综述 REVIEW

3-硝基氧基丙醇降低反刍动物瘤胃甲烷排放的作用机理以及在生产中的应用前景

  • 周孝康 ,
  • 李昊 ,
  • 张立阳 ,
  • 高腾云
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  • 河南农业大学动物科技学院, 河南省家畜营养调控与生态养殖国际联合实验室, 郑州 450002
周孝康(1992—),男,河南漯河人,硕士研究生,研究方向为反刍动物营养与饲料科学。E-mail:746080308@qq.com

收稿日期: 2021-10-12

  网络出版日期: 2022-06-14

基金资助

国家现代农业产业技术体系资助

Mechanism of 3-Nitroxypropanol in Reducing Methane Emission from Ruminants' Rumen and Its Application Prospect in Production

  • ZHOU Xiaokang ,
  • LI Hao ,
  • ZHANG Liyang ,
  • GAO Tengyun
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  • Henan International Joint Laboratory of Nutrition Regulation and Ecological Raising of Domestic Animal, College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China

Received date: 2021-10-12

  Online published: 2022-06-14

摘要

反刍动物胃肠道中所排出的甲烷在一定程度上被认为是全球温室气体排放的重要来源,同时也代表饲粮能量的损失。研究发现,3-硝基氧基丙醇(3-NOP)中的硝基酯基团可以选择性地与甲基辅酶M还原酶结合,并通过在活性位点将镍离子从+1价暂时氧化为+2价来灭活其酶,从而抑制甲烷生成过程中的最后一步通路,进而持续抑制甲烷的生成,并且对反刍动物的健康没有影响。本文就以甲烷生成的特异性抑制剂3-NOP的相关研究进行综述,旨在阐明抑制甲烷产生的内在机制,为反刍动物生产以及3-NOP的应用前景提供理论支撑和参考。

本文引用格式

周孝康 , 李昊 , 张立阳 , 高腾云 . 3-硝基氧基丙醇降低反刍动物瘤胃甲烷排放的作用机理以及在生产中的应用前景[J]. 动物营养学报, 2022 , 34(6) : 3454 -3460 . DOI: 10.3969/j.issn.1006-267x.2022.06.007

Abstract

Methane emitted from ruminant gastrointestinal tract is considered as an important source of global greenhouse gas emission to a certain extent, and it also represents the loss of dietary energy. It was found that the nitroester group in 3-nitroxypropanol (3-NOP) can selectively combine with methyl coenzyme M reductase, and inactivate the enzyme by temporarily oxidizing nickel ions from +1 to +2 at the active site, thus inhibiting the last step in the process of methane generation continuously inhibiting methane generation, and having no effect on the health of ruminants. In this paper, the research on 3-NOP, a specific inhibitor of methane production, was reviewed, aiming at clarifying the internal mechanism of methane production inhibition and providing substantial theoretical support and reference for ruminant production and the application prospect of 3-NOP.

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