综述 REVIEW

微流控肠道芯片研究进展

  • 李英洁 ,
  • 张琛 ,
  • 王蕾 ,
  • 车炼强
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  • 1. 四川农业大学动物营养研究所, 成都 611130;
    2. 中国科学院过程工程研究所, 生化工程国家重点实验室, 北京 100089;
    3. 山东省食品药品检验研究院, 济南 250101
李英洁(1997-),女,四川成都人,硕士研究生,从事动物营养与饲料科学研究。E-mail:yingjieli1997@163.com

收稿日期: 2020-08-17

  网络出版日期: 2021-04-15

基金资助

留学回国人员科技活动项目择优资助入选项目

Research Progress on Microfluidic Gut-on-a-Chip

  • LI Yingjie ,
  • ZHANG Chen ,
  • WANG Lei ,
  • CHE Lianqiang
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  • 1. Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China;
    2. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100089, China;
    3. Shandong Institute for Food and Drug Control, Jinan 250101, China

Received date: 2020-08-17

  Online published: 2021-04-15

Supported by

 

摘要

近年来,微流控技术的出现为生物医学研究提供了新的体外试验平台。动物肠道与机体免疫、营养代谢等生理活动密切相关,但目前肠道功能研究受限于单一体外细胞培养技术。微流控肠道芯片的研发拓展了肠道功能研究方法与技术手段,成为当前研究热点和前沿。本文概述了微流控技术和肠道芯片的发展历程与研究进展,阐述了微流控肠道芯片的结构与功能,比较了其较传统体外模型的优势,包括高度仿生性、高效性和精准可重复性等,并通过具体研究实例阐明了微流控肠道芯片在医学及营养学领域的应用,最后展望了微流控肠道芯片在动物营养学研究中的开发应用前景。

本文引用格式

李英洁 , 张琛 , 王蕾 , 车炼强 . 微流控肠道芯片研究进展[J]. 动物营养学报, 2021 , 33(4) : 1891 -1900 . DOI: 10.3969/j.issn.1006-267x.2021.04.010

Abstract

In recent years, the emergence of microfluidic technology provides a new in vitro experimental platform for biomedical research. The animal intestine is closely related to physiological activities such as immunity and nutrition metabolism, however, the current study methods towards intestine are limited by a single cell culture technology in vitro. The development and utilization of microfluidic gut-on-a-chip can effectively expand and improve the research methods about intestinal functions, which has been becoming a research hot topic. This review summarizes the recent progress of developing microfluidic technology and gut-on-a-chip, clarifying the physical structure and function of microfluidic gut-on-a-chip, comparing the advantages of gut-on-a-chip to traditional in vitro cell models, including highly bionic, efficiency and repeatability. Then, we illustrate the applying progress of microfluidic gut-on-a-chip research in the field of medicine and nutrition through specific case studies, and the potential applicant of microfluidic chip on intestinal development in animal nutrition is discussed.

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