综述 REVIEW

吻素-1基因调控食欲的研究进展

  • 徐少奇 ,
  • 唐妮 ,
  • 陈德芳 ,
  • 李志琼
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  • 四川农业大学动物科技学院, 成都 611130
徐少奇(1994-),男,四川巴中人,硕士研究生,从事鱼类食欲和能量代谢研究。E-mail:1292620313@qq.com

收稿日期: 2020-04-30

  网络出版日期: 2020-12-07

基金资助

四川省科技厅项目(2019YJ0438)

Research Progress on KISS-1 Gene Regulate Appetite

  • XU Shaoqi ,
  • TANG Ni ,
  • CHEN Defang ,
  • LI Zhiqiong
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  • College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2020-04-30

  Online published: 2020-12-07

摘要

吻素-1(KISS-1)基因于1996年在人类黑色素瘤细胞中被发现,其广泛分布于中枢神经系统和外周组织。KISS-1基因编码前体蛋白亲吻促动素(Kisspeptin)具有调控食欲、抑制肿瘤转移和促进繁殖等功能。KISS-1基因可能通过核连蛋白2(NUCB2)和催产素(OXT)途径、前阿片网膜皮质素(POMC)和神经肽Y(NPY)途径以及与瘦素、胰高血糖素样肽-1(GLP-1)和胃饥饿素等食欲调节因子互作来抑制绝大多数动物摄食。本文综述了KISS-1基因的结构、组织分布及食欲调控作用的研究进展,以期为动物的摄食和生长提供参考。

本文引用格式

徐少奇 , 唐妮 , 陈德芳 , 李志琼 . 吻素-1基因调控食欲的研究进展[J]. 动物营养学报, 2020 , 32(12) : 5614 -5621 . DOI: 10.3969/j.issn.1006-267x.2020.12.015

Abstract

KISS-1 gene was first discovered in human melanoma cells in 1996, and it is widely distributed in the central nervous system and peripheral tissues. Previous research shows that KISS-1 encodes the precursor protein Kisspeptin, which has various biological functions such as regulating appetite, inhibiting tumor metastasis and promoting reproduction. KISS-1 gene may inhibit feed intake in the majority of animals through the nesfatin-1 and oxytocin (OXT) pathway, pro-opiomelanocortin (POMC) and nueropeptide Y (NPY) pathway and interaction with leptin, glucagon like peptide-1 (GLP-1) and ghrelin. In this review, we focus on the main research progress of KISS-1 gene in structure, tissue distribution and the function of appetite to providing a reference for further research on animal feeding and growth.

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