饲料营养研究进展专栏 SPECIAL COLUMN:RESEARCH PROGRESS ON FEED NUTRITION

猪、禽病原性肠道损伤营养调控研究进展

  • 张焱焱 ,
  • 张倩 ,
  • 郭双双 ,
  • 侯永清
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  • 武汉轻工大学动物科学与营养工程学院, 湖北省动物营养与肠道健康国际科技合作基地, 武汉 430023
张焱焱(1989-),男,山西临汾人,讲师,博士,主要从事猪肠道健康与营养调控机制研究。E-mail:zhangyanyana305@163.com

收稿日期: 2022-08-01

  网络出版日期: 2022-10-17

基金资助

国家自然科学基金项目(32172763);湖北省重点研发计划项目(2021BBA083, 2019ABA083)

Research Progress on Nutritional Regulation of Pathogenic Intestinal Injury in Pigs and Poultry

  • ZHANG Yanyan ,
  • ZHANG Qian ,
  • GUO Shuangshuang ,
  • HOU Yongqing
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  • Hubei International Scientific and Technological Cooperation Base of Animal Nutrition and Gut Health, School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China

Received date: 2022-08-01

  Online published: 2022-10-17

摘要

肠道损伤是猪、禽养殖中的常见病理状态,多种因素包括病原微生物、过敏原、抗营养因子、毒素或致病性化合物皆可引起猪、禽肠道损伤,其中由病原性微生物引起的肠道损伤严重制约着猪、禽养殖业健康发展。为了解决病原性肠道损伤对猪、禽养殖造成的困扰,有必要阐明猪、禽病原性肠道损伤的致病机理以及营养修复机制。本文总结了常见猪、禽肠道损伤及机理,并结合已报道营养调控物质,包括天然植物提取物、微生态制剂和功能性氨基酸等营养调控物质在猪、禽病原性肠道损伤中发挥作用机理的研究进展,为多靶标调控猪、禽肠道损伤营养技术的研究和应用提供参考。

本文引用格式

张焱焱 , 张倩 , 郭双双 , 侯永清 . 猪、禽病原性肠道损伤营养调控研究进展[J]. 动物营养学报, 2022 , 34(10) : 6271 -6280 . DOI: 10.3969/j.issn.1006-267x.2022.10.019

Abstract

Intestinal injury is a common disease that affects the healthy growth of pigs and poultry. A variety of factors including pathogenic microorganisms, allergens, antinutritional factor, toxin or pathogenic compounds can cause intestinal injury in pigs and poultry. The intestinal injury caused by pathogenic microorganisms seriously restricts the healthy development of pig and poultry breeding industry. In order to solve the problems, it is necessary to explore the mechanism of pathogenic intestinal injury and nutritional repair mechanism in pig and poultry. In this paper, we summarized the models of porcine and avian pathogenic intestinal injury and related injury mechanisms, and the research progress on the mechanism of the nutritional regulatory factors, including natural plant extracts, microecological agents and functional amino acids of pathogenic intestinal injury in pig and poultry, which provide a basis for the research and application of multi-target regulation of intestinal injury nutrition technology in pig and poultry.

参考文献

[1] ZHENG L,DUARTE M E,SEVAROLLI LOFTUS A,et al.Intestinal health of pigs upon weaning:challenges and nutritional intervention[J].Frontiers in Veterinary Science,2021,8:628258.
[2] WICKRAMASURIYA S S,PARK I,LEE K,et al.Role of physiology,immunity,microbiota,and infectious diseases in the gut health of poultry[J].Vaccines,2022,10(2):172.
[3] LEE I K,KYE Y C,KIM G,et al.Stress,nutrition,and intestinal immune responses in pigs-a review[J].Asian-Australasian Journal of Animal Sciences,2016,29(8):1075-1082.  
[4] 徐子伟.仔猪肠道损伤修复营养调控及其机制和应用[J].动物营养学报,2014,26(10):3033-3045. XU Z W.Mechanism and application for nutritional regulations of intestine damage repair in piglets[J].Chinese Journal of Animal Nutrition,2014,26(10):3033-3045.(in Chinese)
[5] PATRA A K,AMASHEH S,ASCHENBACH J R.Modulation of gastrointestinal barrier and nutrient transport function in farm animals by natural plant bioactive compounds-a comprehensive review[J].Critical Reviews in Food Science and Nutrition,2019,59(20):3237-3266.  
[6] XING Y Y,GU X Y,RUAN G J,et al.Probiotics for the treatment of gastric diseases[J].Nutrition and Cancer,2022,20:1-7.
[7] WU G Y,BAZER F W,DAI Z L,et al.Amino acid nutrition in animals:protein synthesis and beyond[J].Annual Review of Animal Biosciences,2014,2:387-417.
[8] HOU Y Q,WU G Y.Nutritionally nonessential amino acids:a misnomer in nutritional sciences[J].Advances in Nutrition,2017,8(1):137-139.  
[9] ZHANG Q,WU T,LI S Y,et al.Protective effect of zinc oxide and its association with neutrophil degranulation in piglets infected with porcine epidemic diarrhea virus[J].Oxidative Medicine and Cellular Longevity,2021,2021:3055810.
[10] LIU Y L,CHEN F,ODLE J,et al.Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge[J].The Journal of Nutrition,2012,142(11):2017-2024.  
[11] ZHANG Q,YI D,JI C Z,et al.Monolaurin confers a protective effect against porcine epidemic diarrhea virus infection in piglets by regulating the interferon pathway[J].Frontiers in Immunology,2021,12:797476.
[12] YANG P,MA Y X.Recent advances of vitamin D in immune,reproduction,performance for pig:a review[J].Animal Health Research Reviews,2021,22(1):85-95.  
[13] LIU Q,WANG H Y.Porcine enteric coronaviruses:an updated overview of the pathogenesis,prevalence,and diagnosis[J].Veterinary Research Communications,2021,45(2/3):75-86.
[14] DOERKSEN T,CHRISTENSEN T,LU A,et al.Assessment of porcine Rotavirus-associated virome variations in pigs with enteric disease[J].Veterinary Microbiology,2022,270:109447.
[15] ANNAMALAI T,SAIF L J,LU Z Y,et al.Age-dependent variation in innate immune responses to porcine epidemic diarrhea virus infection in suckling versus weaned pigs[J].Veterinary Immunology and Immunopathology,2015,168(3/4):193-202.
[16] LI Y C,WU Q X,HUANG L L,et al.An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine[J].Nature Communications,2018,9(1):3811.
[17] CURRY S M,SCHWARTZ K J,YOON K J,et al.Effects of porcine epidemic diarrhea virus infection on nursery pig intestinal function and barrier integrity[J].Veterinary Microbiology,2017,211:58-66.
[18] JUNG K,MIYAZAKI A,SAIF L J.Immunohistochemical detection of the vomiting-inducing monoamine neurotransmitter serotonin and enterochromaffin cells in the intestines of conventional or gnotobiotic (Gn) pigs infected with porcine epidemic diarrhea virus (PEDV) and serum cytokine responses of Gn pigs to acute PEDV infection[J].Research in Veterinary Science,2018,119:99-108.
[19] JUNG K,SAIF L J,WANG Q H.Porcine epidemic diarrhea virus (PEDV):an update on etiology,transmission,pathogenesis,and prevention and control[J].Virus Research,2020,286:198045.
[20] OUYANG K,SHYU D L,DHAKAL S,et al.Evaluation of humoral immune status in porcine epidemic diarrhea virus (PEDV) infected sows under field conditions[J].Veterinary Research,2015,46:140.
[21] ANNAMALAI T,LIN C M,GAO X,et al.Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain[J].Veterinary Research,2017,48(1):61.
[22] GIMENEZ-LIROLA L G,ZHANG J Q,CARRILLO-AVILA J A,et al.Reactivity of porcine epidemic diarrhea virus structural proteins to antibodies against porcine enteric coronaviruses:diagnostic implications[J].Journal of Clinical Microbiology,2017,55(5):1426-1436.  
[23] KOONPAEW S,TEERAVECHYAN S,FRANTZ P N,et al.PEDV and PDCoV pathogenesis:the interplay between host innate immune responses and porcine enteric coronaviruses[J].Frontiers in Veterinary Science,2019,6:34.
[24] DUBREUIL J D.Enterotoxigenic Escherichia coli and probiotics in swine:what the bleep do we know?[J].Bioscience of Microbiota,Food and Health,2017,36(3):75-90.  
[25] MIRHOSEINI A,AMANI J,NAZARIAN S.Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it[J].Microbial Pathogenesis,2018,117:162-169.
[26] WANG H X,ZHONG Z F,LUO Y,et al.Heat-stable enterotoxins of enterotoxigenic Escherichia coli and their impact on host immunity[J].Toxins,2019,11(1):24.
[27] WU T,LV Y,LI X N,et al.Establishment of a recombinant Escherichia coli-induced piglet diarrhea model[J].Frontiers in Bioscience,2018,23(8):1517-1534.  
[28] ZHANG Q,ZHANG L J,LYU Y,et al.Dietary supplementation of Lactobacillus zeae regulated the gut microbiome in piglets infected with enterotoxigenic Escherichia coli[J].Czech Journal of Animal Science,2022,67(1):27-38.  
[29] SONG X K,GAO Y L,XU L X,et al.Partial protection against four species of chicken coccidia induced by multivalent subunit vaccine[J].Veterinary Parasitology,2015,212(3/4):80-85.
[30] MADLALA T,OKPEKU M,ADELEKE M A.Understanding the interactions between Eimeria infection and gut microbiota,towards the control of chicken coccidiosis:a review[J].Parasite,2021,28:48.
[31] DAHIYA J P,WILKIE D C,VAN KESSEL A G,et al.Potential strategies for controlling necrotic enteritis in broiler chickens in post-antibiotic era[J].Animal Feed Science and Technology,2006,129(1/2):60-88.
[32] EMAMI N K,DALLOUL R A.Centennial review:recent developments in host-pathogen interactions during necrotic enteritis in poultry[J].Poultry Science,2021,100(9):101330.
[33] PRESCOTT J F,PARREIRA V R,MEHDIZADEH GOHARI I,et al.The pathogenesis of necrotic enteritis in chickens:what we know and what we need to know:a review[J].Avian Pathology,2016,45(3):288-294.  
[34] SHOJADOOST B,VINCE A R,PRESCOTT J F.The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens:a critical review[J].Veterinary Research,2012,43(1):74.
[35] WADE B,KEYBURN A.The true cost of necrotic enteritis[J].World Poultry,2015,31:16-17.
[36] DZIVA F,STEVENS M P.Colibacillosis in poultry:unravelling the molecular basis of virulence of avian pathogenic Escherichia coli in their natural hosts[J].Avian Pathology,2008,37(4):355-366.  
[37] KATHAYAT D,LOKESH D,RANJIT S,et al.Avian pathogenic Escherichia coli(APEC):an overview of virulence and pathogenesis factors,zoonotic potential,and control strategies[J].Pathogens,2021,10(4):467.
[38] MELLATA M.Human and avian extraintestinal pathogenic Escherichia coli:infections,zoonotic risks,and antibiotic resistance trends[J].Foodborne Pathogens and Disease,2013,10(11):916-932.  
[39] FOLEY S L,JOHNSON T J,RICKE S C,et al.Salmonella pathogenicity and host adaptation in chicken-associated serovars[J].Microbiology and Molecular Biology Reviews,2013,77(4):582-607.  
[40] AWAD W A,HESS C,HESS M.Re-thinking the chicken-Campylobacter jejuni interaction:a review[J].Avian Pathology,2018,47(4):352-363.  
[41] 易丹,侯永清.天然植物活性成分与猪肠道健康的研究进展[J].动物营养学报,2020,32(10):4518-4524. YI D,HOU Y Q.Research progress on natural plant bioactive compounds and swine intestinal health[J].Chinese Journal of Animal Nutrition,2020,32(10):4518-4524.(in Chinese)
[42] 李鹏,高铭坤,呙于明.植物提取物在家禽和猪生产中的应用研究进展[J/OL].中国畜牧杂志:1-15[2022-07-25].https://kns.cnki.net/kcms/detail/detail.aspx?FileName=ZGXM20220318002&DbName=CAPJ2022.DOI:10.19556/j.0258-7033.20211019-08. LI P,GAO M K,GUO Y M.Advances in biological functions of plant extracts and its application in poultry and pig production[J/OL].Chinese Journal of Animal Science:1-15[2022-07-25].https://kns.cnki.net/kcms/detail/detail.aspx?FileName=ZGXM20220318002&DbName=CAPJ2022.DOI:10.19556/j.0258-7033.20211019-08.(in Chinese)
[43] HUANG C Y,WANG Y B,HE X,et al.The involvement of NF-κB/P38 pathways in Scutellaria baicalensis extracts attenuating of Escherichia coli K88-induced acute intestinal injury in weaned piglets[J].British Journal of Nutrition,2019,122(2):152-161.  
[44] WU M J,ZHANG Q,YI D,et al.Quantitative proteomic analysis reveals antiviral and anti-inflammatory effects of puerarin in piglets infected with porcine epidemic diarrhea virus[J].Frontiers in Immunology,2020,11:169.
[45] WU M J,YI D,ZHANG Q,et al.Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus[J].Scientific Reports,2021,11(1):6552.
[46] LI Z H,CAO H,CHENG Y F,et al.Inhibition of porcine epidemic diarrhea virus replication and viral 3C-like protease by quercetin[J].International Journal of Molecular Sciences,2020,21(21):8095.
[47] AL-MNASER A,DAKHEEL M,ALKANDARI F,et al.Polyphenolic phytochemicals as natural feed additives to control bacterial pathogens in the chicken gut[J].Archives of Microbiology,2022,204(5):253.
[48] DU E C,WANG W W,GAN L P,et al.Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens[J].Journal of Animal Science and Biotechnology,2016,7:19.
[49] YIN D F,DU E C,YUAN J M,et al.Supplemental thymol and carvacrol increases ileum Lactobacillus population and reduces effect of necrotic enteritis caused by Clostridium perfringes in chickens[J].Scientific Reports,2017,7(1):7334.
[50] BETANCOURT L,HUME M,RODRÍGUEZ F,et al.Effects of Colombian oregano essential oil (Lippia origanoides Kunth) and Eimeria species on broiler production and cecal microbiota[J].Poultry Science,2019,98(10):4777-4786.  
[51] UPADHAYA S D,CHO S H,CHUNG T K,et al.Anti-coccidial effect of essential oil blends and vitamin D on broiler chickens vaccinated with purified mixture of coccidian oocyst from Eimeria tenella and Eimeria maxima[J].Poultry Science,2019,98(7):2919-2926.  
[52] CHANG L Y,DI K Q,XU J,et al.Effect of natural garlic essential oil on chickens with artificially infected Eimeria tenella[J].Veterinary Parasitology,2021,300:109614.
[53] KELLY C,GUNDOGDU O,PIRCALABIORU G,et al.The in vitro and in vivo effect of carvacrol in preventing campylobacter infection,colonization and in improving productivity of chicken broilers[J].Foodborne Pathogens and Disease,2017,14(6):341-349.  
[54] ALLAOUA M,BONNAFÉ E,ETIENNE P,et al.A carvacrol-based product reduces Campylobacter jejuni load and alters microbiota composition in the caeca of chickens[J].Journal of Applied Microbiology,2022,132(6):4501-4516.  
[55] WOJNICKI S J,MORRIS A,SMITH B N,et al.Immunomodulatory effects of whole yeast cells and capsicum in weanling pigs challenged with pathogenic Escherichia coli[J].Journal of Animal Science,2019,97(4):1784-1795.  
[56] XU X,HUA H W,WANG L M,et al.Holly polyphenols alleviate intestinal inflammation and alter microbiota composition in lipopolysaccharide-challenged pigs[J].British Journal of Nutrition,2020,123(8):881-891.  
[57] ZHONG X L,SHI Y R,CHEN J J,et al.Polyphenol extracts from Punica granatum and Terminalia chebula are anti-inflammatory and increase the survival rate of chickens challenged with Escherichia coli[J].Biological&Pharmaceutical Bulletin,2014,37(10):1575-1582.  
[58] SALAHEEN S,JAISWAL E,JOO J,et al.Bioactive extracts from berry byproducts on the pathogenicity of Salmonella Typhimurium[J].International Journal of Food Microbiology,2016,237:128-135.
[59] SIMA F,STRATAKOS A C,WARD P,et al.A novel natural antimicrobial can reduce the in vitro and in vivo pathogenicity of T6SS positive Campylobacter jejuni and Campylobacter coli chicken isolates[J].Frontiers in Microbiology,2018,9:2139.
[60] MAO X B,HU H Y,XIAO X C,et al.Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model[J].Food&Function,2019,10(4):2094-2101.  
[61] SONG B C,LI P,YAN S J,et al.Effects of dietary astragalus polysaccharide supplementation on the Th17/Treg balance and the gut microbiota of broiler chickens challenged with necrotic enteritis[J].Frontiers in Immunology,2022,13:781934.
[62] WU T,SHI Y T,ZHANG Y Y,et al.Lactobacillus rhamnosus LB1 alleviates enterotoxigenic Escherichia coli-induced adverse effects in piglets by improving host immune response and anti-oxidation stress and restoring intestinal integrity[J].Frontiers in Cellular and Infection Microbiology,2021,11:724401.
[63] 李海花,梁东梅,乔家运.植物乳杆菌抑制产肠毒素型大肠杆菌诱发猪肠上皮细胞炎症反应的分子机制[J].动物营养学报,2021,33(7):4018-4029. LI H H,LIANG D M,QIAO J Y.Molecular mechanism of Lactobacillus plantarum inhibiting inflammatory response induced by enterotoxigenic Escherichia coli in porcine intestinal epithelial cells[J].Chinese Journal of Animal Nutrition,2021,33(7):4018-4029.(in Chinese)
[64] MA M P,ZHAO Z T,LIANG Q Y,et al.Overexpression of pEGF improved the gut protective function of Clostridium butyricum partly through STAT3 signal pathway[J].Applied Microbiology and Biotechnology,2021,105(14):5973-5991.
[65] KULKARNI R R,GAGHAN C,GORRELL K,et al.Probiotics as alternatives to antibiotics for the prevention and control of necrotic enteritis in chickens[J].Pathogens,2022,11(6):692.
[66] WAN J,ZHANG J,XU Q S,et al.Alginate oligosaccharide protects against enterotoxigenic Escherichia coli-induced porcine intestinal barrier injury[J].Carbohydrate Polymers,2021,270:118316.
[67] WAN J,ZHANG J,CHEN D W,et al.Alginate oligosaccharide alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal disruption in weaned pigs[J].Food&Function,2018,9(12):6401-6413.  
[68] LIU L,CHEN D W,YU B,et al.Fructooligosaccharides improve growth performance and intestinal epithelium function in weaned pigs exposed to enterotoxigenic Escherichia coli[J].Food&Function,2020,11(11):9599-9612.  
[69] YU E,CHEN D W,YU B,et al.Manno-oligosaccharide attenuates inflammation and intestinal epithelium injury in weaned pigs upon enterotoxigenic Escherichia coli K88 challenge[J].British Journal of Nutrition,2021,126(7):993-1002.  
[70] LIU G M,GU K,WANG F,et al.Tryptophan ameliorates barrier integrity and alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 through the CaSR/Rac1/PLC-γ1 signaling pathway in porcine intestinal epithelial cells[J].Frontiers in Immunology,2021,12:748497.
[71] MAO X B,LIU M H,TANG J,et al.Dietary leucine supplementation improves the mucin production in the jejunal mucosa of the weaned pigs challenged by porcine rotavirus[J].PLoS One,2015,10(9):e0137380.
[72] WANG L,ZHOU J,HOU Y Q,et al.N-acetylcysteine supplementation alleviates intestinal injury in piglets infected by porcine epidemic diarrhea virus[J].Amino Acids,2017,49(12):1931-1943.  
[73] WU T,LYU Y,LI X N,et al.Impact of N-acetylcysteine on the gut microbiota in the piglets infected with porcine epidemic diarrhea virus[J].Frontiers in Veterinary Science,2020,7:582338.
[74] YI D,HOU Y Q,XIAO H,et al.N-acetylcysteine improves intestinal function in lipopolysaccharides-challenged piglets through multiple signaling pathways[J].Amino Acids,2017,49(12):1915-1929.  
[75] ZHANG B B,LV Z P,LI Z,et al.Dietary L-arginine supplementation alleviates the intestinal injury and modulates the gut microbiota in broiler chickens challenged by Clostridium perfringens[J].Frontiers in Microbiology,2018,9:1716.
[76] ZHANG B B,LI G,SHAHID M S,et al.Dietary L-arginine supplementation ameliorates inflammatory response and alters gut microbiota composition in broiler chickens infected with Salmonella enterica serovar Typhimurium[J].Poultry Science,2020,99(4):1862-1874.  
[77] XUE G D,BAREKATAIN R,WU S B,et al.Dietary L-glutamine supplementation improves growth performance,gut morphology,and serum biochemical indices of broiler chickens during necrotic enteritis challenge[J].Poultry Science,2018,97(4):1334-1341.  
[78] TAN J Z,APPLEGATE T J,LIU S S,et al.Supplemental dietary L-arginine attenuates intestinal mucosal disruption during a coccidial vaccine challenge in broiler chickens[J].British Journal of Nutrition,2014,112(7):1098-1109.  
[79] GOTTARDO E T,PROKOSKI K,HORN D,et al.Regeneration of the intestinal mucosa in Eimeria and E. coli challenged broilers supplemented with amino acids[J].Poultry Science,2016,95(5):1056-1065.  
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