综述 REVIEW

胶原蛋白动态平衡及其对动物肠道健康的作用

  • 唐青松 ,
  • 徐娥 ,
  • 王丽 ,
  • 易宏波
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  • 1. 广东省农业科学院动物科学研究所, 畜禽育种国家重点实验室, 农业农村部华南动物营养与饲料重点实验室, 广东省畜禽育种与营养研究重点实验室, 岭南现代农业科学与技术广东省实验室茂名分中心, 广州 510640;
    2. 贵州大学动物科学学院, 贵阳 550025
唐青松(1996-),男,贵州盘州人,硕士研究生,动物营养与饲料科学专业。E-mail:tqs5213@foxmail.com

收稿日期: 2020-04-21

  网络出版日期: 2020-12-07

基金资助

国家重点研发计划项目(2018YFD0501101);国家自然科学基金项目(31902199);科技创新战略专项资金(高水平农科院建设);广东省现代农业产业技术体系生猪创新团队项目(2019KJ126)

Collagen Homeostasis and Its Effects on Intestinal Health of Animal

  • TANG Qingsong ,
  • XU E ,
  • WANG Li ,
  • YI Hongbo
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  • 1. State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Animal Breeding and Nutrition, Maoming Branch of Guangdong Laboratory for Lingnan Modern Agriculture, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
    2. College of Animal Science, Guizhou University, Guiyang 550025, China

Received date: 2020-04-21

  Online published: 2020-12-07

摘要

胶原蛋白是细胞外基质的主要组成成分,在组织形态、细胞黏附、趋化、迁移、损伤修复等生理过程中发挥重要作用。近年来研究发现,胶原蛋白能够调节动物肠道形态和肠道屏障功能,并在肠道组织免疫微环境中发挥重要作用,而胶原蛋白的严重缺失或过度沉积会引起肠道疾病,提示胶原蛋白动态平衡对于维持动物肠道健康意义重大。然而,在畜禽上有关肠道胶原蛋白的研究还未引起足够重视。因此,本文综述了胶原蛋白的结构分类、动态平衡调控机理及其对肠道健康的影响,并总结了细胞因子及营养物质对胶原蛋白的调控作用,以期为营养调控畜禽肠道胶原蛋白、改善肠道健康提供参考。

本文引用格式

唐青松 , 徐娥 , 王丽 , 易宏波 . 胶原蛋白动态平衡及其对动物肠道健康的作用[J]. 动物营养学报, 2020 , 32(12) : 5578 -5586 . DOI: 10.3969/j.issn.1006-267x.2020.12.011

Abstract

Collagen is the main component of the extracellular matrix, and plays an important role in physiological processes such as tissue morphology, cell adhesion, chemotaxis, migration, and damage repair. Recent studies have found that collagen can regulate the intestinal morphology, barrier function, and the immune micro-environment in intestines of animals. The serious loss or excessive deposition of collagen causes intestinal diseases, suggesting that the dynamic balance of collagen is important for maintaining intestinal health. However, research on intestinal collagen has attracted little attention in livestock and poultry. Therefore, this article reviewed the structure, classification, homeostasis mechanism, and intestinal regulation of collagen, and also summarized effects of cytokines and nutrients on intestinal collagen. The aim is to provide information for nutritional regulation of collagen and improving intestinal health in the intestine of livestock and poultry.

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