综述 REVIEW

牛磺酸在母猪生产中的应用及其作用机理

  • 车龙 ,
  • 许蒙蒙 ,
  • 李君 ,
  • 李梦云
展开
  • 河南牧业经济学院动物科技学院, 郑州 450046
车龙(1989-),男,四川眉山人,讲师,博士,主要从事母猪营养研究。E-mail:chelong1989@126.com

收稿日期: 2021-08-03

  网络出版日期: 2022-02-15

基金资助

河南省科技攻关计划(212102110012);河南省高等学校重点科研项目(21A230007);河南牧业经济学院博士科研启动资金项目(2020HNUAHEDF024,2020HNUAHEDF025);河南牧业经济学院科研创新基金项目(XKYCXJJ2020001)

Application of Taurine in Sow Production and Its Mechanism

  • CHE Long ,
  • XU Mengmeng ,
  • LI Jun ,
  • LI Mengyun
Expand
  • College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China

Received date: 2021-08-03

  Online published: 2022-02-15

摘要

牛磺酸在母猪生产中的应用及其作用机理牛磺酸作为一种重要的条件性必需氨基酸,对母猪和仔猪营养起着至关重要的作用,但通过内源合成和传统饲粮供给并不能满足母猪适宜营养需要。近期研究发现,母猪妊娠和泌乳饲粮中添加适量牛磺酸对母猪乳腺发育、抗氧化能力以及仔猪生长性能、免疫功能有积极的调控作用。本文综述了近年来牛磺酸在母猪生产中的应用效果及作用机制,以期引起畜牧生产者对牛磺酸的关注,为牛磺酸在母猪生产中的正确应用提供参考。

本文引用格式

车龙 , 许蒙蒙 , 李君 , 李梦云 . 牛磺酸在母猪生产中的应用及其作用机理[J]. 动物营养学报, 2022 , 34(2) : 681 -688 . DOI: 10.3969/j.issn.1006-267x.2022.02.001

Abstract

Taurine as an important conditionally necessary amino acid, which plays an important role in the nutrition of sows and piglets, however, taurine from endogenous synthesis as well as the traditional diet provision can not meet the optimal nutritional needs of sows. Recent studies have found that dietary supplementation of taurine during gestation and lactation has a positive effect on mammary gland development, antioxidant capacity of sows and growth performance, immune system of piglets. This article reviewed the application of taurine and its mechanism in sow production to try to draw the attention of livestock producers to taurine and provide theoretical basis for the correct application of taurine in sow production.

参考文献

[1] WU G, KNABE D A.Free and protein-bound amino acids in sow's colostrum and milk[J].The Journal of Nutrition, 1994, 124(3):415-424.  
[2] SEIDEL U, HUEBBE P, RIMBACH G.Taurine:a regulator of cellular redox homeostasis and skeletal muscle function[J].Molecular Nutrition & Food Research, 2019, 63(16):e1800569.
[3] XU M M, CHE L, GAO K G, et al.Effects of dietary taurine supplementation to gilts during late gestation and lactation on offspring growth and oxidative stress[J].Animals, 2019, 9(5):220.
[4] 陈钊, 王明江, 兰家暖, 等.牛磺酸对夏季母猪哺乳期生产性能影响的研究[J].广西畜牧兽医, 2017, 33(5):252-253. CHEN Z, WANG M J, LAN J N, et al.Effect of taurine on performance of sows during lactation in summer[J].Guangxi Journal of Animal Husbandry & Veterinary Medicine, 2017, 33(5):252-253.(in Chinese)
[5] BALIOU S, ADAMAKI M, IOANNOU P, et al.Protective role of taurine against oxidative stress (review)[J].Molecular Medicine Reports, 2021, 24(2):605.
[6] CHE L, XU M M, GAO K G, et al.Effects of dietary valine supplementation during late gestation on the reproductive performance and mammary gland development of gilts[J].Journal of Animal Science and Biotechnology, 2020, 11(1):15.
[7] PICONE G, ZAPPATERRA M, LUISE D, et al.Metabolomics characterization of colostrum in three sow breeds and its influences on piglets' survival and litter growth rates[J].Journal of Animal Science and Biotechnology, 2018, 9:23.
[8] 刘悦.牛磺酸对断奶仔猪生长性能、组织病理学和肠道健康影响的研究[D].硕士学位论文.雅安:四川农业大学, 2014:35-36. LIU Y.Effects of taurine on growth performance, histopathology and intestinal health of weaned piglets[D].Master's Thesis.Ya'an:Sichuan Agricultural University, 2014:35-36.(in Chinese)
[9] 黄仁术, 彭志玲.日粮类型及牛磺酸添加对断奶仔猪生长性能的影响[J].粮食与饲料工业, 2008(9):44-45. HUANG R S, PENG Z L.Effects of dietary types and taurine supplementation on growth performance of weaned piglets[J].Cereal & Feed Industry, 2008(9):44-45.(in Chinese)
[10] AKERS R M.Lactation and the mammary gland[M].Ames:Iowa State University Press, 2002:105-128.
[11] NIELSEN O L, PEDERSEN A R, SØRENSEN M T.Relationships between piglet growth rate and mammary gland size of the sow[J].Livestock Production Science, 2001, 67(3):273-279.  
[12] XIAO D F, ZENG L M, YAO K, et al.The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications[J].Amino Acids, 2016, 48(9):2067-2080.  
[13] JIANG Q, HE L Q, HOU Y Q, et al.Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells[J].Amino Acids, 2016, 48(9):2179-2188.  
[14] 许蒙蒙, 高开国, 王丽, 等.妊娠后期和泌乳期饲粮牛磺酸添加对母猪繁殖性能和乳腺发育的影响[C]//第三届中国猪业科技大会暨中国畜牧兽医学会2019年学术年会论文集.青岛:中国畜牧兽医学会, 2019:125. XU M M, GAO K G, WANG L, et al.Effects of taurine supplementation in late pregnancy and lactation on reproductive performance and mammary gland development of sows[C]//Proceedings of the Third China Pig Technology Conference and Animal Nutrition Branch of Chinese Association of Animal and Veterinary Sciences.Qingdao:Chinese Association of Animal Science and Veterinary Medicine, 2019:125.(in Chinese)
[15] KIM S W, WEAVER A C, SHEN Y B, et al.Improving efficiency of sow productivity:nutrition and health[J].Journal of Animal Science and Biotechnology, 2013, 4(1):26.
[16] HUNG I F.The effect of dietary nucleotides in sow and nursery piglet diets on reproduction, growth, and immune response[D].Ph.D.Thesis.Lexington:University of Kentucky, 2015:21-23.
[17] GREEN T R, FELLMAN J H, EICHER A L, et al.Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils[J].Biochimica et Biophysica Acta, 1991, 1073(1):91-97.  
[18] 张建斌, 车向荣, 陈娟娟.谷氨酰胺和牛磺酸对断奶仔猪外周血液免疫功能的影响[J].中国畜牧兽医, 2011, 38(10):45-47. ZHANG J B, CHE X R, CHEN J J.Effect of glycyl-glutamine and taurine on the immune function of peripheral blood in early weaned piglets[J].China Animal Husbandry & Veterinary Medicine, 2011, 38(10):45-47.(in Chinese)
[19] 薛可.牛磺酸对LPS诱导仔猪炎症激活的抑制作用研究[D].硕士学位论文.沈阳:沈阳农业大学, 2018:32-33. XUE K.Inhibitory effect of taurine on LPS induced inflammatory activation in piglets[D].Master's Thesis.Shenyang:Shenyang Agricultural University, 2018:32-33.(in Chinese)
[20] 文超越.氧化应激对猪肌肉组织的损伤以及牛磺酸的缓解作用机制[D].硕士学位论文.长沙:湖南师范大学, 2019:18-19. WEN C Y.The mechanism of taurine alleviate muscle injury induced by oxidative stress in pig[D].Master's Thesis.Changsha:Hunan Normal University, 2019:18-19.(in Chinese)
[21] FARMER C, LAPOINTE J, PALIN M F.Effects of the plant extract silymarin on prolactin concentrations, mammary gland development, and oxidative stress in gestating gilts[J].Journal of Animal Science, 2014, 92(7):2922-2930.  
[22] WEN C Y, LI F N, ZHANG L Y, et al.Taurine is involved in energy metabolism in muscles, adipose tissue, and the liver[J].Molecular Nutrition & Food Research, 2019, 63(2):e1800536.
[23] JONG C J, AZUMA J N H, SCHAFFER S.Mechanism underlying the antioxidant activity of taurine:prevention of mitochondrial oxidant production[J].Amino Acids, 2012, 42(6):2223-2232.  
[24] BORCK P C, VETTORAZZI J F, BRANCO R C S, et al.Taurine supplementation induces long-term beneficial effects on glucose homeostasis in ob/ob mice[J].Amino Acids, 2018, 50(6):765-774.  
[25] HASAN M S, CRENSHAW M A, LIAO S F.Dietary lysine affects amino acid metabolism and growth performance, which may not involve the GH/IGF-1 axis, in young growing pigs[J].Journal of Animal Science, 2020, 98(1):skaa004.
[26] ROMAN-GARCIA P, QUIROS-GONZALEZ I, MOTTRAM L, et al.Vitamin B12-dependent taurine synthesis regulates growth and bone mass[J].The Journal of Clinical Investigation, 2014, 124(7):2988-3002.  
[27] 牟藤.牛磺酸对雌性大鼠生殖激素分泌及卵泡发育作用的研究[D].博士学位论文.沈阳:沈阳农业大学, 2015:73-76. MU T.Effects of taurine on the secretion of reproductive hormones and follicular development in female rats[D].Ph.D.Thesis.Shenyang:Shenyang Agricultural University, 2015:73-76.(in Chinese)
[28] 肖世平, 傅伟龙, 江青艳.饲粮中添加牛磺酸对黄鸡性腺发育及其内分泌的影响[J].华南农业大学学报, 1997(2):97-102. XIAO S P, FU W L, JIANG Q Y.Effects of taurine on development and endocrine of gonads of Yuehuang broilers[J].Journal of South China Agricultural University, 1997(2):97-102.(in Chinese)
[29] TIAN R, GENG Y P, YANG Y, et al.Oxidative stress drives divergent evolution of the glutathione peroxidase (GPx) gene family in mammals[J].Integrative Zoology, 2021, 16(5):696-711.  
[30] BAI J, YAO X F, JIANG L P, et al.Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway[J].Biochimie, 2016, 123:1-6.
[31] LEE D S, JO H G, KIM M J, et al.Antioxidant and anti-stress effects of taurine against electric foot-shock-induced acute stress in rats[J].Advances in Experimental Medicine and Biology, 2019, 1155:185-196.
[32] INCE S, ARSLAN-ACAROZ D, DEMIREL H H, et al.Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats[J].Biomedicine & Pharmacotherapy, 2017, 96:263-268.
[33] MA Q.Role of Nrf2 in oxidative stress and toxicity[J].Annual Review of Pharmacology and Toxicology, 2013, 53:401-426.
[34] LU Z, HE X F, MA B B, et al.Dietary taurine supplementation improves breast meat quality in chronic heat-stressed broilers via activating the Nrf2 pathway and protecting mitochondria from oxidative attack[J].Journal of the Science of Food and Agriculture, 2019, 99(3):1066-1072.  
[35] SUN Q R, JIA N, YANG J, et al.Nrf2 signaling pathway mediates the antioxidative effects of taurine against corticosterone-induced cell death in human SK-N-SH cells[J].Neurochemical Research, 2018, 43(2):276-286.  
[36] KIM W, KIM H U, LEE H N, et al.Taurine chloramine stimulates efferocytosis through upregulation of Nrf2-mediated heme oxygenase-1 expression in murine macrophages:possible involvement of carbon monoxide[J].Antioxidants & Redox Signaling, 2015, 23(2):163-177.  
[37] FANG H, MENG F P, PIAO F Y, et al.Effect of taurine on intestinal microbiota and immune cells in Peyer's patches of immunosuppressive mice[J].Advances in Experimental Medicine and Biology, 2019, 1155:13-24.
[38] KAESLER S, SOBIESIAK M, KNEILLING M, et al.Effective T-cell recall responses require the taurine transporter Taut[J].European Journal of Immunology, 2012, 42(4):831-841.  
[39] MARCINKIEWICZ J.Taurine bromamine (TauBr)-its role in immunity and new perspectives for clinical use[J].Journal of Biomedical Science, 2010, 17(Supp.l1):S3.
[40] TOKUNAGA S, KANAYAMA A, MIYAMOTO Y.Modification of ikappa B alpha by taurine bromamine inhibits tumor necrosis factor alpha-induced NF-kappa B activation[J].Inflammation Research, 2007, 56(11):479-486.  
[41] KONTNY E, CHORAżY-MASSALSKA M, RUDNICKA W, et al.Comparison of taurine chloramine and taurine bromamine effects on rheumatoid arthritis synoviocytes[J].Amino Acids, 2007, 32(3):447-452.  
[42] OLSZANECKI R, MARCINKIEWICZ J.Taurine chloramine and taurine bromamine induce heme oxygenase-1 in resting and LPS-stimulated J774.2 macrophages[J].Amino Acids, 2004, 27(1):29-35.
[43] KLAMT F, SHACTER E.Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage[J].Journal of Biological Chemistry, 2005, 280(22):21346-21352.  
[44] KIM K S, CHOI H M, OH D H, et al.Effect of taurine chloramine on the production of matrix metalloproteinases (MMPs) in adiponectin- or IL-1 beta-stimulated fibroblast-like synoviocytes[J].Journal of Biomedical Science, 2010, 17(Suppl.1):S27.
文章导航

/