[1] VINH P T,SHINOHARA Y,YAMADA A,et al.Baicalein inhibits Stx1 and 2 of EHE:effects of baicalein on the cytotoxicity,production,and secretion of shiga toxins of enterohaemorrhagic
Escherichia coli[J].Toxins,2019,11(9):505.
[2] JANG H,LEE J,PARK S,et al.Baicalein mitigates radiation-induced enteritis by improving endothelial dysfunction[J].Frontiers in Pharmacology,2019,10:892.
[3] LI Q,YU Z J,XIAO D D,et al.Baicalein inhibits mitochondrial apoptosis induced by oxidative stress in cardiomyocytes by stabilizing
MARCH5 expression[J].Journal of Cellular and Molecular Medicine,2019,24(2):2040-2051.
[4] ZHAO T T,TANG H L,XIE L,et al.
Scutellaria baicalensis Georgi.(Lamiaceae):a review of its traditional uses,botany,phytochemistry,pharmacology and toxicology[J].Journal of Pharmacy and Pharmacology,2019,71(9):1353-1369.
[5] 陈清华.战"疫"禁抗背景下如何做好饲料[J].饲料工业,2020,41(18):1-5. CHEN Q H.How to make good feed under the background of banning antibiotics in the "epidemic"[J].Feed Industry,2020,41(18):1-5.(in Chinese)
[6] MUROTA K,NAKAMURA Y,UEHARA M.Flavonoid metabolism:the interaction of metabolites and gut microbiota[J].Bioscience,Biotechnology,and Biochemistry,2018,82(4):600-610.
[7] 侯珏卓,陈喆.黄芩素结构修饰的研究[J].吉林化工学院学报,2014,31(5):46-49,58. HOU Y Z,CHEN Z.Study on structural modification of baicalein[J].Journal of Jilin Institute of Chemical Technology,2014,31(5):46-49,58.(in Chinese)
[8] 朱芳,陈晓靓,邓红军,等.黄芩的研究进展[J].广东化工,2020,47(12):135-136. ZHU F,CHEN X L,DENG H J,et al.Research progress in
Scutellaria baicalensis[J].Guangdong Chemical Industry,2020,47(12):135-136.(in Chinese)
[9] 李晓燕,赵韶华,韩桂茹,等.自身酶解水提取黄芩中黄芩素及汉黄芩素的方法[J].中国药业,2013,22(24):43-45. LI X Y,ZHAO S H,HAN G R,et al.Method of extracting baicalein and wogonin from
Scutellaria baicalensis Georgi by self-digestion water[J].Chinese Pharmaceutical,2013,22(24):43-45.(in Chinese)
[10] 张涛,张晓虎,沈艳霞,等.黄芩中黄芩素的提取与抑菌效果的初步研究[J].陕西农业科学,2018,64(4):53-57. ZHANG T,ZHANG X H,SHEN Y X,et al.Preliminary study on extraction and antibacterial effect of baicalein from
Scutellaria baicalensis Georgi[J].Shaanxi Agricultural Sciences,2018,64(4):53-57.(in Chinese)
[11] 张海涛.黄芩素对金黄色葡萄球菌vWbp的抑制作用及机制研究[D].硕士学位论文.长春:吉林大学,2020. ZHANG H T.Study on the inhibitory effect and mechanism of baicalein on
Staphylococcus aureus vWbp[D].Master's Thesis.Changchun:Jilin University,2020.(in Chinese)
[12] ZHANG L,LIN G,CHANG Q,et al.Role of intestinal first-pass metabolism of baicalein in its absorption process[J].Pharmaceutical Research,2005,22(7):1050-1058.
[13] 解立科,田小亭,郭小珍,等.黄芩素与黄芩苷微生物和肝脏代谢异同研究[J].中成药,2020,42(7):1830-1836. XIE L K,TIAN X T,GUO X Z,et al.Differences and similarities in microbial and liver metabolisms between baicalein and baicalin[J].Chinese Traditional Patent Medicine,2020,42(7):1830-1836.(in Chinese)
[14] 彭雯雯.黄芩素和七种代谢物液-质联用分析方法的建立及应用[D].硕士学位论文.长春:吉林大学,2017. PENG W W.Establishment and application of a LC-MS/MS analytical method for the determination of baicalein and its seven metabolites and its application[D].Master's Thesis.Changchun:Jilin University,2017.(in Chinese)
[15] 沈安,吴璐,朱卫丰.黄芩中黄芩苷与黄芩素的体内外转化研究进展[J].江西中医药,2017,48(9):71-74. SHEN A,WU L,ZHU W F.Research progress on transformation of baicalin and baicalein in
Scutellaria baicalensis Georgi
in vitro and
in vivo[J].Jiangxi Journal of Traditional Chinese Medicine,2017,48(9):71-74.(in Chinese)
[16] 许伯慧,严菲.黄芩苷及其苷元黄芩素体内过程的研究进展[J].南通大学学报(医学版),2010,30(3):220-223. XU B H,YAN F.Research progress of baicalin and its aglycone baicalein
in vivo[J].Journal of Nantong University (Medical Edition),2010,30(3):220-223.(in Chinese)
[17] 向净匀,吴杰,王琰,等.基于网络药理学的黄芩素、京尼平抗脑缺血作用机制研究[J].中草药,2019,50(23):5802-5811. XIANG J Y,WU J,WNAG Y,et al.Mechanism of baicalein and genipin against cerebral ischemia based on network pharmacology[J].Chinese Traditional and Herbal Drugs,2019,50(23):5802-5811.(in Chinese)
[18] 杨迪,袁婷婷,干舒蕾,等.静脉注射黄芩苷、黄芩素在大鼠体内的药代规律比较研究[J].中国临床药理学与治疗学,2017,22(4):394-400. YANG D,YUAN T T,GAN S L,et al.Comparative study on the pharmacokinetics of baicalin and baicalein in rats after intravenous administration[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2017,22(4):394-400.(in Chinese)
[19] PELLOCK S J,CREEKMORE B C,WALTON W G,et al.Gut microbial β-glucuronidase inhibition via catalytic cycle interception[J].ACS Central Science,2018,4(7):868-879.
[20] WENG Z M,WANG P,GE G B,et al.Structure-activity relationships of flavonoids as natural inhibitors against
E. coli β-glucuronidase[J].Food and Chemical Toxicology,2017,109:975-983.
[21] 刘连,林航,黄若诗,等.黄芩苷、黄芩素对变形链球菌生物膜抑制作用的研究[J].中药新药与临床药理,2017,28(4):464-467. L L.Study on Inhibitory Effect of baicalin and baicalein on the formation of
Streptococcus mutans biofilm[J].Traditional Chinese Drug Research and Clinical Pharmacology,2017,28(4):464-467.(in Chinese)
[22] FARHADI F,KHAMENEH B,IRANSHAHI M,et al.Antibacterial activity of flavonoids and their structure-activity relationship:an update review[J].Phytotherapy Research,2019,33(1):13-40.
[23] 董梦依.几种黄酮类化合物抗氧化、抗肿瘤活性研究及构效关系初探[D].硕士学位论文.南昌:南昌大学,2019. DONG M Y.Study on Antioxidant and anti-tumor activities of several flavonoids and their structure-activity relationship[D].Master's Thesis.Nanchang:Nanchang University,2019.(in Chinese)
[24] CHEN Y,LIU T J,WANG K,et al.Baicalein inhibits staphylococcus aureus biofilm formation and the quorum sensing system
in vitro[J].PLoS One,2016,11(4):e0153468.
[25] KOLOUCHOVÁ I,MAŤÁTKOVÁ O,PALDRYCHOVÁ M,et al.Resveratrol,pterostilbene,and baicalein:plant-derived anti-biofilm agents[J].Folia Microbiologica,2018,63(3):261-272.
[26] 王珍,郑霞,宋隽.黄芩素铜配合物的合成及抑菌效果的初步研究[J].连云港师范高等专科学校学报,2016,33(3):104-108. WANG Z,ZHENG X,SONG J.Synthesis of baicalein copper complex and exploration of its bacteriostasic activity[J].Journal of Lianyungang Normal College,2016,33(3):104-108.(in Chinese)
[27] 张洺嘉,谢明杰.黄芩素抑制金黄色葡萄球菌生物被膜的形成[J].中国生物化学与分子生物学报,2018,34(3):334-340. ZHANG M J,XIE M J.Inhibition of
Staphylococcus aureus biofilm by baicalein[J].Chinese Journal of Biochemistry and Molecular Biology,2018,34(3):334-340.(in Chinese)
[28] 薛芳翰,范秋雨,周雨哲,等.黄芩素对鼠伤寒沙门氏菌抑制作用的研究[J].现代畜牧兽医,2019(9):12-15. XIE F H,FAN Q Y,ZHOU Y Z,et al.Inhibitory effect of baicalein on
Salmonella typhimurium[J].Modern Journal of Animal Husbandry and Veterinary Medicine,2019(9):12-15.(in Chinese)
[29] 商利娜,王亚静,赵鑫,等.基于谱-效关系探究黄芩抑制白色念珠菌的质量标志物[J].中成药,2020,42(5):1357-1361. SHANG L N,WANG Y J,ZHAO X,et al.Study on quality markers of inhibition of
Candida albicans by
Scutellaria baicalensis Georgi based on spectrum-effect relationship[J].Chinese Traditional Patent Medicine,2020,42(5):1357-1361.(in Chinese)
[30] CHAN B C L,IP M,LAU C B S,et al.Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant
Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase[J].Journal of Ethnopharmacology,2011,137(1):767-773.
[31] WANG M F,DONG Y P,WU J,et al.Baicalein ameliorates ionizing radiation-induced injuries by rebalancing gut microbiota and inhibiting apoptosis[J].Life Sciences,2020,261:118463.
[32] MATSUMOTO T,KANEKO A,KOSEKI J,et al.Pharmacokinetic study of bioactive flavonoids in the traditional Japanese medicine keigairengyoto exerting antibacterial effects against
Staphylococcus aureus[J].International Journal of Molecular Sciences,2018,19(2):328.
[33] 李慧.基于NF-κB信号通路调控的黄酮类化合物抗炎活性及抗炎/抗氧化联运机制[D].博士学位论文.武汉:华中农业大学,2019. LI H.Anti-inflammation and anti-inflammatory/antioxidant linkage mechanism of flavonoids based on NF-κB signaling pathway[D].Master's Thesis.Wuhan:Huazhong Agricultural University,2019.(in Chinese)
[34] 张倩,李惠香,刘攀,等.黄芩素的体外抗炎及抗氧化活性研究[J].烟台大学学报(自然科学与工程版),2018,31(3):232-238. ZHANG Q,LI H X,LIU P,et al.
In vitro anti-inflammatory and antioxidative activity of baicalein[J].Journal of Yantai University (Natural Science and Engineering Edition),2018,31(3):232-238.(in Chinese)
[35] KIM Y J,KIM H J,LEE J Y.Anti-inflammatory effect of baicalein on polyinosinic-polycytidylic acid-induced rAW 264.7 mouse macrophages[J].Viruses,2018,10(5):224.
[36] DUAN D D,WANG K X,ZHOU Y Z,et al.Baicalein exerts beneficial effects in
D-galactose-induced aging rats through attenuation of inflammation and metabolic dysfunction[J].Rejuvenation Research,2017,20(6):506-516.
[37] ZHANG R Y,CUI Y L,WANG Y,et al.Catechol-O-methyltransferase and UDP-glucuronosyltransferases in the metabolism of baicalein in different species[J].European Journal of Drug Metabolism and Pharmacokinetics,2017,42(6):981-992.
[38] ZHOU W,LIU X T,TANG J J,et al.Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome[J].Oncotarget,2017,8(35):58903-58917.
[39] 俞文英,张欢欢,吴月国,等.黄酮类化合物的构效关系及其在肺部炎症疾病中的应用[J].中草药,2018,49(20):4912-4918. YU W Y,ZHANG H H,WU Y G,et al.Structure-activity relationship of flavonoids and its application in pulmonary inflammatory diseases[J].Chinese Traditional and Herbal Drugs,2018,49(20):4912-4918.(in Chinese)
[40] DINDA B,DINDA S,DASSHARMA S,et al.Therapeutic potentials of baicalin and its aglycone,baicalein against inflammatory disorders[J].European Journal of Medicinal Chemistry,2017,131:68-80.
[41] 朱晓琳,赵海燕,杨吉林.黄芩素对重症急性胰腺炎大鼠肺组织损伤的影响[J].郑州大学学报(医学版),2020,55(1):37-40. ZHU X L,ZHAO H Y,YANG J L.Effects of baicalein on lung tissue injury in rats with severe acute pancre-atitis[J].Journal of Zhengzhou University (Medical Edition),2020,55(1):37-40.(in Chinese)
[42] 陈美珍,陈简庆,吴红莲.黄芩素对肥胖小鼠体脂及胰岛素抵抗的作用研究[J].西南医科大学学报,2019,42(6):527-532. CHEN M Z,CHEN J Q,WU L H.Effects of baicalein on body fat and insulin resistance in obese mice[J].Journal of Southwest Medical University,2019,42(6):527-532.(in Chinese)
[43] 田华,王小平,张峰利.黄芩素对慢性萎缩性胃炎大鼠胃黏膜保护作用的实验研究[J].中医药通报,2015,14(5):62-64. TIAN H,WANG X P,ZHANG F L.Experimental study on protective effect of baicalein on gastric mucosa in rats with chronic atrophic gastritis[J].Traditional Chinese Medicine Journal,2015,14(5):62-64.(in Chinese)
[44] WU C C,CHEN Y R,LU D H,et al.Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes:an
in vitro study using baicalein[J].Regenerative Therapy,2020,14:177-183.
[45] HE X X,WEI Z K,ZHOU E S,et al.Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-κB and MAPK signaling pathways in LPS-induced mastitis in mice[J].International Immunopharmacology,2015,28(1):470-476.
[46] 代重山,汤树生,张青杰,等.黄芩苷和黄芩素的生物学功能及其在动物生产中的应用[J].中国饲料,2015(8):11-14,18. DAI C S,TANG S S.ZHANG Q J,et al.Biological functions of baicalin and baicalein and their application in animal production[J].Chinese Feed,2015(8):11-14,18.(in Chinese)
[47] 涂保.黄酮类化合物生物效应及构效关系研究[D].硕士学位论文.黄石:湖北师范大学,2016. TU B.Research on biological activities and structure-activity relationship of flavonoids[D].Master's Thesis.Huangshi:Hubei Normal University,2016.(in Chinese)
[48] DE OLIVEIRA M R,NABAVI S F,HABTEMARIAM S,et al.The effects of baicalein and baicalin on mitochondrial function and dynamics:a review[J].Pharmacological Research,2015,100:296-308.
[49] GRIGALIUS I,PETRIKAITE V.Relationship between antioxidant and anticancer activity of trihydroxyflavones[J].Molecules,2017,22(12):2169.
[50] 刘靖丽,崔莹超.黄芩素和黄芩苷抗氧化活性与结构关系的密度泛函理论研究[J].云南民族大学学报(自然科学版),2017,26(6):461-464. LIU J L,CUI Y C.The density functional theory studies on the relationship between antioxidant activity and structure of baicalein and baicalin[J].Journal of Yunnan Nationalities University (Natural Sciences Edition),2017,26(6):461-464.(in Chinese)
[51] JIANG W B,ZHAO W,CHEN H,et al.Baicalin protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis and oxidative stress through activation of mitochondrial aldehyde dehydrogenase 2[J].Clinical and Experimental Pharmacology and Physiology,2018,45(3):303-311.
[52] HA T K,HANSEN A H,KOL S,et al.Baicalein reduces oxidative stress in CHO cell cultures and improves recombinant antibody productivity[J].Biotechnology Journal,2018,13(3):1700425.
[53] CHOI E O,JEONG J W,PARK C,et al.Baicalein protects C6 glial cells against hydrogen peroxide-induced oxidative stress and apoptosis through regulation of the Nrf2 signaling pathway[J].International Journal of Molecular Medicine,2016,37(3):798-806.
[54] LIAU P R,WU M S,LEE C K.Inhibitory effects of
Scutellaria baicalensis root extract on linoleic acid hydroperoxide-induced lung mitochondrial lipid peroxidation and antioxidant activities[J].Molecules,2019,24(11):2143.
[55] ZHOU Y F,MAO S G,ZHOU M X.Effect of the flavonoid baicalein as a feed additive on the growth performance,immunity,and antioxidant capacity of broiler chickens[J].Poultry Science,2019,98(7):2790-2799.
[56] 王捷.番茄红素、芝麻酚和黄芩素对猪精子冷冻保存效果的影响[D].硕士学位论文.杨凌:西北农林科技大学,2017. WANG J.Effects of lycopene,sesamol and baicalein on cryopreservation of boar spematozoa[D].Master's Thesis.Yangling:North West Agriculture and Forestry University,2017.(in Chinese)
[57] ZHOU H C,WANG H,SHI K,et al.Hepatoprotective effect of baicalein against acetaminophen-induced acute liver injury in mice[J].Molecules,2018,24(1):131.
[58] PARK Y G,CHOI J,JUNG H K,et al.Baicalein inhibits tumor progression by inhibiting tumor cell growth and tumor angiogenesis[J].Oncology Reports,2017,38(5):3011-3018.
[59] 朱亚南,杨七妹,张硕,等.黄芩苷与黄芩素药理作用及机制研究进展[J].时珍国医国药,2020,31(4):921-925. ZHU Y N,YANG Q M,ZHANG S,et al.Advances in pharmacological effects and mechanisms of baicalin and baicalein[J].Lishizhen Medicine and Materia Medica Research,2020,31(4):921-925.(in Chinese)
[60] YAN W J,MA X C,ZHAO X Y,et al.Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway
in vivo and
vitro[J].Drug Design,Development and Therapy,2018,12:3961-3972.
[61] MU J S,LIU T R,JIANG L,et al.The traditional Chinese medicine baicalein potently inhibits gastric cancer cells[J].Journal of Cancer,2016,7(4):453-461.
[62] 魏雪芳,林绍彬,熊红萍,等.黄芩素对糖尿病大鼠胰岛功能的影响及其机制探讨[J].中西医结合心脑血管病杂志,2019,17(19):2933-2935. WEI X F,LIN S B,XIONG H P,et al.The influence of baicalein on islet function in diabetic rats[J].Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease,2019,17(19):2933-2935.(in Chinese)
[63] 区梓聪,何秋星,李馨恩,等.黄芩素在化妆品中多功效研究及安全性评价[J].天然产物研究与开发,2016,28(12):2006-2010,1958. QU Z C,HE Q X,LI X E,et al.Multiple efficiency and safety of baicalein in cosmetics[J].Natural Product Research and Development,2016,28(12):2006-2010,1958.(in Chinese)
[64] 黄强,彭玉麟,栾超.禁抗下功能性饲料添加剂的营养健康作用[J].饲料工业,2020,41(23):49-58. HUANG Q,PENG Y L,LUAN C.Nutritional and health role of functional feed additives after antibiotic free in feed[J].Feed Industry,2020,41(23):49-58.(in Chinese)
[65] 卢德勋.健康养殖的营养技术策略的系统观[J].饲料工业,2019,40(2):1-5. LU D X.The systemic concept on a nutritional strategy for healthy animal production[J].Feed Industry,2019,40(2):1-5.(in Chinese)
京公网安备 11010802041926号