综述 REVIEW

肠道菌群对围产期母猪能量失衡的影响及作用机制

  • 张龙林 ,
  • 李浩 ,
  • 谭碧娥 ,
  • 范志勇
展开
  • 湖南农业大学动物科学技术学院, 长沙 410128
张龙林(1997-),女,湖南株洲人,硕士研究生,从事动物营养生理与代谢调控研究。E-mail:834510050@qq.com

收稿日期: 2020-12-13

  网络出版日期: 2021-07-06

基金资助

国家自然科学基金项目(U20A2054)

Effects of Gut Microbiota on Energy Imbalance in Perinatal Sows and Its Mechanism

  • ZHANG Longlin ,
  • LI Hao ,
  • TAN Bi'e ,
  • FAN Zhiyong
Expand
  • College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2020-12-13

  Online published: 2021-07-06

Supported by

 

摘要

母猪围产期是指分娩前10天至分娩后10天,是母猪繁殖周期中相当特殊而关键的高风险期。围产期母猪极易由于生理代谢以及营养需求等急剧变化发生氧化应激,从而引起母猪肠道菌群紊乱,进而造成能量失衡。而肠道菌群的特征性变化可能是加剧母猪能量代谢障碍的重要外源因素,这使其成为调控母猪围产期能量平衡的重要靶点。本文就围产期阶段母猪自身生理变化、饲粮结构变化特点及肠道菌群特征进行剖析,以探讨围产期母猪能量代谢障碍的原因,旨在为生产中母猪能量平衡的调控和相关研究提供一定的参考。

本文引用格式

张龙林 , 李浩 , 谭碧娥 , 范志勇 . 肠道菌群对围产期母猪能量失衡的影响及作用机制[J]. 动物营养学报, 2021 , 33(7) : 3665 -3675 . DOI: 10.3969/j.issn.1006-267x.2021.07.008

Abstract

The perinatal period of sows is usually defined as ten days before or after delivery, and it is a very specific and critical high-risk period in the reproductive cycle of sows. The perinatal sows are prone to oxidative stress due to drastic changes in physiological metabolism and nutritional needs, which causes gut microbiota disorders in sows and even further can lead to energy imbalance. The characteristic changes of gut microbiota may be an important exogenous factor that exacerbates energy metabolism disorder in sows, which makes the gut microbiota is an important target for regulating energy balance in the perinatal period. In this review, we summarized the literature on physiological changes, changes of dietary structure characteristics and gut microbiota characteristics of the perinatal period, which tried to explore the possible causes of energy metabolism disorders in perinatal sows and intended to provide a background reference for the regulation of energy balance in producing sows and related studies.

参考文献

[1] KAISER M,JACOBSON M,ANDERSEN P H,et al.Inflammatory markers before and after farrowing in healthy sows and in sows affected with postpartum dysgalactia syndrome[J].BMC Veterinary Research,2018,14(1):83.
[2] AMABEBE E,ROBERT F O,AGBALALAH T,et al.Microbial dysbiosis-induced obesity:role of gut microbiota in homoeostasis of energy metabolism[J].British Journal of Nutrition,2020,123(10):1127-1137.  
[3] JI X L,HOU C Y,GAO Y G,et al.Metagenomic analysis of gut microbiota modulatory effects of jujube (Ziziphus jujuba Mill.) polysaccharides in a colorectal cancer mouse model[J].Food & Function,2020,11(1):163-173.  
[4] 杨利娜,边高瑞,朱伟云.单胃动物肠道微生物菌群与肠道免疫功能的相互作用[J].微生物学报,2014,54(5):480-486. YANG L N,BIAN G R,ZHU W Y.Interactions between the monogastric animal gut microbiota and the intestinal immune function-a review[J].Acta Microbiologica Sinica,2014,54(5):480-486.(in Chinese)
[5] 郭亮,陈国薇,谢曼曼,等.肠道菌群功能与影响因素研究进展[J].微生物学杂志,2017,37(4):108-114. GUO L,CHEN G W,XIE M M,et al.Advances in function and influencing factors of gut microbian[J].Journal of Microbiology,2017,37(4):108-114.(in Chinese)
[6] ZHOU P,ZHAO Y,ZHANG P,et al.Microbial mechanistic insight into the role of inulin in improving maternal health in a pregnant sow model[J].Frontiers in Microbiology,2017,8:2242.
[7] 陆东东,倪冬姣,黄翔,等.日粮纤维对猪肠道微生物的影响[J].中国饲料,2018(9):15-18. LU D D,NI D J,HUANG X,et al. Effects of dietary fiber on intestinal microorganism in pigs[J].China Feed,2018(9):15-18.(in Chinese)
[8] LIU H B,HOU C L,LI N,et al.Microbial and metabolic alterations in gut microbiota of sows during pregnancy and lactation[J].The FASEB Journal,2019,33(3):4490-4501.  
[9] JI Y J,LI H,XIE P F,et al.Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows[J].Journal of Applied Microbiology,2019,127(3):867-879.  
[10] COOKE M S,EVANS M D,DIZDAROGLU M,et al.Oxidative DNA damage:mechanisms,mutation,and disease[J].FASEB Journal,2003,17(10):1195-1214.  
[11] 李浩,谷雪玲,吕宏伟,等.仔猪肠道菌群的母源传递[J].动物营养学报,2019,31(9):3983-3990. LI H,GU X L,LYU Z W,et al.Maternal transmission of intestinal microflora in piglets[J].Chinese Journal of Animal Nutrition,2019,31(9):3983-3990.(in Chinese)
[12] BAZOTTE R B,SILVA L G,SCHIAVON F P.Insulin resistance in the liver:deficiency or excess of insulin?[J].Cell Cycle,2014,13(16):2494-2500.  
[13] SMITH G I,POLIDORI D C,YOSHINO M,et al.Influence of adiposity,insulin resistance,and intrahepatic triglyceride content on insulin kinetics[J].Journal of Clinical Investigation,2020,130(6):3305-3314.  
[14] KRISTENSEN N B,WU G.Metabolic functions of the porcine liver[M]//BACH K E,KNUDSEN N J,KJELDSEN H D,et al.Nutritional physiology of pigs.Copenhagen,Denmark:Danish Pig Research Center,2012.
[15] RAI R,SARASWAT V A,DHIMAN R K.Gut microbiota:its role in hepatic encephalopathy[J].Journal of Clinical and Experimental Hepatology,2015,5(Suppl):S29-S36.
[16] MIURA K,OHNISHI H.Role of gut microbiota and toll-like receptors in nonalcoholic fatty liver disease[J].World Journal of Gastroenterology,2014,20(23):7381-7391.  
[17] 张真玲,段志军.肠肝轴-肝病防治中的重要目标[J].世界华人消化杂志,2016,24(23):3454-3460. ZHANG Z L,DUAN Z J.Gut-liver axis:an important target for prevention and treatment of liver diseases[J].World Chinese Journal of Digestology,2016,24(23):3454-3460.(in Chinese)
[18] PEREIRA R D,DE LONG N E,WANG R C,et al.Angiogenesis in the placenta:the role of reactive oxygen species signaling[J].BioMed Research International,2015,2015:814543.
[19] LEE P C,ROBERTS J M,CATOV J M,et al.First trimester exposure to ambient air pollution,pregnancy complications and adverse birth outcomes in Allegheny county,PA[J].Maternal and Child Health Journal,2013,17(3):545-555.  
[20] MILTON-LASKÍBAR I,GÓMEZ-ZORITA S,ARIAS N,et al.Effects of resveratrol and its derivative pterostilbene on brown adipose tissue thermogenic activation and on white adipose tissue browning process[J].Journal of Physiology and Biochemistry,2020,76(2):269-278.  
[21] ZHENG Q T,LIN J,HUANG J J,et al.Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity[J].Proceedings of the National Academy of Sciences of the United States of America,2017,114(45):E9474-E9482.
[22] 李秀钧.脂肪组织是又一个新的内分泌器官[J].国外医学内(分泌学分册),2002,22(3):129-131. LI X J.Adipose tissue:another new endocrine organ[J].Foreign Medical Sciences (Section of Endocrinology),2002,22(3):129-131.(in Chinese)
[23] LAPPAS M,YEE K,PERMEZEL M,et al.Release and regulation of leptin,resistin and adiponectin from human placenta,fetal membranes,and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies[J].The Journal of Endocrinology,2005,186(3):457-465.  
[24] 胡群,叶南,史泽宇,等.猪妊娠过程中胎盘发育及其调控基因研究进展[J].中国畜牧兽医,2018,45(6):1633-1638. HU Q,YE N,SHI Z Y,et al.Research advance on placenta development and its regulated genes in pig[J].China Animal Husbandry & Veterinary Medicine,2018,45(6):1633-1638.(in Chinese)
[25] OSIKOYA O,AHMED H,PANAHI S,et al.Uterine perivascular adipose tissue is a novel mediator of uterine artery blood flow and reactivity in rat pregnancy[J].The Journal of Physiology,2019,597(15):3833-3852.  
[26] CHEN X H,STEIN T P,STEER R A,et al.Individual free fatty acids have unique associations with inflammatory biomarkers,insulin resistance and insulin secretion in healthy and gestational diabetic pregnant women[J].BMJ Open Diabetes Research & Care,2019,7(1):e000632.
[27] LEE D G,NAM J,KIM S W,et al.Proteomic analysis of reproduction proteins involved in litter size from porcine placenta[J].Bioscience,Biotechnology,and Biochemistry,2015,79(9):1414-1421.  
[28] ROSEBOOM T J,PAINTER R C,DE ROOIJ S R,et al.Effects of famine on placental size and efficiency[J].Placenta,2011,32(5):395-399.  
[29] JANSSON T,POWELL T L.Human placental transport in altered fetal growth:does the placenta function as a nutrient sensor? -a review[J].Placenta,2006,27(Suppl.1):91-97.
[30] CHE L,YANG Z G,XU M M,et al.Maternal nutrition modulates fetal development by inducing placental efficiency changes in gilts[J].BMC Genomics,2017,18(1):213.
[31] PōRE M C,ETIENNE M.Insulin sensitivity during pregnancy,lactation,and postweaning in primiparous gilts[J].Journal of Animal Science,2007,85(1):101-110.  
[32] ZHOU Y F,XU T,CAI A L,et al.Excessive backfat of sows at 109 d of gestation induces lipotoxic placental environment and is associated with declining reproductive performance[J].Journal of Animal Science,2018,96(1):250-257.  
[33] BENSALEM A,MURTAZA B,HICHAMI A,et al.Bile acid receptor TGR5 is critically involved in preference for dietary lipids and obesity[J].The Journal of Nutritional Biochemistry,2020,76:108298.
[34] HUNT J E,BILLESCHOU A,WINDELØV J A,et al.Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice[J].American Journal of Physiology-Gastrointestinal and Liver Physiology,2020,318(5):G980-G987.
[35] PSICHAS A,SLEETH M L,MURPHY K G,et al.The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents[J].International Journal of Obesity,2015,39(3):424-429.  
[36] TOLHURST G,HEFFRON H,LAM Y S,et al.Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2[J].Diabetes,2012,61(2):364-371.  
[37] VAN DE WOUW M,SCHELLEKENS H,DINAN T G,et al.Microbiota-gut-brain axis:modulator of host metabolism and appetite[J].The Journal of Nutrition,2017,147(5):727-745.  
[38] PERRY R J,PENG L,BARRY N A,et al.Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome[J].Nature,2016,534(7606):213-217.  
[39] ERICSON M D,SCHNELL S M,FREEMAN K T,et al.A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist[J].Bioorganic & Medicinal Chemistry Letters,2015,25(22):5306-5308.  
[40] DE CLERCQ N C,FRISSEN M N,GROEN A K,et al.Gut microbiota and the gut-brain axis:new insights in the pathophysiology of metabolic syndrome[J].Psychosomatic Medicine,2017,79(8):874-879.  
[41] KIM H K,YOUN B S,SHIN M S,et al.Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight[J].Diabetes,2010,59(11):2772-2780.  
[42] WANG Y H,VISCARRA J,KIM S J,et al.Transcriptional regulation of hepatic lipogenesis[J].Nature Reviews Molecular Cell Biology,2015,16(11):678-689.  
[43] BÄCKHED F,MANCHESTER J K,SEMENKOVICH C F,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(3):979-984.  
[44] SWARTZ T D,SAKAR Y,DUCA F A,et al.Preserved adiposity in the Fischer 344 rat devoid of gut microbiota[J].The FASEB Journal,2013,27(4):1701-1710.  
[45] LI W F,YANG H Y,ZHAO Q,et al.Polyphenol-rich loquat fruit extract prevents fructose-induced nonalcoholic fatty liver disease by modulating glycometabolism,lipometabolism,oxidative stress,inflammation,intestinal barrier,and gut microbiota in mice[J].Journal of Agricultural and Food Chemistry,2019,67(27):7726-7737.  
[46] DEN BESTEN G,BLEEKER A,GERDING A,et al.Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation[J].Diabetes,2015,64(7):2398-2408.  
[47] SUN L J,MA L J,MA Y B,et al.Insights into the role of gut microbiota in obesity:pathogenesis,mechanisms,and therapeutic perspectives[J].Protein & Cell,2018,9(5):397-403.  
[48] PARSÉUS A,SOMMER N,SOMMER F,et al.Microbiota-induced obesity requires farnesoid X receptor[J].Gut,2017,66(3):429-437.  
[49] KIMURA I,OZAWA K,INOUE D,et al.The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43[J].Nature Communications,2013,4:1829.
[50] BEIN A,ZILBERSHTEIN A,GOLOSOVSKY M,et al.LPS induces hyper-permeability of intestinal epithelial cells[J].Journal of Cellular Physiology,2017,232(2):381-390.  
[51] GUO S H,NIGHOT M,AL-SADI R,et al.Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88[J].The Journal of Immunology,2015,195(10):4999-5010.  
[52] TORRES-FUENTES C,SCHELLEKENS H,DINAN T G,et al.The microbiota-gut-brain axis in obesity[J].The Lancet Gastroenterology & Hepatology,2017,2(10):747-756.  
[53] TURRONI F,MILANI C,DURANTI S,et al.Glycan utilization and cross-feeding activities by bifidobacteria[J].Trends in Microbiology,2018,26(4):339-350.  
[54] TONG L C,WANG Y,WANG Z B,et al.Propionate ameliorates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress[J].Frontiers in Pharmacology,2016,7:253.
[55] KIM M H,KANG S G,PARK J H,et al.Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice[J].Gastroenterology,2013,145(2):396-406.e10.  
[56] ROH Y,LEE J,KIM W G,et al.Effect of diet change on gut microbiota:observational pilot study of four urban couples[J].Journal of Obesity & Metabolic Syndrome,2017,26(4):257-265.  
[57] 魏星,沈秀平,赵秋华.母猪便秘的原因及防治对策[J].国外畜牧学(猪与禽),2007,27(6):65-66. WEI X,SHEN X P,ZHAO Q H.Causes of constipation in sows and countermeasures[J].Animal Science Abroad (Pigs and Poultry):2007,27(6):65-66.(in Chinese)
[58] DAVILA A M,BLACHIER F,GOTTELAND M,et al.Intestinal luminal nitrogen metabolism:role of the gut microbiota and consequences for the host[J].Pharmacological Research,2013,68(1):95-107.  
[59] SHORTT C,HASSELWANDER O,MEYNIER A,et al.Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients[J].European Journal of Nutrition,2018,57(1):25-49.  
[60] MASLOWSKI K M,MACKAY C R.Diet,gut microbiota and immune responses[J].Nature Immunology,2011,12(1):5-9.  
文章导航

/