饲料营养研究进展专栏 SPECIAL COLUMN:RESEARCH PROGRESS ON FEED NUTRITION

呕吐毒素对猪肠道屏障的影响及其营养调控研究进展

  • 张薇 ,
  • 牛军龙 ,
  • 郭永鹏 ,
  • 王志祥
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  • 河南农业大学动物科技学院, 郑州 450046
张薇(1991-),女,湖北荆门人,讲师,博士,主要从事单胃动物营养研究。E-mail:weizhang@henau.edu.cn

收稿日期: 2022-08-01

  网络出版日期: 2022-10-17

基金资助

河南省自然科学基金青年基金项目(212300410156)

Research Progress of Effects of Deoxynivalenol on Intestinal Barrier and Its Nutritional Regulation in Pigs

  • ZHANG Wei ,
  • NIU Junlong ,
  • GUO Yongpeng ,
  • WANG Zhixiang
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  • College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China

Received date: 2022-08-01

  Online published: 2022-10-17

摘要

肠道的屏障功能是防御外源性有毒有害物质损伤机体的重要途径。呕吐毒素被猪摄入后,可以通过改变微生物区系组成,降低黏蛋白、紧密连接蛋白的表达水平以及调控免疫因子,破坏肠道的生物屏障、化学屏障、物理屏障和免疫屏障,对猪机体造成严重的危害。通过营养调控缓解呕吐毒素对猪肠道屏障功能的损伤,是一种有效途径。本文主要对呕吐毒素诱导的猪肠道屏障功能损伤及植物提取物和不同营养物质对该损伤的缓解作用进行总结,旨在为饲料及饲料原料呕吐毒素污染预防、猪肠道健康保护提供参考。

本文引用格式

张薇 , 牛军龙 , 郭永鹏 , 王志祥 . 呕吐毒素对猪肠道屏障的影响及其营养调控研究进展[J]. 动物营养学报, 2022 , 34(10) : 6249 -6256 . DOI: 10.3969/j.issn.1006-267x.2022.10.016

Abstract

Intestinal barrier function is an important way to prevent exogenous toxic and harmful substances from damaging the body. Deoxynivalenol (DON) ingested by pigs can destroy the biological, chemical, physical and immune barriers of intestinal tract by changing the composition of microbiota, reducing the expression levels of mucin and tight junction proteins and regulating immune factors, causing serious harm to the body of pigs. It is an effective way to alleviate the damage of intestinal barrier function in pigs by DON through nutritional regulation. This article mainly summarized the damage of intestinal barrier function in pigs induced by DON infection and the alleviating effects of plant extracts and different nutrients on the damage, so as to provide data support for the prevention of DON contamination of feed and materials and the protection of intestinal health of pigs.

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