闫昭明 , 李文睿 , 刘霜莉 , 陈清华 . 单端孢霉烯族毒素的致病机理及防治措施研究进展[J]. 动物营养学报, 2020 , 32(6) : 2543 -2550 . DOI: 10.3969/j.issn.1006-267x.2020.06.013

[1] SNYDER A B,WOROBO R W.Risk mitigation for immunocompromised consumers of mucormycete spoiled and fermented foods:germane guidance and remaining needs[J].Microorganisms,2018,6(2):45.
[2] PALENCIA E R,HINTON D M,BACON C W.The black Aspergillus species of maize and peanuts and their potential for mycotoxin production[J].Toxins,2010,2(4):399-416.  
[3] WILD C P,GONG Y Y.Mycotoxins and human disease:a largely ignored global health issue[J].Carcinogenesis,2010,31(1):71-82.  
[4] JARVIS B B.Chemistry and toxicology of molds isolated from water-damaged buildings[M]//DEVRIES J W,TRUCKSESS M W,JACKSON L S.Mycotoxins and food safety.Boston,MA:Springer,2002,504:43-52.
[5] GRENIER B,BRACARENSE A P,LESLIE J F,et al.Physical and chemical methods for mycotoxin decontamination in maize[M]//LESLIE J F,LOGRIECO A F.Mycotoxin reduction in grain chains.New Delhi:Wiley Blackwell,2014.
[6] AWAD W A,GHAREEB K,BÖHM J,et al.Decontamination and detoxification strategies for the Fusarium mycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation[J].Food Additives & Contaminants:Part A,2010,27(4):510-520.  
[7] SCHMEITZL C,VARGA E,WARTH B,et al.Identification and characterization of carboxylesterases from Brachypodium distachyon deacetylating trichothecene mycotoxins[J].Toxins,2015,8(1):6.
[8] MENEELY J P,RICCI F,VAN EGMOND H P,et al.Current methods of analysis for the determination of trichothecene mycotoxins in food[J].TrAC Trends in Analytical Chemistry,2011,30(2):192-203.  
[9] KLÖTZEL M,LAUBER U,HUMPF H U.A new solid phase extraction clean-up method for the determination of 12 type A and B trichothecenes in cereals and cereal-based food by LC-MS/MS[J].Molecular Nutrition & Food Research,2010,50(3):261-269.
[10] GRENIER B,OSWALD I.Mycotoxin co-contamination of food and feed:meta-analysis of publications describing toxicological interactions[J].World Mycotoxin Journal,2011,4(3):285-313.  
[11] HE Y Y,LUO Q H,GE P H,et al.Review on mould contamination and hygrothermal effect in indoor environment[J].Journal of Environmental Protection,2018,9(2):100-110.  
[12] JANSSEN E M,LIU C,VAN DER FELS-KLERX H J.Fusarium infection and trichothecenes in barley and its comparison with wheat[J].World Mycotoxin Journal,2018,11(1):33-46.  
[13] KIRAN S,SUREKHA M,REDDY S M S.Influence of water activity (aw) on mould infestation and mycotoxin contamination of rice fodder[J].Asian Journal of Biological Sciences,2019,12(4):797-803.  
[14] MAEDA K,TANAKA A,SUGIURA R,et al.Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes:evolution of alternative pathways in the nivalenol chemotype[J].Environmental Microbiology,2016,18(11):3798-3811.  
[15] TORP M,LANGSETH W.Production of T-2 toxin by a Fusarium resembling Fusarium poae[J].Mycopathologia,1999,147(2):89-96.  
[16] WU W D,ZHOU H R,BURSIAN S J,et al.Emetic responses to T-2 toxin,HT-2 toxin and emetine correspond to plasma elevations of peptide YY3-36 and 5-hydroxytryptamine[J].Archives of Toxicology,2016,90(4):997-1007.  
[17] SOKOLOVI? M,GARAJ-VRHOVAC V,ŠIMPRAGA B.T-2 toxin:incidence and toxicity in poultry[J].Archives of Industrial Hygiene and Toxicology,2008,59(1):43-52.  
[18] KUCA K,DOHNAL V,JEZKOVA A,et al.Metabolic pathways of T-2 toxin[J].Current Drug Metabolism,2008,9(1):77-82.  
[19] KAPETANOV M,POTKONJAK D,STOJANOV I,et al.Importance of clinical and pathological diagnostics of mycotoxicosis in fat tening turkeys caused by T-2 trichothecene[C]//Ⅹ Ⅴ International Feed Technology Symposium "feed-to-food".Cost feed for Health Joint Workshop.Novi Sad,Serbia,2012.
[20] SEHATA S,KIYOSAWA N,ATSUMI F,et al.Microarray analysis of T-2 toxin-induced liver,placenta and fetal liver lesions in pregnant rats[J].Experimental and Toxicologic Pathology,2005,57(1):15-28.  
[21] ATROSHI F,RIZZO A,SANKARI S,et al.Liver enzyme activities of rats exposed to ochratoxin A and T-2 toxin with antioxidants[J].Bulletin of Environmental Contamination and Toxicology,2000,64(4):586-592.  
[22] WU J,JING L,YUAN H,et al.T-2 toxin induces apoptosis in ovarian granulosa cells of rats through reactive oxygen species-mediated mitochondrial pathway[J].Toxicology Letters,2011,202(3):168-177.  
[23] CHAUDHARY M,RAO P V L.Brain oxidative stress after dermal and subcutaneous exposure of T-2 toxin in mice[J].Food and Chemical Toxicology,2010,48(12):3436-3442.  
[24] DOI K,ISHIGAMI N,SEHATA S.T-2 toxin-induced toxicity in pregnant mice and rats[J].International Journal of Molecular Sciences,2008,9(11):2146-2158.  
[25] GUO P,LIU A M,HUANG D Y,et al.Brain damage and neurological symptoms induced by T-2 toxin in rat brain[J].Toxicology Letters,2018,286:96-107.
[26] DAI C S,XIAO X L,SUN F F,et al.T-2 toxin neurotoxicity:role of oxidative stress and mitochondrial dysfunction[J].Archives of Toxicology,2019,93(11):3041-3056.  
[27] 杨凌宸.T-2/HT-2毒素对肉鸡毒性机理及其减控作用研究[D].博士学位论文.南京:南京农业大学,2015.
[28] HJELKREM A G R,AAMOT H U,BRODAL G,et al.HT-2 and T-2 toxins in Norwegian oat grains related to weather conditions at different growth stages[J].European Journal of Plant Pathology,2018,151(4):501-514.
[29] 林妮妮.基于肝微粒体的T-2毒素体外代谢研究[D].博士学位论文.北京:中国人民解放军军事医学科学院,2013.
[30] RICHARD J L.Some major mycotoxins and their mycotoxicoses-an overview[J].International Journal of Food Microbiology,2007,119(1/2):3-10.
[31] YU Y H,HSIAO F S H,PROSKURA W S,et al.An impact of deoxynivalenol produced by Fusarium graminearum on broiler chickens[J].Journal of Animal Physiology and Animal Nutrition,2018,102(4):1012-1019.  
[32] TURAY S A,LIANG S,ZHANG M I N,et al.Wrong perception and scanty knowledge on food handling:a recipe for food contamination and poisoning[J].International Journal For Research in Health Sciences and Nursing,2017,3(12):29-50.
[33] WU W D,BATES M A,BURSIAN S J,et al.Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin)[J].Toxicological Sciences,2013,133(1):186-195.  
[34] PESTKA J J.Deoxynivalenol:toxicity,mechanisms and animal health risks[J].Animal Feed Science and Technology,2007,137(3/4):283-298.
[35] WA?KIEWICZ A,BESZTERDA M,KOSTECKI M,et al.Deoxynivalenol in the gastrointestinal tract of immature gilts under per os toxin application[J].Toxins,2014,6(3):973-987.  
[36] AWAD W A,VAHJEN W,ASCHENBACH J R,et al.A diet naturally contaminated with the Fusarium mycotoxin deoxynivalenol (DON) downregulates gene expression of glucose transporters in the intestine of broiler chickens[J].Livestock Science,2011,140(1/2/3):72-79.
[37] WACHÉ Y J,VALAT C,POSTOLLEC G,et al.Impact of deoxynivalenol on the intestinal microflora of pigs[J].International Journal of Molecular Sciences,2008,10(1):1-17.  
[38] VN DE WALLE J,SERGENT T,PIRONT N,et al.Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis[J].Toxicology and Applied Pharmacology,2010,245(3):291-298.  
[39] AWAD W A,GHAREEB K,DADAK A,et al.Genotoxic effects of deoxynivalenol in broiler chickens fed low-protein feeds[J].Poultry Science,2012,91(3):550-555,doi:10.3382/ps.2011-01742.
[40] CHANG C,WANG K,ZHOU S N,et al.Protective effect of Saccharomyces boulardii on deoxynivalenol-induced injury of porcine macrophage via attenuating p38 MAPK signal pathway[J].Applied Biochemistry and Biotechnology,2017,182(1):411-427.  
[41] 张晓莉.脱氧雪腐镰刀菌烯醇产毒菌的筛选及产毒分子机制探究[D].硕士学位论文.南京:江苏大学,2016.
[42] KARLOVSKY P,SUMAN M,BERTHILLER F,et al.Impact of food processing and detoxification treatments on mycotoxin contamination[J].Mycotoxin Research,2016,32(4):179-205.  
[43] CHOUDHARY A K,KUMARI P,MEGHVANSI M K.Management of mycotoxin contamination in pre-harvest and post-harvest crops:present status and future prospects[J].Journal of Phytology,2010,2(7):37-52.
[44] ZHOU H T.Mixture of palygorskite and montmorillonite (Paly-Mont) and its adsorptive application for mycotoxins[J].Applied Clay Science,2016,131:140-143.
[45] 张伟.霉菌毒素吸附剂的种类和特点[J].饲料与畜牧,2018(6):71-73.
[46] 姚丽欣.霉菌毒素对饲料原料的危害以及酵母细胞壁脱霉菌毒素的研究应用[J].饲料广角,2011(1):24-27.
[47] VAN LE THANH B,LESSARD M,CHORFI Y,et al.The efficacy of anti-mycotoxin feed additives in preventing the adverse effects of wheat naturally contaminated with Fusarium mycotoxins on performance,intestinal barrier function and nutrient digestibility and retention in weanling pigs[J].Canadian Journal of Animal Science,2015,95(2):197-209.  
[48] PARK D L,LEE L S,PRICE R L,et al.Review of the decontamination of aflatoxins by ammoniation:current status and regulation.[J].Journal-Association of Official Analytical Chemists,1988,71(4):685-703.
[49] KARACA H,VELIOGLU Y S,NAS S.Mycotoxins:contamination of dried fruits and degradation by ozone[J].Toxin Reviews,2010,29(2):51-59.  
[50] 张立阳,赵雪娇,刘帅,等.食品及饲料中黄曲霉毒素生物脱毒的研究进展[J].动物营养学报,2019,31(2):521-529.
[51] 闫昭明,陈清华,陈凤鸣.玉米赤霉烯酮毒性研究[J].动物营养学报,2018,30(9):3453-3458.
[52] KARLOVSKY P.Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives[J].Applied Microbiology and Biotechnology,2011,91(3):491-504.  
[53] YU H,ZHOU T,GONG J H,et al.Isolation of deoxynivalenol-transforming bacteria from the chicken intestines using the approach of PCR-DGGE guided microbial selection[J].BMC microbiology,2010,10:182-186.
[54] ALBERTS J F,ENGELBRECHT Y,STEYN P S,et al.Biological degradation of aflatoxin B₁ by Rhodococcus erythropolis cultures[J].International Journal of Food Microbiology,2006,109(1/2):121-126.
[55] 计成.饲料中霉菌毒素生物降解的研究进展[J].中国农业科学,2012,45(1):153-158.
[56] 计成,贾如,赵丽红.基因工程技术在黄曲霉毒素生物降解中的应用[J].中国农业科学,2017,50(17):3422-3428.
[57] HE W J,ZHANG L M,YI S Y,et al.An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain[J].Scientific Reports,2017,7:9549.