综述 REVIEW

自噬调节动物氧化应激反应的分子机制

  • 齐鸣 ,
  • 谭碧娥
展开
  • 1. 中国科学院亚热带农业生态研究所, 亚热带农业生态过程重点实验室, 动物营养生理与代谢过程湖南省重点实验室, 长沙 410125;
    2. 中国科学院大学, 北京 100008;
    3. 湖南农业大学动物科技学院, 长沙 410128
齐鸣(1994-),男,湖北武汉人,博士研究生,从事单胃动物营养研究。E-mail:qiming429@163.com

收稿日期: 2020-02-24

  网络出版日期: 2020-09-17

基金资助

国家自然科学基金项目(31672433);湖南省重点研发计划项目(2018WK2070)

Molecular Mechanism of Autophagy Regulating Oxidative Stress in Animals

  • QI Ming ,
  • TAN Bi'e
Expand
  • 1. Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China;
    2. University of Chinese Academy of Sciences, Beijing 100008, China;
    3. College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2020-02-24

  Online published: 2020-09-17

摘要

氧化应激是机体氧化还原状态的失衡,会导致大量活性氧产生,不可逆地氧化细胞DNA和生物分子;同时,氧化应激可以诱导自噬的产生。细胞自噬是一种细胞降解胞内物质的生理过程,其通过清除错误折叠蛋白质、损伤的细胞器以及入侵的微生物以维持细胞自身稳态。本文主要对自噬的类型与形成过程、自噬的调控方式、氧化应激诱导自噬的原因、自噬缓解氧化应激的机制及营养物质调控自噬发生等进行综述,以期为畜禽生产中通过营养调控自噬缓解氧化应激提供理论依据。

本文引用格式

齐鸣 , 谭碧娥 . 自噬调节动物氧化应激反应的分子机制[J]. 动物营养学报, 2020 , 32(9) : 3993 -4002 . DOI: 10.3969/j.issn.1006-267x.2020.09.005

Abstract

Oxidative stress is a stress status when the balance of oxidation and anti-oxidation system breaks down, which results in excess reactive oxygen species and irreversibly oxidizes cellular DNA and biomolecules. In addition, oxidative stress can induce autophagy. Autophagy is a physiological process degrading damaged intracellular materials. It preserves cellular homeostasis by degrading misfolded proteins, damaged organelles and invading microorganisms. This article mainly described the types and processes of autophagy, the way regulating autophagy, the causes of autophagy induced by oxidative stress, the mechanisms by which autophagy mitigates oxidative stress, and the pathway of autophagy mediated by nutrients. We attempt to provide a theoretical basis for nutrients alleviating oxidative stress in livestock production through mediating autophagy.

参考文献

[1] SÁNCHEZ-ÁLVAREZ M,STRIPPOLI R,DONADELLI M,et al.Sestrins as a therapeutic bridge between ROS and autophagy in cancer[J].Cancers,2019,11(10):E1415.
[2] WANG T,WANG Q W,SONG R L,et al.Autophagy plays a cytoprotective role during cadmium-induced oxidative damage in primary neuronal cultures[J].Biological Trace Element Research,2015,168(2):481-489.  
[3] TANG Y L,LI J J,LI F N,et al.Autophagy protects intestinal epithelial cells against deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway[J].Free Radical Biology and Medicine,2015,89:944-951.
[4] CHEN Y Q,KLIONSKY D.The regulation of autophagy-unanswered questions[J].Journal of Cell Science,2011,124(2):161-170.  
[5] HOSOKAWA N,HARA T,KAIZUKA T,et al.Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy[J].Molecular Biology of the Cell,2009,20(7):1981-1991.  
[6] RAVANAN P,SRIKUMAR I F,TALWAR P.Autophagy:the spotlight for cellular stress responses[J].Life Science,2017,188:53-67.
[7] LEVINE B,KROEMER G.Biological functions of autophagy genes:a disease perspective[J].Cell,2019,176(1/2):11-42.
[8] GATICA D,LAHIRI V,KLIONSKY D.Cargo recognition and degradation by selective autophagy[J].Nature Cell Biology,2018,20(3):233-242.  
[9] DRAKE L E,SPRINGER M Z,POOLE L P,et al.Expanding perspectives on the significance of mitophagy in cancer[J].Seminars in Cancer Biology,2017,47:110-124.
[10] WYANT G,ABU-REMAILEH M,FRENKEL E,et al.NUFIP1 is a ribosome receptor for starvation-induced ribophagy[J].Science,2018,360(6390):751-758.  
[11] CHAUHAN S,KUMAR S,JAIN A,et al.TRIMs and galectins globally cooperate and TRIM16 and galectin-3 co-direct autophagy in endomembrane damage homeostasis[J].Developmental Cell,2016,39(1):13-27.  
[12] YOSHIDA Y,YASUDA S,FUJITA T,et al.Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy[J].Proceedings of the National Academy of Sciences of the United States of America,2017,114(32):8574-8579.  
[13] CIPOLLA C M,LODHI I J.Peroxisomal dysfunction in age-related diseases[J].Trends in Endocrinology and Metabolism,2017,28(4):297-308.  
[14] ZECHNER R,MADEO F,KRATKY D.Cytosolic lipolysis and lipophagy:two sides of the same coin[J].Nature Reviews Molecular Cell Biology,2017,18(11):671-684.  
[15] FRANCO L H,NAIR V R,SCHARN C R,et al.The ubiquitin ligase SMURF1 functions in selective autophagy of Mycobacterium tuberculosis and anti-tuberculous host defense[J].Cell Host and Microbe,2017,21(1):59-72.  
[16] MITCHELL G,ISBERG R R.Innate immunity to intracellular pathogens:balancing microbial elimination and inflammation[J].Cell Host and Microbe,2017,22(2):166-175.  
[17] LIU G,SABATINI D M.mTOR at the nexus of nutrition,growth,ageing and disease[J].Nature Reviews Molecular Cell Biology,2020,doi:10.1038/s41580-019-0199-y.
[18] ZACHARI M,GANLEY I G.The mammalian ULK1 complex and autophagy initiation[J].Essays in Biochemistry,2017,61(6):585-596.  
[19] LAND S C,TEE A R.Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif[J].The Journal of Biological Chemistry,2007,282(28):20534-20543.  
[20] GÖRLACH A,BONELLO S.The cross-talk between NF-κB and HIF-1:further evidence for a significant liaison[J].Biochemical Journal,2008,412(3):e17-e19.
[21] HUANG J,LAM G Y,BRUMELL J H.Autophagy signaling through reactive oxygen species[J].Antioxidants & Redox Signaling,2011,14(11):2215-2231.  
[22] SU Z D,BURCHFIELD J G,YANG P Y,et al.Global redox proteome and phosphoproteome analysis reveals redox switch in Akt[J].Nature Communication,2019,10:5486.
[23] SCHERZ-SHOUVAL R,SHVETS E,FASS E,et al.Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4[J].EMBO Journal,2007,26(7):1749-1760.  
[24] LIU B,CHENG Y,ZHANG B,et al.Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway[J].Cancer Letters,2009,275(1):54-60.  
[25] WANG S H,SHIH Y,KUO T C,et al.Cadmium toxicity toward autophagy through ROS-activated GSK-3β in mesangial cells[J].Toxicological Sciences,2009,108(1):124-131.  
[26] CHO S H,LEE C H,AHN Y,et al.Redox regulation of PTEN and protein tyrosine phosphatases in H2O2-mediated cell signaling[J].FEBS Letters,2004,560(1/2/3):7-13.
[27] COOKE M S,EVANS M D,DIZDAROGLU M,et al.Oxidative DNA damage:mechanisms,mutation,and disease[J].The FASEB Journal,2003,17(10):1195-1214.  
[28] NARENDRA D,TANAKA A,SUEN D F,et al.Parkin is recruited selectively to impaired mitochondria and promotes their autophagy[J].The Journal of Cell Biology,2008,183(5):795-803.  
[29] WU H,CHEN Q.Hypoxia activation of mitophagy and its role in disease pathogenesis[J].Antioxidants and Redox Signaling,2015,22(12):1032-1046.  
[30] ROOS W P,KAINA B.DNA damage-induced cell death:from specific DNA lesions to the DNA damage response and apoptosis[J].Cancer Letters,2013,332(2):237-248.  
[31] DOTIWALA F,EAPEN V V,HARRISON J C,et al.DNA damage checkpoint triggers autophagy to regulate the initiation of anaphase[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(1):E41-E49.
[32] RODRÍGUEZ-VARGAS J,RUIZ-MAGAÑA M,RUIZ-RUIZ C,et al.ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy[J].Cell Research,2012,22(7):1181-1198.  
[33] ALEXANDER A,CAI S L,KIM J,et al.ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(9):4153-4158.  
[34] CHEN T W,LUO W,WU G J,et al.A novel MyD88 inhibitor LM9 prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages[J].Toxicology and Applied Pharmacology,2019,370:44-55.
[35] DERETIC V,LEVINE B.Autophagy balances inflammation in innate immunity[J].Autophagy,2018,14(2):243-251.  
[36] SAITOH T,FUJITA N,JANG M H,et al.Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production[J].Nature,2008,456(7219):264-268.  
[37] SUMPTER R,Jr,SIRASANAGANDLA S,FERNÁNDEZ Á F,et al.Fanconi anemia proteins function in mitophagy and immunity[J].Cell,2016,165(4):867-881.  
[38] KIMURA T,JAIN A,CHOI S W,et al.TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity[J].The Journal of Cell Biology,2015,210(6):973-989.  
[39] LIU T,TANG Q,LIU K P,et al.TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy[J].Cell Reports,2016,16(7):1988-2002.  
[40] MATSUZAWA-ISHIMOTO Y,HWANG S,CADWELL K.Autophagy and inflammation[J].Annual Review of Immunology,2018,36:73-101.
[41] STRANKS A J,HANSEN A L,PANSE I,et al.Autophagy controls acquisition of aging features in macrophages[J].Journal of Innate Immunity,2015,7(4):375-391.  
[42] LEE J P W,FOOTE A,FAN H P,et al.Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages[J].Autophagy,2016,12(6):907-916.  
[43] TAL M C,SASAI M,LEE H K,et al.Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling[J].Proceedings of the National Academy of Sciences of the United States of America,2009,106(8):2770-2775.  
[44] RAVINDRAN R,KHAN N,NAKAYA H I,et al.Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation[J].Science,2014,343(6168):313-317.  
[45] KHAN N,VIDYARTHI A,PAHARI S,et al.Signaling through NOD-2 and TLR-4 bolsters the T cell priming capability of dendritic cells by inducing autophagy[J].Scientific Reports,2016,6:19084.
[46] CASTILLO E F,DEKONENKO A,ARKO-MENSAH J,et al.Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109(46):E3168-E3176.
[47] MITROULIS I,KOURTZELIS I,KAMBAS K,et al.Regulation of the autophagic machinery in human neutrophils[J].European Journal of Immunology,2010,40(5):1461-1472.  
[48] REMIJSEN Q,BERGHE T V,WIRAWAN E,et al.Neutrophil extracellular trap cell death requires both autophagy and superoxide generation[J].Cell Research,2011,21(2):290-304.  
[49] PEI B,ZHAO M,MILLER B C,et al.Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation[J].The Journal of Immunology,2015,194(12):5872-5884.  
[50] O'SULLIVAN T E,JOHNSON L R,KANG H H,et al.BNIP3-and BNIP3L-mediated mitophagy promotes the generation of natural killer cell memory[J].Immunity,2015,43(2):331-342.  
[51] O'SULLIVAN T E,GEARY C D,WEIZMAN O E,et al.Atg5 is essential for the development and survival of innate lymphocytes[J].Cell Reports,2016,15(9):1910-1919.  
[52] MATSUZAWA Y,OSHIMA S,TAKAHARA M,et al.TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy[J].Autophagy,2015,11(7):1052-1062.  
[53] JIA W,HE M X,MCLEOD I X,et al.Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1[J].Autophagy,2015,11(12):2335-2345.  
[54] CHEN M,HONG M J,SUN H H,et al.Essential role for autophagy in the maintenance of immunological memory against influenza infection[J].Nature Medicine,2014,20(5):503-510.  
[55] PAPADOPOULOS C,KIRCHNER P,BUG M,et al.VCP/p97 cooperates with YOD1,UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy[J].EMBO Journal,2017,36(2):135-150.  
[56] YOSHII S R,KISHI C,ISHIHARA N,et al.Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane[J].The Journal of Biological Chemistry,2011,286(22):19630-19640.  
[57] WEI Y J,CHIANG W C,SUMPTER R,et al.Prohibitin 2 is an inner mitochondrial membrane mitophagy receptor[J].Cell,2017,168(1/2):224-238.e10.
[58] ZHOU H L,WERTZ I,O'ROURKE K,et al.Bcl10 activates the NF-κB pathway through ubiquitination of NEMO[J].Nature,2003,427(6970):167-171.
[59] GU X,OROZCO J M,SAXTON R A,et al.SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway[J].Science,2017,358(6364):813-818.  
[60] TAN S H,SHUI G,ZHOU J,et al.Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin)[J].The Journal of Biological Chemistry,2012,287(18):14364-14376.  
[61] KOGA H,KAUSHIK S,CUERVO A M.Altered lipid content inhibits autophagic vesicular fusion[J].The FASEB Journal,2010,24(8):3052-3065.  
[62] CHU Q,YU X,JIA R Y,et al.Flavonoids from Apios americana Medikus leaves protect RAW264.7 cells against inflammation via inhibition of MAPKs,Akt-mTOR pathways,and Nfr2 activation[J].Oxidative Medicine and Cellular Longevity,2019,2019:1563024.
[63] ASHRAFIZADEH M,AHMADI Z,FARKHONDEH T,et al.Autophagy as a molecular target of quercetin underlying its protective effects in human diseases[J].Archives of Physiology and Biochemistry,2019,28:1-9.
[64] ZHANG E X,YIN S T,ZHAO S,et al.Protective effects of glycycoumarin on liver diseases[J].Phytotherapy Research,2019:1-7,doi:10.1002/ptr.6598.
[65] XUAN H Z,OU A Q,HAO S Y,et al.Galangin protects against symptoms of dextran sodium sulfate-induced acute colitis by activating autophagy and modulating the gut microbiota[J].Nutrients,2020,12(2):347.
[66] BRIDGEMAN B B,WANG P,YE B P,et al.Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes:a new implication of skin cancer prevention[J].Cellular Signalling,2016,28(5):460-468.  
[67] LIU L Y,WU Y X,HUANG X L.Orientin protects myocardial cells against hypoxia-reoxygenation injury through induction of autophagy[J].European Journal of Pharmacology,2016,776:90-98.
[68] JOHANSON I,MONSEN V T,PETTERSEN K,et al.The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells[J].Autophagy,2015,11(9):1636-1651.  
[69] WU Y P,WANG B K,XU H,et al.Probiotic Bacillus attenuates oxidative stress-induced intestinal injury via p38-mediated autophagy[J].Frontiers in Microbiology,2019,10:2185.
[70] YANG J H,CHEN Q,TIAN S Y,et al.The role of 1,25-dyhydroxyvitamin D3 in mouse liver ischemia reperfusion injury:regulation of autophagy through activation of MEK/ERK signaling and PTEN/PI3K/Akt/mTORC1 signaling[J].American Journal of Translational Research,2015,7(12):2630-2645.
[71] SEBORI R,KUNO A,HOSODA R,et al.Resveratrol decreases oxidative stress by restoring mitophagy and improves the pathophysiology of dystrophin-deficient mdx mice[J].Oxidative Medicine and Cellular Longevity,2018,2018:9179270.
[72] KIM S H,KIM H.Astaxanthin modulation of signaling pathways that regulate autophagy[J].Marine Drugs,2019,17(10):546.
文章导航

/