综述 REVIEW

脂肪酸对小鼠和猪乳腺发育的调控作用及机制研究进展

  • 杨强 ,
  • 郑吉松 ,
  • 孟莹莹 ,
  • 王松波
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  • 华南农业大学动物科学学院, 广东省动物营养调控重点实验室, 优百特脂立方功能性脂肪酸研究中心, 广州 510642
杨强(1995-),男,湖北恩施人,硕士研究生,从事动物乳腺发育研究。E-mail:395586140@qq.com

收稿日期: 2019-11-23

  网络出版日期: 2020-06-16

基金资助

国家重点研发计划项目(2016YFD0500503)

Advances in Regulation and Mechanism of Mammary Gland Development of Mice and Pigs by Fatty Acids

  • YANG Qiang ,
  • ZHENG Jisong ,
  • MENG Yingying ,
  • WANG Songbo
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  • Guangdong Provincial Key Laboratory of Animal Nutrition Control, UBT Lipid Suite Functional Fatty Acids Research Center, College of Animal Sciences, South China Agricultural University, Guangzhou 510642, China

Received date: 2019-11-23

  Online published: 2020-06-16

摘要

哺乳动物乳腺的良好发育是其泌乳功能充分发挥的前提。哺乳动物出生后乳腺的发育包括初情期、妊娠期、泌乳期和退化期等不同阶段。乳腺发育不仅受遗传、激素和环境等因素的影响,营养对乳腺发育也具有重要的调控作用。研究表明,脂肪酸不仅可为生命活动提供能量,其生物合成过程形成的许多信号分子还参与乳腺发育调控。本文综述了小鼠和猪乳腺发育过程及其影响因素、脂肪酸对小鼠和猪乳腺发育的调控作用,并探讨了脂肪酸调控小鼠和猪乳腺发育的可能机制,为脂肪酸在调控动物乳腺发育、提高动物泌乳性能方面的应用提供理论依据。

本文引用格式

杨强 , 郑吉松 , 孟莹莹 , 王松波 . 脂肪酸对小鼠和猪乳腺发育的调控作用及机制研究进展[J]. 动物营养学报, 2020 , 32(6) : 2551 -2557 . DOI: 10.3969/j.issn.1006-267x.2020.06.014

Abstract

The better development of mammalian mammary gland is a prerequisite for its full play of lactation. The development of mammalian mammary gland after birth occurs in several different stages, including puberty, pregnancy, lactation and involution. The mammary gland development is not only affected by genetic, hormonal and environmental factors, but also regulated by nutrition. Studies show that fatty acids can not only provide energy for life activities, but also many signal molecules formed by their biosynthesis participate in regulation of mammary gland development. In this review, mammary gland development process of mice and pigs and its influence factors, as well as regulation of fatty acids on the mammary gland development were summarized, and possible mechanism involved in regulation on mammary gland development of mice and pigs by fatty acids were discussed, to provide a theoretical basis for application of fatty acids in regulating animal mammary gland development and improving animal lactation performance.

参考文献

[1] HA W T,JEONG H Y,LEE S Y,et al.Effects of the insulin-like growth factor pathway on the regulation of mammary gland development[J].Development & Reproduction,2016,20(3):179-185.  
[2] MACIAS H,HINCK L.Mammary gland development[J].Wiley Interdisciplinary Reviews:Developmental Biology,2012,1(4):533-557.  
[3] AKERS R M.A 100-year review:mammary development and lactation[J].Journal of Dairy Science,2017,100(12):10332-10352.  
[4] WATSON C J,KREUZALER P A.Remodeling mechanisms of the mammary gland during involution[J].International Journal of Developmental Biology,2011,55(7/8/9):757-762.
[5] FARMER C,RENSEN M T.Factors affecting mammary development in gilts[J].Livestock Production Science,2001,70(1/2):141-148.
[6] FARMER C,HURLEY W L.Mammary development[M]//Farmer C.The gestating and lactating sow.The Netherlands:Wageningen Academic Publishers,2015:73-94.
[7] HURLEY W L.Review:mammary gland development in swine:embryo to early lactation[J].Animal,2019,13(Suppl.1):S11-S19.
[8] SØRENSEN M T,SEJRSEN K,PURUP S.Mammary gland development in gilts[J].Livestock Production Science,2002,75(2):143-148.  
[9] JI F,HURLEY W L,KIM S W.Characterization of mammary gland development in pregnant gilts[J].Journal of Animal Science,2006,84(3):579-587.  
[10] KIM S W,HURLEY W L,HAN I K,et al.Changes in tissue composition associated with mammary gland growth during lactation in sows[J].Journal of Animal Science,1999,77(9):2510-2516.  
[11] FORD J A,Jr.,KIM S W,RODRIGUEZ-ZAS S L,et al.Quantification of mammary gland tissue size and composition changes after weaning in sows[J].Journal of Animal Science,2003,81(10):2583-2589.  
[12] FARMER C,何忠武.激素状态、营养水平与饲养管理方案对猪乳腺发育的影响[J].中国猪业,2014,9(1):50-53.
[13] FARMER C.Review:mammary development in swine:effects of hormonal status,nutrition and management[J].Canadian Journal of Animal Science,2013,93(1):1-7.  
[14] MCNALLY S,STEIN T.Overview of mammary gland development:a comparison of mouse and human[M]//MARTIN F,STEIN T,HOWLIN J.Mammary gland development.New York, Humana Press,2017.
[15] HOLANDA D M,MARCOLLA C S,GUIMARÃES S E F,et al.Dietary L-arginine supplementation increased mammary gland vascularity of lactating sows[J].Animal,2019,13(4):790-798.  
[16] REZAEI R,WU Z L,HOU Y Q,et al.Amino acids and mammary gland development:nutritional implications for milk production and neonatal growth[J].Journal of Animal Science and Biotechnology,2016,7:20.
[17] FARMER C,PALIN M F,MARTEL-KENNES Y.Impact of diet deprivation and subsequent over-allowance during prepuberty.Part 1.Effects on growth performance,metabolite status,and mammary gland development in gilts[J].Journal of Animal Science,2012,90(3):863-871.  
[18] FARMER C,PALIN M F,MARTEL-KENNES Y.Impact of diet deprivation and subsequent over-allowance during prepuberty.Part 2.Effects on mammary gland development and lactation performance of sows[J].Journal of Animal Science,2012,90(3):872-880.  
[19] FARMER C,PALIN M F.Feeding flaxseed to sows during late-gestation and lactation affects mammary development but not mammary expression of selected genes in their offspring[J].Canadian Journal of Animal Science,2008,88(4):585-590.  
[20] TAN J K,MCKENZIE C,MARIÑO E,et al.Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation[J].Annual Review of Immunology,2017,35:371-402.
[21] SONG T X,ZHOU Y F,PENG J,et al.GPR120 promotes adipogenesis through intracellular calcium and extracellular signal-regulated kinase 1/2 signal pathway[J].Molecular and Cellular Endocrinology,2016,434:1-13.
[22] MIYAMOTO J,HASEGAWA S,KASUBUCHI M,et al.Nutritional signaling via free fatty acid receptors[J].International Journal of Molecular Science,2016,17(4):450.
[23] WANG S B,XIANG N N,YANG L S,et al.Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells[J].Biochemical and Biophysical Research Communications,2016,471(4):566-571.  
[24] MENG Y Y,ZHANG J,YUAN C,et al.Oleic acid stimulates HC11 mammary epithelial cells proliferation and mammary gland development in peripubertal mice through activation of CD36-Ca2+ and PI3K/Akt signaling pathway[J].Oncotarget,2018,9(16):12982-12994.  
[25] MENG Y Y,ZHANG J,ZHANG F L,et al.Lauric acid stimulates mammary gland development of pubertal mice through activation of GPR84 and PI3K/Akt signaling pathway[J].Journal of Agricultural and Food Chemistry,2017,65(1):95-103.  
[26] MENG Y Y,YUAN C,ZHANG J,et al.Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice[J].Biochemical and Biophysical Research Communications,2017,491(1):192-197.  
[27] 孟莹莹,张静,张枫琳,等.高脂日粮对初情期小鼠乳腺发育的影响及分子机制[J].华南农业大学学报,2017,38(3):9-14.
[28] KAMIKAWA A,ICHII O,YAMAJI D,et al.Diet-induced obesity disrupts ductal development in the mammary glands of nonpregnant mice[J].Developmental Dynamics,2009,238(5):1092-1099.  
[29] LEUNG Y K,GOVINDARAJAH V,CHEONG A,et al.Gestational high-fat diet and bisphenol A exposure heightens mammary cancer risk[J].Endocrine-Related Cancer,2017,24(7):365-378.
[30] SIMMEN R.Maternal high fat diet promotion of mammary tumor risk in adult progeny is associated with early expansion of mammary cancer stem-like cells and increased maternal oxidative environment[J].The FASEB Journal,2013,27(1):235.2-.2.
[31] FARMER C,COMI M,DUARTE C R A,et al.Differences in body condition of gilts that are maintained from mating to the end of gestation affect mammary development[J].Journal of Animal Science,2016,94(8):3206-3214.  
[32] PENG X,YAN C,HU L,et al.Effects of fat supplementation during gestation on reproductive performance,milk composition of sows and intestinal development of their offspring[J].Animals,2019,9(4):E125.
[33] LAURIDSEN C,DANIELSEN V.Lactational dietary fat levels and sources influence milk composition and performance of sows and their progeny[J].Livestock Production Science,2004,91(1/2):95-105.
[34] ANDERSON B M,MACLENNAN M B,HILLYER L M,et al.Lifelong exposure to n-3 PUFA affects pubertal mammary gland development[J].Applied Physiology Nutrition and Metabolism,2014,39(6):699-706.  
[35] LIU J J,ABDELMAGID S A,PINELLI C J,et al.Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors[J].The Journal of Nutritional Biochemistry,2018,55(6):41-52.
[36] BERRYHILL G E,GLOVICZKI J M,TROTT J F,et al.Diet-induced metabolic change induces estrogen-independent allometric mammary growth[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109(40):16294-16299.  
[37] LIU Y E,PU W P,WANG J D,et al.Activation of Stat5 and induction of a pregnancy-like mammary gland differentiation by eicosapentaenoic and docosapentaenoic omega-3 fatty acids[J].The FEBS Journal,2007,274(13):3351-3362.  
[38] HILL E M,ESPER R M,SEN A,et al.Dietary polyunsaturated fatty acids modulate adipose secretome and is associated with changes in mammary epithelial stem cell self-renewal[J].The Journal of Nutritional Biochemistry,2019,71:45-53.
[39] LAVERY A,LAWLOR P G,MILLER H M,et al.The effect of dietary oil type and energy intake in lactating sows on the fatty acid profile of colostrum and milk,and piglet growth to weaning[J].Animals,2019,9(12):1092.
[40] MCAFEE J M,KATTESH H G,LINDEMANN M D,et al.Effect of omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation to lactating sows on growth and indicators of stress in the postweaned pig[J].Journal of Animal Science,2019,97(11):4453-4463.  
[41] FLUMMER C,THEIL P K.Effect of β-hydroxy β-methyl butyrate supplementation of sows in late gestation and lactation on sow production of colostrum and milk and piglet performance[J].Journal of Animal Science,2012,90(Suppl.4):372-374.
[42] KROGH U,FLUMMER C,JENSEN S K,et al.Colostrum and milk production of sows is affected by dietary conjugated linoleic acid[J].Journal of Animal Science,2012,90(Suppl.4):366-368.
[43] SANDRI E C,HARVATINE K J,OLIVEIRA D E.Trans-10,cis-12 conjugated linoleic acid reduces milk fat content and lipogenic gene expression in the mammary gland of sows without altering litter performance[J].British Journal of Nutrition,2019,123(6):610-618.
[44] LV Y T,ZHANG S H,GUAN W T,et al.Metabolic transition of milk triacylglycerol synthesis in response to varying levels of palmitate in porcine mammary epithelial cells[J].Genes & Nutrition,2018,13:18.
[45] 孟莹莹.脂肪酸对初情期小鼠乳腺发育的影响及其分子机制研究[D].硕士学位论文.广州:华南农业大学,2017.
[46] OLSON L K,TAN Y,ZHAO Y,et al.Pubertal exposure to high fat diet causes mouse strain-dependent alterations in mammary gland development and estrogen responsiveness[J].International Journal of Obesity,2010,34(9):1415-1426.  
[47] HILAKIVI-CLARKE L,CHO E,CABANES A,et al.Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring[J].Clinical Cancer Research,2002,8(11):3601-3610.
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