综述 REVIEW

基于网络药理学探讨植物提取物在饲料添加剂领域的研究进展

  • 丁浩轩 ,
  • 赵阳 ,
  • 冯杰
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  • 浙江大学饲料科学研究所, 浙江省动物营养重点实验室, 杭州 310058
丁浩轩(1995-),男,浙江台州人,博士研究生,从事微量养分营养研究。E-mail:11717014@zju.edu.cn

收稿日期: 2020-11-09

  网络出版日期: 2021-06-10

基金资助

浙江省重大科技专项重点农业项目(2019C02051);国家自然科学基金项目(31772607)

Research Progress on Discussion of Plant Extracts in Field of Feed Additives Based on Network Pharmacology

  • DING Haoxuan ,
  • ZHAO Yang ,
  • FENG Jie
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  • Zhejiang Key Laboratory of Animal Nutrition, Institute of Feed Science, Zhejiang University, Hangzhou 310058, China

Received date: 2020-11-09

  Online published: 2021-06-10

摘要

近年来,畜禽细菌耐药性不断提高,不仅影响畜禽产品品质,而且威胁人用抑菌药物储备。促生长药物饲料添加剂的禁用推动了畜禽养殖无抗化的发展,但畜牧企业面临了饲养周期延长、畜禽发病率提高等一系列难题。中草药作为饲用抗生素的替代品逐步成为了无抗化养殖的重要添加剂之一,但具体作用机制仍存在空缺。网络药理学通过计算模拟药物分子靶点,实现化合物-靶点-信号通路可视化,可在一定程度上揭示中草药中各活性成分的具体作用功效。因此,本文基于网络药理学对植物提取物在畜禽饲料添加剂中的应用进行总结,旨在为畜禽营养研究提供系统药理学工具。

本文引用格式

丁浩轩 , 赵阳 , 冯杰 . 基于网络药理学探讨植物提取物在饲料添加剂领域的研究进展[J]. 动物营养学报, 2021 , 33(6) : 3065 -3071 . DOI: 10.3969/j.issn.1006-267x.2021.06.008

Abstract

In recent years, the antibiotic resistance of livestock and poultry bacteria has continued to increase, which not only affects the quality of livestock and poultry products, but also threatens the stock of antibacterial drugs for human use. The prohibition of growth-promoting drug feed additives has promoted the development of livestock and poultry breeding without antibiotic, but animal husbandry companies are facing a series of problems such as the extension of the feeding cycle and the increase in the incidence of livestock and poultry. Chinese herbal medicine, as a substitute for feed antibiotics, has gradually become one of the most important magic weapons for antibiotic-free agriculture, but there are still gaps in the specific mechanism. Network pharmacology realizes visualization of compound-target-signal pathways by calculating and simulating drug molecular targets, which can reveal the specific effects of each active ingredient in Chinese herbal medicine to a certain extent. Therefore, this article summarizes the application of plant extracts in livestock and poultry feed additives based on network pharmacology, and aims to provide systemic pharmacology tools for livestock and poultry nutrition research.

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