综述 REVIEW

细胞凋亡及其与肌纤维的关联机制研究进展

  • 徐丽媛 ,
  • 窦露 ,
  • 靳烨 ,
  • 苏琳
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  • 内蒙古农业大学食品科学与工程学院, 呼和浩特 010018
徐丽媛(1996—),女,内蒙古呼和浩特人,硕士研究生,从事肉品科学研究。E-mail:xuliyuan0923@163.com

收稿日期: 2021-10-31

  网络出版日期: 2022-05-14

基金资助

国家自然科学地区科学基金项目(32060519);内蒙古自治区自然科学基金重大专项项目(2020ZD11);肉羊副产品加工利用博士科研工作站项目(BKZ2018-7);内蒙古自治区食品科学与工程一流学科建设项目(SPFC202003)

Research Progress of Apoptosis and Its Correlation Mechanism with Muscle Fibers

  • XU Liyuan ,
  • DOU Lu ,
  • JIN Ye ,
  • SU Lin
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  • College of Food Science and Engineering, Inner Mongolia Agricultural University, Huhhot 010018, China

Received date: 2021-10-31

  Online published: 2022-05-14

摘要

细胞凋亡是机体内细胞的主动、程序性的死亡过程,对于保持细胞内环境稳态至关重要。研究表明,细胞凋亡参与畜禽的宰后成熟过程,且不同类型肌纤维的凋亡进程和速率存在较大差异。因此,本文将从细胞凋亡概念、细胞凋亡路径、细胞凋亡对宰后成熟过程的影响、控制宰后成熟过程中细胞凋亡的方法等方面进行综述,最终将细胞凋亡与肌纤维特性联系起来,深入探讨细胞凋亡与肌纤维的关联机制,为控制宰后不同部位肌肉的成熟过程提供参考依据。

本文引用格式

徐丽媛 , 窦露 , 靳烨 , 苏琳 . 细胞凋亡及其与肌纤维的关联机制研究进展[J]. 动物营养学报, 2022 , 34(5) : 2847 -2855 . DOI: 10.3969/j.issn.1006-267x.2022.05.014

Abstract

Apoptosis is an active and procedural death process of cells in the body, which is essential to maintain the homeostasis of intracellular environment. Studies have shown that apoptosis is involved in the postmortem aging process of livestock and poultry, and the apoptosis process and rate of different types of muscle fibers are quite different. Therefore, the apoptosis concept, apoptosis pathway, the effect of apoptosis on the postmortem aging process and the methods for controlling apoptosis in the postmortem maturation process were reviewed in this study. Finally, the apoptosis is related to the characteristics of muscle fibers, and the association mechanism between apoptosis and muscle fibers is deeply explored to provide a theoretical basis for controlling the aging process of different parts of the muscle.

参考文献

[1] KAUR A P, AGRAWAL S.A review of the molecular mechanism of apoptosis and its role in pathological conditions[J].International Journal of Pharma and Bio Sciences, 2019, 10(2):124-131.
[2] XIA P, LIU Y N, CHENG Z K.Signaling pathways in cardiac myocyte apoptosis[J].BioMed Research International, 2016, 2016:9583268.
[3] D'ARCY M S.Cell death:a review of the major forms of apoptosis, necrosis and autophagy[J].Cell Biology International, 2019, 43(6):582-592.  
[4] MUSUMECI G, IMBESI R, SZYCHLINSKA M A, et al.Apoptosis and skeletal muscle in aging[J].Open Journal of Apoptosis, 2015, 4(2):41-46.  
[5] GRUNEWALD S, FITZL G, SPRINGSGUTH C.Induction of ultra-morphological features of apoptosis in mature and immature sperm[J].Asian Journal of Andrology, 2017, 19(5):533-537.  
[6] ASHKENAZI A, DIXIT V M.Death receptors:signaling and modulation[J].Science, 1998, 281(5381):1305-1308.  
[7] GUPTA S, GOLLAPUDI S.Susceptibility of naïve and subsets of memory T cells to apoptosis via multiple signaling pathways[J].Autoimmunity Reviews, 2007, 6(7):476-481.  
[8] THORNTON C, LEAW B, MALLARD C, et al.Cell death in the developing brain after hypoxia-ischemia[J].Frontiers in Cellular Neuroscience, 2017, 11:248.
[9] MONDAL J, DAS J, SHAH R, et al.A homeopathic nosode, hepatitis C 30 demonstrates anticancer effect against liver cancer cells in vitro by modulating telomerase and topoisomerase Ⅱ activities as also by promoting apoptosis via intrinsic mitochondrial pathway[J].Journal of Integrative Medicine, 2016, 14(3):209-218.  
[10] YANG S P, ZHANG Y G, LUO Y, et al.Hinokiflavone induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion[J].Biomedicine & Pharmacotherapy, 2018, 103:101-110.
[11] ZHANG J Y, YU Q L, HAN L, et al.Study on the apoptosis mediated by cytochrome c and factors that affect the activation of bovine longissimus muscle during postmortem aging[J].Apoptosis, 2017, 22(6):777-785.  
[12] PATWARDHAN G A, BEVERLY L J, SISKIND L J, et al.Sphingolipids and mitochondrial apoptosis[J].Journal of Bioenergetics and Biomembranes, 2016, 48:153-168.
[13] PHANEUF S, LEEUWENBURGH C.Cytochrome c release from mitochondria in the aging heart:a possible mechanism for apoptosis with age[J].American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 2002, 282(2):R423-R430.
[14] 吉木斯, 李存保.Bcl-2家族在线粒体细胞凋亡途径中的作用[J].内蒙古医科大学学报, 2013, 35(2):152-157. JI M S, LI C B.Bcl-2 family proteins:the sentinels of the mitochondrial apoptosis pathway[J].Journal of Inner Mongolia Medical University, 2013, 35(2):152-157.(in Chinese)
[15] ADAMS J M, CORY S.The Bcl-2 protein family:arbiters of cell survival[J].Science, 1998, 281(5381):1322-1326.  
[16] 卢晓晔, 钟雪云.Caspases与细胞凋亡(综述)[J].暨南大学学报(自然科学与医学版), 2000, 21(6):120-124. LU X Y, ZHONG X Y.Caspases and apoptosis[J].Journal of Jinan University (Natural Science & Medicine Edition), 2000, 21(6):120-124.(in Chinese)
[17] LIU G, YUAN Y, LONG M F, et al.Beclin-1-mediated autophagy protects against cadmium-activated apoptosis via the Fas/Fasl pathway in primary rat proximal tubular cell culture[J].Scientific Reports, 2017, 7(1):977.
[18] KOUTSOGIANNAKI S, HOU L F, BABAZADA H, et al.The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction[J].The FASEB Journal, 2019, 33(11):12668-12679.  
[19] CAI G D, SI M X, LI X, et al.Zearalenone induces apoptosis of rat Sertoli cells through Fas-Fas ligand and mitochondrial pathway[J].Environmental Toxicology, 2019, 34(4):424-433.  
[20] BHAT T A, CHAUDHARY A K, KUMAR S, et al.Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer[J].Biochimica et Biophysica Acta (BBA):Reviews on Cancer, 2017, 1867(1):58-66.  
[21] 方向楠, 秦彦文, 岳卫东.内质网应激与缺血性脑血管病的研究进展[J].中华老年心脑血管病杂志, 2016, 18(4):441-443. FANG X N, QIN Y W, YUE W D.Research progress of endoplasmic reticulum stress and ischemic cerebrovascular disease[J].Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 2016, 18(4):441-443.(in Chinese)
[22] ADAMS J M.Ways of dying:multiple pathways to apoptosis[J].Genes & Development, 2003, 17(20):2481-2495.  
[23] ZHANG J Y, YU Q L, HAN L, et al.Effects of lysosomal iron involvement in the mechanism of mitochondrial apoptosis on postmortem muscle protein degradation[J].Food Chemistry, 2020, 328:127174.
[24] WANG L L, HAN L, MA X L, et al.Effect of mitochondrial apoptotic activation through the mitochondrial membrane permeability transition pore on yak meat tenderness during postmortem aging[J].Food Chemistry, 2017, 234:323-331.
[25] 杨致昊, 刘畅, 窦露, 等.Caspases的研究进展及其与肉嫩度的关联机制[J].食品与发酵工业, 2021, 47(17):277-282. YANG Z H, LIU C, DOU L, et al.Research progress of caspases and its association mechanism with meat tenderness[J].Food and Fermentation Industries, 2021, 47(17):277-282.(in Chinese)
[26] HUANG F, HUANG M, ZHANG H, et al.Changes in apoptotic factors and caspase activation pathways during the postmortem aging of beef muscle[J].Food Chemistry, 2016, 190:110-114.
[27] HUANG M, HUANG F, XU X L, et al.Influence of caspase3 selective inhibitor on proteolysis of chicken skeletal muscle proteins during post mortem aging[J].Food Chemistry, 2009, 115(1):181-186.  
[28] 孙志昶.宰后牦牛肉成熟过程中细胞凋亡的发生及其对肉品质与微观结构变化的影响[D].博士学位论文.兰州:甘肃农业大学, 2015. SUN Z C.The research in the mechanism of apoptosis occurrence on yak meat quality and microstructure changes during postmortem aging[D].Ph.D.Thesis.Lanzhou:Gansu Agricultural University, 2015.(in Chinese)
[29] 王琳琳, 马君义, 余群力, 等.宰后牦牛肉细胞凋亡对肌肉内环境与嫩度的影响[J].农业机械学报, 2017, 48(7):317-324. WANG L L, MA J Y, YU Q L, et al.Effects of apoptosis on muscle internal environment and tenderness during yak meat postmortem aging[J].Transactions of the Chinese Society for Agricultural Machinery, 2017, 48(7):317-324.(in Chinese)
[30] CHEN L, FENG X C, LU F, et al.Effects of camptothecin, etoposide and Ca2+ on caspase-3 activity and myofibrillar disruption of chicken during postmortem ageing[J].Meat Science, 2011, 87(3):165-174.  
[31] CHEN L, FENG X C, ZHANG W G, et al.Effects of inhibitors on the synergistic interaction between calpain and caspase-3 during post-mortem aging of chicken meat[J].Journal of Agricultural and Food Chemistry, 2012, 60(34):8465-8472.  
[32] 李文东, 韩玲, 宋仁德, 等.快速冷却对宰后牦牛肉成熟过程中细胞凋亡酶活力与嫩度的影响[J].现代食品科技, 2019, 35(3):73-79. LI W D, HAN L, SONG R D, et al.The effect of rapid chilling on tenderness and apoptotic activity during yak meat postmortem aging[J].Modern Food Science & Technology, 2019, 35(3):73-79.(in Chinese)
[33] 王琳琳, 陈炼红, 韩玲, 等.茶多酚对宰后牦牛肉线粒体细胞凋亡和肌肉嫩度的影响[J].农业机械学报, 2019, 50(10):352-359, 366. WANG L L, CHEN L H, HAN L, et al.Effects of tea polyphenols on mitochondrial apoptosis and meat tenderness in post-mortem yak meat[J].Transactions of the Chinese Society for Agricultural Machinery, 2019, 50(10):352-359, 366.(in Chinese)
[34] 张爽.细胞凋亡诱导剂对羊肉成熟过程Caspase-3激活通路的机制研究[D].硕士学位论文.杨凌:西北农林科技大学, 2018. ZHANG S.The mechanism of apoptosis inducers on caspase-3 activation pathway during matutation of lamb[D].Master's Thesis.Yangling:Northwest A&F University, 2018.(in Chinese)
[35] CHEN C, ZHANG J Y, GUO Z B, et al.Effect of oxidative stress on AIF-mediated apoptosis and bovine muscle tenderness during postmortem aging[J].Journal of Food Science, 2020, 85(1):77-85.  
[36] 陈琳.Caspase-3在鸡肉成熟过程中的作用以及与calpain的交互关系研究[D].博士学位论文.南京:南京农业大学, 2011. CHEN L.Study on the effects of caspase-3 and its association with calpain during postmortem ageing of chicken meat[D].Ph.D.Thesis.Nanjing:Nanjing Agricultural University, 2011.(in Chinese)
[37] 尹靖东.动物肌肉生物学与肉品科学[M].北京:中国农业大学出版社, 2011. YIN J D.Animal muscle biology and meat quality[M].Beijing:China Agricultural University Press, 2011.(in Chinese)
[38] 章杰, 李学伟, 勇立.肌纤维与肉质的关系[J].猪业科学, 2013, 30(3):116-118. ZHANG J, LI X W, YONG L.Relationship between muscle fiber and meat quality[J].Swine Industry Science, 2013, 30(3):116-118.(in Chinese)
[39] LIBERA L D, ZENNARO R, SANDRI M, et al.Apoptosis and atrophy in rat slow skeletal muscles in chronic heart failure[J].American Journal of Physiology, 1999, 277(5):C982-C986.
[40] YAMADA H, NAKAGAWA M, HIGUCHI I, et al.Type Ⅱ muscle fibers are stained by anti-Fas antibody[J].Journal of the Neurological Sciences, 1995, 134(1/2):115-118.
[41] 周婕, 汤长发, 李善妮, 等.不同强度运动对大鼠骨骼肌细胞凋亡的影响[J].体育科学, 2005 (5):55-58. ZHOU J, TANG C F, LI S N, et al.Influence of different training intensity on skeletal muscle apoptosis in rats[J].China Sport Science, 2005(5):55-58.(in Chinese)
[42] RIVA C, CHEVRIER C, PASQUAL N, et al.Bcl-2/Bax protein expression in heart, slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions[J].Molecular and Cellular Biochemistry, 2001, 226(1/2):9-16.  
[43] 曹锦轩.宰后牛肉成熟过程中肌细胞死亡生理研究[D].博士学位论文.南京:南京农业大学, 2010. CAO J X.The research on the physiology of the death of myocytes in beef during postmortem conditioning[D].Ph.D.Thesis.Nanjing:Nanjing Agricultural University, 2010.(in Chinese)
[44] SHAN R T, LIU N, YAN Y Y, et al.Apoptosis, autophagy and atherosclerosis:relationships and the role of Hsp27[J].Pharmacological Research, 2021, 166:105169.
[45] 李婕, 师希雄, 韩玲, 等.热休克蛋白对宰后成熟过程中肉品质影响的研究进展[J].食品工业科技, 2016, 37(1):392-395, 399. LI J, SHI X X, HAN L, et al.Advances in research of the effect of heat shock proteins on meat quality during postmortem aging[J].Science and Technology of Food Idustry, 2016, 37(1):392-395, 399.(in Chinese)
[46] GUILLEMIN N, JURIE C, CASSAR-MALEK I, et al.Variations in the abundance of 24 protein biomarkers of beef tenderness according to muscle and animal type[J].Animal, 2011, 5(6):885-894.  
[47] BOCK F J, TAIT S W G.Mitochondria as multifaceted regulators of cell death[J].Nature Reviews Molecular Cell Biology, 2020, 21(2):85-100.  
[48] KOPEINA G S, PROKHOROVA E A, LAVRIK I N, et al.Alterations in the nucleocytoplasmic transport in apoptosis:caspases lead the way[J].Cell Proliferation, 2018 51(5):e12467.
[49] CRAMER T, PENICK M L, WADDELL J N, et al.A new insight into meat toughness of callipyge lamb loins-the relevance of anti-apoptotic systems to decreased proteolysis[J].Meat Science, 2018, 140:66-71.
[50] KE Y L, MITACEK R M, ABRAHAM A, et al.Effects of muscle-specific oxidative stress on cytochrome c release and oxidation-reduction potential properties[J].Journal of Agricultural and Food Chemistry, 2017, 65(35):7749-7755.  
[51] 张佳莹.线粒体通路信号介导细胞凋亡机制及对宰后牛肉嫩化影响[D].博士学位论文.兰州:甘肃农业大学, 2020. ZHANG J Y.The mechanism of effects of mitochondrial pathway signaling mediated apoptosis on bovine muscle tenderization during postmortem aging[D].Ph.D.Thesis.Lanzhou:Gansu Agricultural University, 2020.(in Chinese)
[52] RODRIGUES G S, GODINHO R O, KIYOMOTO B H, et al.Integrated analysis of the involvement of nitric oxide synthesis in mitochondrial proliferation, mitochondrial deficiency and apoptosis in skeletal muscle fibres[J].Scientific Reports, 2016, 6:20780.
[53] GAO W X, ZHAO J, GAO Z H, et al.Synergistic interaction of light alcohol administration in the presence of mild iron overload in a mouse model of liver injury:involvement of triosephosphate isomerase nitration and inactivation[J].PLoS One, 2017, 12(1):e0170350.
[54] MONCADA S, ERUSALIMSKY J D.Does nitric oxide modulate mitochondrial energy generation and apoptosis?[J].Nature Reviews Molecular Cell Biology, 2002, 3(3):214-220.  
[55] PLANITZER G, MIETHKE A, BAUM O.Nitric oxide synthase-1 is enriched in fast-twitch oxidative myofibers[J].Cell and Tissue Research, 2001, 306(2):325-333.  
[56] LIU R, LI Y P, ZHANG W G, et al.Activity and expression of nitric oxide synthase in pork skeletal muscles[J].Meat Science, 2015, 99:25-31.
[57] ZHANG L L, LIU R, CHENG Y P, et al.Effects of protein S-nitrosylation on the glycogen metabolism in postmortem pork[J].Food Chemistry, 2019, 272:613-618.
[58] WANG Y Y, LIU R, TIAN X N, et al.Comparison of activity, expression, and S-nitrosylation of calcium transfer proteins between pale, soft, and exudative and red, firm, and non-exudative pork during post-mortem aging[J].Journal of Agricultural and Food Chemistry, 2019, 67(11):3242-3248.  
[59] LIU R, WARNER R D, ZHOU G H, et al.Contribution of nitric oxide and protein S-nitrosylation to variation in fresh meat quality[J].Meat Science, 2018, 144:135-148.
[60] MANNICK J B, SCHONHOFF C, PAPETA N, et al.S-nitrosylation of mitochondrial caspases[J].Journal of Cell Biology, 2001, 154(6):1111-1116.  
[61] HOU Q, LIU R, TIAN X N, et al.Involvement of protein S-nitrosylation in regulating beef apoptosis during postmortem aging[J].Food Chemistry, 2020, 326:126975.
[62] ZHANG W G.Involvement of protein degradation, calpain autolysis and protein nitrosylation in fresh meat quality during early postmortem refrigerated storage[D].Ph.D.Thesis.Ames, Iowa:Iowa State University, 2009.
[63] 赵康涛, 海春旭.H2O2调控下HepG2细胞pH值与Ca2+的剂量效应关系[J].毒理学杂志, 2009, 23(4):278-281. ZHAO K T, HAI C X.Dose-effect relationship between pH and Ca2+ in HepG2 cell induced by H2O2[J].Journal of Health Toxicology, 2009, 23(4):278-281.(in Chinese)
[64] 贾青.细胞凋亡酶-3及其抑制剂对宰后牦牛肉品质变化的影响[D].硕士学位论文.兰州:甘肃农业大学, 2016. JIA Q.Influence of caspases-3 and the inhibitors on yak meat quality changes[D].Master's Thesis.Lanzhou:Gansu Agricultural University, 2016.(in Chinese)
[65] 王勇峰.肌纤维类型差异对牛肉品质及细胞凋亡酶3影响研究[D].硕士学位论文.北京:中国农业科学院, 2017. WANG Y F.Effects of different muscle fiber type on beef quality and caspase-3[D].Master's Thesis.Beijing:Chinese Academy of Agricultural Sciences, 2017.(in Chinese)
[66] RYU Y C, KIM B C.Comparison of histochemical characteristics in various pork groups categorized by postmortem metabolic rate and pork quality[J].Journal of Animal Science, 2006, 84(4):894-901.  
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