综述 REVIEW

奶牛激素相关的乳腺MicroRNA研究进展

  • 刘子豪 ,
  • 蒋林树 ,
  • 南雪梅 ,
  • 熊本海
展开
  • 1. 中国农业科学院北京畜牧兽医研究所, 动物营养学国家重点实验室, 北京 100193;
    2. 北京农学院动物科学技术学院, 北京 102206
刘子豪(1997-),男,河北石家庄人,硕士研究生,从事动物营养与饲料科学研究。E-mail:13343241927@163.com

收稿日期: 2020-05-17

  网络出版日期: 2021-01-18

基金资助

国家"十三五"国家重点研发计划(2017YFD0701604,2016YFD0700205,2016YFD0700201)

Research Progress of Mammary MicroRNA Related to Hormones in Dairy Cows

  • LIU Zihao ,
  • JIANG Linshu ,
  • NAN Xuemei ,
  • XIONG Benhai
Expand
  • 1. State key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
    2. Beijing University of Agriculture, Beijing 102206, China

Received date: 2020-05-17

  Online published: 2021-01-18

摘要

MicroRNA(miRNA)是一种非编码RNA,在调节细胞增殖、分化和凋亡的过程中起重要作用。研究表明,激素通过单独或相互作用完成对奶牛乳腺发育和泌乳进程的调控。本文从激素对奶牛乳腺miRNA表达谱影响及miRNA通过激素受体及其下游通路调控乳腺功能2个方面,综述了激素与相关miRNA的研究现状,以期助力于乳腺生物学的发展及奶产品质量的提高。

关键词: 奶牛; 激素; miRNA; 乳腺发育

本文引用格式

刘子豪 , 蒋林树 , 南雪梅 , 熊本海 . 奶牛激素相关的乳腺MicroRNA研究进展[J]. 动物营养学报, 2021 , 33(1) : 101 -106 . DOI: 10.3969/j.issn.1006-267x.2021.01.011

Abstract

MicroRNA (miRNA) is a kind of non-coding RNA that plays an important role in regulating various cell processes, including replication, differentiation and apoptosis. The research has showed that hormones can regulate the development and lactation of the mammary gland of dairy cows individually or interactively. This article reviewed the research progress of hormones related miRNA from two aspects: the effects of hormones on the expression profile of miRNA in dairy cow mammary and the regulation of mammary functions by the miRNA through hormone receptors and their downstream pathways, in order to help the development of mammary biology and the improvement of milk product quality.

参考文献

[1] 李文清,南雪梅,卜登攀.奶牛乳腺发育和泌乳相关的microRNA[J].动物营养学报,2014,26(1):1-6. LI W Q,NAN X M,BU D P.MicroRNAs associated with bovine mammary development and lactation[J].Chinese Journal of Animal Nutrition,2014,26(1):1-6.(in Chinese)
[2] FILIPOWICZ W,BHATTACHARYYA S N,SONENBERG N.Mechanisms of post-transcriptional regulation by microRNAs:are the answers in sight?[J].Nature Reviews Genetics,2008,9(2):102-114.  
[3] YIN H D,HE H R,SHEN X X,et al.MicroRNA profiling reveals an abundant miR-200a-3p promotes skeletal muscle satellite cell development by targeting TGF-β2 and regulating the TGF-β2/SMAD signaling pathway[J].International Journal of Molecular Science,2020,21(9):3274.
[4] 王亨琴,王晓梅,孟凯,等.卵泡液中细胞外囊泡及其携带的microRNA对卵泡发育的作用[J].生物工程学报,2020,36(4):632-642. WANG H T,WANG X M,MENG K,et al.Effect of extracellular vesicles and microRNAs in follicular fluid on follicular development[J].Chinese Journal of Biotechnology,2020,36(4):632-642.(in Chinese)
[5] ZHANG C Y,CHANG C F,GAO H,et al.miR-429 regulates rat liver regeneration and hepatocyte proliferation by targeting JUN/MYC/BCL2/CCND1 signaling pathway[J].Cellular Signalling,2018,50:80-89.
[6] LIU H F,JIANG B.Let-7a-5p represses proliferation,migration,invasion and epithelial-mesenchymal transition by targeting Smad2 in TGF-β2-induced human lens epithelial cells[J].Journal of Biosciences,2020,45:59.
[7] TAPEH B E G,MOSAYYEBI B,SAMEI M,et al.microRNAs involved in T-cell development,selection,activation,and hemostasis[J].Journal of Cellular Physiology,2020,doi:10.1002/jcp.29689.
[8] MACIAS H,HINCK L.Mammary gland development[J].Wiley Interdisciplinary Reviews Developmental Biology,2012,1(4):533-557.  
[9] WANG M,MOISÁ S,KHAN M J,et al.MicroRNA expression patterns in the bovine mammary gland are affected by stage of lactation[J].Journal of Dairy Science,2012,95(11):6529-6535.  
[10] LUORENG Z M,WANG X P,MEI C G,et al.Comparison of microRNA profiles between bovine mammary glands infected with Staphylococcus aureus and Escherichia coli[J].International Journal of Biological Sciences,2018,14(1):87-99.  
[11] LAI Y C,LAI Y T,RAHMAN M M,et al.Bovine milk transcriptome analysis reveals microRNAs and RNU2 involved in mastitis[J].The FEBS Journal,2020,287(9):1899-1918.  
[12] LI Q L,YANG C H,DU J,et al.Characterization of miRNA profiles in the mammary tissue of dairy cattle in response to heat stress[J].BMC Genomics,2018,19:975.
[13] LI R,BEAUDOIN F,AMMAH A A,et al.Deep sequencing shows microRNA involvement in bovine mammary gland adaptation to diets supplemented with linseed oil or safflower oil[J].BMC Genomics,2015,16:884.
[14] MUROYA S,HAGI T,KIMURA A,et al.Lactogenic hormones alter cellular and extracellular microRNA expression in bovine mammary epithelial cell culture[J].Journal of Animal Science and Biotechnology,2016,7:8.
[15] CHEN X,GAO C,LI H J,et al.Identification and characterization of microRNAs in raw milk during different periods of lactation,commercial fluid,and powdered milk products[J].Cell Research,2010,20(10):1128-1137.  
[16] GU Y R,LI M Z,WANG T,et al.Lactation-related microRNA expression profiles of porcine breast milk exosomes[J].PLoS One,2012,7(8):e43691.
[17] JIAO P X,YUAN Y,ZHANG M M,et al.PRL/microRNA-183/IRS1 pathway regulates milk fat metabolism in cow mammary epithelial cells[J].Genes,2020,1(2):196.
[18] 万中英,佟慧丽,李庆章,等.中药王不留行增乳活性单体及催乳素对奶牛乳腺上皮细胞特异性miRNA的影响[J].中国畜牧兽医,2010,37(8):230-232. WAN Z Y,TONG H L,LI Q Z,et al.Influence on the specific microRNAs in bovine mammary gland epithelial cells by semen vaccariae active monomer and prolactin[J].China Animal Husbandry & Veterinary Medicine,2010,37(8):230-232.(in Chinese)
[19] KITTRELL F S,CARLETTI M Z,KERBAWY S,et al.Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential[J].Breast Cancer Research,2011,13(2):R41.
[20] ELSARRAJ H S,STECKLEIN S R,VALDEZ K,et al.Emerging functions of microRNA-146a/b in development and breast cancer:microRNA-146a/b in development and breast cancer[J].Journal of Mammary Gland Biology and Neoplasia,2012,17(1):79-87.  
[21] WANG Z R,HOU X M,QU B,et al.Pten regulates development and lactation in the mammary glands of dairy cows[J].PLoS One,2014,9(7):e102118.
[22] CHEN C C,STAIRS D B,BOXER R B,et al.Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways[J].Genes & Development,2012,26(19):2154-2168.  
[23] DO D N,LI R,DUDEMAINE P L,et al.MicroRNA roles in signaling during lactation:an insight from differential expression,time course and pathway analyses of deep sequence data[J].Scientific Reports,2017,7:44605.
[24] TIAN L,ZHANG L,CUI Y J,et al.miR-142-3p regulates milk synthesis and structure of murine mammary glands via PRLR-mediated multiple signaling pathways[J].Journal of Agricultural and Food Chemistry,2019,67(34):9532-9542.  
[25] 于蕾,王春梅,崔英俊,等.Bta-miR-142-3p对奶牛乳腺上皮细胞泌乳功能的影响[J].中国乳品工业,2015,43(5):8-11. YU L,WANG C M,CUI Y J,et al.Impact of bta-miR-142-3p on lactation function of dairy cow mammary epithelial cells[J].China Dairy Industry,2015,43(5):8-11.(in Chinese)
[26] GALLEGO M I,BINART N,ROBINSON G W,et al.Prolactin,growth hormone,and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects[J].Developmental Biology,2001,229(1):63-175.
[27] BOCKMEYER C L,CHRISTGEN M,MÜLLER M,et al.MicroRNA profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes[J].Breast Cancer Research and Treatment,2011,130(3):735-745.  
[28] MAO J,MOLENAAR A J,WHEELER T T,et al.STAT5 binding contributes to lactational stimulation of promoter Ⅲ expressing the bovine acetyl-CoA carboxylase alpha-encoding gene in the mammary gland[J].Journal of Molecular Endocrinology,2002,29(1):73-88.  
[29] GALLEGO M I,BINART N,ROBINSON G W,et al.Prolactin,growth hormone,and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects[J].Developmental Biology,2001,229(1):163-175.  
[30] CUI Y J,SUN X,JIN L F,et al.miR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways[J].BMC Veterinary Research,2017,13:350.
[31] SCIASCIA Q,PACHECO D,MCCOARD S A.Increased milk protein synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of rapamycin (mTOR) C1-dependent and independent cell signaling[J].Journal of Dairy Science,2013,96(4):2327-2338.  
[32] GU Z L,ELESWARAPU S,JIANG H L.Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland[J].FEBS Letters,2007,581(5):981-988.  
[33] BANDI N,ZBINDEN S,GUGGER M,et al.miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer[J].Cancer Research,2009,69(13):5553-5559.  
[34] CIMMINO A,CALIN G A,FABBRI M,et al.miR-15 and miR-16 induce apoptosis by targeting BCL2[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(39):13944-13949.  
[35] AQEILAN R I,CALIN G A,CROCE C M.miR-15a and miR-16-1 in cancer:discovery,function and future perspectives[J].Cell Death & Differentiation,2010,17(2):215-220.  
[36] LI H M,WANG C M,LI Q Z,et al.miR-15a decreases bovine mammary epithelial cell viability and lactation and regulates growth hormone receptor expression[J].Molecules,2012,17(10):12037-12048.  
[37] FEUERMANN Y,SHAMAY A,MABJEESH S J.Leptin up-regulates the lactogenic effect of prolactin in the bovine mammary gland in vitro[J].Journal of Dairy Science,2008,91(11):4183-4189.  
[38] FEUERMANN Y,MABJEESH S J,SHAMAY A.Mammary fat can adjust prolactin effect on mammary epithelial cells via leptin and estrogen[J].International Journal of Endocrinology,2009,2009:427260.
[39] 李萌,李庆章.奶山羊乳腺中瘦素及其受体的表达与作用[J].中国农业科学,2008,41(12):4187-4193. LI M,LI Q Z.Expression and function of leptin and its receptor in mammary gland of goat[J].Scientia Agricultura Sinica,2008,41(12):4187-4193.(in Chinese)
[40] 门晶,接晶,高学军,等.靶向奶牛Lepr基因的miR-30d报告基因载体构建及靶向验证[J].中国乳品工业,2011,39(5):4-6,30. MEN J,JIE J,GAO X J,et al.Construction of dairy cow Lepr targeting miR-30d reporter gene vector and verification of its targeting[J].China Dairy Industry,2011,39(5):4-6,30.(in Chinese)
[41] BEQUETTE B J,KYLE C E,CROMPTON L A,et al.Insulin regulates milk production and mammary gland and hind-leg amino acid fluxes and blood flow in lactating goats[J].Journal of Dairy Science,2001,84(1):241-255.  
[42] HU H,WANG J Q,BU D P,et al.In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow[J].PLoS One,2009,4(11):e7636.
[43] 李真,李庆章.奶山羊乳腺发育过程中生长激素、胰岛素及其受体的变化规律研究[J].中国农业科学,2010,43(8):1730-1737. LI Z,LI Q Z.Development change of growth hormone, insulin and their receptors in mammary gland of dairy goats[J].Scientia Agricultura Sinica,2010,43(8):1730-1737.(in Chinese)
[44] JIAO B L,ZHANG X L,WANG S H,et al.MicroRNA-221 regulates proliferation of bovine mammary gland epithelial cells by targeting the STAT5a and IRS1 genes[J].Journal of Dairy Science,2019,102(1):426-435.  
文章导航

/