[1] DOMKE A V,CHARTIER C,GJERDE B,et al.Worm control practice against gastro-intestinal parasites in Norwegian sheep and goat flocks[J].Acta Veterinaria Scandinavica,2011,53(1):29.
[2] MAVROT F,HERTZBERG H,TORGERSON P.Effect of gastro-intestinal nematode infection on sheep performance:a systematic review and Meta-analysis[J].Parasites&Vectors,2015,8:557.
[3] The U.S. Department of Agriculture.Goat and kid predator and nonpredator death loss in the United States,2015[EB/OL].[2018-05-30].https://www.aphis.usda.gov/animal_health/nahms/general/downloads/goat_kid_deathloss_2015.pdf.
[4] PUGH D G,BAIRD A N,EDMONDSON M A,et al.Sheep,goat,and cervid medicine[M].3rd ed.New York:Elsevier,2021:98.
[5] MERCER J G,MITCHELL P I,MOAR K M,et al.Anorexia in rats infected with the nematode,
Nippostrongylus brasiliensis:experimental manipulations[J].Parasitology,2000,120(6):641-647.

[6] FISSIHA W,KINDE M Z.Anthelmintic resistance and its mechanism:a review[J].Infection and Drug Resistance,2021,14:5403-5410.
[7] NIXON S A,WELZ C,WOODS D J,et al.Where are all the anthelmintics?Challenges and opportunities on the path to new anthelmintics[J].International Journal for Parasitology:Drugs and Drug Resistance,2020,14:8-16.
[8] ARSENOPOULOS K V,FTHENAKIS G C,KATSAROU E I,et al.Haemonchosis:a challenging parasitic infection of sheep and goats[J].Animals,2021,11(2):363.
[9] PUGH D G,NAVARRE C B.Internal parasite control strategies[J].Veterinary Clinics of North America:Food Animal Practice,2001,17(2):231-244.

[10] WILLIAMS A R,MYHILL L J,STOLZENBACH S,et al.Emerging interactions between diet,gastrointestinal helminth infection,and the gut microbiota in livestock[J].BMC Veterinary Research,2021,17(1):62.
[11] SWEENY A R,CLERC M,PONTIFES P A,et al.Supplemented nutrition decreases helminth burden and increases drug efficacy in a natural host-helminth system[J].Proceedings of the Royal Society B:Biological Sciences,2021,288(1943):20202722.
[12] KHAN F A,SAHOO A,KARIM S A.Moderate and high levels of dietary protein on clinico-biochemical and production responses of lambs to repeated
Haemonchus contortus infection[J].Small Ruminant Research,2017,150:52-59.
[13] STARLING R Z C,DE ALMEIDA F A,VIANA M V G,et al.Losses caused by gastrointestinal nematode infections in Dorper lambs under two nutritional status[J].Revista Brasileira de Parasitologia Veterinaria,2019,28(4):652-660.

[14] ARSENOS G,FORTOMARIS P,PAPADOPOULOS E,et al.Growth and meat quality of kids of indigenous Greek goats (
Capra prisca) as influenced by dietary protein and gastrointestinal nematode challenge[J].Meat Science,2009,82(3):317-323.

[15] ATIBA E M,SUN Z W,ZHONG Q Z.Influence of metabolizable protein and minerals supplementation on detrimental effects of endoparasitic nematodes infection in small ruminants[J].Tropical Animal Health and Production,2020,52(5):2213-2219.

[16] DIAS E SILVA T P,VENTOSO BOMPADRE T F,DANASEKARAN D K,et al.
Trichostrongylus colubriformis infection:impact on digesta passage rate and lamb performance[J].Veterinary Parasitology,2019,272:17-22.
[17] HOUDIJK J G M,KYRIAZAKIS I,KIDANE A,et al.Manipulating small ruminant parasite epidemiology through the combination of nutritional strategies[J].Veterinary Parasitology,2012,186(1/2):38-50.
[18] ZHONG R Z,LIU H W,ZHOU D W,et al.The effects of road transportation on physiological responses and meat quality in sheep differing in age[J].Journal of Animal Science,2011,89(11):3742-3751.

[19] BONANNO A,DI MICELI G,DI GRIGOLI A,et al.Effects of feeding green forage of sulla (
Hedysarum coronarium L.) on lamb growth and carcass and meat quality[J].Animal,2011,5(1):148-154.

[20] LARSEN M,NANSEN P,GRØNVOLD J,et al.Biological control of gastro-intestinal nematodes-facts,future,or fiction?[J].Veterinary Parasitology,1997,72(3/4):479-492.
[21] TERRILL T H,MILLER J E,BURKE J M,et al.Experiences with integrated concepts for the control of
Haemonchus contortus in sheep and goats in the United States[J].Veterinary Parasitology,2012,186(1/2):28-37.
[22] HEALEY K,LAWLOR C,KNOX M R,et al.Field evaluation of
Duddingtonia flagrans IAH 1297 for the reduction of worm burden in grazing animals:pasture larval studies in horses,cattle and goats[J].Veterinary Parasitology,2018,258:124-132.
[23] EFSA.Panel on additives and products or substances used in animal feed (FEEDAP),scientific opinion on the safety and efficacy of BioWorma
®(
Duddingtonia flagrans NCIMB 30336) as a feed additive for all grazing animals[J].EFSA Journal,2020,18(7):6208.
[24] MONTANER S,GALIANO A,TRELIS M,et al.The role of extracellular vesicles in modulating the host immune response during parasitic infections[J].Frontiers in Immunology,2014,5:433.
[25] TZELOS T,MATTHEWS J B,BUCK A H,et al.A preliminary proteomic characterisation of extracellular vesicles released by the ovine parasitic nematode,
Teladorsagia circumcincta[J].Veterinary Parasitology,2016,221:84-92.
[26] COAKLEY G,MAIZELS R M,BUCK A H.Exosomes and other extracellular vesicles:the new communicators in parasite infections[J].Trends in Parasitology,2015,31(10):477-489.

[27] WANG L F,LI Z T,SHEN J,et al.Exosome-like vesicles derived by
Schistosoma japonicum adult worms mediates M1 type immune-activity of macrophage[J].Parasitology Research,2015,114(5):1865-1873.

[28] BUCK A H,COAKLEY G,SIMBARI F,et al.Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity[J].Nature Communications,2014,5:5488.
[29] HANSEN E P,FROMM B,ANDERSEN S D,et al.Exploration of extracellular vesicles from
Ascaris suum provides evidence of parasite-host cross talk[J].Journal of Extracellular Vesicles,2019,8(1):1578116.
[30] HARRIS N L,LOKE P.Recent advances in type-2-cell-mediated immunity:insights from helminth infection[J].Immunity,2017,47(6):1024-1036.

[31] CORTÉS A,TOLEDO R,CANTACESSI C.Classic models for new perspectives:delving into helminth-microbiota-immune system interactions[J].Trends in Parasitology,2018,34(8):640-654.

[32] RODRIGUES G C,VALE V L C,SILVA M C,et al.Immune response against
Haemonchus contortus and the Th1-Th2 paradigm in helminth infection[J].EC Microbiology,2017,9:152-159.
[33] FINKELMAN F D,SHEA-DONOHUE T,MORRIS S C,et al.Interleukin-4-and interleukin-13-mediated host protection against intestinal nematode parasites[J].Immunological Reviews,2004,201:139-155.
[34] HENDAWY S H M.Immunity to gastrointestinal nematodes in ruminants:effector cell mechanisms and cytokines[J].Journal of Parasitic Diseases,2018,42(4):471-482.

[35] YASUDA K,NAKANISHI K.Host responses to intestinal nematodes[J].International Immunology,2018,30(3):93-102.

[36] CHULANETRA M,CHAICUMPA W.Revisiting the mechanisms of immune evasion employed by human parasites[J].Frontiers in Cellular and Infection Microbiology,2021,11:702125.
[37] BERMINGHAM E N,MCNABB W C,TRELOAR B P,et al.Tissue protein synthesis in lambs infected with
Trichostrongylus colubriformis[J].Journal of Animal and Feed Sciences,2004,13(Suppl.1):589-592.
[38] LIU S M,MASTERS D G,ADAMS N R.Potential impact of nematode parasitism on nutrient partitioning for wool production,growth and reproduction in sheep[J].Australian Journal of Experimental Agriculture,2003,43(12):1409-1417.

[39] YU F,BRUCE L A,CALDER A G,et al.Subclinical infection with the nematode
Trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues[J].Journal of Animal Science,2000,78(2):380-390.

[40] JONES W O,SYMONS L E A.Protein synthesis in the whole body,liver,skeletal muscle and kidney cortex of lambs infected by the nematode
Trichostrongylus colubriformis[J].International Journal for Parasitology,1982,12(4):295-301.

[41] BERMINGHAM E N,MCNABB W C,REYNOLDS G W,et al.Whole-body irreversible loss rate of cysteine and valine in sheep with or without a
Trichostrongylus colubriformis infection[J].Asian-Australasian Journal of Animal Sciences,2000,13(Supplement):196-199.
[42] HOSKIN S O,LOBLEY G E,COOP R L,et al.The effect of cysteine and glutamine supplementation on sheep infected with
Trichostrongylus colubriformis[J].Proceedings of the New Zealand Society of Animal Production,2002,62:72-76.
[43] LEEMING E R,LOUCA P,GIBSON R,et al.The complexities of the diet-microbiome relationship:advances and perspectives[J].Genome Medicine,2021,13(1):10.
[44] BANCROFT A J,HAYES K S,GRENCIS R K.Life on the edge:the balance between macrofauna,microflora and host immunity[J].Trends in Parasitology,2012,28(3):93-98.

[45] LI R W,LI W Z,SUN J J,et al.The effect of helminth infection on the microbial composition and structure of the caprine abomasal microbiome[J].Scientific Reports,2016,6:20606.
[46] SIMCOCK D C,JOBLIN K N,SCOTT I,et al.Hypergastrinaemia,abomasal bacterial population densities and pH in sheep infected with
Ostertagia circumcincta[J].International Journal for Parasitology,1999,29(7):1053-1063.

[47] NICHOLLS C D,HAYES P R,LEE D L.Physiological and microbiological changes in the abomasum of sheep infected with large doses of
Haemonchus contortus[J].Journal of Comparative Pathology,1987,97(3):299-308.

[48] BROSSCHOT T P,REYNOLDS L A.The impact of a helminth-modified microbiome on host immunity[J].Mucosal Immunology,2018,11(4):1039-1046.

[49] FRICKE W F,SONG Y,WANG A J,et al.Type 2 immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite
Nippostrongylus brasiliensis[J].Microbiome,2015,3(1):40.
[50] RAMANAN D,BOWCUTT R,LEE S C,et al.Helminth infection promotes colonization resistance via type 2 immunity[J].Science,2016,352(6285):608-612.

[51] WANG T,VAN STEENDAM K,DHAENENS M,et al.Proteomic analysis of the excretory-secretory products from larval stages of
Ascaris suum reveals high abundance of glycosyl hydrolases[J].PLoS Neglected Tropical Diseases,2013,7(10):e2467.
[52] WALKER N D,MCEWAN N R,WALLACE R J.A pepD-like peptidase from the ruminal bacterium,
Prevotella albensis[J].FEMS Microbiology Letters,2005,243(2):399-404.

[53] AFRIN T,MURASE K,KOUNOSU A,et al.Sequential changes in the host gut microbiota during infection with the intestinal parasitic nematode
Strongyloides venezuelensis[J].Frontiers in Cellular and Infection Microbiology,2019,9:217.