[1] JENSEN R G.The composition of bovine milk lipids:January 1995 to December 2000[J].Journal of Dairy Science,2002,85(2):295-350.

[2] LOPEZ C,MENARD O.Human milk fat globules:polar lipid composition and in situ structural investigations revealing the heterogeneous distribution of proteins and the lateral segregation of sphingomyelin in the biological membrane[J].Colloids and Surfaces B:Biointerfaces,2011,83(1):29-41.

[3] CAVALETTO M,GIUFFRIDA M G,CONTI A.Milk fat globule membrane components-a proteomic approach[J].Advances in Experimental Medicine and Biology,2008,606:129-141.
[4] LOPEZ C,CAUTY C,GUYOMARC'H F.Organization of lipids in milks, infant milk formulas and various dairy products:role of technological processes and potential impacts[J].Dairy Science & Technology,2015,95(6):863-893.

[5] LEE H,PADHI E,HASEGAWA Y,et al.Compositional dynamics of the milk fat globule and its role in infant development[J].Frontiers in Pediatrics,2018,6(313):1-21.
[6] ARRANZ E,CORREDIG M.Invited review:Milk phospholipid vesicles,their colloidal properties, and potential as delivery vehicles for bioactive molecules[J].Journal of Dairy Science,2017,100(6):4213-4222.

[7] BARGMANN W,KNOOP A.Morphology of lactation;light & electro-microscopic studies on the mammary glands of rats] [J].Zeitschrift fur Zellforschung and Mikroskopische Anatomie,1959,49(3):344-388.

[8] KEENAN T W,DYLEWSKI D P.Intracellular origin of milk lipid globules and the nature and structure of the milk lipid globule membrane.Advanced dairy chemistry-2-lipids[M].2nd ed.London:Chapman&Hall,1995.
[9] KEENAN T W,MATHUR I H.Intracellular origin of milk lipid globules and the nature of the milk lipid globule membrane.Advanced dairy chemistry-2-lipids[M].3rd ed.New York:Springer,2006.
[10] MEAD J N.Structure of milk fat globule membrane in the mammary alveolus,by mead Johnson nutrition,CC BY 4.0[EB/OL].(2017-09-22)[2019-04-07].https://commons.wikimedia.org/w/index.php?curid=62832771.
[11] KEENAN T W,MATHER I H,DYLEWSKI D P.Fundamentals of dairy chemistry[M].3rd ed.New York:Van Nostrand Reinhold,1988.
[12] FOX P F,UNIACKE-LOWE T,MCSWEENEY P L H,et al.Dairy chemistry and biochemistry.Chapter 3 lipids[M].Switzerland:Springer,2015.
[13] WOODING F B,SARGEANT T J.Immunocytochemical evidence for golgi vesicle involvement in milk fat globule secretion[J].Journal of Histochemistry & Cytochemistry,2015,63(12):943-951.

[14] HAYASHI S,SMITH L M.Membranous material of bovine milk fat globules.Ⅰ.Comparison of membranous fractions released by deoxycholate and by churning[J].Biochemistry,1965,4(12):2550-2557.

[15] WOODING F B P.The structure of the milk fat globule membrane[J].Journal of Ultrastructure Research,1971,37(3):388-400.
[16] KEENAN T W,PATTON S.The structure of milk:Handbook of milk composition.[M].San Diego:Academic Press,Inc.,1995.
[17] MATHER I H.Milk fat globule membrane.In Encyclopedia of dairy sciences.[M].2nd ed.Oxford:Academic,2011.
[18] MC PHERSON G A.A practical computer-based approach to the analysis of radioligand binding experiments[J].Comput Methods Programs Biomed,1983,17(1/2):107-113.
[19] KEENAN T W,DYLEWSKI D P,WOODFORD T A,et al.Developments in dairy chemistry-2-lipids[M].London:Applied Science Publishers,1983.
[20] BRUNNER J R.Fundamentals of dairy chemistry[M].2nd ed.Westport:AVI Publishing Co.,Inc.,1974.
[21] MULDER H,WALSTRA P.The milk fat globule:emulsion science as applied to milk products and comparable foods.[M].Wageningen:Podoc,1974.
[22] MATHER I H.A review and proposed nomenclature for major proteins of the milk-fat globule membrane[J].Journal of Dairy Science,2000,83(2):203-247.

[23] YANG Y,ANDERSON E,ZHANG S.Evaluation of six sample preparation procedures for qualitative and quantitative proteomics analysis of milk fat globule membrane[J].Electrophoresis,2018,39(18):2332-2339.

[24] 张娜娜,李万宏,李发弟,等.羊乳脂球膜蛋白研究的新进展[J].动物营养学报,2017,29(4):1117-1123.
[25] 赵小伟,杨永新,黄冬维,等.牛奶和山羊奶中乳脂球膜蛋白的比较研究[J].中国畜牧兽医, 2016,43(11):2963-2969.
[26] 叶清,杨梅,梁肖娜,等.人初乳与牛初乳中乳脂肪球膜蛋白质组成的对比研究[J].乳业科学与技术,2016,39(05):13-18.
[27] 杨梅,彭秀明,武俊瑞,等.人乳与牛乳乳脂肪球膜蛋白质组的对比研究[J].现代食品科技,2016,32(8):284-289.
[28] 景萌娜,姜铁民,刘斌,等.母乳和牛乳中乳脂肪球膜蛋白质的差异分析[J].食品科学,2016,37(20):69-74.
[29] BENYACOUB J,BLUM-SPERISEN S,BOSCO M N,et al.Infant formula with probiotics and milk fat globule membrane components:US, No.2012/0321600A1[P/OL].[2011-06-16] [2019-04-07].http://europepmc.org/patents/PAT/WO2011069987.
[30] RUEDA R,BARRANCO A,RAMIREZ M,et al.Infant formulas for early brain development:US,No.2008/0003330A1[P/OL].[2009-04-22] [2019-04-07].http://www.freepatentsonline.com/EP2048973.html.
[31] PARKER P,SANDO L,PEARSON R,et al.Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells[J].Glycoconjugate Journal,2010,27(1):89-97.

[32] MARTIN H M,HANCOCK J T,SALISBURY V,et al.Role of xanthine oxidoreductase as an antimicrobial agent[J].Infection and Immunity,2004,72(9):4933-4939.

[33] SNOW D R,WARD R E,OLSEN A,et al.Membrane-rich milk fat diet provides protection against gastrointestinal leakiness in mice treated with lipopolysaccharide[J].Journal of Dairy Science,2011,94(5):2201-2212.

[34] DEMMER E,VAN LOAN M D,RIVERA N,et al.Addition of a dairy fraction rich in milk fat globule membrane to a high-saturated fat meal reduces the postprandial insulinaemic and inflammatory response in overweight and obese adults[J].Journal of Nutritional Science,2016(5):1-14.
[35] LI T,GAO J,DU M,et al.Milk at globule membrane attenuates high-fat diet-induced obesity by inhibiting adipogenesis and increasing uncoupling protein 1 expression in white adipose tissue of mice[J].Nutrients,2018,10(331):1-12.
[36] ROGERS T S,DEMMER E,RIVERA N,et al.The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults:an exploratory study[J].Nutrition&Metabolism,2017,14(36):1-9.
[37] BEALS E,KAMITA S G,SACCHI R,et al.Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects[J].Journal of Nutritional Science,2019(8):1-16.
[38] ZANABRIA R,TELLEZ A M,GRIFFITHS M W,et al.The antiproliferative properties of the milk fat globule membrane are affected by extensive heating[J].Dairy Science&Technology,2014,94(5):439-453.
[39] SHARMA S,CHOPRA K,KULKARNIS K,et al.Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway[J].Clinical and Experimental Immunology,2007,147(1):155-163.
[40] LI H,XU W,MA Y,et al.Milk fat globule membrane protein promotes C2C12 cell proliferation through the PI3K/Akt signaling pathway[J].International journal of biological macromolecules,2018,114:1305-1314.
[41] HARAMIZU S,MORI T,YANO M,et al.Habitual exercise plus dietary supplementation with milk fat globule membrane improves muscle function deficits via neuromuscular development in senescence-accelerated mice[J].Springerplus,2014,3(339):1-17.
[42] ZANABRIA R,TELLEZ A M,GRIFFITHS M,et al.Milk fat globule membrane isolate induces apoptosis in HT-29 human colon cancer cells[J].Food & Function,2013,4(2):222-230.

[43] ZANABRIA R,TELLEZ A M,GRIFFITHS M,et al.Modulation of immune function by milk fat globule membrane isolates[J].Journal of Dairy Science,2014,97(4):2017-2026.

[44] XU S,WALKLING-RIBEIRO M,GRIFFITHS M W,et al.Pulsed electric field processing preserves the antiproliferative activity of the milk fat globule membrane on colon carcinoma cells[J].Journal of Dairy Science,2015,98(5):2867-2874.

[45] JI X,XU W,CUI J,et al.Goat and buffalo milk fat globule membranes exhibit better effects at inducing apoptosis and reduction the viability of HT-29 cells[J].Scientific Reports,2019,9(1):2577:e1-14.
[46] SNOW D R,JIMENEZ-FLORES R,WARD R E,et al.Dietary milk fat globule membrane reduces the incidence of aberrant crypt foci in Fischer-344 rats[J].Journal of Agricultural and Food Chemistry,2010,58(4):2157-2163.

[47] CLARE D A,ZHENG Z,HASSAN H M,et al.Antimicrobial properties of milkfat globule membrane fractions[J].Journal of Food Protection,2008,71(1):126-133.

[48] GURI A,GRIFFITHS M,KHURSIGARA C M,et al.The effect of milk fat globules on adherence and internalization of
Salmonella enteritidis to HT-29 cells[J].Journal of Dairy Science,2012,95(12):6937-6945.

[49] TELLEZ A,CORREDIG M,GURI A,et al.Bovine milk fat globule membrane affects virulence expression in
Escherichia coli O157:H7[J].Journal of Dairy Science,2012,95(11):6313-6319.

[50] TIMBY N,HERNELL O,VAARALA O,et al.Infections in infants fed formula supplemented with bovine milk fat globule membranes[J].Journal of Pediatric Gastroenterology and Nutrition,2015,60(3):384-389.

[51] WANG X,HIRMO S,WILLEN R,et al.Inhibition of helicobacter pylori infection by bovine milk glycoconjugates in a BAlb/cA mouse model[J].Journal of Medical Microbiology,2001,50(5):430-435.

[52] FULLER K L,KUHLENSCHMIDT T B,KUHLENSCHMIDT M S,et al.Milk fat globule membrane isolated from buttermilk or whey cream and their lipid components inhibit infectivity of rotavirus
in vitro[J].Journal of Dairy Science,2013,96(6):3488-3497.

[53] DOUELLOU T,MONTEL M C,THEVENOT SERGENTET D.Invited review:Anti-adhesive properties of bovine oligosaccharides and bovine milk fat globule membrane-associated glycoconjugates against bacterial food enteropathogens[J].Journal of dairy science,2017,100(5):3348-3359.

[54] LOPEZ C,MAILLARD M B,BRIARD-BION V,et al.Lipolysis during ripening of Emmental cheese considering organization of fat and preferential localization of bacteria[J].Journal of agricultural and food chemistry,2006,54(16):5855-5867.

[55] KUO M I, GUNASEKARAN S.Effect of freezing and frozen storage on microstructure of Mozzarella and pizza cheeses[J].LWT-Food Science and Technology,2009,42(1):9-16.

[56] STEIL D,SCHEPERS C L,POHLENTZ G,et al.Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment[J].Journal of lipid research,2015,56(12):2322-2336.

[57] TIMBY N,DOMELLOF M,LONNERDAL B,et al.Supplementation of infant formula with bovine milk fat globule membranes[J].Advances in Nutrition,2017,8(2):351-355.

[58] BILLEAUD C,PUCCIO G,SALIBA E,et al.Safety and tolerance evaluation of milk fat globule membrane-enriched infant formulas:a randomized controlled multicenter non-inferiority trial in healthy term infants[J].Clinical Medicine Insights Pediatrics,2014(8):51-60.
[59] GURNIDA D A,ROWAN A M,IDJRADINATA P,et al.Association of complex lipids containing gangliosides with cognitive development of 6-month-old infants[J].Early Human Development,2012,88(8):595-601.

[60] TIMBY N,LONNERDAL B,HERNELL O,et al.Cardiovascular risk markers until 12 mo of age in infants fed a formula supplemented with bovine milk fat globule membranes[J].Pediatrics Researth,2014,76(4):394-400.

[61] BAARS A,OOSTING A,ENGELS E,et al.Milk fat globule membrane coating of large lipid droplets in the diet of young mice prevents body fat accumulation in adulthood[J].British Journal of Nutrition,2016,115(11):1930-1937.

[62] 张丹丹,周洁菲,钱林溪.乳脂球膜在婴幼儿及中老年人群中的应用进展[J].医学研究生学报,2019,32(2):211-215.
[63] 张波,苏宜香,杨玉凤.乳脂球膜与婴幼儿脑发育及健康的研究进展[J].中国儿童保健杂志,2016,24(1):43-47.
[64] HERNELL O,TIMBY N,DOMELLOF M,et al.Clinical benefits of milk fat globule membranes for infants and children[J].The Journal of pediatrics,2016,173(Suppl.):60-65.
[65] SOGA S,OTA N,SHIMOTOYODOME A.Dietary milk fat globule membrane supplementation combined with regular exercise improves skeletal muscle strength in healthy adults:a randomized double-blind, placebo-controlled, crossover trial[J].Nutrition Journal,2015,14(85):1-6.
[66] KIM H,SUZUKI T,KIM M,et al.Effects of exercise and milk fat globule membrane(MFGM)supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women:a randomized double blind,placebo-controlled,follow-up trial[J].PLoS One,2015,10(2):e0116256.