综述 REVIEW

丁酸对脂肪代谢的调节及其作用机制

  • 徐进 ,
  • 王劼 ,
  • 舒鼎铭 ,
  • 王旭溟
展开
  • 1. 华南农业大学动物科学学院, 广州 510642;
    2. 广东省农业科学院动物科学研究所, 广东省动物育种与营养公共实验室, 广东省畜禽育种与营养研究重点实验室, 畜禽育种国家重点实验室, 广州 510640
徐进(1997—),男,江西抚州人,硕士研究生,动物营养与饲料科学专业。E-mail:1817788288@qq.com

收稿日期: 2021-11-21

  网络出版日期: 2022-06-14

基金资助

科技创新战略专项资金(高水平农科院建设)-杰出人才(R2020PY-JC001);财政部和农业农村部国家现代农业产业技术体系(CARS-41);广东省农业科学院学科团队建设(202107TD);广东省科研事业单位重点领域研发计划(2020B0202090004);清远市清城区清远鸡产业园(GDSCYY2018-032,2021-022)

Regulation and Mechanism of Butyric Acid on Fat Metabolism

  • XU Jin ,
  • WANG Jie ,
  • SHU Dingming ,
  • WANG Xuming
Expand
  • 1. College of Animal Science, South China Agricultural University, Guangzhou 510642, China;
    2. State Key Laboratory of Livestock and Poultry Breeding, Guangdong Key Laboratory of Animal Breeding and Nutrition, Guangdong Public Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China

Received date: 2021-11-21

  Online published: 2022-06-14

摘要

丁酸作为肠道菌群发酵产物之一,不仅可为生物体提供能量,还能以信号分子形式调节体内能量和物质代谢。近年来,在饲粮中添加丁酸能够有效减少动物过多脂肪沉积而受到广泛关注,然而一些研究发现丁酸表现出促进脂肪合成的作用。丁酸一方面作为脂肪合成的底物,另一方面以信号分子形式即通过结合G蛋白偶联受体(GPCRs)或者抑制组蛋白去乙酰化酶(HDACs)的活性来调节脂肪代谢。本文主要从这2方面来探讨丁酸与脂肪代谢之间的联系,为畜禽养殖中如何减少过多脂肪沉积或抑制肥胖提供理论参考。

本文引用格式

徐进 , 王劼 , 舒鼎铭 , 王旭溟 . 丁酸对脂肪代谢的调节及其作用机制[J]. 动物营养学报, 2022 , 34(6) : 3495 -3502 . DOI: 10.3969/j.issn.1006-267x.2022.06.011

Abstract

Butyric acid, one of the fermentation products of gut flora, may supply energy to organisms while also regulating energy and material metabolism in the form of signal molecules. In recent years, the addition of butyric acid to the diet has successfully prevented excessive fat deposition in animals, gaining extensive interest. On the other hand, butyric acid has been shown in several tests to stimulate fat production. While recent research reported that butyric acid influences fat metabolism via interacting with G-protein coupled receptors (GPCRs) or decreasing the activity of histone deacetylases (HDACs). This article focuses on the interaction between butyric acid and fat metabolism to give theoretical references for minimizing excessive fat deposition or suppressing obesity in cattle and poultry breeding.

参考文献

[1] CHANDLER M, CUNNINGHAM S, LUND E M, et al.Obesity and associated comorbidities in people and companion animals:a one health perspective[J].Journal of Comparative Pathology, 2017, 156(4):296-309.  
[2] ADAK A, KHAN M R.An insight into gut microbiota and its functionalities[J].Cellular and Molecular Life Sciences, 2019, 76(3):473-493.  
[3] FANG W J, XUE H L, CHEN X, et al.Supplementation with sodium butyrate modulates the composition of the gut microbiota and ameliorates high-fat diet-induced obesity in mice[J].The Journal of Nutrition, 2019, 149(5):747-754.  
[4] 赵利芹.丁酸钠对肉鸡脂肪沉积的作用及机制研究[D].硕士学位论文.泰安:山东农业大学, 2019. ZHAO L Q.Effect and mechanism of sodium butyrate on fat deposition in broilers[D].Master's Thesis.Tai'an:Shandong Agricultural University, 2019.(in Chinese)
[5] CANFORA E E, VAN DER BEEK C M, JOCKEN J W E, et al.Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men:a randomized crossover trial[J].Scientific Reports, 2017, 7(1):2360.
[6] KIM K N, YAO Y, JU S Y.Short chain fatty acids and fecal microbiota abundance in humans with obesity:a systematic review and Meta-analysis[J].Nutrients, 2019, 11(10):2512.
[7] BARCZYŃSKA R, LITWIN M, SLIŻEWSKA K, et al.Bacterial microbiota and fatty acids in the faeces of overweight and obese children[J].Polish Journal of Microbiology, 2018, 67(3):339-345.  
[8] URRUTIA N, BOMBERGER R, MATAMOROS C, et al.Effect of dietary supplementation of sodium acetate and calcium butyrate on milk fat synthesis in lactating dairy cows[J].Journal of Dairy Science, 2019, 102(6):5172-5181.  
[9] YAN H, AJUWON K M.Mechanism of butyrate stimulation of triglyceride storage and adipokine expression during adipogenic differentiation of porcine stromovascular cells[J].PLoS One, 2015, 10(12):e0145940.
[10] BACH KNUDSEN K E, LÆRKE H N, HEDEMANN M S, et al.Impact of diet-modulated butyrate production on intestinal barrier function and inflammation[J].Nutrients, 2018, 10(10):1499.
[11] 罗永富.脂肪酸体内氧化ATP生成数量计算公式[J].卫生职业教育, 2006, 24(6):87. LUO Y F.Formula for calculating the amount of ATP formed by oxidation of fatty acids in vivo[J].Health Vocational Education, 2006, 24(6):87.(in Chinese)
[12] RIVA A, BORGO F, LASSANDRO C, et al.Pediatric obesity is associated with an altered gut microbiota and discordant shifts in Firmicutes populations[J].Environmental Microbiology, 2017, 19(1):95-105.  
[13] SCHWIERTZ A, TARAS D, SCHÄFER K, et al.Microbiota and SCFA in lean and overweight healthy subjects[J].Obesity, 2010, 18(1):190-195.  
[14] RAHAT-ROZENBLOOM S, FERNANDES J, GLOOR G B, et al.Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans[J].International Journal of Obesity, 2014, 38(12):1525-1531.  
[15] MARTÍNEZ-CUESTA M C, DEL CAMPO R, GARRIGA-GARCÍA M, et al.Taxonomic characterization and short-chain fatty acids production of the obese microbiota[J].Frontiers in Cellular and Infection Microbiology, 2021, 11:598093.
[16] BAASKE L, GABEL G, DENGLER F.Ruminal epithelium:a checkpoint for cattle health[J].Journal of Dairy Research, 2020, 87(3):322-329.  
[17] MAXIN G, RULQUIN H, GLASSER F.Response of milk fat concentration and yield to nutrient supply in dairy cows[J].Animal, 2011, 5(8):1299-1310.  
[18] 孔庆洋.乙酸钠和丁酸钠对奶牛乳腺上皮细胞及腺泡乳脂合成相关基因表达的影响[D].硕士学位论文.哈尔滨:东北农业大学, 2012. KONG Q Y.Effect of sodium acetate and sodium butyrate on expression of genes related to milk fat synthesis of dairy cow mammary epithelial cells and acinus[D].Master's Thesis.Harbin:Northeast Agricultural University, 2012.(in Chinese)
[19] KIMURA I, ICHIMURA A, OHUE-KITANO R, et al.Free fatty acid receptors in health and disease[J].Physiological Reviews, 2020, 100(1):171-210.  
[20] INOUE A, RAIMONDI F, KADJI F M N, et al.Illuminating G-protein-coupling selectivity of GPCRs[J].Cell, 2019, 177(7):1933-1947.e25.  
[21] ZHOU Q T, YANG D H, WU M, et al.Common activation mechanism of class A GPCRs[J].eLife, 2019, 8:e50279.
[22] ZHANG L, LIU C D, JIANG Q Y, et al.Butyrate in energy metabolism:there is still more to learn[J].Trends in Endocrinology & Metabolism, 2021, 32(3):159-169.  
[23] KIMURA I, OZAWA K, INOUE D, et al.The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43[J].Nature Communications, 2013, 4:1829.
[24] BELLAHCENE M, O'DOWD J F, WARGENT E T, et al.Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content[J].British Journal of Nutrition, 2013, 109(10):1755-1764.  
[25] SATO F T, YAP Y A, CRISMA A R, et al.Tributyrin attenuates metabolic and inflammatory changes associated with obesity through a GPR109A-dependent mechanism[J].Cells, 2020, 9(9):2007.
[26] LU Y Y, FAN C N, LI P, et al.Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota[J].Scientific Reports, 2016, 6:37589.
[27] WANG A H, SI H W, LIU D M, et al.Butyrate activates the cAMP-protein kinase A-cAMP response element-binding protein signaling pathway in Caco-2 cells[J].The Journal of Nutrition, 2012, 142(1):1-6.  
[28] SNELSON M, TAN S M, HIGGINS G C, et al.Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy[J].American Journal of Physiology. Renal Physiology, 2020, 318(3):F835-F842.
[29] LU J, FANG B C, ZHENG Y Y, et al.1, 3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors[J].Environmental Toxicology and Pharmacology, 2017, 55:118-126.
[30] CHENG J, ZHANG Y F, GE Y S, et al.Sodium butyrate promotes milk fat synthesis in bovine mammary epithelial cells via GPR41 and its downstream signalling pathways[J].Life Sciences, 2020, 259:118375.
[31] WALTEREIT R, WELLER M.Signaling from cAMP/PKA to MAPK and synaptic plasticity[J].Molecular Neurobiology, 2003, 27(1):99-106.  
[32] 张建梅.SCFAs/GLP-1在肠道微生物调控肉鸡脂肪代谢的作用[D].博士学位论文.泰安:山东农业大学, 2019. ZHANG J M.SCFAs/GLP-1 links the regulation of gut microbiome on lipid metabolism in broiler chickens[D].Ph.D.Thesis.Tai'an:Shandong Agricultural University, 2019.(in Chinese)
[33] SOLIMAN M M, AHMED M M, SALAH-ELDIN A E, et al.Butyrate regulates leptin expression through different signaling pathways in adipocytes[J].Journal of Veterinary Science, 2011, 12(4):319-323.  
[34] HEIMANN E, NYMAN M, DEGERMAN E.Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase insulin-stimulated glucose uptake in primary rat adipocytes[J].Adipocyte, 2015, 4(2):81-88.  
[35] GE H F, LI X F, WEISZMANN J, et al.Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids[J].Endocrinology, 2008, 149(9):4519-4526.  
[36] CUEVAS-RAMOS D, MEHTA R, AGUILAR-SALINAS C A.Fibroblast growth factor 21 and browning of white adipose tissue[J].Frontiers in Physiology, 2019, 10:37.
[37] HUANG Y P, GAO S X, JUN G, et al.Supplementing the maternal diet of rats with butyrate enhances mitochondrial biogenesis in the skeletal muscles of weaned offspring[J].British Journal of Nutrition, 2017, 117(1):12-20.  
[38] CHRIETT S, DABEK A, WOJTALA M, et al.Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule[J].Scientific Reports, 2019, 9(1):742.
[39] MENZIES K J, ZHANG H B, KATSYUBA E, et al.Protein acetylation in metabolism-metabolites and cofactors[J].Nature Reviews Endocrinology, 2016, 12(1):43-60.  
[40] FERRARI A, FIORINO E, GIUDICI M, et al.Linking epigenetics to lipid metabolism:focus on histone deacetylases[J].Molecular Membrane Biology, 2012, 29(7):257-266.  
[41] HONG J, JIA Y M, PAN S F, et al.Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice[J].Oncotarget, 2016, 7(35):56071-56082.  
[42] ZHOU D, CHEN Y W, ZHAO Z H, et al.Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression[J].Experimental & Molecular Medicine, 2018, 50(12):1-12.
[43] WHITT J, WOO V, LEE P, et al.Disruption of epithelial HDAC3 in intestine prevents diet-induced obesity in mice[J].Gastroenterology, 2018, 155(2):501-513.  
[44] LI G L, YAO W, JIANG H L.Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue[J].The Journal of Nutrition, 2014, 144(12):1887-1895.  
[45] HUANG Y P, GAO S X, CHEN J L, et al.Maternal butyrate supplementation induces insulin resistance associated with enhanced intramuscular fat deposition in the offspring[J].Oncotarget, 2017, 8(8):13073-13084.  
[46] ZHAO L Q, LIU S, ZHANG Z H, et al.Low and high concentrations of butyrate regulate fat accumulation in chicken adipocytes via different mechanisms[J].Adipocyte, 2020, 9(1):120-131.  
[47] ZHANG H, REN E D, XU R Y, et al.Transcriptomic responses induced in muscle and adipose tissues of growing pigs by intravenous infusion of sodium butyrate[J].Biology, 2021, 10(6):559.
文章导航

/