［1］HIBBS J B, TAINTOR R R, VAVRIN Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite[J]. Science, 1987, 235:473-476.
[2]PALMER R M, FERRIGE A G, MONCADA S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor[J]. Nature, 1987, 327:524-526.
[3]IGNARRO L J, BUGA G M, WOOD K S, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84:9265-9269.
[4]WU G, MORRIS S M Jr. Arginine metabolism: nitric oxide and beyond[J]. The Journal of Biochemistry, 1998, 336:1-17.
[5]LOSCALZO J. L-arginine and atherothrombosis[J]. The Journal of Nutrition, 2004, 134:2798S-2800S.
[6]MORI M, GOTOH T. Arginine metabolic enzymes, nitric oxide and infection[J]. The Journal of Nutrition, 2004, 134:2820S-2825S.
[7]JOBGEN W S, FRIED S K, FU W J ,et al. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates[J]. The Journal of Nutritional Biochemistry, 2006, 17:571-588.
[8]STUEHR D J. Enzymes of the L-arginine to nitric oxide pathway[J]. The Journal of Nutrition, 2004, 134:2748S-2751S.
[9]ALDERTON W K, COOPER C E, KNOWLES R G. Nitric oxide synthases: structure, function and inhibition[J]. The Journal of Biochemistry, 2001, 357:593-615.
[10]MORRIS S M Jr. Enzymes of arginine metabolism[J]. The Journal of Nutrition, 2004, 134:2743S-2747S.
[11]BATES T E, LOESCH A, BURNSTOCK G, et al. Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?[J]. Biochemical and Biophysical Research Communications, 1996, 218:40-44.
[12]KOHLI R, MEININGER C J, HAYNES T E, et al. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats[J]. The Journal of Nutrition, 2004, 134:600-608.
[13]ROY D, PERREAULT M, MARETTE A. Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is no dependent[J]. American Journal of Physiology, 1998, 274:E692-E699.
[14]BALON T W, JASMAN A P, YOUNG J C. Effects of chronic N (omega)-nitro-L-arginine methyl ester administration on glucose tolerance and skeletal muscle glucose transport in the rat[J]. Nitric Oxide, 1999, 3:312-320.
[15]BARON A D, ZHU J S, MARSHALL S, et al. Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats[J]. American Journal of Physiology, 1995, 269:E709- E715.
[16]LAAKSO M, EDELMAN S V, BRECHTEL G, et al. Impaired insulinmediated skeletal muscle blood flow in patients with INDDM [J]. Diabetes, 1992, 41:1076-1083.
[17]SALIL G, NEVIN K G, RAJAMOHAN T. Arginine rich coconut kernel protein modulates diabetes in alloxan treated rats [J]. Chemico-Biological Interactions, 2010, 189(1/2):107-111.
[18]HORTON R A, CEPPI E D, KNOWLES R G, et al. Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock[J]. The Journal of Biochemistry, 1994, 299:735-739.
[19]SPRANGERS F, SAUERWEIN H P, ROMIJN J A,et al. Nitric oxide inhibits glycogen synthesis in isolated rat hepatocytes [J]. The Journal of Biochemistry， 1998, 330:1045-1049.
[20]BALON T W, NADLER J L. Evidence that nitric oxide increases glucose transport in skeletal muscle[J]. Journal of Applied Physiology, 1997, 82:359-363.
[21]YOUNG M E, RADDA G K, LEIGHTON B. Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro[J]. The Journal of Biochemistry, 1997, 322:223-228.
[22]JESSEN N, GOODYEAR L J. Contraction signaling to glucose transport in skeletal muscle[J]. Journal of Applied Physiology, 2005, 99:330-337.
[23]TANAKA T, NAKATANI K, MORIOKA K, et al. Nitric oxide stimulates glucose transport through insulin-independent GLUT4 translocation in 3T3-L1 adipocytes[J]. European Journal of Endocrinology, 2003, 149:61-67.
[24]ROY D, PERREAULT M, MARETTE A. Insulin stimulation of glucose uptake in skeletal muscles and adipose tissues in vivo is no dependent[J]. American Journal of Physiology, 1998, 274:E692-E699.
[25]MATSUMOTO A, HIRATA Y, MOMOMURA S, et al. Increased nitric oxide production during exercise[J]. Lancet, 1994, 343:849-850.
[26]PATIL R D, DICARLO S E, COLLINS H L. Acute exercise enhances nitric oxide modulation of vascular response to phenylephrine[J]. American Journal of Physiology, 1993, 265:H1184-H1188.
[27]SESSA W C, PRITCHARD K, SEYEDI N, et al. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression[J]. Circulation Research, 1994, 74:349-353.
[28]ROBERTS C K, BARNARD R J, JASMAN A, et al. Acute exercise increases nitric oxide synthase activity in skeletal muscle[J]. American Journal of Physiology, 1999, 277:E390-E394.
[29]ROBERTS C K, BARNARD R J, SCHECK S H, et al. Exercise-stimulated glucose transport in skeletal muscle is nitric oxide dependent[J]. American Journal of Physiology, 1997, 273:E220-E225.
[30]SHEARER J, FUEGER P T, VORNDICK B, et al. AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide[J]. Diabetes, 2004, 53:1429-1435.
[31]YOUNG M, RADDA G, LEIGHTON B. Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro[J]. The Journal of Biochemistry, 1997, 322:223-228.
[32]YOUNG M E, LEIGHTON B. Fuel oxidation in skeletal muscle is increased by nitric oxide/cGMP-evidence for involvement of cGMP-dependent protein kinase[J]. FEBS Letters, 1998, 424:79-83.
[33]YOUNG M E, LEIGHTON B. Evidence for altered sensitivity of the nitric oxide/cGMP signalling cascade in insulin-resistant skeletal muscle[J]. The Journal of Biochemistry, 1998, 329:73-79.
[34]MONTI L D, VALSECCHI G, COSTA S, et al. Effects of endothelin-1 and nitric oxide on glucokinase activity in isolated rat hepatocytes[J]. Metabolism-Clinical and Experimental, 2000, 49:73-80.
[35]STADLER J, BARTON D, BEIL-MOELLER H, et al. Hepatocyte nitric oxide biosynthesis inhibits glucose output and competes with urea synthesis for L-arginine[J]. American Journal of Physiology, 1995, 268:G183-G188.
[36]ZHONG W, ZOU G, GU J, et al. L-arginine attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells[J]. Diabetes Research and Clinical Practice, 2010, 89(1):38-45.
[37]GIORDANO A, TONELLO C, BULBARELLI A, et al. Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus[J]. FEBS Letters, 2002, 514:135-140.
[38]ENGELI S, JANKE J, GORZELNIAK K, et al. Regulation of the nitric oxide system in human adipose tissue[J]. The Journal of Lipid Research, 2004, 45:1640-1648.
[39]GAUDIOT N, JAUBERT A M, CHARBONNIER E, et al. Modulation of white adipose tissue lipolysis by nitric oxide[J]. The Journal of Biochemistry, 1998, 273:13475-13481.
[40]GAUDIOT N, RIBIERE C, JAUBERT A M, et al. Endogenous nitric oxide is implicated in the regulation of lipolysis through antioxidantrelated effect[J]. American Journal of Physiology-Cell Physiology, 2000, 279:C1603-C1610.
[41]FRUHBECK G, GOMEZ-AMBROSI J. Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide[J]. Cellular Signaling, 2001, 13:827-833.
[42]LINCOVA D, ISEKOVA D, KMONICKOVA E, et al. Effect of nitric oxide donors on isoprenaline-induced lipolysis in rat epididymal adipose tissue: studies in isolated adipose tissues and immobilized perfused adipocytes[J]. Physiological Research, 2002, 51:387-394.
[43]FAIN J N, KANU A, BAHOUTH S W, et al. Inhibition of leptin release by atrial natriuretic peptide (ANP) in human adipocytes[J]. Biochemical Pharmacology, 2003, 65:1883-1888.
[44]TAN B, YIN Y, LIU Z ,et al. Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle[J]. Journal of Nutritional Biochemistry, 2010, 1(2):118-130.
[45]FU W J, HAYNES T E, KOHLI R, et al. Dietary L-arginine supplementation reduces fat mass in zucker diabetic fatty rats[J]. The Journal of Nutrition, 2005, 135:714-721.
[46]KHEDARA A, GOTO T, MORISHIMA M, et al. Elevated body fat in rats by the dietary nitric oxide synthase inhibitor, L-N omega nitroarginine[J]. Bioscience Biotechnology and Biochemistry, 1999, 63:698-702.
[47]FRUHBECK G, GOMEZ-AMBROSI G. Modulation of the leptin-induced white adipose tissue lipolysis by nitric oxide[J]. Cellular Signaling, 2001, 13:827-833.
[48]KUROWSKA E M, CARROLL K K. Hypocholesterolemic properties of nitric oxide. In vivo and in vitro studies using nitric oxide donors[J]. Biochimica et Biophysica Acta, 1998, 1392:41-50.
[49]KHEDARA A, KAWAI Y, KAYASHITA J, et al. Feeding rats the nitric oxide synthase inhibitor, l-nn-nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation[J]. The Journal of Nutrition, 1996, 126:2563-2567.
[50]GARCIA-VILLAFRANCA J, GUILLEN A, CASTRO J. Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes[J]. Biochemical Pharmacology, 2003, 65:807-812.
[51]FARGHALI H, HYNIE S, VOHNIKOVA Z, et al. Possible dual role of nitric oxide in oxidative stress injury: a study in perfused hepatocytes[J]. International Journal of Immunopharmacology, 1997, 19:599-605.
[52]DESVERGNE B, MICHALIK L, WAHLI W. Be fit or sick: peroxisomal proliferations-activated receptors are down the road[J]. International Journal of Immunopharmacology, 2004, 18:1321-1332.
[53]BUCK M, CHOJKIER M. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants[J]. EMBO Journal, 1996, 15:1753-1765.
[54]IGNARRO L J, BUGA G M, WEI L H, et al. Role of the arginine-nitric oxide pathway in the regulation of vascular smooth muscle cell proliferation [J]. Proceedings of the National Academy of Sciences of the United States of America, 2001, 98:4202-4208.
[55]MARINOS R S, ZHANG W, WU G, et al. Tetrahydrobiopterin levels regulate endothelial cell proliferation[J]. American Journal of Physiology, 2001, 281:H482-H489.
[56]WU G, MORRIS S M, Jr. Arginine metabolism: nitric oxide and beyond[J]. The Journal of Biochemistry, 1998, 336:1-17.
[57]BREDT D S, SNYDER S H. Isolation of nitric oxide synthetase, acalmodulin-requiring enzyme[J]. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87:682-685.
[58]CARDOUNEL A J, XIA Y, ZWEIER J L. Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase[J]. The Journal of Biological Chemistry, 2005, 280:7540-7549.
[59]ALDERTON W K, COOPER C E, KNOWLES R G. Nitric oxide synthases: structure, function and inhibition[J]. The Journal of Biochemistry, 2001, 357:593-615.
[60]GOOKIN J L, CHIANG S, ALLEN J, et al. Nf-κb-mediated expression of iNOS promotes epithelial defense against infection by cryptosporidium parvum in neonatal piglets[J]. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2006, 290:G164-G174.
[61]GOKCE N. L-arginine and hypertension[J]. The Journal of Nutrition, 2004, 134:2807S-2811S.
[62]LEE J, RYU H, FERRANTE R J, et al. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox[J]. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100:4843-4848.
[63]BROSHAN M E, BROSNAN J T. Renal arginine metabolism[J]. The Journal of Nutrition, 2004, 134:2791S-2795S.
[64]GRANIK V G. Metabolism of L-arginine[J]. Pharmaceutical Chemistry Journal, 2003, 37(3):3-20.
[65]WILMORE D. Enteral and parenteral arginine supplementation to improve medical outcomes in hospitalized patients[J]. The Journal of Nutrition, 2004, 134:2863S-2867S.
[66]叶帅，瞿明仁，游金明，等.精氨酸对左旋硝基精氨酸甲酯诱导猪宫内生长受限的缓解作用[J].动物营养学报，2010,22（4）：879-885.
