靳宇航 , 贾海 , 王仁杰 , 武振龙 . 内质网应激信号影响猪肠道屏障功能的研究进展[J]. 动物营养学报, 2021 , 33(6) : 3072 -3080 . DOI: 10.3969/j.issn.1006-267x.2021.06.009

[1] PABST R,RUSSELL M W,BRANDTZAEG P.Tissue distribution of lymphocytes and plasma cells and the role of the gut[J].Trends in Immunology,2008,29(5):206-208.  
[2] JACOBI S K,ODLE J.Nutritional factors influencing intestinal health of the neonate[J].Advances in Nutrition,2012,3(5):687-696.  
[3] CAO S S.Endoplasmic reticulum stress and unfolded protein response in inflammatory bowel disease[J].Inflammatory Bowel Diseases,2015,21(3):636-644.  
[4] GOTOH T,ENDO M,OIKE Y.Endoplasmic reticulum stress-related inflammation and cardiovascular diseases[J].International Journal of Inflammation,2011,2011:259462.
[5] 洪盼.β-胡萝卜素对早期断奶仔猪肠道内质网应激及其信号通路的影响[D].博士学位论文.长春:吉林农业大学,2018. HONG P.Effects of β-carotene on intestinal endoplasmic reticulum stress and its signaling pathway in early weaned piglets[D].Ph.D.Thesis.Changchun:Jilin Agricultural University,2018.(in Chinese).
[6] HE Y,FAN X X,LIU N,et al.L-glutamine represses the unfolded protein response in the small intestine of weanling piglets[J].The Journal of Nutrition,2019,149(11):1904-1910.  
[7] RODA G,SARTINI A,ZAMBON E,et al.Intestinal epithelial cells in inflammatory bowel diseases[J].World Journal of Gastroenterology,2010,16(34):4264-4271.  
[8] HAMPSON D J.Alterations in piglet small intestinal structure at weaning[J].Research in Veterinary Science,1986,40(1):32-40.  
[9] YANG H S,XIONG X,WANG X C,et al.Effects of weaning on intestinal upper villus epithelial cells of piglets[J].PLoS One,2016,11(3):e0150216.
[10] WIJTTEN P J A,VAN DER MEULEN J,VERSTEGEN M W A.Intestinal barrier function and absorption in pigs after weaning:a review[J].British Journal of Nutrition,2011,105(7):967-981.  
[11] WILLING B P,MALIK G,VAN KESSEL A G.Nutrition and gut health in swine[M]//CHIBA L I.Sustainable swine nutrition.Chichester,UK:John Wiley & Sons,2012:197-213.
[12] BEVINS C L,SALZMAN N H.Paneth cells,antimicrobial peptides and maintenance of intestinal homeostasis[J].Nature Reviews Microbiology,2011,9(5):356-368.  
[13] GOTO Y,KIYONO H.Epithelial barrier:an interface for the cross-communication between gut flora and immune system[J].Immunological Reviews,2012,245(1):147-163.  
[14] GILL N,WLODARSKA M,FINLAY B B.Roadblocks in the gut:barriers to enteric infection[J].Cellular Microbiology,2011,13(5):660-669.  
[15] GROSCHWITZ K R,HOGAN S P.Intestinal barrier function:molecular regulation and disease pathogenesis[J].Journal of Allergy and Clinical Immunology,2009,124(1):3-20.  
[16] CORAZZARI M,GAGLIARDI M,FIMIA G M,et al.Endoplasmic reticulum stress,unfolded protein response,and cancer cell fate[J].Frontiers in Oncology,2017,7:78.
[17] CAO S S,KAUFMAN R J.Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease[J].Antioxidants & Redox Signaling,2014,21(3):396-413.  
[18] SCHRÖDER M,KAUFMAN R J.The mammalian unfolded protein response[J].Annual Review of Biochemistry,2005,74:739-789.
[19] WANG S Y,KAUFMAN R J.The impact of the unfolded protein response on human disease[J].Journal of Cell Biology,2012,197(7):857-867.  
[20] LUO K,CAO S S.Endoplasmic reticulum stress in intestinal epithelial cell function and inflammatory bowel disease[J].Gastroenterology Research and Practice,2015,2015:328791.
[21] CALFON M,ZENG H Q,URANO F,et al.IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA[J].Nature,2002,415(6867):92-96.  
[22] BYRD A E,BREWER J W.Intricately regulated:a cellular toolbox for fine-tuning XBP1 expression and activity[J].Cells,2012,1(4):738-753.  
[23] TABAS I,RON D.Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress[J].Nature Cell Biology,2011,13(3):184-190.  
[24] HOLLIEN J,LIN J H,LI H,et al.Regulated ire1-dependent decay of messenger rnas in mammalian cells[J].Journal of Cell Biology,2009,186(3):323-331.  
[25] CAO S S,ZIMMERMANN E M,CHUANG B M,et al.The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice[J].Gastroenterology,2013,144(5):989-1000.e6.  
[26] WEK R C,CAVENER D R.Translational control and the unfolded protein response[J].Antioxidants & Redox Signaling,2007,9(12):2357-2371.  
[27] LU P D,HARDING H P,RON D.Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response[J].Journal of Cell Biology,2004,167(1):27-33.  
[28] PALAM L R,BAIRD T D,WEK R C.Phosphorylation of EIF2 facilitates ribosomal bypass of an inhibitory upstream orf to enhance CHOP translation[J].Journal of Biological Chemistry,2011,286(13):10939-10949.  
[29] ADACHI Y,YAMAMOTO K,OKADA T,et al.Atf6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum[J].Cell Structure and Function,2008,33(1):75-89.  
[30] WU J,RUTKOWSKI D T,DUBOIS M,et al.Atf6α optimizes long-term endoplasmic reticulum function to protect cells from chronic stress[J].Developmental Cell,2007,13(3):351-364.  
[31] CHEN X Q,KARNOVSKY A,SANS M D,et al.Molecular characterization of the endoplasmic reticulum:insights from proteomic studies[J].Proteomics,2010,10(22):4040-4052.  
[32] HAN J,BACK S H,HUR J,et al.Er-stress-induced transcriptional regulation increases protein synthesis leading to cell death[J].Nature Cell Biology,2013,15(5):481-490.  
[33] NAMBA T,ISHIHARA T,TANAKA K I,et al.Transcriptional activation of atf6 by endoplasmic reticulum stressors[J].Biochemical and Biophysical Research Communications,2007,355(2):543-548.  
[34] BISCHOFF S C,BARBARA G,BUURMAN W,et al.Intestinal permeability-a new target for disease prevention and therapy[J].BMC Gastroenterology,2014,14:189.
[35] MICHIELAN A,D'INCÀ R.Intestinal permeability in inflammatory bowel disease:pathogenesis,clinical evaluation,and therapy of leaky gut[J].Mediators of Inflammation,2015,2015:628157.
[36] SZABO G.Gut-liver axis in alcoholic liver disease[J].Gastroenterology,2015,148(1):30-36.  
[37] LI B,LEE C,ZANI A,et al.Early maternal separation induces alterations of colonic epithelial permeability and morphology[J].Pediatric Surgery International,2014,30(12):1217-1222.  
[38] LI B,ZANI A,LEE C,et al.Endoplasmic reticulum stress is involved in the colonic epithelium damage induced by maternal separation[J].Journal of Pediatric Surgery,2016,51(6):1001-1004.  
[39] FAN X X,LI S,WU Z L,et al.Glycine supplementation to breast-fed piglets attenuates post-weaning jejunal epithelial apoptosis:a functional role of chop signaling[J].Amino Acids,2019,51(3):463-473.  
[40] YUAN L,CAO Y,KNÖCHEL W.Endoplasmic reticulum stress induced by tunicamycin disables germ layer formation in Xenopus laevis embryos[J].Developmental Dynamics,2007,236(10):2844-2851.  
[41] KAWADA K,IEKUMO T,SAITO R,et al.Aberrant neuronal differentiation and inhibition of dendrite outgrowth resulting from endoplasmic reticulum stress[J].Journal of Neuroscience Research,2014,92(9):1122-1133.  
[42] SUGANYA N,BHAKKIYALAKSHMI E,SURIYANARAYANAN S,et al.Quercetin ameliorates tunicamycin-induced endoplasmic reticulum stress in endothelial cells[J].Cell Proliferation,2014,47(3):231-240.  
[43] HUANG C,YAO R Y,ZHU Z K,et al.A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress[J].International Journal of Biological Macromolecules,2019,130:508-514.
[44] LI R N,YANG Y,HONG Z P,et al.β-carotene attenuates weaning-induced apoptosis via inhibition of perk-chop and ire1-jnk/p38 mapk signalling pathways in piglet jejunum[J].Journal of Animal Physiology and Animal Nutrition,2020,104(1):280-290.  
[45] JIANG Q,TIAN J Q,LIU G,et al.Endoplasmic reticulum stress and unfolded protein response pathways involved in the health-promoting effects of allicin on the jejunum[J].Journal of Agricultural and Food Chemistry,2019,67(21):6019-6031.  
[46] JIANG Q,CHEN J S,LIU S J,et al.L-glutamine attenuates apoptosis induced by endoplasmic reticulum stress by activating the ire1α-XBP1 axis in ipec-j2:a novel mechanism of l-glutamine in promoting intestinal health[J].International Journal of Molecular Sciences,2017,18(12):2617.
[47] ARCE C,RAMIREZ-BOO M,LUCENA C,et al.Innate immune activation of swine intestinal epithelial cell lines (IPEC-J2 And IPI-2I) in response to lps from Salmonella typhimurium[J].Comparative Immunology,Microbiology and Infectious Diseases,2010,33(2):161-174.  
[48] JIANG Q,CHEN S,REN W K,et al.Escherichia coli aggravates endoplasmic reticulum stress and triggers chop-dependent apoptosis in weaned pigs[J].Amino Acids,2017,49(12):2073-2082.  
[49] JIANG Q,LIU G,CHEN J S,et al.Crosstalk between nuclear glucose-regulated protein 78 and tumor protein 53 contributes to the lipopolysaccharide aggravated apoptosis of endoplasmic reticulum stress-responsive porcine intestinal epithelial cells[J].Cellular Physiology and Biochemistry,2018,48(6):2441-2455.  
[50] YANG G Y,XIA B,SU J H,et al.Anti-inflammatory effects of Lactobacillus johnsonii L531 in a pig model of salmonella infantis infection involves modulation of CCR6⁺ T cell responses and ER stress[J].Veterinary Research,2020,51(1):26.
[51] LEE C.Porcine epidemic diarrhea virus:an emerging and re-emerging epizootic swine virus[J].Virology Journal,2015,12:193.
[52] XU X G,ZHANG H L,ZHANG Q,et al.Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle,induces endoplasmic reticulum stress,and up-regulates interleukin-8 expression[J].Veterinary Microbiology,2013,164(3/4):212-221.
[53] MASTERS P S.The molecular biology of coronaviruses[J].Advances in Virus Research,2006,66:193-292.
[54] CRUZ J L G,SOLA I,BECARES M,et al.Coronavirus gene 7 counteracts host defenses and modulates virus virulence[J].PLoS Pathogens,2011,7(6):e1002090.
[55] ZHANG Q,XU Y,CHANG R,et al.Transmissible gastroenteritis virus n protein causes endoplasmic reticulum stress,up-regulates interleukin-8 expression and its subcellular localization in the porcine intestinal epithelial cell[J].Research in Veterinary Science,2018,119:109-115.
[56] XUE M,FU F,MA Y L,et al.The perk arm of the unfolded protein response negatively regulates transmissible gastroenteritis virus replication by suppressing protein translation and promoting type Ⅰ interferon production[J].Journal of Virology,2018,92(15):e00431-18.
[57] MA Y L,WANG C L,XUE M,et al.The coronavirus transmissible gastroenteritis virus evades the type Ⅰ interferon response through ire1α-mediated manipulation of the microrna mir-30a-5p/socs1/3 axis[J].Journal of Virology,2018,92(22):e00728-18.
[58] PARK W,PARK M Y,SONG G,et al.Exposure to aflatoxin B₁ attenuates cell viability and induces endoplasmic reticulum-mediated cell death in a bovine mammary epithelial cell line (MAC-T)[J].Toxicology in Vitro,2019,61:104591.
[59] GAO Y N,LI S L,WANG J Q,et al.Modulation of intestinal epithelial permeability in differentiated Caco-2 cells exposed to aflatoxin M1 and ochratoxin a individually or collectively[J].Toxins (Basel),2017,10(1):13.
[60] LIU N,YANG Y,CHEN J Q,et al.3-acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages[J].Environmental Pollution,2020,265:114697.
[61] MARIN S,RAMOS A J,CANO-SANCHO G,et al.Mycotoxins:occurrence,toxicology,and exposure assessment[J].Food and Chemical Toxicology,2013,60:218-237.
[62] LONG M,CHEN X L,WANG N,et al.Proanthocyanidins protect epithelial cells from zearalenone-induced apoptosis via inhibition of endoplasmic reticulum stress-induced apoptosis pathways in mouse small intestines[J].Molecules,2018,23(7):1508.