综述 REVIEW

黄酮类化合物在脂肪代谢中的作用机制研究进展

  • 钟港 ,
  • 陈东
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  • 湖南农业大学动物科学技术学院, 长沙 410128
钟港(1997—),男,湖南醴陵人,硕士研究生,从事反刍动物营养与饲料研究。E-mail:861149076@qq.com

收稿日期: 2021-11-11

  网络出版日期: 2022-06-14

基金资助

国家自然科学青年基金项目(32002202);湖南省自然科学基金项目(2019JJ50267);湖南省教育厅科学研究项目(19A237)

Research Progress on Mechanism of Flavonoids in Fat Metabolism

  • ZHONG Gang ,
  • CHEN Dong
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  • College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China

Received date: 2021-11-11

  Online published: 2022-06-14

摘要

近年来,黄酮类化合物在脂肪代谢中的作用被广泛研究,大量的体内外试验发现黄酮类化合物具有明显的降脂作用,是一种天然的调控脂肪代谢物质。本文主要介绍了黄酮类化合物的来源、分类、主要化合物及其与脂肪代谢的关系,并从miRNAs、肝脏组织腺苷酸活化蛋白激酶(AMPK)、脂肪组织AMPK、有丝分裂克隆扩增(MCE)和神经系统等途径探讨了黄酮类化合物调控机体脂肪代谢的分子机制,以期为黄酮类化合物的科学应用提供理论依据。

本文引用格式

钟港 , 陈东 . 黄酮类化合物在脂肪代谢中的作用机制研究进展[J]. 动物营养学报, 2022 , 34(6) : 3483 -3494 . DOI: 10.3969/j.issn.1006-267x.2022.06.010

Abstract

In recent years, the role of flavonoids in fat metabolism has been widely studied. A large number of in vivo and in vitro experiments have found that flavonoids have obvious lipid-lowering effects and are a natural regulation of fat metabolism. In this paper we mainly discussed the sources, classification, main compounds and their relationship with fat metabolism of flavonoids, and summarized the studies focusing on the molecular mechanisms of fat metabolism regulated by flavonoids through miRNAs, adenosine-activated protein kinase (AMPK) in liver tissue, AMPK in adipose tissue, mitotic clone amplification (MCE) and nervous system, in order to provide theoretical basis for the scientific application of flavonoids.

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