综述 REVIEW

脂联素与其受体的结构及在脂类代谢中的作用机制

  • 郑言 ,
  • 曹中赞 ,
  • 邱云桥 ,
  • 栾新红
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  • 沈阳农业大学动物科学与医学学院, 沈阳 110866
郑言(1997—),男,黑龙江鹤岗人,硕士研究生,从事动物生理与生殖生物学方面的研究。E-mail:2021220583@stu.syau.edu.cn

收稿日期: 2021-11-27

  网络出版日期: 2022-06-14

基金资助

国家自然科学基金项目(32072810);辽宁省教育厅自然科学类面上项目(LJKZ0668)

Structure of Adiponectin and Their Receptors and Action Mechanisms in Lipid Metabolism

  • ZHENG Yan ,
  • CAO Zhongzan ,
  • QIU Yunqiao ,
  • LUAN Xinhong
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  • College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China

Received date: 2021-11-27

  Online published: 2022-06-14

摘要

脂联素(AdipoQ)是一种主要由脂肪组织分泌的内源性细胞因子,在调节脂类代谢中发挥重要作用。AdipoQ首先与其受体[脂联素受体1(AdipoRl)和脂联素受体2(AdipoR2)]位于膜外的C端结合,再通过AdipoQ受体N端与信号接头蛋白结合,进而激活下游腺苷酸活化蛋白激酶(AMPK)与过氧化物酶体增殖物激活受体α(PPARα)等多条信号通路,促进脂肪酸氧化,抑制脂质合成,从而调节脂类代谢。本文就AdipoQ及其受体的结构、信号接头蛋白和AdipoQ对动物脂质代谢的调节机制进行综述。

本文引用格式

郑言 , 曹中赞 , 邱云桥 , 栾新红 . 脂联素与其受体的结构及在脂类代谢中的作用机制[J]. 动物营养学报, 2022 , 34(6) : 3503 -3510 . DOI: 10.3969/j.issn.1006-267x.2022.06.012

Abstract

Adiponectin (AdipoQ), an endogenous cytokine mainly secreted by adipose tissue, plays an important role in regulating lipid metabolism. AdipoQ binds first to its receptors (AdipoRl and AdipoR2) located at the C-terminus outside the membrane and then to signal adaptor proteins N-terminally through AdipoQ receptors, thereby activating downstream adenylate activated protein kinase (AMPK) to bind to peroxisome proliferators activate receptor alpha (PPAR-α) and other multiple signaling pathways, which promote fatty acid oxidation and inhibit lipid synthesis, thereby regulating lipid metabolism. In this review, we summarize the structure of AdipoQ and its receptors, the signaling adaptor proteins and the regulatory mechanisms of AdipoQ on lipid metabolism in animals.

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