综述 REVIEW

奶牛瘤胃微生物移植研究进展

  • 杨卓 ,
  • 马勇 ,
  • 张力莉 ,
  • 徐晓锋
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  • 1. 宁夏大学农学院, 银川 750021;
    2. 硕腾(上海)企业管理有限公司, 上海 200050
杨卓(1990-),女,宁夏银川人,硕士研究生,从事反刍动物营养研究。E-mail:jennyyangzhuo@126.com

收稿日期: 2020-07-24

  网络出版日期: 2021-03-18

基金资助

宁夏重点研发中西部合作项目"奶牛绿色养殖与优质生鲜乳生产体系研究与示范"(20190410110);国家自然科学基金项目(31660675)

Research Advances on Rumen Microbiota Transplantation in Dairy Cattle

  • YANG Zhuo ,
  • MA Yong ,
  • ZHANG Lili ,
  • XU Xiaofeng
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  • 1. College of Agriculture, Ningxia University, Yinchuan 750021, China;
    2. Zoetis(Shanghai) Enterprise Management Co., Ltd., Shanghai 200050, China

Received date: 2020-07-24

  Online published: 2021-03-18

Supported by

 

摘要

奶牛瘤胃微生物移植(RMT)是一种将健康供体奶牛瘤胃微生物转移给受体牛的技术。目前,针对RMT的报道还相对有限,但越来越多的研究结果显示,RMT具有重建奶牛瘤胃微生物区系、提高饲料效率的潜力,并对多种肠道疾病有较好的辅助治疗效果。本文综述了RMT在重建瘤胃菌群、可能作用机理及其对奶牛生产性能影响等方面的研究进展,为进一步研究提供参考。

本文引用格式

杨卓 , 马勇 , 张力莉 , 徐晓锋 . 奶牛瘤胃微生物移植研究进展[J]. 动物营养学报, 2021 , 33(3) : 1286 -1291 . DOI: 10.3969/j.issn.1006-267x.2021.03.011

Abstract

Rumen microbiota transplantation (RMT) is a technique of transferring ruminal microbial flora from healthy donor ruminants to recipients. At present, the reports on RMT are still relatively limited, but an increasing number of researches have shown that RMT has the potential of re-establishing microbial flora of dairy cattle, by which the feed efficiency has been improved. Also, it has been used as a supporting treatment in curing multiple intestinal disorders. In order to provide references for further study on RMT, this paper summarized the research advances of RMT in ruminal flora re-establishment, possible mechanisms and its effects on performance of dairy cattle.

参考文献

[1] BUCHON N,BRODERICK N A,LEMAITRE B.Gut homeostasis in a microbial world:insights from Drosophila melanogaster[J].Nature Reviews Microbiology,2013,11(9):615-626.  
[2] MALMUTHUGE N,GUAN L L.Understanding host-microbial interactions in rumen:searching the best opportunity for microbiota manipulation[J].Journal of Animal Science and Biotechnology,2017,8:8.
[3] BEN SHABAT S K,SASSON G,DORON-FAIGENBOIM A,et al.Specific microbiome-dependent mechanisms underlie the energy harvest efficiency of ruminants[J].The ISME Journal,2016,10(12):2958-2972.  
[4] 马健,SHAH A M,王之盛.瘤胃微生物区系的影响因素及其调控措施[J].动物营养学报,2020,32(5):1957-1964. MA J,SHAH A M,WANG Z S,et al.Influencing factors and regulating measures of rumen microbial flora[J].Chinese Journal of Animal Nutrition,2020,32(5):1957-1964.(in Chinese)
[5] FIORE E,ARMATO L,MORGANTE M,et al.Methaphylactic effect of tulathromycin treatment on rumen fluid parameters in feedlot beef cattle[J].Canadian Journal of Veterinary Research,2016,80(1):60-65.
[6] BRUNNER N,GROEGER S,RAPOSO J C,et al.Prevalence of subclinical ketosis and production diseases in dairy cows in Central and South America,Africa,Asia,Australia,New Zealand,and Eastern Europe[J].Translational Animal Science,2019,3(1):84-92.  
[7] MCART J A A,NYDAM D V,OVERTON M W.Hyperketonemia in early lactation dairy cattle:a deterministic estimate of component and total cost per case[J].Journal of Dairy Science,2015,98(3):2043-2054.  
[8] JI S K,TAO J,HUI Y,et al.Ecological restoration of antibiotic-disturbed gastrointestinal microbiota in foregut and hindgut of cows[J].Frontiers in Cellular and Infection Microbiology,2018,8:79.
[9] ZHOU M,PENG Y J,CHEN Y H,et al.Assessment of microbiome changes after rumen transfaunation:implications on improving feed efficiency in beef cattle[J].Microbiome,2018,6:62.
[10] LIU J H,LI H W,ZHU W Y,et al.Dynamic changes in rumen fermentation and bacterial community following rumen fluid transplantation in a sheep model of rumen acidosis:implications for rumen health in ruminants[J].The FASEB Journal,2019,33(7):8453-8467.  
[11] 米见对,廖新悌,周建伟,等.反刍动物瘤胃微生物的建立过程与调控研究进展[J].家畜生态学报,2019,40(7):1-8. MI J D,LIAO X D,ZHOU J W,et al.Progress in the establishment and manipulation of the rumen micribiota[J].Journal of Domestic Animal Ecology,2019,40(7):1-8.(in Chinese)
[12] KHAN M A,BACH A,WEARY D M,et al.Invited review:transitioning from milk to solid feed in dairy heifers[J].Journal of Dairy Science,2016,99(2):885-902.  
[13] WOLFF S M,ELLISON M J,HAO Y,et al.Diet shifts provoke complex and variable changes in the metabolic networks of the ruminal microbiome[J].Microbiome,2017,5:60.
[14] LI F Y,LI C X,CHEN Y H,et al.Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle[J].Microbiome,2019,7:92.
[15] WANAPAT M,KONGMUN P,POUNGCHOMPU O,et al.Effects of plants containing secondary compounds and plant oils on rumen fermentation and ecology[J].Tropical Animal Health and Production,2012,44(3):399-405.  
[16] DEPETERS E J,GEORGE L W.Rumen transfaunation[J].Immunology Letters,2014,162(2):69-76.  
[17] RAGER K D,GEORGE L W,HOUSE J K,et al.Evaluation of rumen transfaunation after surgical correction of left-sided displacement of the abomasum in cows[J].Journal of the American Veterinary Medical Association,2004,225(6):915-920.  
[18] WEIMER P J,STEVENSON D M,MANTOVANI H C,et al.Host specificity of the ruminal bacterial community in the dairy cow following near-total exchange of ruminal contents[J].Journal of Dairy Science,2010,93(12):5902-5912.  
[19] SHANKS M.Transfaunation-a practical technique for the bovine practitioner[J].Cattle Practice,2012,20:81-83.
[20] BU D P,ZHANG X,MA L,et al.Repeated inoculation of young calves with rumen microbiota does not significantly modulate the rumen prokaryotic microbiota consistently but decreases diarrhea[J].Frontiers in Microbiology,2020,11:1403.
[21] POUNDEN W D,HIBBS J W.Rumen inoculations in young calves[J].Journal of the American Veterinary Medical Association,1949,114(862):33-35.
[22] STEINER S,LINHART N,NEIDL A,et al.Evaluation of the therapeutic efficacy of rumen transfaunation[J].Journal of Animal Physiology and Animal Nutrition,2019,104(1):56-63.
[23] RICO D E,YING Y,CLARKE A R,et al.The effect of rumen digesta inoculation on the time course of recovery from classical diet-induced milk fat depression in dairy cows[J].Journal of Dairy Science,2014,97(6):3852-3760.
[24] JONES R J,MEGARRITY R G.Successful transfer of DHP-degrading bacteria from Hawaiian goats to Australian ruminants to overcome the toxicity of Leucaena[J].Australian Veterinary Journal,1986,63(8):259-262.  
[25] DRIEHUIS F,WILKINSON J M,JIANG Y,et al.Silage review:animal and human health risks from silage[J].Journal of Dairy Science,2018,101(5):4093-4110.  
[26] 蒋涛.瘤胃微生物重塑对围产后期奶牛采食量和采食行为的影响[D].博士学位论文.北京:中国农业大学,2018:1-135. JIANG T.Influence of rumen microbial reshaping on feed intake and feeding behavior of Holstein cows during the late perinatal period[D].Ph.D.Thesis.Beijing:China Agricultural University,2018:1-135.(in Chinese)
[27] WEIMER P J,COX M S,DE PAULA T V,et al.Transient changes in milk production efficiency and bacterial community composition resulting from near-total exchange of ruminal contents between high-and low-efficiency Holstein cows[J].Journal of Dairy Science,2017,100(9):7165-7182.  
[28] CERSOSIMO L M,RADLOFF W,ZANTON G I.Microbial inoculum composition and pre-weaned dairy calf age alter the developing rumen microbial environment[J].Frontiers in Microbiology,2019,10:1651.
[29] YU S B,ZHANG G Y,LIU Z B,et al.Repeated inoculation with fresh rumen fluid before or during weaning modulates the microbiota composition and co-occurrence of the rumen and colon of lambs[J].BMC Microbiology,2020,20:29.
[30] TANKERSLEY N S,DEPETERS E J,GRAHAM T W.Case study:effects of water,fresh cow YMCP plus,and rumen fluid transfaunate supplementation following calving on milk yield,reproductive efficiency,and incidence of common health disorders in Holstein cows[J].The Professional Animal Scientist,2007,23(5):513-520.  
[31] KUNDE S,PHAM A,BONCZYK S,et al.Safety,tolerability,and clinical response after fecal transplantation in children and young adults with ulcerative colitis[J].Journal of Pediatric Gastroenterology and Nutrition,2013,56(6):597-601.  
[32] DERAKHSHANI H,TUN H M,CARDOSO F C,et al.Linking peripartal dynamics of ruminal microbiota to dietary changes and production parameters[J].Frontiers in Microbiology,2017,7:2143.
[33] XIAO J X,ALUGONGO G M,CHUNG R,et al.Effects of Saccharomyces cerevisiae fermentation products on dairy calves:ruminal fermentation,gastrointestinal morphology,and microbial community[J].Journal of Dairy Science,2016,99(7):5401-5412.  
[34] MOULD F L,KLIEM K E,MORGAN R,et al.In vitro microbial inoculum:a review of its function and properties[J].Animal Feed Science and Technology,2005,123/124:31-50.
[35] DE BARBIERI I,HEGARTY R S,SILVEIRA C,et al.Programming rumen bacterial communities in newborn Merino lambs[J].Small Ruminant Research,2015,129:48-59.
[36] SALEEM F,BOUATRA S,GUO A C,et al.The bovine ruminal fluid metabolome[J].Metabolomics,2013,9(2):360-378.  
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