[1] ADRIAENSSENS A E,REIMANN F,GRIBBLE F M.Distribution and stimulus secretion coupling of enteroendocrine cells along the intestinal tract[J].Comprehensive Physiology,2018,8(4):1603-1638.
[2] MACE O J,TEHAN B,MARSHALL F.Pharmacology and physiology of gastrointestinal enteroendocrine cells[J].Pharmacology Research & Perspectives,2015,3(4):e00155.
[3] SANTOS-HERNÁNDEZ M,MIRALLES B,AMIGO L,et al.Intestinal signaling of proteins and digestion-derived products relevant to satiety[J].Journal of Agricultural and Food Chemistry,2018,66(39):10123-10131.
[4] REIMANN F,TOLHURST G,GRIBBLE F M.G-protein-coupled receptors in intestinal chemosensation[J].Cell Metabolism,2012,15(4):421-431.
[5] SYMONDS E L,PEIRIS M,PAGE A J,et al.Mechanisms of activation of mouse and human enteroendocrine cells by nutrients[J].Gut,2015,64(4):618-626.
[6] TIAN M,HENG J H,SONG H Q,et al.Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1/T1R3 using an
in vitro porcine jejunum model[J].Food & Function,2018,10(6):3356-3367.
[7] XIAN Y H,ZHAO X Y,WANG C,et al.Phenylalanine and tryptophan stimulate gastrin and somatostatin secretion and H
+-K
+-ATPase activity in pigs through calcium-sensing receptor[J].General and Comparative Endocrinology,2018,267:1-8.
[8] ZHAO X Y,XIAN Y H,WANG C,et al.Calcium-sensing receptor-mediated
L-tryptophan-induced secretion of cholecystokinin and glucose-dependent insulinotropic peptide in swine duodenum[J].Journal of Veterinary Science,2018,19(2):179-187.
[9] FENG J Y,KANG C C,WANG C,et al.
L-phenylalanine increased gut hormone secretion through calcium-sensing receptor in the porcine duodenum[J].Animals,2019,9(8):476.
[10] WANG C,KANG C C,XIAN Y H,et al.Sensing of
L-arginine by gut-expressed calcium sensing receptor stimulates gut satiety hormones cholecystokinin and glucose-dependent insulinotropic peptide secretion in pig model[J].Journal of Food Science,2018,83(9):2394-2401.
[11] STEENSELS S,DEPOORTERE I.Chemoreceptors in the gut[J].Annual Review of Physiology,2018,80:117-141.
[12] TODA N,HAO X L,OGAWA Y,et al.Potent and orally bioavailable GPR142 agonists as novel insulin secretagogues for the treatment of type 2 diabetes[J].ACS Medicinal Chemistry Letters,2013,4(8):790-794.
[13] HAID D,WIDMAYER P,BREER H.Nutrient sensing receptors in gastric endocrine cells[J].Journal of Molecular Histology,2011,42(4):355-364.
[14] LIOU A P,SEI Y,ZHAO X L,et al.The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to
L-phenylalanine in acutely isolated intestinal I cells[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2011,300(4):G538-G546.
[15] HERSEY S J,SACHS G.Gastric acid secretion[J].Physiological Reviews,1995,75(1):155-189.
[16] DUFNER M M,KIRCHHOFF P,REMY C,et al.The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2005,289(6):G1084-G1090.
[17] 赵秀英,孟祥龙,伍力,等.日粮不同蛋白水平对猪小肠
CaSR基因表达及胃肠激素分泌的影响[J].畜牧与兽医,2016,48(12):30-35.
[18] KLEPAC K,KILI? A,GNAD T,et al.The Gq signalling pathway inhibits brown and beige adipose tissue[J].Nature Communications,2016,7(1):10895.
[19] COURJARET R,DIB M,MACHAC K.Spatially restricted subcellular Ca
2+ signaling downstream of store-operated calcium entry encoded by a cortical tunneling mechanism[J].Scientific Reports,2018,8(1):11214,doi:10.1038/s41598-018-29562-9.
[20] ZHOU H R,PESTKA J J.Deoxynivalenol (vomitoxin)-induced cholecystokinin and glucagon-like peptide-1 release in the STC-1 enteroendocrine cell model is mediated by calcium-sensing receptor and transient receptor potential ankyrin-1 channel[J].Toxicological Sciences,2015,145(2):407-417.
[21] NELSON G,CHANDRASHEKAR J,HOON M A,et al.An amino-acid taste receptor[J].Nature,2002,416(6877):199-202.
[22] DALY K,AL-RAMMAHI M,MORAN A,et al.Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2013,304(3):G271-G282.
[23] 康翠翠.
L-氨基酸通过感应体调控猪CCK分泌的机制及谷氨酸对大鼠CCK和采食的影响[D].硕士学位论文.南京:南京农业大学,2018.
[24] DE GIORGIO R,MAZZONI M,VALLORANI C,et al.Regulation of α-transducin and α-gustducin expression by a high protein diet in the pig gastrointestinal tract[J].PLoS One,2016,11(2):e0148954.
[25] WANG H X,MURTHY K S,GRIDER J R.Expression patterns of
L-amino acid receptors in the murine STC-1 enteroendocrine cell line[J].Cell and Tissue Research,2019,378(3):471-483.
[26] CROWE M S,WANG H X,BLAKENEY B A,et al.Expression and function of umami receptors T1R1/T1R3 in gastric smooth muscle[J].Neurogastroenterology & Motility,2020,32(2):e13737.
[27] CONIGRAVE A D,HAMPSON D R.Broad-spectrum
L-amino acid sensing by class 3 G-protein-coupled receptors[J].Trends in Endocrinology & Metabolism,2006,17(10):398-407.
[28] NAKAMURA E,HASUMURA M,UNEYAMA H,et al.Luminal amino acid-sensing cells in gastric mucosa[J].Digestion,2011,83(Suppl.1):13-18.
[29] OYA M,KITAGUCHI T,PAIS R,et al.The G Protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells[J].Journal of Biological Chemistry,2012,288(7):4513-4527.
[30] CLEMMENSEN C,JORGENSEN C V,SMAJILOVIC S,et al.Robust GLP-1 secretion by basic
L-amino acids does not require the GPRC6A receptor[J].Diabetes Obesity and Metabolism,2017,19(4):599-603.
[31] FERRIGNO A,BERARDO C,DI PASQUA L G,et al.Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract[J].World Journal of Gastroenterology,2017,23(25):4500-4507.
[32] ZHANG J,YIN Y L,SHU X G,et al.Oral administration of MSG increases expression of glutamate receptors and transporters in the gastrointestinal tract of young piglets[J].Amino Acids,2013,45(5):1169-1177.
[33] YOSHIDA Y,KAWABATA Y,KAWABATA F,et al.Expressions of multiple umami taste receptors in oral and gastrointestinal tissues,and umami taste synergism in chickens[J].Biochemical and Biophysical Research Communications,2015,466(3):346-349.
[34] ENGELSTOFT M S,PARK W M,SAKATA I,et al.Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells[J].Molecular Metabolism,2013,2(4):376-392.
[35] BRÖER S.Amino acid transport across mammalian intestinal and renal epithelia[J].Physiologocal Reviews,2008,88(1):249-286.
[36] BRÖER S,FAIRWEATHER S J.Amino acid transport across the mammalian intestine[J].Comprehensive Physiology,2018,9(1):343-373.
[37] CONDON K J,SABATINI D M.Nutrient regulation of mTORC1 at a glance[J].Journal of Cell Science,2019,132(21):jcs222570.
[38] DUAN Y H,LI F N,TAN K R,et al.Key mediators of intracellular amino acids signaling to mTORC1 activation[J].Amino Acids,2015,47(5):857-867.
[39] GOBERDHAN D C I,WILSON C,HARRIS A L.Amino acid sensing by mTORC1:intracellular transporters mark the spot[J].Cell Metabolism,2016,23(4):580-589.
[40] HAN J M,JEONG S J,PARK M C,et al.Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway[J].Cell,2012,149(2)410-424.
[41] LEI H T,MA J M,MARTINEZ S S.Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state[J].Nature Structural & Molecular Biology,2018,25(6):522-527.
[42] NICKLIN P,BERGMAN P,ZHANG B L,et al.Bidirectional transport of amino acids regulates mTOR and autophagy[J].Cell,2009,136(3):521-534.
[43] EFEYAN A,COMB W C,SABATINI D M.Nutrient-sensing mechanisms and pathways[J].Nature,2015,517(7534):302-310.
[44] JACKSON R J,HELLEN C U T,PESTOVA T V.The mechanism of eukaryotic translation initiation and principles of its regulation[J].Nature Reviews Molecular Cell Biology,2010,11(2):113-127.
[45] HARDING H P,NOVOA I,ZHANG Y H,et al.Regulated translation initiation controls stress-induced gene expression in mammalian cells[J].Molecular Cell,2000,6(5):1099-1108.
[46] BRÖER S.Amino acid homeostasis and signalling in mammalian cells and organisms[J].Biochemical Journal,2017,474(12):1935-1963.
[47] TIMOSENKO E,GHADBANE H,SILK J D,et al.Nutritional stress induced by tryptophan-degrading enzymes results in ATF4-dependent reprogramming of the amino acid transporter profile in tumor cells[J].Cancer Research,2016,76(21):6193-6204.
[48] BALASUBRAMANIAN M N,BUTTERWORTH E A,KILBERG M S.Asparagine synthetase:regulation by cell stress and involvement in tumor biology[J].American Journal of Physiology:Endocrinology and Metabolism,2013,304(8):E789-E799.
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