[1] CLEMENTE J C,URSELL L K,PARFREY L W,et al.The impact of the gut microbiota on human health:an integrative view[J].Cell,2012,148(6):1258-1270.
[2] JIA W,XIE G X,JIA W P.Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis[J].Nature Reviews.Gastroenterology & Hepatology,2018,15(2):111-128.
[3] QUINN R A,MELNIK A V,VRBANAC A,et al.Global chemical effects of the microbiome include new bile-acid conjugations[J].Nature,2020,579(7797):123-129.
[4] RIDLON J M,KANG D J,HYLEMON P B,et al.Bile acids and the gut microbiome[J].Current Opinion in Gastroenterology,2014,30(3):332-338.
[5] TAN H E,SISTI A C,JIN H,et al.The gut-brain axis mediates sugar preference[J].Nature,2020,580(7804):1-6.
[6] DANG A T,MARSLAND B J.Microbes,metabolites,and the gut-lung axis[J].Mucosal Immunology,2019,12(4):843-850.
[7] FARZI A,FRÖHLICH E E,HOLZER P.Gut microbiota and the neuroendocrine system[J].Neurotherapeutics,2018,15(1):5-22.
[8] LYTE M.Microbial endocrinology:host-microbiota neuroendocrine interactions influencing brain and behavior[J].Gut Microbes,2014,5(3):381-389.
[9] TILG H,CANI P D,MAYER E A.Gut microbiome and liver diseases[J].Gut,2016,65(12):2035-2044.
[10] TRIPATHI A,DEBELIUS J,BRENNER D A,et al.Publisher correction:the gut-liver axis and the intersection with the microbiome[J].Nature Reviews:Gastroenterology & Hepatology,2018,15(7):785.
[11] TERATANI T,MIKAMI Y,NAKAMOTO N,et al.The liver-brain-gut neural arc maintains the Treg cell niche in the gut[J].Nature,2020,585(7826):591-596.
[12] The Human Microbiome Project Consortium.Structure,function and diversity of the healthy human microbiome[J].Nature,2012,486(7402):207-214.
[13] DEVLIN A S,FISCHBACH M A.A biosynthetic pathway for a prominent class of microbiota-derived bile acids[J].Nature Chemical Biology,2015,11(9):685-690.
[14] JAROCKI P,TARGOŃSKI Z.Genetic diversity of bile salt hydrolases among human intestinal bifidobacteria[J].Current Microbiology,2013,67(3):286-292.
[15] SAYIN S I,WAHLSTRÖM A,FELIN J,et al.Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid,a naturally occurring FXR antagonist[J].Cell Metabolism,2013,17(2):225-235.
[16] FIORUCCI S,DISTRUTTI E.Bile acid-activated receptors,intestinal microbiota,and the treatment of metabolic disorders[J].Trends in Molecular Medicine,2015,21(11):702-714.
[17] BIAGIOLI M,CARINO A,CIPRIANI S,et al.The bile acid receptor GPBAR1 regulates the M1/M2 phenotype of intestinal macrophages and activation of GPBAR1 rescues mice from murine colitis[J].Journal of Immunology,2017,199(2):718-733.
[18] RIDLON J M,BAJAJ J S.The human gut sterolbiome:bile acid-microbiome endocrine aspects and therapeutics[J].Acta Pharmaceutica Sinica B,2015,5(2):99-105.
[19] ZHANG Y C,LIMAYE P B,RENAUD H J,et al.Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice[J].Toxicology and Applied Pharmacology,2014,277(2):138-145.
[20] ESLAM M,SANYAL A J,GEORGE J.MAFLD:a consensus-driven proposed nomenclature for metabolic associated fatty liver disease[J].Gastroenterology,2020,158(7):1999-2014.e1.
[21] TOLEDO-ARANA A,DUSSURGET O,NIKITAS G,et al.The Listeria transcriptional landscape from saprophytism to virulence[J].Nature,2009,459(7249):950-956.
[22] MULLISH B H,MCDONALD J A K,PECHLIVANIS A,et al.Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent
Clostridioides difficile infection[J].Gut,2019,68(10):1791-1800.
[23] JONES B V,BEGLEY M,HILL C,et al.Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome[J].Proceedings of the National Academy of Sciences of the United States of America,2008,105(36):13580-13585.
[24] RIDLON J M,KANG D J,HYLEMON P B.Bile salt biotransformations by human intestinal bacteria[J].Journal of Lipid Research,2006,47(2):241-259.
[25] THOMAS C,PELLICCIARI R,PRUZANSKI M,et al.Targeting bile-acid signalling for metabolic diseases[J].Nature Reviews Drug Discovery,2008,7(8):678-693.
[26] ALAVI S,MITCHELL J D,CHO J Y,et al.Interpersonal gut microbiome variation drives susceptibility and resistance to cholera infection[J].Cell,2020,181(7):1533-1546.e13.
[27] STERN N J,SVETOCH E A,ERUSLANOV B V,et al.Isolation of a
Lactobacillus salivarius strain and purification of its bacteriocin,which is inhibitory to
Campylobacter jejuni in the chicken gastrointestinal system[J].Antimicrobial Agents and Chemotherapy,2006,50(9):3111-3116.
[28] KUMAR R,GROVER S,MOHANTY A K,et al.Molecular cloning and sequence analysis of bile salt hydrolase gene (BSH) from
Lactobacillus plantarum MBUL90 strain of human origin[J].Food Biotechnology,2010,24(3):215-226.
[29] JIANG J K,HANG X M,ZHANG M,et al.Diversity of bile salt hydrolase activities in different lactobacilli toward human bile salts[J].Annals of Microbiology,2010,60(1):81-88.
[30] TARANTO M P,SESMA F,DE VALDEZ G F.Localization and primary characterization of bile salt hydrolase from Lactobacillus reuteri[J].Biotechnology Letters,1999,21(11):935-938.
[31] TANAKA H,HASHIBA H,KOK J,et al.Bile salt hydrolase of
Bifidobacterium longum-biochemical and genetic characterization[J].Applied and Environmental Microbiology,2000,66(6):2502-2512.
[32] KIM G K,MIYAMOTO C M,MEIGHEN E A et al.Cloning and characterization of the bile salt hydrolase genes (BSH) from
Bifidobacterium bifidum strains[J].Applied and Environmental Microbiology,2004,70(9):5603-5612.
[33] JAROCKI P.Molecular characterization of bile salt hydrolase from
Bifidobacterium animalis subsp.lactis Bi30[J].Journal of Microbiology and Biotechnology,2011,21(8):838-845.
[34] MILANI C,MANGIFESTA M,MANCABELLI L,et al.Unveiling bifidobacterial biogeography across the mammalian branch of the tree of life[J].The ISME Journal,2017,11(12):2834-2847.
[35] TRIVEDI P,PANDEY A.Recovery of plant growth-promoting rhizobacteria from sodium alginate beads after 3 years following storage at 4 C[J].Journal of Industrial Microbiology and Biotechnology,2008,35(3):205-209.
[36] COLEMAN J P,HUDSON L L.Cloning and characterization of a conjugated bile acid hydrolase gene from
Clostridium perfringens[J].Applied and Environmental Microbiology,1995,61(7):2514-2520.
[37] AZIZ R K,BARTELS D,BEST A A,et al.The RAST server:rapid annotations using subsystems technology[J].BMC Genomics,2008,9:75.
[38] RUSHTON-GREEN R,DARNELL R L,TAIAROA G,et al.Agricultural origins of a highly persistent lineage of vancomycin-resistant enterococcus faecalis in New Zealand[J].Applied and Environmental Microbiology,2019,85(13):e00137.
[39] BERGHOLZ T M,DEN BAKKER H C,KATZ L S,et al.Determination of evolutionary relationships of outbreak-associated
Listeria monocytogenes strains of serotypes 1/2a and 1/2b by whole-genome sequencing[J].Applied and Environmental Microbiology,2016,82(3):928-938.
[40] YABUUCHI E,KOSEKI M.Morphology of the type strain of
Bacillus anthracis EY 3169
T=ATCC 14578
T grown either aerobically or anaerobically on agar plates-observation by light and laser microscopes[J].Microbiology and Immunology,2013,47(7):491-497.
[41] DEGIROLAMO C,RAINALDI S,BOVENGA F,et al.Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice[J].Cell Reports,2014,7(1):12-18.
[42] WINSTON J A,THERIOT C M.Diversification of host bile acids by members of the gut microbiota[J].Gut Microbes,2020,11(2):158-171.
[43] ZHENG M M,WANG R F,LI C X,et al.Two-step enzymatic synthesis of ursodeoxycholic acid with a new 7β-hydroxysteroid dehydrogenase from
Ruminococcus torques[J].Process Biochemistry,2015,50(4):598-604.
[44] RIDLON J M,HARRIS S C,BHOWMIK S,et al.Consequences of bile salt biotransformations by intestinal bacteria[J].Gut Microbes,2016,7(1):22-39.
[45] CHIANG J Y L C.Bile acids:regulation of synthesis:thematic review series:bile acids[J].Journal of Lipid Research,2009,50(10):1955-1966.
[46] GRARD P.Metabolism of cholesterol and bile acids by the gut microbiota[J].Pathogens,2014,3(1):14-24
[47] EYSSEN H,DE PAUW G,STRAGIER J,et al.Cooperative formation of omega-muricholic acid by intestinal microorganisms[J].Applied and Environmental Microbiology,45(1):141-147.
[48] KISIELA M,SKARKA A,EBERT B,et al.Hydroxysteroid dehydrogenases (HSDs) in bacteria-a bioinformatic perspective[J].The Journal of Steroid Biochemistry and Molecular Biology,2012,129(1/2):31-46.
[49] DUBOC H,RAJCA S,RAINTEAU D,et al.Connecting dysbiosis,bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases[J].Gut,2013,62(4):531-539.
[50] MARTINEZ-MOYA P,ROMERO-CALVO I,REQUENA P,et al.Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis[J].International Immunopharmacology,2013,15(2):372-380.
[51] CAMPBELL C,MCKENNEY P T,KONSTANTINOVSKY D,et al.Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells[J].Nature,2020,581(7809):475-479.
[52] JOSEFOWICZ S Z,NIEC R E,KIM H Y,et al.Extrathymically generated regulatory T cells control mucosal TH2 inflammation[J].Nature,2012,482(7385):395-399.
[53] HIRANO S,MASUDA N.Transformation of bile acids by
Eubacterium lentum[J].Applied and Environmental Microbiology,1981,42(5):912-915.
[54] BATTA A K,SALEN G,SHEFER S.Transformation of bile acids into iso-bile acids by
Clostridium perfringens:possible transport of 3β-hydrogen via the coenzyme[J].Hepatology,1985,5(6):1126-1131.
[55] VANG S,LONGLEY K,STEER C J,et al.The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases[J].Global Advances in Health and Medicine,2014,3(3):58-69.
[56] DE A K,SANA S,DATTA S,et al.Protective efficacy of ursodeoxycholic acid nanoparticles in animal model of inflammatory bowel disease[J].Journal of Microencapsulation,2014,31(8):725-737.
[57] VAN DEN BOSSCHE L,BORSBOOM D,DEVRIESE S,et al.Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn's disease-like ileitis[J].Laboratory Investigation,2016,97(5):519-529.
[58] KULLMANN F,ARNDT H,GROSS V,et al.Beneficial effect of ursodeoxycholic acid on mucosal damage in trinitrobenzene sulphonic acid-induced colitis[J].European Journal of Gastroenterology & Hepatology,1997,9(12):1205-1211.
[59] SEUNG K,HOON C,HYUK C,et al.Ursodeoxycholic acid attenuates 5-fluorouracil-induced mucositis in a rat model[J].Oncology Letters,2018,16(2):2585-2590.
[60] KULLMANN F,GROSS V,RVSCHOFF J,et al.Effect of ursodeoxycholic acid on the inflammatory activity of indomethacin-induced intestinal inflammation in rats[J].Ztschrift Für Gastroenterologie,1997,35(3):171-178.
[61] WARD J B J,LAJCZAK N K,KELLY O B,et al.Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon[J].AJP Gastrointestinal and Liver Physiology,2017,312(6):G550-G558.
[62] SÖNMEZGÖZ E,TAKCI S,GVL A,et al.Ursodeoxycholic acid protects neonatal rats from necrotizing enterocolitis:a biochemical,histopathological,and immunohistochemical study[J].The Journal of Maternal-fetal & Neonatal Medicine,2020,doi:10.1080/14767058.2020.1818210.
[63] UCHIDA A,YAMADA T,HAYAKAWA T,et al.Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation[J].American Journal of Physiology,1997,272(5 Pt 1):G1249-G1257.
[64] BARRASA J I,OLMO N,LIZARBE M A,et al.Bile acids in the colon,from healthy to cytotoxic molecules[J].Toxicology in Vitro,2012,27(2):964-977.
[65] KOZONI V,TSIOULIAS G,SHIFF S,et al.The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis:differential effect on apoptosis in the presence of a colon carcinogen[J].Carcinogenesis,2000,21(5):999-1005.
[66] HANG S Y,PAIK D,YAO L N,et al.Bile acid metabolites control TH17 and Treg cell differentiation[J].Nature,2019,576(7785):143-148.
[67] SONG X Y,SUN X M,OH S F,et al.Microbial bile acid metabolites modulate gut RORγ
+ regulatory T cell homeostasis[J].Nature,2020,577(7790):410-415.
[68] WANG H,LATORRE J D,BANSAL M,et al.Microbial metabolite deoxycholic acid controls
Clostridium perfringens-induced chicken necrotic enteritis through attenuating inflammatory cyclooxygenase signaling[J].Scientific Reports,2019,9:14541.
[69] BELKAID Y,SEGRE J A.Dialogue between skin microbiota and immunity[J].Science,2014,346(6212):954-959.
[70] AGACE W W,MCCOY K D.Regionalized development and maintenance of the intestinal adaptive immune landscape[J].Immunity,2017,46(4):532-548.
[71] KONJAR Š,FERREIRA C,BLANKENHAUS B,et al.Intestinal barrier interactions with specialized CD8 T cells[J].Frontiers in Immunology,2017,8:1281.
[72] ZEISSIG S,BLUMBERG R S.Commensal microbiota and NKT cells in the control of inflammatory diseases at mucosal surfaces[J].Current Opinion in Immunology,2013,25(6):690-696.
[73] COOMBES J L,SIDDIQUI K R R,ARANCIBIA-CÁRCAMO C V,et al.A functionally specialized population of mucosal CD103
+ DCs induces Foxp3
+ regulatory T cells via a TGF-β-and retinoic acid-dependent mechanism[J].Journal of Experimental Medicine,2007,204(8):1757-1764.
[74] SUZUKI K,OIDA T,HAMADA H,et al.Gut cryptopatches:direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis[J].Immunity,2000,13(6):691-702.
[75] KASER A,BLUMBERG R S.Autophagy,microbial sensing,endoplasmic reticulum stress,and epithelial function in inflammatory bowel disease[J].Gastroenterology,2011,140(6):1738-1747.e2.
[76] PETERSON L W,ARTIS D.Intestinal epithelial cells:regulators of barrier function and immune homeostasis[J].Nature Reviews Immunology,2014,14(3):141-153.
[77] HOOPER L V.Epithelial cell contributions to intestinal immunity[J].Advances in Immunology,2015,126:129-172.
京公网安备 11010802041926号