综述 REVIEW

三丁酸甘油酯的生理调控机制及在动物生产中的应用

  • 薛永强 ,
  • 马永喜 ,
  • 赵虎 ,
  • 杨博
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  • 1. 华南理工大学生物科学与工程学院, 广州 510006;
    2. 广东省脂类科学与应用工程技术研究中心, 广州 510006;
    3. 中国农业大学农业部饲料工业中心, 北京 100193
薛永强(1992-),男,甘肃通渭人,硕士,从事功能性脂质的研究。E-mail:yongqiangxue@126.com

收稿日期: 2020-04-15

  网络出版日期: 2020-12-07

基金资助

"十三五"国家重点研发计划专项(2019YFD1002403);国家杰出青年科学基金项目(31725022)

Physiological Regulation Mechanism of Tributyrin and Its Application in Animal Production

  • XUE Yongqiang ,
  • MA Yongxi ,
  • ZHAO Hu ,
  • YANG Bo
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  • 1. School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China;
    2. Guangdong Provincial Research Center for Lipid Science and Applied Engineering Technology, Guangzhou 510006, China;
    3. Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing 100193, China

Received date: 2020-04-15

  Online published: 2020-12-07

摘要

三丁酸甘油酯作为丁酸和甘油的酯化产物,可在动物肠道内胰脂肪酶作用下分解为丁酸和甘油,从而被运输至各组织器官发挥相应的生理作用,例如维持肠道完整性、调节肠道菌群、参与机体免疫调节和能量代谢等。同时,鉴于三丁酸甘油酯的多种生理功能和安全性,其可作为动物生产中抗生素的潜在替代品。本文就三丁酸甘油酯的理化特性、代谢途径、生理功能、作用机制及在动物生产中的应用进行综述,旨在为探究其在动物生产中的应用提供理论参考。

本文引用格式

薛永强 , 马永喜 , 赵虎 , 杨博 . 三丁酸甘油酯的生理调控机制及在动物生产中的应用[J]. 动物营养学报, 2020 , 32(12) : 5547 -5555 . DOI: 10.3969/j.issn.1006-267x.2020.12.008

Abstract

Tributyrin, as the esterification product of butyric acid and glycerol, is decomposed into butyric acids and glycerin by pancreatic lipase in the animal gastrointestinal tract, and then transported to various tissues and organs to exert a physiological role. For instance, tributyrin maintains intestinal integrity, regulates intestinal microbiota, participates in immune regulation and energy metabolism and so on. Meanwhile, given that its various physiological function and safety, the tributyrin can be used as a potential alternative for antibiotics in animal production. This paper reviewed physicochemical properties, metabolic pathways, physiological functions, molecular mechanisms and their application in animal production, aiming to provide a theoretical reference for exploring its application in animal production.

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