[1] KOGUT M H.Impact of nutrition on the innate immune response to infection in poultry[J].Journal of Applied Poultry Research,2009,18(1):111-124.

[2] ALKIE T N,YITBAREK A,HODGINS D C,et al.Development of innate immunity in chicken embryos and newly hatched chicks:a disease control perspective[J].Avian Pathology,2019,48(4):288-310.

[3] LI Y L,LEI X Y,GUO W,et al.Transgenerational endotoxin tolerance-like effect caused by paternal dietary
Astragalus polysaccharides in broilers'jejunum[J].International Journal of Biological Macromolecules,2018,111:769-779.
[4] FAN H,LV Z P,GAN L P,et al.Transcriptomics-related mechanisms of supplementing laying broiler breeder hens with dietary daidzein to improve the immune function and growth performance of offspring[J].Journal of Agricultural and Food Chemistry,2018,66(8):2049-2060.

[5] ZHU Y F,LI S Z,DUAN Y L,et al.Effects of
in ovo feeding of vitamin C on post-hatch performance,immune status and DNA methylation-related gene expression in broiler chickens[J].The British Journal of Nutrition,2020,124(9):903-911.

[6] KARLSSON E A,BECK M A,MACIVER N J.Editorial:nutritional aspects of immunity and immunometabolism in health and disease[J].Frontiers in Immunology,2020,11:595115.
[7] 李德生,娄玉杰.胚蛋给养对家禽早期营养及免疫应答影响研究进展[J].中国畜牧杂志,2016,52(7):86-91. LI D S,LOU Y J.Research progress of
in ovo feeding on early nutrition and immune response in poultry[J].Chinese Journal of Animal Science,2016,52(7):86-91.(in Chinese)
[8] OVIEDO-RONDÓN E O,LEANDRO N M,ALI R,et al.Broiler breeder feeding programs and trace minerals on maternal antibody transfer and broiler humoral immune response1[J].Journal of Applied Poultry Research,2013,22(3):499-510.

[9] TRIQUES G E,DE CRISTO A B,CANEVESE M,et al.Effect of antioxidant supplementation in diets of roosters during the post-peak phase on reproduction and production characteristics of offspring[J].Ciência Animal Brasileira,2019,20:1-13,e-43072.
[10] PAPARO L,DI COSTANZO M,DI SCALA C,et al.The influence of early life nutrition on epigenetic regulatory mechanisms of the immune system[J].Nutrients,2014,6(11):4706-4719.

[11] MAKOWSKI L,CHAIB M,RATHMELL J C.Immunometabolism:from basic mechanisms to translation[J].Immunological Reviews,2020,295(1):5-14.

[12] HUMPHREY B D,RUDRAPPA S G.Increased glucose availability activates chicken thymocyte metabolism and survival[J].The Journal of Nutrition,2008,138(6):1153-1157.

[13] RUDRAPPA S G,HUMPHREY B D.Energy metabolism in developing chicken lymphocytes is altered during the embryonic to posthatch transition[J].The Journal of Nutrition,2007,137(2):427-432.

[14] HENDRIKS W H,VERSTEGEN M W A,BABINSZKY L.Poultry and pig nutrition:challenges of the 21st century[M].Wageningen:Wageningen Academic Publishers,2019:428.
[15] BERROCOSO J D,KIDA R,SINGH A K,et al.Effect of
in ovo injection of raffinose on growth performance and gut health parameters of broiler chicken[J].Poultry Science,2017,96(6):1573-1580.

[16] KADAM M M,BHANJA S K,MANDAL A B,et al.Effect of
in ovo threonine supplementation on early growth,immunological responses and digestive enzyme activities in broiler chickens[J].British Poultry Science,2008,49(6):736-741.

[17] LEE S H,LILLEHOJ H S,JANG S I,et al.Effects of
in ovo injection with Selenium on immune and antioxidant responses during experimental necrotic enteritis in broiler chickens[J].Poultry Science,2014,93(5):1113-1121.

[18] GUO S S,CHENG Q,LI Y H,et al.Effects of dietary coated-oleum cinnamomi supplementation on the immunity and intestinal integrity of broiler chickens[J].Animal Science Journal,2018,89(11):1581-1590.

[19] PAN T R,LIU T Q,TAN S R,et al.Lower selenoprotein T expression and immune response in the immune organs of broilers with exudative diathesis due to selenium deficiency[J].Biological Trace Element Research,2018,182(2):364-372.

[20] KOGUT M H.Issues and Consequences of using nutrition to modulate the avian immune response[J].Journal of Applied Poultry Research,2017,26(4):605-612.

[21] LIU L,SHEN J,ZHAO C,et al.Dietary
Astragalus polysaccharide alleviated immunological stress in broilers exposed to lipopolysaccharide[J].International Journal of Biological Macromolecules,2015,72:624-632.
[22] LI R,SONG Z H,ZHAO J F,et al.Dietary
L-theanine alleviated lipopolysaccharide-induced immunological stress in yellow-feathered broilers[J].Animal Nutrition,2018,4(3):265-272.

[23] BI Y,NAN X M,ZHENG S S,et al.Effects of dietary threonine and immune stress on growth performance,carcass trait,serum immune parameters,and intestinal
MUC2 and
NF-
κB gene expression in Pekin ducks from hatch to 21 days[J].Poultry Science,2018,97(1):177-187.

[24] CHEN Z,ZHOU Y W,LIANG C,et al.Effects of γ-aminobutyric acid on the tissue structure,antioxidant activity,cell apoptosis,and cytokine contents of bursa of Fabricius in chicks under heat stress[J].Archives Animal Breeding,2016,59(1):97-105.

[25] HU H,DAI S F,LI J Q,et al.Glutamine improves heat stress-induced oxidative damage in the broiler thigh muscle by activating the nuclear factor erythroid 2-related 2/Kelch-like ECH-associated protein 1 signaling pathway[J].Poultry Science,2020,99(3):1454-1461.

[26] HUANG Y L,LUO Q H,XIAO F,et al.Research note:responses of growth performance,immune traits,and small intestinal morphology to dietary supplementation of Chromium propionate in heat-stressed broilers[J].Poultry Science,2020,99(10):5070-5073.

[27] MIN Y N,NIU Z Y,SUN T T,et al.Vitamin E and vitamin C supplementation improves antioxidant status and immune function in oxidative-stressed breeder roosters by up-regulating expression of
GSH-
Px gene[J].Poultry Science,2018,97(4):1238-1244.

[28] CHEN Y P,ZHANG H,CHENG Y F,et al.Dietary
L-threonine supplementation attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage of broiler chickens at an early age[J].The British Journal of Nutrition,2018,119(11):1254-1262.

[29] XIAO M,MI Y L,LIU L J,et al.Taurine regulates mucosal barrier function to alleviate lipopolysaccharide-induced duodenal inflammation in chicken[J].Amino Acids,2018,50(11):1637-1646.

[30] DU E C,WANG W W,GAN L P,et al.Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with
Clostridium perfringens[J].Journal of Animal Science and Biotechnology,2016,7(1):19.
[31] ZHAO X N,YANG J,WANG L L,et al.Protection mechanism of
Clostridium butyricum against
Salmonella enteritidis infection in broilers[J].Frontiers in Microbiology,2017,8:1523.
[32] SUN J J,ZHANG C,ZHANG B K.Research note:effects of organic Zinc on broiler intestinal permeability and integrity in clostridium perfringens-challenged condition[J].Poultry Science,2020,99(12):6653-6656.

[33] OKOROAFOR O N,OGUNNIRAN T M,IKENNA-EZEH N H,et al.Effects of dietary supplementation of vitamins E and C on oxidative stress induced by a Nigerian velogenic strain of the Newcastle disease virus (KUDU 113) in the brain and bursa of Fabricius of broiler chickens[J].Veterinary World,2021,14(9):2452-2461.
[34] MING K,HE M,SU L L,et al.The inhibitory effect of phosphorylated
Codonopsis pilosula polysaccharide on autophagosomes formation contributes to the inhibition of duck hepatitis A virus replication[J].Poultry Science,2020,99(4):2146-2156.

[35] AKHTAR T,ARA G,ALI N,et al.Effects of dietary supplementation of mannan-oligosaccharide on virus shedding in avian influenza (H
9N
2) challenged broilers[J].Iranian Journal of Veterinary Research,2016,17(4):268-272.
[36] SHOJADOOST B,KULKARNI R R,YITBAREK A,et al.Dietary selenium supplementation enhances antiviral immunity in chickens challenged with low pathogenic avian influenza virus subtype H
9N
2[J].Veterinary Immunology and Immunopathology,2019,207:62-68.
[37] KLASING K C.Nutritional modulation of resistance to infectious diseases[J].Poultry Science,1998,77(8):1119-1125.

[38] HUGHES V.Epigenetics:the sins of the father[J].Nature,2014,507(7490):22-24.

[39] CLAYCOMBE K J,BRISSETTE C A,GHRIBI O.Epigenetics of inflammation,maternal infection,and nutrition[J].The Journal of Nutrition,2015,145(5):1109S-1115S.
[40] VAN DER HEIJDEN C D C C,NOZ M P,JOOSTEN L A B,et al.Epigenetics and trained immunity[J].Antioxidants&Redox Signaling,2018,29(11):1023-1040.

[41] 李昌武.肉种鸡锌营养对子代肉鸡免疫机能的影响及其分子机制[D].博士学位论文.北京:中国农业大学,2015. LI C W.Effects of dietary zinc nutrition of the broiler breeders on the immunity function of their offsprings and the related molecular mechanism[D].Ph.D. Thesis.Beijing:China Agricultural University,2015.(in Chinese)
[42] 任小春,李玉龙,武圣儒,等.黄芪多糖对种公鸡不同组织miR-16表达的影响及其功能预测分析[J].动物营养学报,2016,28(6):1887-1898. REN X C,LI Y L,WU S R,et al.Effects and bioinformatic analysis of
Astragalus polysaccharide on miR-16 expression in different tissue of breeder cocks[J].Chinese Journal of Animal Nutrition,2016,28(6):1887-1898.(in Chinese)
[43] LI S Z,ZHI L H,LIU Y L,et al.Effect of
in ovo feeding of folic acid on the folate metabolism,immune function and epigenetic modification of immune effector molecules of broiler[J].The British Journal of Nutrition,2016,115(3):411-421.

[44] LILLYCROP K A,PHILLIPS E S,TORRENS C,et al.Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring[J].The British Journal of Nutrition,2008,100(2):278-282.

[45] BAO B,AHMAD A,KONG D J,et al.Hypoxia induced aggressiveness of prostate cancer cells is linked with deregulated expression of VEGF,IL-6 and miRNAs that are attenuated by CDF[J].PLoS One,2012,7(8):e43726.
[46] SZARC VEL SZIC K,NDLOVU M N,HAEGEMAN G,et al.Nature or nurture:let food be your epigenetic medicine in chronic inflammatory disorders[J].Biochemical Pharmacology,2010,80(12):1816-1832.

[47] ALEXANDER M,TURNBAUGH P J.Deconstructing mechanisms of diet-microbiome-immune interactions[J].Immunity,2020,53(2):264-276.

[48] KLASING K C.Nutrition and the immune system[J].British Poultry Science,2007,48(5):525-537.

[49] BELKAID Y,HAND T W.Role of the microbiota in immunity and inflammation[J].Cell,2014,157(1):121-141.

[50] LIN L,ZHANG J Q.Role of intestinal microbiota and metabolites on gut homeostasis and human diseases[J].BMC Immunology,2017,18(1):2.
[51] SATYARAJ E.Emerging paradigms in immunonutrition[J].Topics in Companion Animal Medicine,2011,26(1):25-32.

[52] KIM C H.Immune regulation by microbiome metabolites[J].Immunology,2018,154(2):220-229.

[53] PENDER C M,KIM S,POTTER T D,et al.
In ovo supplementation of probiotics and its effects on performance and immune-related gene expression in broiler chicks[J].Poultry Science,2017,96(5):1052-1062.

[54] LI X Y,WU S R,LI X Y,et al.Simultaneous supplementation of
Bacillus subtilis and antibiotic growth promoters by stages improved intestinal function of pullets by altering gut microbiota[J].Frontiers in Microbiology,2018,9:2328.
[55] LEE K,HWANG S,PAIK D J,et al.
Bacillus-derived poly-γ-glutamic acid reciprocally regulates the differentiation of T helper 17 and regulatory T cells and attenuates experimental autoimmune encephalomyelitis[J].Clinical and Experimental Immunology,2012,170(1):66-76.

[56] GONG H Z,WU M,LANG W Y,et al.Effects of laying breeder hens dietary β-carotene,curcumin,allicin,and sodium butyrate supplementation on the growth performance,immunity,and jejunum morphology of their offspring chicks[J].Poultry Science,2020,99(1):151-162.

[57] SHOJADOOST B,KULKARNI R R,BRISBIN J T,et al.Interactions between
Lactobacilli and chicken macrophages induce antiviral responses against avian influenza virus[J].Research in Veterinary Science,2019,125:441-450.
[58] LUO D,LI J L,XING T,et al.Combined effects of xylo-oligosaccharides and coated sodium butyrate on growth performance,immune function,and intestinal physical barrier function of broilers[J].Animal Science Journal,2021,92(1):e13545.
[59] ZHOU Z Y,PACKIALAKSHMI B,MAKKAR S K,et al.Effect of butyrate on immune response of a chicken macrophage cell line[J].Veterinary Immunology and Immunopathology,2014,162(1/2):24-32.
[60] SHAH Y M,MA X C,MORIMURA K,et al.Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression[J].American Journal of Physiology Gastrointestinal and Liver Physiology,2007,292(4):G1114-G1122.
[61] WILS-PLOTZ E L,KLASING K C.Effects of immunomodulatory nutrients on growth performance and immune-related gene expression in layer chicks challenged with lipopolysaccharide[J].Poultry Science,2017,96(3):548-555.