综述 REVIEW

益生菌对胃肠道黏膜屏障的调控机制研究进展

  • 张海龙 ,
  • 李晓 ,
  • 王彩莲 ,
  • 郎侠
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  • 1. 甘肃农业大学动物科学技术学院, 兰州 730070;
    2. 甘肃省农业科学院畜草与绿色农业研究所, 甘肃省牛羊种质与秸秆饲料化重点实验室, 兰州 730070
张海龙(1994-),男,甘肃张掖人,博士研究生,从事反刍动物营养调控。E-mail:1711786760@qq.com

收稿日期: 2021-09-08

  网络出版日期: 2022-04-14

基金资助

兰州市人才创新创业项目(2019-RC-90);甘肃省牛羊种质与秸秆饲料化重点实验室(18JR2RA032)

Research Progress on Regulation Mechanism of Probiotics on Gastrointestinal Mucosal Barrier

  • ZHANG Hailong ,
  • LI Xiao ,
  • WANG Cailian ,
  • LANG Xia
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  • 1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
    2. Key Laboratory for Sheep, Goat and Cattle Germplasm and Straw Feed in Gansu Province, Institute of Livestock Grass and Green Agriculture, Gansu Academy of Agricultural Sciences, Lanzhou 730070, China

Received date: 2021-09-08

  Online published: 2022-04-14

摘要

哺乳动物胃肠道内存在大量微生物,其与宿主的健康息息相关。胃肠道黏膜屏障作为宿主与外界环境接触的“门户”,在宿主免疫调节、营养代谢和抵御有害菌的入侵等方面发挥着重要的作用。益生菌与宿主的互作是个复杂的过程,其中之一的关键点是胃肠道黏膜屏障,但益生菌是如何调控胃肠道黏膜屏障的,其作用机制尚不明晰。本文总结了益生菌对胃肠道黏膜屏障调控的相关研究进展,从益生菌对胃肠道上皮屏障紧密连接的调控、对胃肠道黏液层的调控以及对炎症反应的调控等方面进行论述,以期为益生菌对宿主健康的调控提供一定的理论依据。

本文引用格式

张海龙 , 李晓 , 王彩莲 , 郎侠 . 益生菌对胃肠道黏膜屏障的调控机制研究进展[J]. 动物营养学报, 2022 , 34(4) : 2087 -2096 . DOI: 10.3969/j.issn.1006-267x.2022.04.004

Abstract

A large number of microorganisms are present within the mammalian gastrointestinal tract, which are critically involved in the health of the host. As a "gateway" for the host to come into contact with the external environment, the gastrointestinal mucosal barrier plays an important role in host immune regulation, nutrient metabolism, and defense against the invasion of harmful bacteria. The interaction between probiotics and host is a complex process, and one of the key points is the gastrointestinal mucosal barrier. However, how probiotics regulate the gastrointestinal mucosal barrier and their mechanisms of action are unclear. In this review, we summarized the relevant research progresses on the regulation of gastrointestinal mucosal barrier by probiotics, discussed these aspects from the regulation of tight junctions of epithelial barriers, regulation of mucous layer and inflammatory response in the gastrointestinal tract by probiotics, in order to provide some theoretical basis for the regulation of host health by probiotics.

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