综述 REVIEW

氧化应激对家禽卵泡闭锁的影响及机制

  • 王建萍 ,
  • 张克英
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  • 四川农业大学动物营养研究所, 动物抗病营养教育部重点实验室, 动物抗病营养农业农村部重点实验室, 动物抗病营养四川省重点实验室, 成都 611130
王建萍(1983-),女,四川成都人,副教授,博士,研究方向为营养对家禽卵巢功能和鸡蛋质量的影响。E-mail:wangjianping@sicau.edu.cn

收稿日期: 2020-10-31

  网络出版日期: 2021-06-10

基金资助

国家自然科学基金面上项目(31872792);四川省科技厅国际合作项目(2019YFH0062);四川省蛋鸡产业链项目(2018NZ20009)

Effects of Oxidative Stress on Follicular Atresia in Poultry and Its Mechanism

  • WANG Jianping ,
  • ZHANG Keying
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  • Key Laboratory for Animal Disease-Resistance Nutrition of Sichuan Province, Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Agriculture and Rural Affairs, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2020-10-31

  Online published: 2021-06-10

摘要

氧自由基的过度堆积会引起氧化应激,导致卵泡闭锁,降低卵巢中各阶段卵泡的数量,从而造成繁殖性能衰退。本文首先对家禽卵泡的命运、氧化应激对卵泡闭锁的影响等进行概述,然后对氧化应激引起颗粒细胞和卵母细胞凋亡的途径以及细胞自噬在氧化应激诱导卵泡闭锁中的作用机制等进行综述,并概述了抗氧化剂对卵泡闭锁的影响,以期为通过营养手段缓解氧化应激和进一步调控家禽繁殖和产蛋性能提供理论依据。

本文引用格式

王建萍 , 张克英 . 氧化应激对家禽卵泡闭锁的影响及机制[J]. 动物营养学报, 2021 , 33(6) : 3001 -3009 . DOI: 10.3969/j.issn.1006-267x.2021.06.001

Abstract

Excessive accumulation of oxygen free radicals can cause oxidative stress, leading to atresia of follicles, reducing the number of follicles in each stage of the ovary, and causing decline in reproductive performance. This article first summarized the fate of poultry follicles and the influence of oxidative stress on follicular atresia, and then discussed the pathways of oxidative stress causes granulosa cells and oocytes to undergo apoptosis. This paper also reviewed the mechanism of autophagy in oxidative stress-induced follicular atresia, and the effects of antioxidants on follicle atresia, aiming to provide a theoretical basis for alleviating oxidative stress through nutritional means and further regulating reproduction and laying performance in poultry industry.

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