综述 REVIEW

奶牛肝脏功能及其免疫调节作用的研究进展

  • 牛慧 ,
  • 童津津 ,
  • 熊本海 ,
  • 蒋林树
展开
  • 1. 北京农学院动物科学技术学院, 奶牛营养学北京市重点实验室, 北京 102206;
    2. 中国农业科学院北京畜牧兽医研究所, 北京 100193
牛慧(1995-),女,河北保定人,硕士研究生,研究方向为反刍动物营养与免疫。E-mail:1525219258@qq.com

收稿日期: 2020-07-30

  网络出版日期: 2021-03-18

基金资助

国家自然科学基金项目(31802091,31772629,31702302);北京市现代农业产业技术体系奶牛创新团队;北京市百千万工程

Research Advance on Functions and Immune Regulation of Liver in Dairy Cows

  • NIU Hui ,
  • TONG Jinjin ,
  • XIONG Benhai ,
  • JIANG Linshu
Expand
  • 1. Beijing Key Laboratory of Cow Nutrition, Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China;
    2. Beijing Institute of Animal Husbandry and Veterinary Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received date: 2020-07-30

  Online published: 2021-03-18

Supported by

 

摘要

肝脏是机体免疫的重要器官,在奶牛疾病发生、发展和防御过程中发挥着重要作用。肝脏免疫相关细胞通过受体分泌免疫相关活性物质发挥免疫调节作用,这些由肝脏合成和分泌的免疫相关活性物质直接参与构成免疫系统。此外,肝脏还参与构成肝-脑轴,调控血糖水平,进而调节奶牛的免疫功能。本文重点讨论了肝脏中的免疫相关细胞、肝细胞合成并分泌入血的免疫相关活性物质、肝-脑轴在奶牛疾病中的作用,以期强调肝脏健康在奶牛养殖中的巨大作用。

本文引用格式

牛慧 , 童津津 , 熊本海 , 蒋林树 . 奶牛肝脏功能及其免疫调节作用的研究进展[J]. 动物营养学报, 2021 , 33(3) : 1292 -1298 . DOI: 10.3969/j.issn.1006-267x.2021.03.012

Abstract

Liver is an important immune organ, which plays an important role in the occurrence, development and defense of dairy cattle diseases. The liver immune cells secrete immune related active substances through receptors, and the immune related active substances synthesized and secreted by the liver into the blood directly participate in the formation of the immune system. In addition, the liver is also involved in the formation of liver-brain axis, involved in the regulation of blood sugar level, and then regulated the immune function of dairy cows. Therefore, the objective of present review was to elucidate the role of liver immune related cells, the immune related active substances synthesized and secreted by the liver into the blood, and the liver-brain axis in dairy cow disease, in order to emphasize the great role of liver health in dairy cows feeding.

参考文献

[1] BU D P,BIONAZ M,WANG M Z,et al.Transcriptome difference and potential crosstalk between liver and mammary tissue in mid-lactation primiparous dairy cows[J].PLoS One,2017,12(3):e173082.
[2] BYRNE A W,GRAHAM J,MCCONVILLE J,et al.Liver fluke (Fasciola hepatica) co-infection with bovine tuberculosis in cattle:a prospective herd-level assessment of herd bTB risk in dairy enterprises[J].Transboundary and Emerging Diseases,2019,66(4):1727-1736.
[3] 常广军,张凯,郭峻菲,等.消化道来源的LPS诱导奶牛肝脏中免疫基因发生表观遗传修饰[C]//2015年中国畜牧兽医学会兽医外科学分会第九届会员代表大会暨第21次学术研讨会论文集.昆明:中国畜牧兽医学会兽医外科学分会,2015. CHANG G J,ZHANG K,GUO J F,et al.LPS from the digestive tract induces epigenetic modification of immune genes in dairy cow liver[C]//Proceedings of the 9th Member Congress and the 21st Academic Seminar of Veterinary Surgery Branch of China Animal Husbandry and Veterinary Association in 2015.Kunming:Veterinary Surgery Branch of China Animal Husbandry and Veterinary Association,2015.(in Chinese)
[4] TREVISI E,MINUTI A.Assessment of the innate immune response in the periparturient cow[J].Research in Veterinary Science,2018,116:47-54.
[5] ZHOU Z,XU M J,GAO B.Hepatocytes:a key cell type for innate immunity[J].Cellular & Molecular Immunology,2016,13(3):301-315.  
[6] DUARTE N,COELHO I C,PATARRÃO R S,et al.How inflammation impinges on NAFLD:a role for kupffer cells[J].Biomed Research International,2015,2015:984578.
[7] LI P Z,HE K,LI J Z,et al.The role of Kupffer cells in hepatic diseases[J].Molecular Immunology,2017,85:222-229.
[8] HINES D J,CHOI H B,HINES R M,et al.Prevention of LPS-induced microglia activation,cytokine production and sickness behavior with TLR4 receptor interfering peptides[J].PLoS One,2013,8(3):e60388.
[9] 征黎.高精料日粮对反刍动物肝脏NOD样受体表达的影响和调控[D].硕士学位论文.南京:南京农业大学,2016. ZHENG L.Effect and regulation of high concentrate diets on expression of NOD like receptors in liver of the ruminant[D].Master's Thesis.Nanjing:Nanjing Agricultural University,2016.(in Chinese)
[10] ZHANG L L,BAO H D,WEI C R,et al.Characterization and partial genomic analysis of a lytic Myoviridae bacteriophage against Staphylococcus aureus isolated from dairy cows with mastitis in mid-east of China[J].Virus Genes,2015,50(1):111-117.  
[11] REHFELD I S,GUEDES M I M C,MATOS A C D,et al.Clinical,hematological and biochemical parameters of dairy cows experimentally infected with Vaccinia virus[J].Research in Veterinary Science,2013,95(2):752-757.  
[12] LYONS N A,STÄRK K D C,VAN MAANEN C,et al.Epidemiological analysis of an outbreak of foot-and-mouth disease (serotype SAT2) on a large dairy farm in Kenya using regular vaccination[J].Acta Tropica,2015,143:103-111.
[13] 盛晓丹,黄迪海,郭卉,等.RIG-Ⅰ样受体信号传导通路与调控机制研究进展[J].动物医学进展,2020,41(1):87-92. SHENG X D,HUANG H D,GUO H,et al.Progress on RIG-Ⅰ like receptors signaling pathway and regulation mechanism[J].Progress in Veterinary Medicine,2020,41(1):87-92.(in Chinese)
[14] 张晨曦,卞勉励,陈星燃,等.肝窦内皮细胞在肝脏疾病中的作用[J].中国药理学通报,2017,33(2):149-152,153. ZHANG C X,BIAN M L,CHENG X R,et al.Roles of liver sinusoidal endothelial cells in liver diseases[J].Chinese Pharmacological Bulletin,2017,33(2):149-152,153.(in Chinese)
[15] CECILIANI F,LECCHI C,URH C,et al.Proteomics and metabolomics characterizing the pathophysiology of adaptive reactions to the metabolic challenges during the transition from late pregnancy to early lactation in dairy cows[J].Journal of Proteomics,2018,178:92-106.
[16] MCMAHAN R H,PORSCHE C E,EDWARDS M G,et al.Free fatty acids differentially downregulate chemokines in liver sinusoidal endothelial cells:insights into non-alcoholic fatty liver disease[J].PLoS One,2016,11(7):e0159217.
[17] KUHLA B,ALBRECHT D,KUHLA S,et al.Proteome analysis of fatty liver in feed-deprived dairy cows reveals interaction of fuel sensing,calcium,fatty acid,and glycogen metabolism[J].Physiological Genomics,2009,37(2):88-98.  
[18] LIASKOU E,WILSON D V,OO Y H.Innate immune cells in liver inflammation[J].Mediators of Inflammation,2012,2012:949157.
[19] BARFOOT R,DENHAM S,GYURE L A,et al.Some properties of dendritic macrophages from peripheral lymph[J].Immunology,1989,68(2):233-239.
[20] 叶素成.奶牛MHC多态性及其与牛乳中体细胞数关系的研究[D].硕士学位论文.扬州:扬州大学,2003. YE S C.Study on polymorphism of MHC and its relationship with somatic cell counts in cow milk[D].Master's Thesis.Yangzhou:YangZhou University,2003.(in Chinese)
[21] 张锦生.肝星状细胞激活的内在机制[J].世界华人消化杂志,2005,13(7):831-834. ZHANG J S.The internal mechanism of activation of hepatic stellate cells[J].World Chinese Journal of Digestology,2005(07):831-834.(in Chinese)
[22] 刘一诺.ASIP基因对牛脂肪代谢相关性状的影响研究[D].博士学位论文.长春:吉林大学,2019. LIU Y N.The effect of ASIP gene on bovine lipid metabolism related traits[D].Ph.D.Thesis.Changchun:Jilin University,2019.(in Chinese)
[23] LI B,XI P P,WANG Z L,et al.PI3K/Akt/mTOR signaling pathway participates in Streptococcus uberis-induced inflammation in mammary epithelial cells in concert with the classical TLRs/NF-κB pathway[J].Veterinary Microbiology,2018,227:103-111.
[24] 陈艳梅,洪汝涛,岳彩飞.褪黑素对肝星状细胞中PI3K/AKT信号通路的影响[J].安徽医科大学学报,2019,54(12):1908-1912. CHENG Y M,HONG R T,YUE C F.Effect of melatonin on PI3K/AKT signaling pathway in hepatic stellate cells[J].Acta Universitatis Medicinalis Anhui,2019,54(12):1908-1912.(in Chinese)
[25] 黄河玉,方峰.补体在适应性免疫中的调节作用[J].中国免疫学杂志,2016,32(4):600-604,608. HUANG H Y,FANG F.Regulatory role of complement in adaptive immunity[J].Chinese Journal of Immunology,2016,32(4):600-604,608.(in Chinese)
[26] MIN L,CHENG J B,ZHAO S G,et al.Plasma-based proteomics reveals immune response,complement and coagulation cascades pathway shifts in heat-stressed lactating dairy cows[J].Journal of Proteomics,2016,146:99-108.
[27] RHOADS R P,LA NOCE A J,WHEELOCK J B,et al.Short communication:alterations in expression of gluconeogenic genes during heat stress and exogenous bovine somatotropin administration[J].Journal of Dairy Science,2011,94(4):1917-1921.  
[28] GHAFFARI M H,SCHUH K,KULEŠ J,et al.Plasma proteomic profiling and pathway analysis of normal and overconditioned dairy cows during the transition from late pregnancy to early lactation[J].Journal of Dairy Science,2020,103(5):4806-4821.  
[29] JACOB T,SUBRAMANI G,SIVAPRAKASAM P,et al.Immuno-detection of C3a,a C3 complement activated product in mastitis milk,a potential diagnostic marker[J].Veterinary Sciences,2017,4(1):13.
[30] 刘娜,刘治,刘玲,等.调理素的研究进展[J].中国兽药杂志,2016,50(7):62-65. LIU N,LIU Z,LIU L,et al.Research advances in opsonins[J].Chinese Journal of Veterinary Drug,2016,50(7):62-65.(in Chinese)
[31] ILIEVSKA K,ATANASOV B,DOVENSKI T,et al.Acute phase proteins-as indicators of claw diseases in dairy cattle[J].Macedonian Veterinary Review,2019,42(1):95-100.  
[32] ZHANG H Y,WEI Y,ZHANG F Y,et al.Polymorphisms of MASP2 gene and its relationship with mastitis and milk production in Chinese Holstein cattle[J].Biotechnology & Biotechnological Equipment,2019,33(1):589-596.  
[33] RYU J K,KIM S J,RAH S H,et al.Reconstruction of LPS transfer cascade reveals structural determinants within LBP,CD14,and TLR4-MD2 for efficient LPS recognition and transfer[J].Immunity,2017,46(1):38-50.  
[34] KIM S J,KIM H M.Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14[J].BMB Reports,2017,50(2):55-57.  
[35] WANG J F,ZHANG X,HE X J,et al.LPS-induced reduction of triglyceride synthesis and secretion in dairy cow mammary epithelial cells via decreased SREBP1 expression and activity[J].Journal of Dairy Research,2018,85(4):439-444.  
[36] SHIMIZU T,ISHIZAWA S,MAGATA F,et al.Involvement of lipopolysaccharide in ovarian cystic follicles in dairy cow:expressions of LPS receptors and steroidogenesis-related genes in follicular cells of cystic follicles[J].Animal Reproduction Science,2018,195:89-95.
[37] WU H C,DAI A L,CHEN X X,et al.Leonurine ameliorates the inflammatory responses in lipopolysaccharide-induced endometritis[J].International Immunopharmacology,2018,61:156-161.
[38] MOSESSON M W.Fibrinogen and fibrin structure and functions[J].Journal of Thrombosis and Haemostasis,2005,3(8):1894-1904.  
[39] OBATA J,TANAKA N,MIZUNO R,et al.Plasma fibrinogen level:an independent prognostic factor for disease-free survival and cancer-specific survival in patients with localised renal cell carcinoma[J].BJU International,2016,118(4):598-603.  
[40] PÅHLMAN L I,MÖRGELIN M,KASETTY G,et al.Antimicrobial activity of fibrinogen and fibrinogen-derived peptides-a novel link between coagulation and innate immunity[J].Thrombosis and Haemostasis,2013,109(5):930-939.  
[41] PAPAREDDY P,RYDENGÅRD V,PASUPULETI M,et al.Proteolysis of human thrombin generates novel host defense peptides[J].PLoS Pathogens,2010,6(4):e1000857.
[42] 王佳."肠-肝-脑"轴介导的番茄红素改善糖脂代谢紊乱及认知障碍的作用机制研究[D].博士学位论文.杨凌:西北农林科技大学,2019. WANG J.Lycopene attenuates the impairment of cognitive function via improving glycolipid metabolism dysfunction in gut-liver-brain axis[D].Ph.D.Thesis.Yangling:Northwest A&F University,2019.(in Chinese)
[43] 曲明姿,王广猛,颜培实.夏季奶牛产量与其糖脂代谢相关功能蛋白对比分析[C]//中国畜牧兽医学会家畜环境卫生学分会2014年学术年会论文集.武汉:中国畜牧兽医学会家畜环境卫生学分会,2014:57-61. QU M Z,WANG G M,YAN P S.Comparative study of glucose and lipid metabolism of high and low producing Holstein cows in hot environment[C]//Proceedings of the Annual Meeting of the Livestock Environmental Hygiene Branch of the Chinese Society of Animal Husbandry and Veterinary Medicine in 2014.Wuhan:Livestock Environmental Hygiene Branch of the Chinese Society of Animal Husbandry and Veterinary Medicine,2014:57-61.(in Chinese)
[44] GEIGER T L,SUN J C.Development and maturation of natural killer cells[J].Current Opinion in Immunology,2016,39:82-89.
[45] 柳忠辉,杨煜,卢爱萍.糖尿病患者sIL-2R、IL-2水平及T淋巴细胞转化活性的检测[J].白求恩医科大学学报,1997,23(6):41-42. LIU Z H,YANG Y,LU A P.Detection of sIL-2R,IL-2 and T lymphocyte transformation activity in patients with diabetes mellitus[J].Journal of Norman Bethune University of Medical Science,1997,23(6):41-42.(in Chinese)
文章导航

/