魏筱诗 , 姚军虎 , 王翀 . 烟酸和烟酰胺在反刍动物机体代谢及生产研究中的异同性[J]. 动物营养学报, 2020 , 32(12) : 5509 -5515 . DOI: 10.3969/j.issn.1006-267x.2020.12.003

[1] BELENKY P,BOGAN K L,BRENNER C.NAD⁺ metabolism in health and disease[J].Trends in Biochemical Science,2007,32:12-19.
[2] ROMANI M,HOFER D C,KATSYUBA E,et al.Niacin:an old lipid drug in a new NAD⁺ dress[J].Journal of Lipid Research,2019,60:741-746.
[3] CHEN J,YANG Z,DONG G.Niacin nutrition and rumen-protected niacin supplementation in dairy cows:an updated review[J].British Journal of Nutrition,2019,122:1103-1112.
[4] FRYE T,WILLIAMS S N,GRAHAM T W.Vitamin deficiencies in cattle[J].Veterinary Clinics of North America:Food Animal Practice,1991,7:217-275.
[5] BENAVENTE C A,JACOBSON M K,JACOBSON E L,et al.NAD in skin:therapeutic approaches for niacin[J].Current Pharmaceutical Design,2009,15(1):29-38.  
[6] NIEHOFF I D,HÜTHER L,LEBZIEN P.Niacin for dairy cattle:a review[J].British Journal of Nutrition,2008,101:5-19.
[7] SECK M,LINTON J V,ALLEN M,et al.Apparent ruminal synthesis of B vitamins in lactating dairy cows fed diets with different forage-to-concentrate ratios[J].Journal of Dairy Science,2017,100:1914-1922.
[8] NIEHOFF I D,HUTHE L,LEBZIEN P,et al.Investigations on the effect of a niacin supplementation to three diets differing in forage-to-concentrate ratio on several blood and milk variables of dairy cows[J].Archives of Animal Nutrition,2009,63(3):203-218.  
[9] SANTSCHI D E,BERTHIAUME R,MATTE J J,et al.Fate of supplementary B-vitamins in the gastrointestinal tract of dairy cows[J].Journal of Dairy Science,2005,88(6):2043-2054.  
[10] SCHWAB E C,CARAVIELLO D Z,SHAVER R D. Review:a Meta-analysis of lactation responses to supplemental dietary niacin in dairy cows[J].The Professional Animal Scientist,2005,21(4):239-247.  
[11] PIRES J A A,STUMPF L F,SOUTULLO I D,et al.Effects of abomasal infusion of nicotinic acid on responses to glucose and β-agonist challenges in underfed lactating cows[J].Journal of Dairy Science,2016,99:2297-2307.
[12] TIENKEN R,KERSTEN S,FRAHM J,et al.Effects of prepartum dietary energy level and nicotinic acid supplementation on immunological, hematological and biochemical parameters of periparturient dairy cows differing in parity[J].Animals,2015,5(3):910-933.  
[13] WEI X S,CAI C J,HE J J,et al.Effects of biotin and nicotinamide supplementation on glucose and lipid metabolism and milk production of transition dairy cows[J].Animal Feed Science and Technology,2018,237:106-117.
[14] MOREY S D,MAMEDOVA L K,ANDERSON D E,et al.Effects of encapsulated niacin on metabolism and production of periparturient dairy cows[J].Journal of Dairy Science,2011,94(10):5090-5104.  
[15] 魏筱诗.烟酰胺对围产期奶畜糖脂代谢及其子代肠道发育的影响和机制[D].博士学位论文.杨凌:西北农林科技大学,2019.
[16] 高雨飞.高精料日粮条件下烟酸对牛瘤胃微生物区系的影响[D].硕士学位论文.南昌:江西农业大学,2016.
[17] GILLE A,BODOR E T,AHMED K,et al.Nicotinic acid:pharmacological effects and mechanisms of action[J].Annual Review of Pharmacology and Toxicology,2008,48:79-106.
[18] 颜研.泌乳奶牛日粮烟酰胺适宜补饲量研究[D].硕士学位论文.山东:山东农业大学,2011.
[19] WEI X S,YIN Q Y,ZHAO H H,et al.Metabolomics for the effect of biotin and nicotinamide on transition dairy cows[J].Journal of Agricultural and Food Chemistry,2018,66:5723-5732.
[20] 赵会会.围产期奶山羊添加烟酰胺对羔羊糖脂代谢的影响及其机制[D].硕士学位论文.杨凌:西北农林科技大学,2018.
[21] LI M,SUN X,ZHOU Y,et al.Nicotinamide and resveratrol regulate bovine adipogenesis through a SIRT1-dependent mechanism[J].Journal of Functional Foods,2015,18:492-500.
[22] BAI L,PANG W J,YANG Y J,et al.Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes[J].Molecular and Cellular Biochemistry,2008,307(1/2):129-140.
[23] SHAPIRO A L B,BOYLE K E,DABELEA D,et al.Nicotinamide promotes adipogenesis in umbilical cord-derived mesenchymal stem cells and is associated with neonatal adiposity:the healthy start baby BUMP project[J].Plos One,2016,11(7):e0159575.
[24] WANG H,QIANG L,FARMER S R.Identification of a domain within peroxisome proliferator-activated receptor {gamma} regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes[J].Molecular and Cellular Biology,2008,28(1):188-200.  
[25] HWANG E S,SONG S B.Nicotinamide is an inhibitor of SIRT1in vitro, but can be a stimulator in cells[J].Cellular and Molecular Life Sciences,2017,74(1):3347.
[26] YANG S J,CHOI J M,KIM L,et al.Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes[J].Journal of Nutritional Biochemistry,2014,25(1):66-72.  
[27] ZIMBELMAN R B,COLLIER R J,BILBY T R.Effects of utilizing rumen protected niacin on core body temperature as well as milk production and composition in lactating dairy cows during heat stress[J].Animal Feed Science and Technology,2013,180(1):26-33.
[28] 王雪莹,王之盛,薛白,等.烟酸对热应激牦牛生长性能、营养物质表观消化率和血液指标的影响[J].动物营养学报,2020,32(5):2228-2240.
[29] GANJI S H,QIN S,ZHANG L,et al.Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells[J].Atherosclerosis,2009,202:68-75.
[30] GANJI S H,KASHYAP M L,KAMANNA V S.Niacin inhibits fat accumulation,oxidative stress,and inflammatory cytokine IL-8 in cultured hepatocytes:impact on non-alcoholic fatty liver disease[J].Metabolism,2015,64(9):982-990.  
[31] WEI X S,ZHAO H H,HE J J,et al.Maternal nicotinamide supplementation during the perinatal period modifies the small intestine morphology and antioxidative status of offspring kids[J].Animal Feed Science and Technology,2019,252:41-50.
[32] ERSHUN Z,YIMENG L,MINJUN Y,et al.Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms[J].International Immunopharmacology,2014,23:121-126.
[33] LAPPAS M,PERMEZEL M.The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B₃ derivative, are elicited by FoxO3 in human gestational tissues:implications for preterm birth[J].Journal of Nutritional Biochemistry,2011,22(12):1195-1201.  
[34] GRANGE P A,RAINGEAUD J,CALVEZ V,et al.Nicotinamide inhibits propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kappa B and MAPK pathways[J].Journal of Dermatological Science,2009,56:106-112.
[35] LI D,SUN W P,ZHOU Y M,et al.Chronic niacin overload may be involved in the increased prevalence of obesity in US children[J].World Journal of Gastroenterology,2010,16,2378-2387.
[36] MROCHEK J E,JOLLEY R L,YOUNG D S,et al.Metabolic response of humans to ingestion of nicotinic acid andnicotinamide[J].Clinical Chemistry,1976,22,1821-1827.
[37] LI D,TIAN Y J,GUO J,et al.Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats[J].British Journal of Nutrition,2013,110:2156-2164.
[38] TIAN Y J,LUO N,CHEN N N,et al.Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats[J].British Journal of Nutrition,2014,111:1594-1601.
[39] BEDARD K, KRAUSE K H.The NOX family of ROS-generating NADPH oxidases:physiology and pathophysiology[J].Physiological Reviews,2007,87:245-313.
[40] RUTKOWSKI B,SLOMINSKA E,SZOLKIEWICZ M,et al.N-methyl-2-pyridone-5-carboxamide:a novel uremic toxin[J]Kidney International,2003,63:S19-S21.
[41] RUTKOWSKI B, RUTKOWSKI P, S?OMINSKA E,et al.Cellular toxicity of nicotinamide metabolites[J].Journal of Renal Nutrition,2012,22:95-97.