[1] CACABELOS R,CARRIL J C,CACABELOS N,et al.Sirtuins in Alzheimer's disease:SIRT2-related genophenotypes and implications for pharmacoepigenetics[J].International Journal of Molecular Sciences,2019,20(5):1249.
[2] LEE D,GOLDBERG A L.SIRT1 protein,by blocking the activities of transcription factors FoxO1 and FoxO3,inhibits muscle atrophy and promotes muscle growth[J].Journal of Biological Chemistry,2013,288(42):30515-30526.
[3] CARAFA V,ROTILI D,FORGIONE M,et al.Sirtuin functions and modulation:from chemistry to the clinic[J].Clinical Epigenetics,2016,8:61.
[4] KUMAR A,CHAUHAN S.How much successful are the medicinal chemists in modulation of SIRT1:a critical review[J].European Journal of Medicinal Chemistry,2016,119:45-69.
[5] YANAGISAWA S,BAKER J R,VUPPUSETTY C,et al.The dynamic shuttling of SIRT1 between cytoplasm and nuclei in bronchial epithelial cells by single and repeated cigarette smoke exposure[J].PLoS One,2018,13(3):e0193921.
[6] SCHER M B,VAQUERO A,REINBERG D.SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress[J].Genes&Development,2007,21(8):920-928.
[7] DAVENPORT A M,HUBER F M,HOELZ A.Structural and functional analysis of human SIRT1[J].Journal of Molecular Biology,2014,426(3):526-541.
[8] WOJCIK M,MAC-MARCJANEK K,WOZNIAK L A.Physiological and pathophysiological functions of SIRT1[J].Mini Reviews in Medicinal Chemistry,2009,9(3):386-394.
[9] JIANG H,KHAN S,WANG Y,et al.SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine[J].Nature,2013,496(7443):110-113.
[10] ONG A L C,RAMASAMY T S.Role of sirtuin1-p53 regulatory axis in aging,cancer and cellular reprogramming[J].Ageing Research Reviews,2018,43:64-80.
[11] LAMICHANE S,BAEK S H,KIM Y J,et al.MHY2233 attenuates replicative cellular senescence in human endothelial progenitor cells via SIRT1 signaling[J].Oxidative Medicine and Cellular Longevity,2019,2019:6492029.
[12] KHANH V C,ZULKIFLI A F,TOKUNAGA C,et al.Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of sirtuin 1[J].Biochemical and Biophysical Research Communications,2018,500(3):682-690.
[13] POULOSE N,RAJU R.Sirtuin regulation in aging and injury[J].Biochimica et Biophysica Acta,2015,1852(11):2442-2455.
[14] LIU T,ZHANG L Y,JOO D,et al.NF-κB signaling in inflammation[J].Signal Transduction and Targeted Therapy,2017,2:17023.
[15] LUEDDE T,SCHWABE R F.NF-κB in the liver-linking injury,fibrosis and hepatocellular carcinoma[J].Nature Reviews Gastroenterology&Hepatology,2011,8(2):108-118.
[16] BAUD V,DERUDDER E.Control of NF-κB activity by proteolysis[J].Current Topics in Microbiology and Immunology,2011,349:97-114.
[17] KAUPPINEN A,SUURONEN T,OJALA J,et al.Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders[J].Cellular Signalling,2013,25(10):1939-1948.
[18] ROTHGIESSER K M,FEY M,HOTTIGER M O.Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression[J].BMC Genomics,2010,11:22.
[19] ZHAO H S,CHEN S R,GAO K,et al.Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1/AMPK signaling pathway[J].Neuroscience,2017,348:241-251.
[20] GANESAN R,HOS N J,GUTIERREZ S,et al.Salmonella typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy[J].PLoS Pathogens,2017,13(2):e1006227.
[21] HOU J L,CHONG Z Z,SHANG Y C,et al.Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling,forkhead trafficking,bad,and mitochondrial caspase activation[J].Current Neurovascular Research,2010,7(2):95-112.
[22] CHANG C M,SU H,ZHANG D H,et al.AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation[J].Molecular Cell,2015,60(6):930-940.
[23] VILLENA J A.New insights into PGC-1 coactivators:redefining their role in the regulation of mitochondrial function and beyond[J].The FEBS Journal,2015,282(4):647-672.
[24] REN Z H,HE H Y,ZUO Z C,et al.The role of different SIRT1-mediated signaling pathways in toxic injury[J].Cellular&Molecular Biology Letters,2019,24:36.
[25] OLMOS Y,SÁNCHEZ-GÓMEZ F J,WILD B,et al.SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex[J].Antioxidants&Redox Signaling,2013,19(13):1507-1521.
[26] LAGOUGE M,ARGMANN C,GERHART-HINES Z,et al.Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha[J].Cell,2006,127(6):1109-1122.
[27] RODGERS J T,LERIN C,HAAS W,et al.Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1[J].Nature,2005,434(7029):113-118.
[28] CHEN D,BRUNO J,EASLON E,et al.Tissue-specific regulation of SIRT1 by calorie restriction[J].Genes&Development,2008,22(13):1753-1757.
[29] WANG Z,SUN W S,SUN X,et al.Kaempferol ameliorates Cisplatin induced nephrotoxicity by modulating oxidative stress,inflammation and apoptosis via ERK and NF-κB pathways[J].AMB Express,2020,10(1):58.
[30] DISABATO D J,QUAN N,GODBOUT J P.Neuroinflammation:the devil is in the details[J].Journal of Neurochemistry,2016,139(Suppl 2):136-153.
[31] ZHANG Y,ANOOPKUMAR-DUKIE S,ARORA D,et al.Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases[J].European Journal of Pharmacology,2020,867:172847.
[32] MAIESE K.Cognitive impairment with diabetes mellitus and metabolic disease:innovative insights with the mechanistic target of rapamycin and circadian clock gene pathways[J].Expert Review of Clinical Pharmacology,2020,13(1):23-34.
[33] KHAN R S,FONSECA-KELLY Z,CALLINAN C,et al.SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells[J].Frontiers in Cellular Neuroscience,2012,6:63.
[34] YE J M,LIU Z H,WEI J P,et al.Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway[J].Neuroscience Letters,2013,553:72-77.
[35] ABE-HIGUCHI N,UCHIDA S,YAMAGATA H,et al.Hippocampal sirtuin 1 signaling mediates depression-like behavior[J].Biological Psychiatry,2016,80(11):815-826.
[36] LIBERT S,POINTER K,BELL E L,et al.SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive[J].Cell,2011,147(7):1459-1472.
[37] KILIC U,GOK O,BACAKSIZ A,et al.SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases[J].PLoS One,2014,9(2):e90428.
[38] CHEN Y X,ZHANG M,CAI Y H,et al.The Sirt1 activator SRT1720 attenuates angiotensin Ⅱ-induced atherosclerosis in apoE-/- mice through inhibiting vascular inflammatory response[J].Biochemical and Biophysical Research Communications,2015,465(4):732-738.
[39] PROLA A,PIRES DA SILVA J,GUILBERT A,et al.SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation[J].Cell Death and Differentiation,2017,24(2):343-356.
[40] STEIN S,MATTER C M.Protective roles of SIRT1 in atherosclerosis[J].Cell Cycle,2011,10(4):640-647.
[41] DOULAMIS I P,TZANI A I,KONSTANTOPOULOS P S,et al.A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease[J].International Journal of Cardiology,2017,230:447-453.
[42] VIKRAM A,LEWARCHIK C M,YOON J Y,et al.Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel[J].Nature Medicine,2017,23(3):361-367.
[43] MATSUSHIMA S,SADOSHIMA J.The role of sirtuins in cardiac disease[J].American Journal of Physiology.Heart and Circulatory Physiology,2015,309(9):H1375-H1389.
[44] ALCENDOR R R,GAO S M,ZHAI P Y,et al.Sirt1 regulates aging and resistance to oxidative stress in the heart[J].Circulation Research,2007,100(10):1512-1521.
[45] THOMPSON A M,WAGNER R,RZUCIDLO E M.Age-related loss of SirT1 expression results in dysregulated human vascular smooth muscle cell function[J].American Journal of Physiology.Heart and Circulatory Physiology,2014,307(4):H533-H541.
[46] KABRA N,LI Z Y,CHEN L H,et al.SirT1 is an inhibitor of proliferation and tumor formation in colon cancer[J].The Journal of Biological Chemistry,2009,284(27):18210-18217.
[47] REN N S X,JI M,TOKAR E J,et al.Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development[J].Current Biology,2017,27(4):483-494.
[48] CHUNG S Y,JUNG Y Y,PARK I A,et al.Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis,and poor disease-free survival in triple negative breast cancer[J].Clinical&Experimental Metastasis,2016,33(2):179-185.
[49] SIMMONS G E,Jr,PANDEY S,NEDELJKOVIC-KUREPA A,et al.Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells[J].PLoS One,2014,9(6):e98861.
[50] RODGERS J T,PUIGSERVER P.Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(31):12861-12866.
[51] LI Y,ZOU S P,DING H Y,et al.Low expression of sirtuin 1 in the dairy cows with mild fatty liver alters hepatic lipid metabolism[J].Animals,2020,10(4):560.
[52] YANG Y,BAI T,YAO Y L,et al.Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury[J].Toxicology Letters,2016,262:80-91.
[53] DU X L,YANG Y C,XU C,et al.Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis[J].Oncotarget,2017,8(53):91362-91378.
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