综述 REVIEW

白藜芦醇缓解家禽热应激作用机制与应用研究进展

  • 邓菊婴 ,
  • 胡睿智 ,
  • 肖定福 ,
  • 贺建华
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  • 湖南农业大学动物科学技术学院, 长沙 410128
邓菊婴(1996—),女,湖南永州人,硕士研究生,研究方向为单胃动物营养。E-mail:2075205861@qq.com

收稿日期: 2021-10-17

  网络出版日期: 2022-05-14

基金资助

国家自然科学基金(31972600);湖南省自然科学基金(2020JJ4364);湖南省科技特派员创新创业项目(2020NK4247)

Research Progress on Mechanism and Application of Resveratrol in Alleviating Heat Stress in Poultry

  • DENG Juying ,
  • HU Ruizhi ,
  • XIAO Dingfu ,
  • HE Jianhua
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  • College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2021-10-17

  Online published: 2022-05-14

摘要

热应激一直是家禽生产受到影响的重要因素之一。白藜芦醇是一类天然的植物抗毒素,属于非黄酮类多酚化合物,近年因其具有抗氧化、抗菌和免疫调节作用而备受关注。本文总结了热应激对家禽造成的影响,从白藜芦醇能增强能量代谢、改善线粒体功能障碍和缓解机体氧化应激方面重点阐述了白藜芦醇缓解家禽热应激的潜在作用机制,并进一步综述了白藜芦醇在热应激家禽生产中的应用。

本文引用格式

邓菊婴 , 胡睿智 , 肖定福 , 贺建华 . 白藜芦醇缓解家禽热应激作用机制与应用研究进展[J]. 动物营养学报, 2022 , 34(5) : 2773 -2780 . DOI: 10.3969/j.issn.1006-267x.2022.05.006

Abstract

Heat stress has always been one of the important factors affecting poultry production. Resveratrol is a kind of natural plant antitoxin, belonging to non-flavonoid polyphenol compounds, which has attracted much attention in recent years because of its antioxidant, antibacterial and immunomodulatory effects. In this paper, the effects of heat stress on poultry were summarized, and the potential mechanism of resveratrol in alleviating heat stress in poultry was mainly expounded from two aspects:enhancing energy metabolism, improving mitochondrial dysfunction and alleviating oxidative stress, and the application of resveratrol in heat stress poultry production was further reviewed.

参考文献

[1] MEHAISEN G M K, IBRAHIM R M, DESOKY A A, et al.The importance of propolis in alleviating the negative physiological effects of heat stress in quail chicks[J].PLoS One, 2017, 12(10):e0186907.
[2] EL-KHOLY M S, EL-HINDAWY M M, ALAGAWANY M, et al.Use of acetylsalicylic acid as an allostatic modulator in the diets of growing Japanese quails exposed to heat stress[J].Journal of Thermal Biology, 2018, 74:6-13.
[3] MA X Y, LIN Y C, ZHANG H X, et al.Heat stress impairs the nutritional metabolism and reduces the productivity of egg-laying ducks[J].Animal Reproduction Science, 2014, 145(3/4):182-190.
[4] SHAKERI M, COTTRELL J J, WILKINSON S, et al.Betaine and antioxidants improve growth performance, breast muscle development and ameliorate thermoregulatory responses to cyclic heat exposure in broiler chickens[J].Animals, 2018, 8(10):162.
[5] CARVALHO DOS SANTOS T, STEPHEN GATES R, DE FÁTIMA FERREIRA TINÔCO I, et al.Meat quality traits of European quails reared under different conditions of temperature and air velocity[J].Poultry Science, 2020, 99(2):848-856.  
[6] BARRETT N W, ROWLAND K, SCHMIDT C J, et al.Effects of acute and chronic heat stress on the performance, egg quality, body temperature, and blood gas parameters of laying hens[J].Poultry Science, 2019, 98(12):6684-6692.  
[7] GALINIAK S, AEBISHER D, BARTUSIK-AEBISHER D.Health benefits of resveratrol administration[J].Acta Biochimica Polonica, 2019, 66(1):13-21.
[8] TOKUŞOGLU O, UNAL M K, YEMIŞF.Determination of the phytoalexin resveratrol (3, 5, 4'-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (GC-MS)[J].Journal of Agricultural and Food Chemistry, 2005, 53(12):5003-5009.  
[9] VITRAC X, DESMOULIōRE A, BROUILLAUD B, et al.Distribution of[14C] -trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration[J].Life Sciences, 2003, 72(20):2219-2233.  
[10] YANG L, TAN G Y, FU Y Q, et al.Effects of acute heat stress and subsequent stress removal on function of hepatic mitochondrial respiration, ROS production and lipid peroxidation in broiler chickens[J].Comparative Biochemistry and Physiology Part C:Toxicology & Pharmacology, 2010, 151(2):204-208.  
[11] GREENE E S, CAUBLE R, KADHIM H, et al.Protective effects of the phytogenic feed additive"comfort"on growth performance via modulation of hypothalamic feeding- and drinking-related neuropeptides in cyclic heat-stressed broilers[J].Domestic Animal Endocrinology, 2021, 74:106487.
[12] VAN DE VEN T M F N, MCKECHNIE A E, CUNNINGHAM S J.The costs of keeping cool:behavioural trade-offs between foraging and thermoregulation are associated with significant mass losses in an arid-zone bird[J].Oecologia, 2019, 191(1):205-215.  
[13] SAJJANAR B, SIENGDEE P, TRAKOOLJUL N, et al.Cross-talk between energy metabolism and epigenetics during temperature stress response in C2C12 myoblasts[J].International Journal of Hyperthermia, 2019, 36(1):776-784.
[14] MA B B, ZHANG L, LI J L, et al.Heat stress alters muscle protein and amino acid metabolism and accelerates liver gluconeogenesis for energy supply in broilers[J].Poultry Science, 2021, 100(1):215-223.  
[15] LU Z, HE X F, MA B B, et al.Chronic heat stress impairs the quality of breast-muscle meat in broilers by affecting redox status and energy-substance metabolism[J].Journal of Agricultural and Food Chemistry, 2017, 65(51):11251-11258.  
[16] AKBARIAN A, MICHIELS J, DEGROOTE J, et al.Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals[J].Journal of Animal Science and Biotechnology, 2016, 7:37.
[17] PRICE N L, GOMES A P, LING A J Y, et al.SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function[J].Cell Metabolism, 2012, 15(5):675-690.  
[18] ZHANG C, CHEN K K, ZHAO X H, et al.Protective effects of resveratrol against high ambient temperature-induced spleen dysplasia in broilers through modulating splenic redox status and apoptosis[J].Journal of the Science of Food and Agriculture, 2018, 98(14):5409-5417.  
[19] MA S, FENG J, ZHANG R, et al.SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice[J].Oxidative Medicine and Cellular Longevity, 2017, 2017:4602715.
[20] 李琳琳, 曹正宇, 田野.PGC-1α的生理作用与临床疾病[J].医学综述, 2018, 24(13):2532-2536, 2542. LI L L, CAO Z Y, TIAN Y.Physiological function of peroxisome proliferator receptor-γ coactivator 1α and related clinical diseases[J].Medical Recapitulate, 2018, 24(13):2532-2536, 2542.(in Chinese)
[21] 张虎, 梁计陵, 钱帅伟, 等.白藜芦醇对线粒体质量调控研究进展[J].生物学杂志, 2020, 37(6):99-103. ZHANG H, LIANG J L, QIAN S W, et al.Research progress of resveratrol in mitochondrial quality control[J].Journal of Biology, 2020, 37(6):99-103.(in Chinese)
[22] MENG X F, TAN J, LI M M, et al.Sirt1:role under the condition of ischemia/hypoxia[J].Cellular and Molecular Neurobiology, 2017, 37(1):17-28.  
[23] HUANG Y, LU J, ZHAN L, et al.Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism[J].Journal of Biological Chemistry, 2021;297(2):100929.doi:10.1016/j.jbc.2021.100929.
[24] HE L, HE T, FARRAR S, et al.Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species[J].Cellular Physiology and Biochemistry, 2017, 44(2):532-553.  
[25] GONCALVES R L S, WATSON M A, WONG H S, et al.The use of site-specific suppressors to measure the relative contributions of different mitochondrial sites to skeletal muscle superoxide and hydrogen peroxide production[J].Redox Biology, 2020, 28:101341.
[26] WONG H S, BENOIT B, BRAND M D.Mitochondrial and cytosolic sources of hydrogen peroxide in resting C2C12 myoblasts[J].Free Radical Biology & Medicine, 2019, 130:140-150.
[27] QUIJANO C, TRUJILLO M, CASTRO L, et al.Interplay between oxidant species and energy metabolism[J].Redox Biology, 2016, 8:28-42.
[28] MESSNER K R, IMLAY J A.The identification of primary sites of superoxide and hydrogen peroxide formation in the aerobic respiratory chain and sulfite reductase complex of Escherichia coli[J].Journal of Biological Chemistry, 1999, 274(15):10119-10128.  
[29] KIKUSATO M, TOYOMIZU M.Crucial role of membrane potential in heat stress-induced overproduction of reactive oxygen species in avian skeletal muscle mitochondria[J].PLoS One, 2013, 8(5):e64412.
[30] LIOCHEV S I, FRIDOVICH I.Superoxide and iron:partners in crime[J].IUBMB Life, 1999, 48(2):157-161.  
[31] NAGAMI H, YOSHIMOTO N, UMAKOSHI H, et al.Liposome-assisted activity of superoxide dismutase under oxidative stress[J].Journal of Bioscience and Bioengineering, 2005, 99(4):423-428.  
[32] ZACHARA B A.Mammalian selenoproteins[J].Journal of Trace Elements and Electrolytes in Health and Disease, 1992, 6(3):137-151.
[33] CHEN Y P, CHENG Y F, WEN C, et al.Protective effects of dietary mannan oligosaccharide on heat stress-induced hepatic damage in broilers[J].Environmental Science and Pollution Research International, 2020, 27(23):29000-29008.  
[34] FERNÁNDEZ-SÁNCHEZ A, MADRIGAL-SANTILLÁN E, BAUTISTA M, et al.Inflammation, oxidative stress, and obesity[J].International Journal of Molecular Sciences, 2011, 12(5):3117-3132.  
[35] CAO Y, LI Y S, LI Z J, et al.Dietary zinc may attenuate heat-induced testicular oxidative stress in mice via up-regulation of Cu-Zn SOD[J].Genetics and Molecular Research, 2015, 14(4):16616-16626.  
[36] ALBOKHADAIM I F, ALTHNAIAN T A, EL-BAHR S M.Gene expression of heat shoc kproteins/factors (HSP60, HSP70, HSP90, HSF-1, HSF-3) and antioxidant enzyme activities in heat stressed broilers treated with vitamin C[J].Polish Journal of Veterinary Sciences, 2019, 22(3):565-572.
[37] MOSLEH N, SHOMALI T, NEMATOLLAHI F, et al.Effect of different periods of chronic heat stress with or without vitamin C supplementation on bone and selected serum parameters of broiler chickens[J].Avian Pathology, 2018, 47(2):197-205.  
[38] MATHEW S, ABRAHAM T E, ZAKARIA Z A.Reactivity of phenolic compounds towards free radicals under in vitro conditions[J].Journal of Food Science and Technology, 2015, 52(9):5790-5798.  
[39] 王虹玲, 吴优, 于子箫, 等.酿酒葡萄皮渣中白藜芦醇的提取及抗氧化、抗肿瘤活性研究[J].中国酿造, 2018, 37(7):112-116. WANG H L, WU Y, YU Z X, et al.Extraction, antioxidant and antitumor activity of resveratrol from wine grape pomace[J].China Brewing, 2018, 37(7):112-116.(in Chinese)
[40] LIU L L, HE J H, XIE H B, et al.Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens[J].Poultry Science, 2014, 93(1):54-62.  
[41] FENG Z H, GONG J G, ZHAO G X, et al.Effects of dietary supplementation of resveratrol on performance, egg quality, yolk cholesterol and antioxidant enzyme activity of laying hens[J].British Poultry Science, 2017, 58(5):544-549.  
[42] ZHANG C, ZHAO X H, WANG L, et al.Resveratrol beneficially affects meat quality of heat-stressed broilers which is associated with changes in muscle antioxidant status[J].Animal Science Journal, 2017, 88(10):1569-1574.  
[43] XIA N, DAIBER A, FÖRSTERMANN U, et al.Antioxidant effects of resveratrol in the cardiovascular system[J].British Journal of Pharmacology, 2017, 174(12):1633-1646.  
[44] JIANG Y X, LUO W Q, WANG B, et al.Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice[J].Life Sciences, 2020, 246:117422.
[45] HSU C P, ZHAI P Y, YAMAMOTO T, et al.Silent information regulator 1 protects the heart from ischemia/reperfusion[J].Circulation, 2010, 122(21):2170-2182.  
[46] HE S P, YU Q F, HE Y J, et al.Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers[J].Poultry Science, 2019, 98(12):6378-6387.  
[47] SHAKERI M, COTTRELL J J, WILKINSON S, et al.Growth performance and characterization of meat quality of broiler chickens supplemented with betaine and antioxidants under cyclic heat stress[J].Antioxidants, 2019, 8(9):336.
[48] LI G M, LIU L P, YIN B, et al.Heat stress decreases egg production of laying hens by inducing apoptosis of follicular cells via activating the FasL/Fas and TNF-α systems[J].Poultry Science, 2020, 99(11):6084-6093.  
[49] YOUSEFVAND S, HAMIDI F, ZENDEHDEL M, et al.Interaction of neuropeptide Y receptors (NPY1, NPY2 and NPY5) with somatostatin on somatostatin-induced feeding behaviour in neonatal chicken[J].British Poultry Science, 2019, 60(1):71-78.  
[50] HE X F, LU Z, MA B B, et al.Chronic heat stress alters hypothalamus integrity, the serum indexes and attenuates expressions of hypothalamic appetite genes in broilers[J].Journal of Thermal Biology, 2019, 81:110-117.
[51] PAYNE C G.Practical aspects of environmental temperature for laying hens[J].World's Poultry Science Journal, 1966, 22(2):126-139.  
[52] VARASTEH S, BRABER S, AKBARI P, et al.Differences in susceptibility to heat stress along the chicken intestine and the protective effects of galacto-oligosaccharides[J].PLoS One, 2015, 10(9):e0138975.
[53] 贾莉, 丁金雪, 李为民, 等.延胡索酸对急性热应激肉鸡采食量、饮水量及行为学的影响[J].黑龙江畜牧兽医, 2019(20):42-45. JIA L, DING J X, LI W M, et al.Effects of fumaric acid on feed intake, drinking water and behavior of acute heat stress broilers[J].Heilongjiang Animal Science and Veterinary Medicine, 2019(20):42-45.(in Chinese)
[54] LIU L L, FU C X, YAN M L, et al.Resveratrol modulates intestinal morphology and HSP70/90, NF-κB and EGF expression in the jejunal mucosa of black-boned chickens on exposure to circular heat stress[J].Food & Function, 2016, 7(3):1329-1338.  
[55] ZHANG C, ZHAO X H, YANG L, et al.Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers[J].Poultry Science, 2017, 96(12):4325-4332.  
[56] MA B B, HE X F, LU Z, et al.Chronic heat stress affects muscle hypertrophy, muscle protein synthesis and uptake of amino acid in broilers via insulin like growth factor-mammalian target of rapamycin signal pathway[J].Poultry Science, 2018, 97(12):4150-4158.  
[57] HASHIZAWA Y, KUBOTA M, KADOWAKI M, et al.Effect of dietary vitamin E on broiler meat qualities, color, water-holding capacity and shear force value, under heat stress conditions[J].Animal Science Journal, 2013, 84(11):732-736.  
[58] WANG R H, LIANG R R, LIN H, et al.Effect of acute heat stress and slaughter processing on poultry meat quality and postmortem carbohydrate metabolism[J].Poultry Science, 2017, 96(3):738-746.  
[59] MEHAISEN G M K, DESOKY A A, SAKR O G, et al.Propolis alleviates the negative effects of heat stress on egg production, egg quality, physiological and immunological aspects of laying Japanese quail[J].PLoS One, 2019, 14(4):e0214839.
[60] KIM J H, LEE H K, YANG T S, et al.Effect of different sources and inclusion levels of dietary fat on productive performance and egg quality in laying hens raised under hot environmental conditions[J].Asian-Australasian Journal of Animal Sciences, 2019, 32(9):1407-1413.  
[61] SAHIN K, ORHAN C, AKDEMIR F, et al.Resveratrol protects quail hepatocytes against heat stress:modulation of the Nrf2 transcription factor and heat shock proteins[J].Journal of Animal Physiology and Animal Nutrition, 2012, 96(1):66-74.  
[62] 冯志华, 龚建刚, 赵国先, 等.白藜芦醇对蛋鸡生产性能和蛋黄胆固醇含量的影响[C]//中国畜牧兽医学会动物营养学分会第十二次动物营养学术研讨会论文集.武汉:中国畜牧兽医学会, 2016:339. FENG Z H, GONG J G, ZHAO G X, et al.Effects of resveratrol on performance and yolk cholesterol content of laying hens[C]//Proceedings of the 12th Animal Nutrition Symposium of Animal Nutrition Branch of Chinese Animal Husbandry and Veterinary Society.Wuhan:Chinese Association of Animal Science and Veterinary Medicine, 2016:339.(in Chinese)
[63] REIS J H, GEBERT R R, BARRETA M, et al.Addition of grape pomace flour in the diet on laying hens in heat stress:impacts on health and performance as well as the fatty acid profile and total antioxidant capacity in the egg[J].Journal of Thermal Biology, 2019, 80:141-149.
[64] 刘丽莉.白藜芦醇对乌骨鸡热应激损伤的修复机制研究[D].博士学位论文.长沙:湖南农业大学, 2014. LIU L L.Research on the repair mechanisms of resveratrol to heat stress-induced damages in black-boned chicken[D].Ph.D.Thesis.Changsha:Hunan Agricultural University, 2014.(in Chinese)
[65] 何邵平.白藜芦醇对热应激黄羽肉鸡免疫功能调控及分子机制研究[D].博士学位论文.长沙:湖南农业大学, 2019. HE S P.Research on the regulation and molecular mechanism of resveratrol on immune function of yellow-feather broilers under heat stress[D].Ph.D.Thesis.Changsha:Hunan Agricultural University, 2019.(in Chinese)
[66] ZHANG C, WANG L, ZHAO X H, et al.Dietary resveratrol supplementation prevents transport-stress-impaired meat quality of broilers through maintaining muscle energy metabolism and antioxidant status[J].Poultry Science, 2017, 96(7):2219-2225.  
[67] ZHANG C, YANG L, ZHAO X H, et al.Effect of dietary resveratrol supplementation on meat quality, muscle antioxidative capacity and mitochondrial biogenesis of broilers[J].Journal of the Science of Food and Agriculture, 2018, 98(3):1216-1221.  
[68] BAGHBAN KANANI P, DANESHYAR M, ALIAKBARLU J, et al.Effect of dietary turmeric and cinnamon powders on meat quality and lipid peroxidation of broiler chicken under heat stress condition[J].Veterinary Research Forum, 2017, 8(2):163-169.
[69] A AL-SAGAN A, KHALIL S, HUSSEIN E O S, et al.Effects of fennel seed powder supplementation on growth performance, carcass characteristics, meat quality, and economic efficiency of broilers under thermoneutral and chronic heat stress conditions[J].Animals, 2020, 10(2):206.
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