[1] GRANT R W, VESTER BOLER B M, RIDGE T K, et al.Adipose tissue transcriptome changes during obesity development in female dogs[J].Physiological Genomics, 2011, 43(6):295-307.

[2] KING R J, AJJAN R A.Vascular risk in obesity:facts, misconceptions and the unknown[J].Diabetes & Vascular Disease Research, 2017, 14(1):2-13.

[3] PASCUAL-SERRANO A, AROLA-ARNAL A, SUÁREZ-GARCÍA S, et al.Grape seed proanthocyanidin supplementation reduces adipocyte size and increases adipocyte number in obese rats[J].International Journal of Obesity, 2017, 41(8):1246-1255.

[4] MAGUIRE A S, WOODIE L N, JUDD R L, et al.Whole-slide image analysis outperforms micrograph acquisition for adipocyte size quantification[J].Adipocyte, 2020, 9(1):567-575.

[5] MISHRA A K, DUBEY V, GHOSH A R.Obesity:an overview of possible role(s) of gut hormones, lipid sensing and gut microbiota[J].Metabolism, 2016, 65(1):48-65.

[6] EISELE I, WOOD I S, GERMAN A J, et al.Adipokine gene expression in dog adipose tissues and dog white adipocytes differentiated in primary culture[J].Hormone and Metabolic Research, 2005, 37(8):474-481.

[7] 朱文华, 陈丽英, 张佳, 等.基于脂联素及脂联素受体的代谢综合征干预通路的研究进展[J].全科医学临床与教育, 2020, 18(12):1110-1113. ZHU W H, CHEN L Y, ZHANG J, et al.Research progress of metabolic syndrome intervention pathway based on adiponectin and adiponectin receptor[J].Clinical Education of General Practice, 2020, 18(12):1110-1113.(in Chinese)
[8] MARRELLI M, CONFORTI F, ARANITI F, et al.Effects of saponins on lipid metabolism:a review of potential health benefits in the treatment of obesity[J].Molecules, 2016, 21(10):1404.
[9] 王森, 付冠华, 王斌.银杏叶在畜禽生产上的应用研究进展[J].饲料研究, 2021, 44(8):147-149. WANG S, FU G H, WANG B.The development and utilization research progress of
Ginkgo biloba in livestock and poultry production[J].Feed Research, 2021, 44(8):147-149.(in Chinese)
[10] 李艳萍, 张立虎, 吴红雁, 等.银杏叶功效群组分及其功效的研究进展[J].食品研究与开发, 2020, 41(15):182-187. LI Y P, ZHANG L H, WU H Y, et al.Progress in the study of functional groups and health care efficacy of
Ginkgo biloba leaves[J].Food Research and Development, 2020, 41(15):182-187.(in Chinese)
[11] 任小杰, 李祥明, 杨在宾, 等.银杏叶及其提取物对肉鸡生长性能、抗氧化及血清生化指标的影响[J].中国粮油学报, 2018, 33(4):73-79. REN X J, LI X M, YANG Z B, et al.Effects of
Ginkgo biloba leaves and
Ginkgo biloba extract on growth performance, antioxidant and serum biochemical indices of broilers[J].Journal of the Chinese Cereals and Oils Association, 2018, 33(4):73-79.(in Chinese)
[12] 温啸, 贺大方, 倪学勤, 等.干酪乳杆菌与银杏叶提取物对肥胖小鼠血脂及抗氧化功能的影响[J].西北农林科技大学学报(自然科学版), 2014, 42(1):8-12, 17. WEN X, HE D F, NI X Q, et al.Effects of
Lactobacillus casei and
Ginkgo biloba extract on blood lipids and anti-oxidation of obese mice[J].Journal of Northwest A & F University(Natural Science Edition), 2014, 42(1):8-12, 17.(in Chinese)
[13] MURAI T, KAWASUMI K, TOMINAGA K, et al.Effects of astaxanthin supplementation in healthy and obese dogs[J].Veterinary Medicine, 2019, 10:29-35.
[14] MASOODI M, KUDA O, ROSSMEISL M, et al.Lipid signaling in adipose tissue:connecting inflammation & metabolism[J].Biochimica et Biophysica Acta:Molecular and Cell Biology of Lipids, 2015, 1851(4):503-518.

[15] FU C H, JIANG Y, GUO J, et al.Natural products with anti-obesity effects and different mechanisms of action[J].Journal of Agricultural and Food Chemistry, 2016, 64(51):9571-9585.

[16] 陈其燕, 石云, 张言周, 等.滨海白首乌对高脂诱导肥胖小鼠的降脂减肥作用[J].湖北农业科学, 2021, 60(2):126-129. CHEN Q Y, SHI Y, ZHANG Y Z, et al.The alleviation efficacy of
Binhai Cynanchum bungei on high-fat-induced obesity in mice[J].Hubei Agricultural Sciences, 2021, 60(2):126-129.(in Chinese)
[17] BLVHER M.Adipose tissue dysfunction contributes to obesity related metabolic diseases[J].Best Practice & Research.Clinical Endocrinology & Metabolism, 2013, 27(2):163-177.

[18] MCLAUGHLIN T, CRAIG C, LIU L F, et al.Adipose cell size and regional fat deposition as predictors of metabolic response to overfeeding in insulin-resistant and insulin-sensitive humans[J].Diabetes, 2016, 65(5):1245-1254.

[19] ACOSTA J R, DOUAGI I, ANDERSSON D P, et al.Increased fat cell size:a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes[J].Diabetologia, 2016, 59(3):560-570.

[20] MEENA V P, SEENU V, SHARMA M C, et al.Relationship of adipocyte size with adiposity and metabolic risk factors in Asian Indians[J].PLoS One, 2014, 9(9):e108421.
[21] VIRTUE S, VIDAL-PUIG A.Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective[J].Biochimica et Biophysica Acta, 2010, 1801(3):338-349.

[22] 单甄真, 郭继芬, 胡蕾, 等.白色脂肪组织棕色化研究进展[J].药物生物技术, 2019, 26(4):367-371. SHAN Z Z, GUO J F, HU L, et al.Research advances in white adipose tissue browning[J].Chinese Journal of Pharmaceutical Biotechnology, 2019, 26(4):367-371.(in Chinese)
[23] ITTRUP A, LIEBERMAN J.Knocking down disease:a progress report on siRNA therapeutics[J].Nature Reviews Genetics, 2015, 16(9):543-552.

[24] 王正明.siRNA药物研发现状调研[J].科技智囊, 2020(4):23-26. WANG Z M.Progress investigation of siRNA drug research and development[J].Think Tank of Science & Technology, 2020(4):23-26.(in Chinese)