本文旨在研究谷胱甘肽（glutathione,GSH）对育肥羊生长性能及生长激素/胰岛素样生长因子-Ⅰ（GH/IGF-Ⅰ）轴的影响。试验采用单因素随机区组设计，将12只3月龄东北细毛羊与德国肉用美利奴羊杂交一代育肥羊分为3组，每组4个重复，每组羊公母各占1/2。对照组饲喂基础日粮，试验组1和试验组2分别在基础日粮的基础上添加500和800 mg/kg的GSH，试验期为60 d。测定谷胱甘肽对育肥羊生长性能和血清中GH和IGF-Ⅰ浓度及组织中IGF-Ⅰ mRNA表达量的影响。结果表明：日粮中添加GSH显著提高了试验组育肥羊的日增重（P＜0.05），显著降低了试验组育肥羊的料重比（P＜0.05），但对育肥羊的日采食量无显著影响（P＞0.05）；试验20、40和60 d时，试验组育肥羊血清中的生长激素（GH）和胰岛素样生长因子Ⅰ（IGF-Ⅰ）水平显著高于对照组（P＜0.05）；与对照组相比，试验组育肥羊肝脏和背最长肌中IGF-Ⅰ mRNA的表达量有所提高，当GSH添加量达到800 mg/kg时，育肥羊背最长肌中IGF-Ⅰ mRNA的表达量显著高于对照组（P＜0.05）。因此，本试验初步得出，日粮中添加GSH促进了肝脏IGF-Ⅰ的分泌，提高了肌肉中IGF-Ⅰ mRNA的表达量，提高血清中GH与IGF-Ⅰ浓度，从而促进了育肥羊的生长。

This experiment was conducted to study the effects of glutathione (GSH) on growth performance and growth hormone/insulinlike growth factorⅠaxis in fattening sheep. Twelve sheep aged at three months were randomly allocated into three groups: control (basal diets), treatments 1 (basal diets supplemented with 500 mg/kg GSH) and 2 (basal diets supplemented with 800 mg/kg GSH), with 4 replicates in each treatment. The trial lasted for 60 days. Effects of dietary supplementation of GSH on growth, GH and IGF-Ⅰlevels in serum and IGF-Ⅰ mRNA expression in tissues of fattening sheep were studied. The results showed that the average daily gain (ADG) and the ratio of feed to gain (F/G) was decreased significantly (P＜0.05) for sheep supplemented with GSH, and there were no significant differences about average daily feed intake (ADFI) (P＞0.05) in all groups. The serum GH and IGF-Ⅰlevels of sheep in all GSH groups were significantly higher than those in control group (P＜0.05) at trial period 20, 40 and 60 d. Compared with control group, IGF-Ⅰ mRNA expression in liver and muscle of sheep in all GSH groups were increased, and IGF-Ⅰ mRNA expression in muscle of treatment 2 was increased significantly (P＜0.05). These results indicated that dietary GSH supplementation in diets could stimulate the secretion of IGF-Ⅰ in liver and the expression of IGF-Ⅰ mRNA in muscles, increase the serum GH and IGF-Ⅰ levels, and thereby promote the growth of fattening sheep.