Arginine (Arg), as an important essential amino acid, presents many physiological and biochemical functions in young mammals. Deficiency of Arg often occurs in suckling piglets due to insufficient Arg in breast milk. Considering the antagonism and side-effects of exogenous Arg, the endogenous synthesis of Arg plays an important role in Arg balance in piglets. Therefore, the researches on Arg nutrition in suckling piglets focus on the regulation of endogenous synthesis of Arg. This article reviewed the synthesis pathway, synthetic sites and regulation of endogenous synthesis of Arg in piglets in order to facilitate the understanding of regulation technology of endogenous synthesis of Arg in piglet production.［Chinese Journal of Animal Nutrition，2011，23（1）：5-9］