综述 REVIEW

生物素对动物糖、脂代谢的影响及其作用机制

  • 晁碧辉 ,
  • 宋万明 ,
  • 李瑶兰 ,
  • 杨竹青
展开
  • 江西农业大学动物科学技术学院, 南昌 330045
晁碧辉(1996—),女,河南商丘人,硕士研究生,从事水产动物营养学研究。E-mail:306889662@qq.com

收稿日期: 2021-10-31

  网络出版日期: 2022-06-14

基金资助

江西省自然科学基金面上项目(2020BAB205003);江西省重点研发项目(20171BBF60008)

Effects and Mechanisms of Biotin on Glucose and Lipid Metabolism in Animals

  • CHAO Bihui ,
  • SONG Wanming ,
  • LI Yaolan ,
  • YANG Zhuqing
Expand
  • College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China

Received date: 2021-10-31

  Online published: 2022-06-14

摘要

生物素通过激活环鸟苷酸(cGMP)/蛋白激酶G (PKG)信号通路,诱导胰岛素分泌,胰岛素通过磷脂酰肌醇-3-激酶(PI3K)/丝/苏氨酸蛋白激酶(AKT)信号通路激活胰岛素受体,导致葡萄糖激酶活性提高,糖、脂代谢相关基因表达上调。生物素也可与组蛋白和热应激蛋白等发生生物素酰化,从而以表观遗传形式参与甲基化和乙酰化等过程,并对基因表达、细胞信号通路及染色质结构等起着独特的调控作用。因此,本文对生物素对动物糖、脂代谢及脂肪沉积的影响及其作用机制进行归纳总结,以期为动物生产实践提供一些有用信息。

本文引用格式

晁碧辉 , 宋万明 , 李瑶兰 , 杨竹青 . 生物素对动物糖、脂代谢的影响及其作用机制[J]. 动物营养学报, 2022 , 34(6) : 3511 -3518 . DOI: 10.3969/j.issn.1006-267x.2022.06.013

Abstract

Biotin can induce insulin secretion by activating the cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) signaling pathway. And then, insulin activates insulin receptor through the phosphatidylinositol-3-kinase (PI3K)/serine/threonine protein kinase (AKT) signaling pathway, which leads to the up-regulation of glucokinase activity and gene expression related to glucose and lipid metabolism. Biotin can also participate in methylation and acetylation through inducing biotinylation of histones or heat stress proteins, and plays a unique regulatory role in gene expression, cell signaling pathway and chromatin structure. Therefore, in this review, we summarized the effects and mechanisms of biotin on glucose and lipid metabolism and fat deposition in animal, which may provide some useful information for animal production and practice.

参考文献

[1] RIVERON-NEGRETE L, FERNANDEZ-MEJIA C.Pharmacological effects of biotin in animals[J].Mini Reviews in Medicinal Chemistry, 2017, 17(6):529-540.  
[2] SCHERF H.Vitamin for better feed conversion?[J].Pig International, 1988, 18(9):12-13.
[3] MARTELLI G, SARDI L, PARISINI P, et al.The effects of a dietary supplement of biotin on Italian heavy pigs' (160 kg) growth, slaughtering parameters, meat quality and the sensory properties of cured hams[J].Livestock Production Science, 2005, 93(2):117-124.  
[4] WEI X S, YIN Q Y, ZHAO H H, et al.Metabolomics for the effect of biotin and nicotinamide on transition dairy cows[J].Journal of Agricultural and Food Chemistry, 2018, 66(22):5723-5732.  
[5] DUPLESSIS M, GIRARD C L.Response to a glucose tolerance test in early-lactation Holstein cows receiving a supplementation of biotin, folic acid, and vitamin B12[J].Journal of Dairy Science, 2021, 104(1):1111-1122.  
[6] ZEMPLENI J, GRALLA M, CAMPOREALE G, et al.Sodium-dependent multivitamin transporter gene is regulated at the chromatin level by histone biotinylation in human Jurkat lymphoblastoma cells[J].The Journal of Nutrition, 2009, 139(1):163-166.  
[7] CHEW Y C, WEST J T, KRATZER S J, et al.Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster[J].The Journal of Nutrition, 2008, 138(12):2316-2322.  
[8] PESTINGER V, WIJERATNE S S, RODRIGUEZ-MELENDEZ R, et al.Novel histone biotinylation marks are enriched in repeat regions and participate in repression of transcriptionally competent genes[J].The Journal of Nutritional Biochemistry, 2011, 22(4):328-333.  
[9] LI Y, MALKARAM S A, ZHOU J, et al.Lysine biotinylation and methionine oxidation in the heat shock protein HSP60 synergize in the elimination of reactive oxygen species in human cell cultures[J].The Journal of Nutritional Biochemistry, 2014, 25(4):475-482.  
[10] MISIR R, BLAIR R.Biotin bioavailability from protein supplements and cereal grains for weanling pigs[J].Canadian Journal of Animal Science, 1988, 68(2):523-532.  
[11] WOLF B.Biotinidase:its role in biotinidase deficiency and biotin metabolism[J].The Journal of Nutritional Biochemistry, 2005, 16(7):441-445.  
[12] SAID H M, REDHA R.Biotin transport in rat intestinal brush-border membrane vesicles[J].Biochimica et Biophysica Acta, 1988, 945(2):195-201.  
[13] DAKSHINAMURTI K, LI W.Transcriptional regulation of liver phosphoenolpyruvate carboxykinase by biotin in diabetic rats[J].Molecular and Cellular Biochemistry, 1994, 132(2):127-132.  
[14] AGUILERA-MÉNDEZ A, FERNÁNDEZ-MEJÍA C.The hypotriglyceridemic effect of biotin supplementation involves increased levels of cGMP and AMPK activation[J].BioFactors, 2012, 38(5):387-394.  
[15] BÁEZ-SALDAÑA A, ZENDEJAS-RUIZ I, REVILLA-MONSALVE C, et al.Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects[J].The American Journal of Clinical Nutrition, 2004, 79(2):238-243.  
[16] BOONE-VILLA D, AGUILERA-MÉNDEZ A, MIRANDA-CERVANTES A, et al.Effects of biotin supplementation in the diet on adipose tissue cGMP concentrations, AMPK activation, lipolysis, and serum-free fatty acid levels[J].Journal of Medicinal Food, 2015, 18(10):1150-1156.  
[17] CHAUHAN J, DAKSHINAMURTI K.Transcriptional regulation of the glucokinase gene by biotin in starved rats[J].The Journal of Biological Chemistry, 1991, 266(16):10035-10038.  
[18] LARRIETA E, VELASCO F, VITAL P, et al.Pharmacological concentrations of biotin reduce serum triglycerides and the expression of lipogenic genes[J].European Journal of Pharmacology, 2010, 644(1/3):263-268.
[19] LAZO-DE-LA-VEGA-MONROY M L, LARRIETA E, TIXI-VERDUGO W, et al.Effects of dietary biotin supplementation on glucagon production, secretion, and action[J].Nutrition, 2017, 43/44:47-53.
[20] FERNANDEZ-MEJIA C.Pharmacological effects of biotin[J].The Journal of Nutritional Biochemistry, 2005, 16(7):424-427.  
[21] SUGITA Y, SHIRAKAWA H, SUGIMOTO R, et al.Effect of biotin treatment on hepatic gene expression in streptozotocin-induced diabetic rats[J].Bioscience, Biotechnology, and Biochemistry, 2008, 72(5):1290-1298.  
[22] KUROISHI T, SUGAWARA S.Metabolomic analysis of liver from dietary biotin deficient mice[J].Journal of Nutritional Science and Vitaminology, 2020, 66(1):82-85.  
[23] KHAN Y M, KHAN M A.Dietary biotin requirement of fingerling Catla catla (Hamilton) based on growth, feed conversion efficiency, and liver biotin concentration[J].Journal of the World Aquaculture Society, 2019, 50(3):674-683.  
[24] LAZO DE LA VEGA-MONROY M L, LARRIETA E, GERMAN M S, et al.Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion[J].The Journal of Nutritional Biochemistry, 2013, 24(1):169-177.  
[25] DE LA VEGA L A, STOCKERT R J.Regulation of the insulin and asialoglycoprotein receptors via cGMP-dependent protein kinase[J].American Journal of Physiology:Cell Physiology, 2000, 279(6):C2037-C2042.
[26] SOLÓRZANO-VARGAS R S, PACHECO-ALVAREZ D, LEÓN-DEL-RÍO A.Holocarboxylase synthetase is an obligate participant in biotin-mediated regulation of its own expression and of biotin-dependent carboxylases mRNA levels in human cells[J].Proceedings of the National Academy of Sciences of the United States of America, 2002, 99(8):5325-5330.  
[27] VESELY D L.Biotin enhances guanylate cyclase activity[J].Science, 1982, 216(4552):1329-1330.  
[28] VILCHES-FLORES A, TOVAR A R, MARIN-HERNANDEZ A, et al.Biotin increases glucokinase expression via soluble guanylate cyclase/protein kinase G, adenosine triphosphate production and autocrine action of insulin in pancreatic rat islets[J].The Journal of Nutritional Biochemistry, 2010, 21(7):606-612.  
[29] VESELY D L, WORMSER H C, ABRAMSON H N.Biotin analogs activate guanylate cyclase[J].Molecular and Cellular Biochemistry, 1984, 60(2):109-114.
[30] PACHECO-ALVAREZ D, SOLÓRZANO-VARGAS R S, GONZÁLEZ-NORIEGA A, et al.Biotin availability regulates expression of the sodium-dependent multivitamin transporter and the rate of biotin uptake in HepG2 cells[J].Molecular Genetics and Metabolism, 2005, 85(4):301-307.  
[31] RODRIGUEZ-MELENDEZ R, ZEMPLENI J.Nitric oxide signaling depends on biotin in Jurkat human lymphoma cells[J].The Journal of Nutrition, 2009, 139(3):429-433.  
[32] TURGUT M, CINAR V, PALA R, et al.Biotin and chromium histidinate improve glucose metabolism and proteins expression levels of IRS-1, PPAR-γ, and NF-κB in exercise-trained rats[J].Journal of the International Society of Sports Nutrition, 2018, 15(1):45.
[33] REVILLA-MONSALVE C, ZENDEJAS-RUIZ I, ISLAS-ANDRADE S, et al.Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia[J].Biomedicine & Pharmacotherapy, 2006, 60(4):182-185.  
[34] ALBARRACIN C, FUQUA B, GEOHAS J, et al.Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus:a placebo-controlled, double-blind randomized clinical trial[J].Journal of the Cardiometabolic Syndrome, 2007, 2(2):91-97.  
[35] HEMMATI M, BABAEI H, ABDOLSALEHEI M.Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in Kermanshah in Iran (2008-2009)[J].Oman Medical Journal, 2013, 28(3):195-198.  
[36] AGUILERA-MENDEZ A, HERNÁNDEZ-EQUIHUA M G, RUEDA-ROCHA A C, et al.Protective effect of supplementation with biotin against high-fructose-induced metabolic syndrome in rats[J].Nutrition Research, 2018, 57:86-96.
[37] SONE H, KAMIYAMA S, HIGUCHI M, et al.Biotin augments acetyl CoA carboxylase 2 gene expression in the hypothalamus, leading to the suppression of food intake in mice[J].Biochemical and Biophysical Research Communications, 2016, 476(3):134-139.  
[38] XUE J, ZHOU J, ZEMPLENI J.Holocarboxylase synthetase catalyzes biotinylation of heat shock protein 72, thereby inducing RANTES expression in HEK-293 cells[J].American Journal of Physiology.Cell Physiology, 2013, 305(12):C1240-C1245.
[39] CZOGALLA B, PARTENHEIMER A, BADMANN S, et al.Nuclear enolase-1/MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer[J].Translational Oncology, 2021, 14(1):100910.
[40] PETRELLI F, CODERONI S, MORETTI P, et al.Effect of biotin on phosphorylation, acetylation, methylation of rat liver histones[J].Molecular Biology Reports, 1978, 4(2):87-92.  
[41] WATKINS B A, KRATZER F H.Tissue lipid fatty acid composition of biotin-adequate and biotin-deficient chicks[J].Poultry Science, 1987, 66(2):306-313.  
[42] KOPINSKI J S, LEIBHOLZ J, BRYDEN W L, et al.Biotin studies in pigs.1.Biotin deficiency in the young pig[J].The British Journal of Nutrition, 1989, 62(3):751-759.  
[43] QUEIROZ P J B, SILVA D C, BORGES P A C, et al.Effect of biotin supplementation on milk yield of Girolando cows reared in a tropical climate[J].Tropical Animal Health and Production, 2019, 51(6):1661-1665.  
[44] ROSENDO O, STAPLES C R, MCDOWELL L R, et al.Effects of biotin supplementation on peripartum performance and metabolites of Holstein cows[J].Journal of Dairy Science, 2004, 87(8):2535-2545.  
[45] 赵姝.生物素对幼建鲤消化吸收能力、抗氧化能力和免疫功能的影响[D].硕士学位论文.雅安:四川农业大学, 2011. ZHAO S.Effects of dietary biotin on digestive ability, antioxidative ability and immune function of juvenile Jian carp (Cyprinus carpio var. Jian)[D].Master Thesis.Ya'an:Sichuan Agricultural University, 2011.(in Chinese)
[46] HE P, JIANG W D, LIU X A, et al.Dietary biotin deficiency decreased growth performance and impaired the immune function of the head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella)[J].Fish & Shellfish Immunology, 2020, 97:216-234.
[47] LIU D N, ZHANG Y, PAN M Z, et al.Interactive effects of dietary biotin and carbohydrate on growth performance and glucose metabolism in juvenile turbot Scophthalmus maximus L.[J].Aquaculture, 2021, 540:736752.
[48] LI Q, CHEN J, LIU GH, et al.Effects of biotin on promoting anammox bacterial activity[J].Scientific reports, 2021, 11(1):2038.
文章导航

/