综述 REVIEW

霉菌毒素对肠道紧密连接蛋白的影响及其调控机制

  • 杨雪 ,
  • 高亚男 ,
  • 王加启 ,
  • 郑楠
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  • 1. 中国农业科学院北京畜牧兽医研究所, 农业农村部奶及奶制品质量安全控制重点实验室, 北京 100193;
    2. 中国农业科学院北京畜牧兽医研究所, 农业农村部奶产品质量安全风险评估实验室, 北京 100193;
    3. 中国农业科学院北京畜牧兽医研究所, 农业农村部奶及奶制品质量监督检验测试中心, 北京 100193;
    4. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193
杨雪(1996-),女,湖南怀化人,硕士研究生,从事奶产品质量与风险评估与营养功能评价。E-mail:yangxue234723@126.com

收稿日期: 2020-04-26

  网络出版日期: 2020-12-07

基金资助

现代农业产业技术体系专项资金(CARS-36);国家自然科学基金(31972190,31801666);中国农业科学院科技创新工程(ASTIP-IAS12)

Effects of Mycotoxin on Intestinal Tight Junction Protein and Its Regulation Mechanism

  • YANG Xue ,
  • GAO Yanan ,
  • WANG Jiaqi ,
  • ZHENG Nan
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  • 1. Key Laboratory of Quality & Safety Control for Milk and Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Laboratory of Quality and Safety Risk Assessment for Dairy Products of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    3. Milk and Milk Products Inspection Center of Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2020-04-26

  Online published: 2020-12-07

摘要

霉菌毒素是由青霉菌、曲霉菌和镰刀菌属产生的具有毒性作用的次级代谢产物,由于其在各种食物和饲料中的普遍存在性,引起了人们的广泛关注。目前霉菌毒素的风险评估主要集中在其肾脏毒性、肝脏毒性、免疫毒性、基因毒性和潜在致癌性等方面。近年来,霉菌毒素的肠道毒性受到了研究者的广泛关注,肠道紧密连接作为肠道屏障的重要组成部分,在霉菌毒素诱导的肠道毒性中发挥了重要的作用,且越来越多的研究表明了肠道紧密连接损伤与肠毒性的密切相关性。不同的细胞和动物试验均表明,霉菌毒素损伤紧密连接,破坏肠道屏障的完整性并诱发肠道毒性。本文就几种主要的霉菌毒素(玉米赤霉烯酮、伏马菌素、黄曲霉毒素、赭曲霉毒素以及脱氧雪腐镰刀菌烯醇)对紧密连接的损伤作用进行系统地论述,旨在为霉菌毒素的总体风险评估提供理论依据。

本文引用格式

杨雪 , 高亚男 , 王加启 , 郑楠 . 霉菌毒素对肠道紧密连接蛋白的影响及其调控机制[J]. 动物营养学报, 2020 , 32(12) : 5566 -5577 . DOI: 10.3969/j.issn.1006-267x.2020.12.010

Abstract

Mycotoxin is a toxic secondary metabolite produced by Penicillium, Aspergillus and Fusarium, it has attracted wide attention because of its universal existence in all kinds of food and feed. At present, the risk assessment of mycotoxins is mainly focused on its nephrotoxicity, hepatotoxicity, immunotoxicity, genotoxicity and potential carcinogenicity. In recent years, the enterotoxicity of mycotoxin has been widely concerned by researchers. As an important part of the intestinal barrier, intestinal tight junction plays an important role in the enterotoxicity induced by mycotoxins. More and more studies have shown that there is a close relationship between intestinal tight junction injury and enterotoxicity. Different cell and animal experiments show that mycotoxins damage the integrity of intestinal barrier and induce enterotoxicity. In this paper, the damage effects of several major mycotoxins (zearalenone, fumonisin, aflatoxin, ochratoxin and deoxynivalenol) on tight junctions were systematically discussed in order to provide theoretical basis for the overall risk assessment of mycotoxins.

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