综述 REVIEW

细胞外基质网络的动态变化对营养物质代谢调控作用的研究进展

  • 刘春艳 ,
  • 王丽 ,
  • 蒋宗勇 ,
  • 易宏波
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  • 1. 广东省农业科学院动物科学研究所, 畜禽育种国家重点实验室, 农业农村部华南动物营养与饲料重点实验室, 岭南现代农业科学与技术广东省实验室茂名分中心, 广东省畜禽育种与营养研究重点实验室, 广州 510640;
    2. 广西大学动物科学技术学院, 南宁 530004
刘春艳(1998-),女,湖南郴州人,硕士研究生,动物营养与饲料科学专业。E-mail:1838799235@qq.com

收稿日期: 2021-08-31

  网络出版日期: 2022-03-14

基金资助

财政部和农业农村部-国家现代农业产业技术体系;科技创新战略专项资金(高水平农科院建设)(R2016YJ-YB2003,R2019PY-QF005);广东省现代农业产业技术体系生猪创新团队项目(2021KJ126);茂名实验室自主科研项目(2021ZZ003)

Advances of Dynamic Changes of Extracellular Matrix Network and Its Regulating Effects on Nutrient Metabolism

  • LIU Chunyan ,
  • WANG Li ,
  • JIANG Zongyong ,
  • YI Hongbo
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  • 1. Guangdong Key Laboratory of Animal Breeding and Nutrition, Maoming Branch of Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China;
    2. College of Animal Science and Technology, Guangxi University, Nanning 530004, China

Received date: 2021-08-31

  Online published: 2022-03-14

摘要

细胞外基质(ECM)是一个动态的多功能网络结构,是细胞和组织赖以生存的外环境。长期以来,ECM网络被视为细胞生长、黏附以及组织重构等各种生理功能的调节器。近年研究发现,ECM网络是氨基酸等营养物质逐级转运的生理屏障,当ECM网络缺乏或沉积过多时会导致机体代谢异常,揭示其参与调控营养物质的转运代谢。然而,目前有关ECM网络对营养物质代谢的作用及机制尚不清楚。因此,本文系统综述ECM网络的生理屏障功能和动态变化及其对氨基酸等营养物质转运代谢的调控作用,以期为提升畜禽营养物质的利用效率和生产性能提供新思路。

本文引用格式

刘春艳 , 王丽 , 蒋宗勇 , 易宏波 . 细胞外基质网络的动态变化对营养物质代谢调控作用的研究进展[J]. 动物营养学报, 2022 , 34(3) : 1446 -1455 . DOI: 10.3969/j.issn.1006-267x.2022.03.009

Abstract

Extracellular matrix (ECM) is a dynamic multifunctional network structure, which is the external environment for the survival of cells and tissues. The ECM network has long been regarded as regulators of various physiological functions, such as cell growth, adhesion and tissue remodeling. Recent studies have found that the ECM network is a physiological barrier for the gradual transport of nutrients such as amino acids. When ECM network is absent or over deposited, it will lead to metabolic abnormalities, indicating that ECM network is involved in the regulation of nutrient transport and metabolism. However, the role and mechanism of ECM network on nutrient metabolism remain unclear. Therefore, this article reviewed the physiological barrier function and dynamic changes of ECM network and its regulation on the transport and metabolism of nutrients such as amino acids, in order to provide new ideas for improving the utilization efficiency and production performance of livestock and poultry.

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