].Frontiers in Genetics,2015,6:148.
[32] 程漫漫,张廷荣,王宝维,等.饲粮中添加叶酸和维生素B₁₂对雏鹅盲肠菌群结构的影响[J].动物营养学报,2018,30(8):2987-2996.
[33] POMPEI A,CORDISCO L,AMARETTI A,et al.Administration of folate-producing bifidobacteria enhances folate status in wistar rats[J].Journal of Nutrition,2008,137(12):2742-2746.
[34] LEBLANC J G,SYBESMA W,STARRENBURG M,et al.Supplementation with engineered Lactococcus lactis improves the folate status in deficient rats[J].Nutrition,2010,26(7/8):835-841.
[35] STEINBERG S E.Mechanisms of folate homeostasis[J].American Journal of Physiology,1984,246(4):G3194-G324.
[36] TACTACAN G.Characterization of factors influencing the regulation of dietary folic acid deposition in the eggs[D].Ph.D.Thesis.Winnipeg:The University of Manitoba,2011:51-66.
[37] SHERWOOD T A,ALPHIN R L,SAYLOR W W,et al.Folate metabolism and deposition in eggs by laying hens[J].Archives of Biochemistry and Biophysics,1993,307(1):66-72.  
[38] SIU M K Y,KONG D S H,CHAN H Y,et al.Paradoxical impact of two folate receptors,FRα and RFC,in ovarian cancer:effect on cell proliferation,invasion and clinical outcome[J].PLoS One,2012,7(11):e47201.
[39] MATHERLY L H,HOU Z J,DENG Y J.Human reduced folate carrier:translation of basic biology to cancer etiology and therapy[J].Cancer Metastasis Reviews,2007,26(1):111-128.  
[40] STRANDGAARD T,FODER S,HEUCK A,et al.Maternally contributed folate receptor 1 is expressed in ovarian follicles and contributes to preimplantation development[J].Frontiers in Cell and Developmental Biology,2017,5:89.
[41] STEEGERS-THEUNISSEN R P M,STEEGERS E A P,THOMAS C M G,et al.Study on the presence of homocysteine in ovarian follicular fluid[J].Fertility and Sterility,1993,60(6):1006-1010.  
[42] BOXMEER J C.The homocysteine pathway in human subfertility[J].Erasmus University Rotterdam,2009,28(4):21-527.
[43] KWONG W Y,ADAMIAK S J,GWYNN A,et al.Endogenous folates and single-carbon metabolism in the ovarian follicle,oocyte and pre-implantation embryo[J].Reproduction,2010,139(4):705-715.  
[44] ZHAO R B,MATHERLY L H,GOLDMAN I D.Membrane transporters and folate homeostasis:intestinal absorption and transport into systemic compartments and tissues[J].Expert Reviews in Molecular Medicine,2009,11(1):e4.
[45] WANG Y H,ZHAO R B,RUSSELL R G,et al.Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis[J].Biochimica et Biophysica Acta (BBA):Biomembranes,2001,513(1):49-54.
[46] BIRN H,SPIEGELSTEIN O,CHRISTENSEN E I,et al.Renal tubular reabsorption of folate mediated by folate binding protein[J].Journal of the American Society of Nephrology,2005,16(3):608-615.  
[47] HU J,WANG B,SAHYOUN N R.Application of the key events dose-response framework to folate metabolism[J].Critical Reviews in Food Science and Nutrition,2016,56(8):1325-1333.  
[48] FIELD M S,KAMYNINA E,CHON J,et al.Nuclear folate metabolism[J].Annual Review of Nutrition,2018,38(1):219-243.  
[49] FRISO S,UDALI S,DE SANTIS D,et al.One-carbon metabolism and epigenetics[J].Molecular Aspects of Medicine,2017,54:28-36.
[50] 邢晋祎,张渝洁,张宁波,等.叶酸添加水平对肉仔鸡肝脏中脂肪代谢相关基因表达和甲基化的影响[J].动物营养学报,2019,31(5):2098-2106.
[51] NAJAR R A,RAHAT B,HUSSAIN A,et al.Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation[J].Molecular Nutrition & Food Research,2016,60(6):1501-1513.