刘洋 , 戴求仲 , 黄兴国 , 陈立祥 . 阿魏酸的生物学功能及其在畜禽生产上的应用[J]. 动物营养学报, 2020 , 32(12) : 5524 -5531 . DOI: 10.3969/j.issn.1006-267x.2020.12.005

[1] 丁明玉,马帅武,刘德麟.阿魏酸的稳定性及其在川芎和当归药材中的存在形式[J].中草药,2004,35(1):28-30.
[2] MATHEW S,ABRAHAM T E.Ferulic acid:an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications[J].Critical Reviews in Biotechnology,2004,24(2/3):59-83.
[3] 李海刚,胡晒平,周意,等.川芎主要药理活性成分药理研究进展[J].中国临床药理学与治疗学,2018,23(11):1302-1308.
[4] 赵琳,张英锋,马子川.阿魏酸的合成和应用[J].化学教育,2009,30(7):5-7.
[5] 吴嘉仪.生物法生产阿魏酸的技术研究[D].硕士学位论文.武汉:华中科技大学,2015.
[6] KUMAR N,PRUTHI V.Potential applications of ferulic acid from natural sources[J].Biotechnology Reports,2014,4:86-93.
[7] 胡益勇,徐晓玉.阿魏酸的化学和药理研究进展[J].中成药,2006,28(2):253-255.
[8] GRAF E.Antioxidant potential of ferulic acid[J].Free Radical Biology and Medicine,1992,13(4):435-448.  
[9] GOWRI G,BUGOS R C,CAMPBELL W H,et al.Stress responses in alfalfa (Medicago sativa L.):Ⅹ.Molecular cloning and expression of s-adenosyl-L-methionine:caffeic acid 3-O-methyltransferase,a key enzyme of lignin biosynthesis[J].Plant Physiology,1997,97(1):7-14.
[10] SRINIVASAN M,SUDHEER A R,MENON V P.Ferulic acid:therapeutic potential through its antioxidant property[J].Journal of Clinical Biochemistry and Nutrition,2007,40(2):92-100.  
[11] MAURYA D K,DEVASAGAYAM T P A.Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids[J].Food and Chemical Toxicology,2010,48(12):3369-3373.  
[12] MATHEW S,ABRAHAM T E,ZAKARIA Z A.Reactivity of phenolic compounds towards free radicals under in vitro conditions[J].Journal of Food Science and Technology,2015,52(9):5790-5798.  
[13] ALAM M A.Anti-hypertensive effect of cereal antioxidant ferulic acid and its mechanism of action[J].Frontiers in Nutrition,2019,6:121.
[14] 赵东平,杨文钰,陈兴福.阿魏酸的研究进展[J].时珍国医国药,2008,19(8):1839-1841.
[15] 张国治,杨徐宁,张雨.阿魏酸在食品和农业领域的研究进展[J].粮食加工,2019,44(4):41-43.
[16] DAGLIA M.Polyphenols as antimicrobial agents[J].Current Opinion in Biotechnology,2012,23(2):174-181.  
[17] 赵利利,李志田,李彬彬,等.阿魏酸对大肠杆菌和蜡状芽孢杆菌产组胺的影响[J].食品工业科技,2018,39(8):113-118.
[18] ZHANG Y X,WEI J P,QIU Y,et al.Structure-dependent inhibition of Stenotrophomonas maltophilia by polyphenol and its impact on cell membrane[J].Frontiers in Microbiology,2019,10:2646.
[19] SHI C,ZHANG X R,SUN Y,et al.Antimicrobial activity of ferulic acid against Cronobacter sakazakii and possible mechanism of action[J].Foodborne Pathogens and Disease,2016,13(4):196-204.  
[20] SANNA C,RIGANO D,CORONA A,et al.Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni,an endemic species of Sardinia (Italy)[J].Natural Product Research,2018,33(12):1798-1803.
[21] SONAR V P,CORONA A,DISTINTO S,et al.Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase[J].European Journal of Medicinal Chemistry,2017,130:248-260.
[22] YAGI K,OHISHI N.Action of ferulic acid and its derivatives as antioxidants[J].Journal of Nutritional Science and Vitaminology,1979,25(2):127-130.  
[23] KRAJKA-KU?NIAK V,PALUSZCZAK J,SZAEFER H,et al.The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase Ⅱ and antioxidant enzyme expression[J].Journal of Physiology and Biochemistry,2015,71(2):227-238.  
[24] MAHMOUD A M,HUSSEIN O E,HOZAYEN W G,et al.Ferulic acid prevents oxidative stress,inflammation,and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats[J].Environmental Science and Pollution Research,2020,27(10):7910-7921.
[25] PEREZ-TERNERO C,WERNER C M,NICKEL A G,et al.Ferulic acid,a bioactive component of rice bran,improves oxidative stress and mitochondrial biogenesis and dynamics in mice and in human mononuclear cells[J].The Journal of Nutritional Biochemistry,2017,48:51-61.
[26] 林秋珊,杨佩芬,尹曼雪,等.阿魏酸对H₂O₂致PC12细胞氧化损伤的保护作用[J].中国实验方剂学杂志,2019,25(13):66-72.
[27] LAMPIASI N,MONTANA G.The molecular events behind ferulic acid mediated modulation of IL-6 expression in LPS-activated Raw 264.7 cells[J].Immunobiology,2016,221(3):486-493.  
[28] CHOWDHURY S,GHOSH S,DAS A K,et al.Ferulic acid protects hyperglycemia-induced kidney damage by regulating oxidative insult,inflammation and autophagy[J].Frontiers in Pharmacology,2019,10:27.
[29] CAO Y J,ZHANG Y M,QI J P,et al.Ferulic acid inhibits H₂O₂-induced oxidative stress and inflammation in rat vascular smooth muscle cells via inhibition of the NADPH oxidase and NF-κB pathway[J].International Immunopharmacology,2015,28(2):1018-1025.  
[30] SHIN J S,BAEK S R,SOHN S I,et al.Anti-inflammatory effect of pelubiprofen,2-[4-(oxocyclohexylidenemethyl)-phenyl]propionic acid,mediated by dual suppression of COX activity and LPS-induced inflammatory gene expression via NF-κB inactivation[J].Journal of Cellular Biochemistry,2011,112(12):3594-3603.  
[31] LAMPIASI N,MONTANA G.An in vitro inflammation model to study the Nrf2 and NF-κB crosstalk in presence of ferulic acid as modulator[J].Immunobiology,2018,223(4/5):349-355.
[32] 杨艳丽.肥胖研究进展[J].济宁医学院学报,2012,35(1):64-66.
[33] 贾伟平.肥胖与糖尿病及心血管事件:流行现状及研究新进展[J].临床内科杂志,2012,29(3):149-151.
[34] WANG O,LIU J,CHENG Q,et al.Effects of ferulic acid and γ-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats[J].PLoS One,2015,10(2):e0118135.
[35] DE MELO T S,LIMA P R,CARVALHO K M M B,et al.Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic,hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity[J].Brazilian Journal of Medical and Biological Research,2017,50(1):e5630.
[36] GUO X X,ZENG Z,QIAN Y Z,et al.Wheat flour,enriched with γ-oryzanol,phytosterol,and ferulic acid,alleviates lipid and glucose metabolism in high-fat-fructose-fed rats[J].Nutrients,2019,11(7):1697.
[37] NARASIMHAN A,CHINNAIYAN M,KARUNDEVI B.Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat[J].Applied Physiology,Nutrition,and Metabolism,2015,40(8):769-781.  
[38] CHO J,PARK E.Ferulic acid maintains the self-renewal capacity of embryo stem cells and adipose-derived mesenchymal stem cells in high fat diet-induced obese mice[J].The Journal of Nutritional Biochemistry,2019,77:108327.
[39] JEMAL A,BRAY F,CENTER M M,et al.Global cancer statistics[J].A Cancer Journal for Clinicians,2011,61(2):69-90.  
[40] AL-ISHAQ R K,OVERY A J,BUSSELBERG D.Phytochemicals and gastrointestinal cancer:cellular mechanisms and effects to change cancer progression[J].Biomolecules,2020,10(1):105.
[41] GAO J H,YU H,GUO W K,et al.The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells[J].Cancer Cell International,2018,18:102.
[42] SAWATA Y,MATSUKAWA T,DOI S,et al.A novel compound,ferulic acid-bound resveratrol,induces the tumor suppressor gene p15 and inhibits the three-dimensional proliferation of colorectal cancer cells[J].Molecular and Cellular Biochemistry,2019,462(1/2):25-31.
[43] YUE S J,ZHANG P X,ZHU Y,et al.A ferulic acid derivative FXS-3 inhibits proliferation and metastasis of human lung cancer A549 cells via positive JNK signaling pathway and negative ERK/p38,AKT/mTOR and MEK/ERK signaling pathways[J].Molecules,2019,24(11):2165.
[44] 黄湘壹.气体信号分子一氧化氮与心血管疾病研究进展[J].社区医学杂志,2014,12(3):14-16.
[45] SUZUKI A,YAMAMOTO M,JOKURA H,et al.Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats[J].American Journal of Hypertension,2007,20(5):508-513.  
[46] ZHOU Z Y,XU J Q,ZHAO W R,et al.Ferulic acid relaxed rat aortic,small mesenteric and coronary arteries by blocking voltage-gated calcium channel and calcium desensitization via dephosphorylation of ERK1/2 and MYPT1[J].European Journal of Pharmacology,2017,815:26-32.
[47] LUO M,CHEN P P,YANG L,et al.Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats:involvement of cardiac PKC and MAPK signaling pathways[J].Biomedicine & Pharmacotherapy,2019,112:108735.
[48] GHOSH S,BASAK P,DUTTA S,et al.New insights into the ameliorative effects of ferulic acid in pathophysiological conditions[J].Food and Chemical Toxicology,2017,103:41-55.
[49] CHOWDHURY S,GHOSH S,RASHID K,et al.Deciphering the role of ferulic acid against streptozotocin-induced cellular stress in the cardiac tissue of diabetic rats[J].Food and Chemical Toxicology,2016,97:187-198.
[50] SAEED M,ALAGAWANY M,FAZLANI S A,et al.Health promoting and pharmaceutical potential of ferulic acid for the poultry industry[J].World's Poultry Science Journal,2019,75(1):83-92.  
[51] SAEED M,ARAIN M A,KAMBOH A A,et al.Raw propolis as a promising feed additive in poultry nutrition:trends and advances[J].Journal of Animal Health and Production,2017,5(4):132-142.
[52] VAN HUNG P,PHAT N H,PHI N T L.Physicochemical properties and antioxidant capacity of debranched starch-ferulic acid complexes[J].Starch,2013,65(5/6):382-389.
[53] IZYDORCZYK M S,BILIADERIS C G.Cereal arabinoxylans:advances in structure and physicochemical properties[J].Carbohydrate Polymers,1995,28(1):33-48.  
[54] 李夏兰,程珊影,杨道秀,等.阿魏酸酯酶和木聚糖酶协同降解麦糟[J].化工进展,2012,31(5):1096-1102,1108.
[55] LEI Z,SHAO Y X,YIN X N,et al.Combination of xylanase and debranching enzymes specific to wheat arabinoxylan improve the growth performance and gut health of broilers[J].Journal of Agricultural and Food Chemistry,2016,64(24):4932-4942.  
[56] LI Y J,LI L Y,LI J L,et al.Effects of dietary supplementation with ferulic acid or vitamin E individually or in combination on meat quality and antioxidant capacity of finishing pigs[J].Asian Australasian Journal of Animal Sciences,2015,28(3):374-381.  
[57] 杨东,刁其玉,马涛,等.阿魏酸和壳寡糖对蒙古杂交羊生长性能及脂肪沉积的影响[J].粮食与饲料工业,2018(9):43-48.
[58] WANG Y,WANG W W,WANG R F,et al.Dietary supplementation of ferulic acid improves performance and alleviates oxidative stress of lambs in a cold environment[J].Canadian Journal of Animal Science,2018,99(4):705-712.
[59] GONZALEZ-RÍOS H,DÁVILA-RAMIREZ J L,PEÑA-RAMOS E A,et al.Dietary supplementation of ferulic acid to steers under commercial feedlot feeding conditions improves meat quality and shelf life[J].Animal Feed Science and Technology,2016,222:111-121.
[60] ABDEL-RAHMAN M A,MOSAAD G M.Effect of propolis as additive on some behavioural patterns,performance and blood parameters in Muscovy broiler ducks[J].Journal of Advanced Veterinary Research,2013,3(2):64-68.
[61] ABDULLA T A,HASSAN M G.The effect of propolis feed supplementation on hygiene and performance of broiler chickens[J].Iraqi Journal of Veterinary Sciences,2011,25(2):77-82.  
[62] SEVEN P T.The effects of dietary Turkish propolis and vitamin C on performance,digestibility,egg production and egg quality in laying hens under different environmental temperatures[J].Asian-Australasian Journal of Animal Science,2008,21(8):1164-1170.